Aging and Gene Expression in the Primate Brain
Publication Date
August 02, 2005
Journal
PLOS Biology
Authors
Hunter B Fraser, Philipp Khaitovich, Joshua B Plotkin, Svante Pääbo, et al
Volume
3
Issue
9
Pages
e274
DOI
http://doi.org/10.1371/journal.pbio.0030274
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.0030274
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/16048372
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181540
Europe PMC
http://europepmc.org/abstract/MED/16048372
Web of Science
000231820900016
Scopus
24944457649
Mendeley
http://www.mendeley.com/research/aging-gene-expression-primate-brain
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Figshare 5702 Apr 18:48 UTC

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/961848"], "description"=>"<p>The seven regions—anterior cingulate cortex, Broca's area, caudate nucleus, cerebellum, frontal pole, prefrontal cortex, and primary visual cortex—are indicated in red.</p>", "links"=>[], "tags"=>["regions"], "article_id"=>631838, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g001", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Seven_Regions_of_the_Human_Brain_Analyzed_in_This_Work_/631838", "title"=>"The Seven Regions of the Human Brain Analyzed in This Work", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:00:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/962209"], "description"=>"<p>Average expression levels (base two logarithm expression intensity; error bars indicate plus or minus one standard error) in prefrontal cortex were calculated for four sets of genes in both young (two 45-y-old human, or five 7- to 12-y-old chimpanzee) and old (one 70-y-old human, or two older than 40-y-old chimpanzee) samples. Red indicates human genes; blue, chimpanzee genes; solid lines, genes (or orthologs of genes) down-regulated in human frontal pole; and dashed lines, genes (or orthologs) up-regulated in human frontal pole (connecting lines are not meant to imply linear changes in gene expression with age). The chimpanzee expression levels resemble young, but not old, human.</p>", "links"=>[], "tags"=>["chimpanzee"], "article_id"=>632201, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g005", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_Levels_in_Human_and_Chimpanzee_Cortex_/632201", "title"=>"Expression Levels in Human and Chimpanzee Cortex", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:02:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/962016"], "description"=>"<p>Average expression levels (base two logarithm expression intensity; error bars indicate plus or minus one standard error) in prefrontal cortex were calculated for four sets of genes in both young (two 45-y-old) and old (one 70-y-old) human samples. Red indicates cortex expression levels; blue, cerebellum expression levels; solid lines, genes down-regulated in frontal pole; and dashed lines, genes up-regulated in frontal pole (connecting lines are not meant to imply linear changes in gene expression with age). The genes up-regulated with age in cortex are somewhat up-regulated in cerebellum, whereas those down-regulated in cortex do not change at all with age in cerebellum.</p>", "links"=>[], "tags"=>["cortex"], "article_id"=>632007, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g003", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_Levels_in_Human_Cortex_and_Cerebellum_/632007", "title"=>"Expression Levels in Human Cortex and Cerebellum", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:01:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/962061"], "description"=>"<div><p>The abbreviations used are as follows: ACC, anterior cingulate cortex; C, cerebellum; PFC, prefrontal cortex.</p>\n <p>(A) Correlations of aging gene expression patterns between all three possible pairs of the three regions of the chimpanzee brain used in this work (from left to right, number of genes used are 1,343, 2,235, and 1,328). The strong correlation when comparing cortex regions indicates a reproducible pattern of aging in chimpanzee cortex.</p>\n <p>(B) Correlations of aging gene expression patterns between human frontal pole [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b07\" target=\"_blank\">7</a>] and each of the three regions of the chimpanzee brain used in this work (841 genes used in each comparison). The lack of any significant correlation suggests that human and chimpanzee brain aging patterns differ.</p></div>", "links"=>[], "tags"=>["chimpanzee"], "article_id"=>632052, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aging_in_the_Chimpanzee_Brain_/632052", "title"=>"Aging in the Chimpanzee Brain", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:01:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/474620", "https://ndownloader.figshare.com/files/474638"], "description"=>"<div><p>It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes in the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.</p> </div>", "links"=>[], "tags"=>["aging", "primate"], "article_id"=>153559, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.0030274.st001", "https://dx.doi.org/10.1371/journal.pbio.0030274.st002"], "stats"=>{"downloads"=>3, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Aging_and_Gene_Expression_in_the_Primate_Brain/153559", "title"=>"Aging and Gene Expression in the Primate Brain", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-20 13:37:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/961893"], "description"=>"<div><p>The abbreviations used are as follows: ACC, anterior cingulate cortex; BA, Broca's area; C, cerebellum; CN, caudate nucleus; PFC, prefrontal cortex; PVC, primary visual cortex.</p>\n <p>(A) Correlations of aging gene expression patterns between human frontal pole [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b07\" target=\"_blank\">7</a>] and each of the six regions of the human brain from [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b19\" target=\"_blank\">19</a>] (from left to right, number of genes used are 656, 733, 684, 710, 690, and 603). The strong correlation for all four cerebral cortex samples indicates a reproducible aging pattern across all tested regions of cortex; this pattern does not hold for caudate nucleus or cerebellum.</p>\n <p>(B) Correlations of aging gene expression patterns between human prefrontal cortex [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b20\" target=\"_blank\">20</a>] and each of the six regions of the human brain from [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b19\" target=\"_blank\">19</a>] (from left to right, number of genes used are 704, 832, 697, 784, 759, and 674). The strong correlations for all four cortex samples indicates a reproducible aging pattern across all tested regions of cortex but not caudate nucleus or cerebellum, confirming the result of (A).</p>\n <p>(C) Correlations of aging gene expression patterns between cerebellum [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b20\" target=\"_blank\">20</a>] and each of the six regions of the brain from [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b19\" target=\"_blank\">19</a>] (from left to right, number of genes used are 213, 241, 204, 241, 244, and 204). The lack of any significant correlation, even when comparing the two cerebellum aging patterns to each other, suggests that human cerebellum lacks a reproducible aging pattern.</p></div>", "links"=>[], "tags"=>["Computational biology", "neuroscience"], "article_id"=>631881, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aging_in_the_Human_Brain_/631881", "title"=>"Aging in the Human Brain", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:00:27"}
PMC Usage Stats 187514 Jun 18:25 UTC

PMC Usage Stats | Further Information

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Relative Metric 265975505 Apr 16:37 UTC

Relative Metric

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F1000Prime 121 Jun 11:10 UTC

F1000Prime | Further Information

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