CiteULike | Further Information

• {"link"=>{"url"=>"http://www.citeulike.org/user/provero/article/4180723"}, "post_time"=>"2009-03-16 09:32:01", "tag"=>["aging", "brain", "chimp", "crevol", "expression_evolution"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pbio.0030274"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/16048372"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=16048372"}], "username"=>"provero", "article_id"=>"4180723"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/cerca/article/4180723"}, "post_time"=>"2010-02-09 15:51:16", "tag"=>["ageing", "aging", "transcription_factors"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pbio.0030274"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/16048372"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=16048372"}], "username"=>"cerca", "article_id"=>"4180723"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/greg/article/4180723"}, "post_time"=>"2009-07-21 15:12:43", "tag"=>["aging", "brain", "microarrays"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pbio.0030274"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/16048372"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=16048372"}], "username"=>"greg", "article_id"=>"4180723"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/aihardin/article/5244995"}, "post_time"=>"2009-07-24 01:26:17", "tag"=>"no-tag", "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pbio.0030274"}, "username"=>"aihardin", "article_id"=>"5244995"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/rick816us/article/5640502"}, "post_time"=>"2009-08-25 15:52:48", "tag"=>"no-tag", "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pbio.0030274"}, "username"=>"rick816us", "article_id"=>"5640502"}

Mendeley | Further Information

{"title"=>"Aging and gene expression in the primate brain", "type"=>"journal", "authors"=>[{"first_name"=>"Hunter B.", "last_name"=>"Fraser", "scopus_author_id"=>"7201872161"}, {"first_name"=>"Philipp", "last_name"=>"Khaitovich", "scopus_author_id"=>"6602559039"}, {"first_name"=>"Joshua B.", "last_name"=>"Plotkin", "scopus_author_id"=>"7006104476"}, {"first_name"=>"Svante", "last_name"=>"Pääbo", "scopus_author_id"=>"7006151134"}, {"first_name"=>"Michael B.", "last_name"=>"Eisen", "scopus_author_id"=>"7004331829"}], "year"=>2005, "source"=>"PLoS Biology", "identifiers"=>{"pmid"=>"16048372", "sgr"=>"24944457649", "doi"=>"10.1371/journal.pbio.0030274", "scopus"=>"2-s2.0-24944457649", "pui"=>"41306448", "isbn"=>"1545-7885 (Linking)", "issn"=>"15449173"}, "id"=>"3414a240-de40-3b9e-afd5-e06553381bb4", "abstract"=>"It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes in the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.", "link"=>"http://www.mendeley.com/research/aging-gene-expression-primate-brain", "reader_count"=>177, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>15, "Researcher"=>51, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>37, "Student > Postgraduate"=>5, "Student > Master"=>15, "Other"=>10, "Student > Bachelor"=>12, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>22}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>15, "Researcher"=>51, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>37, "Student > Postgraduate"=>5, "Student > Master"=>15, "Other"=>10, "Student > Bachelor"=>12, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>22}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>109, "Arts and Humanities"=>2, "Chemical Engineering"=>1, "Computer Science"=>4, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>16, "Medicine and Dentistry"=>15, "Neuroscience"=>11, "Physics and Astronomy"=>2, "Psychology"=>6, "Social Sciences"=>4, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Social Sciences"=>{"Social Sciences"=>4}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>6}, "Unspecified"=>{"Unspecified"=>5}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>2}, "Engineering"=>{"Engineering"=>1}, "Neuroscience"=>{"Neuroscience"=>11}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>109}, "Computer Science"=>{"Computer Science"=>4}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>16}}, "reader_count_by_country"=>{"United States"=>10, "Japan"=>1, "Serbia and Montenegro"=>1, "Brazil"=>1, "United Kingdom"=>2, "Italy"=>1, "Chile"=>1, "France"=>1, "Germany"=>4, "Indonesia"=>1}, "group_count"=>8}

ORCID | Further Information

CrossRef

• {"issn"=>["1863-2653", "1863-2661"], "journal_title"=>"Brain Structure and Function", "journal_abbreviation"=>"Brain Struct Funct", "article_title"=>"Aerobic glycolysis in the primate brain: reconsidering the implications for growth and maintenance", "contributors"=>{"contributor"=>[{"given_name"=>"Amy L.", "surname"=>"Bauernfeind", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Sarah K.", "surname"=>"Barks", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Tetyana", "surname"=>"Duka", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Lawrence I.", "surname"=>"Grossman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Patrick R.", "surname"=>"Hof", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Chet C.", "surname"=>"Sherwood", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"219", "issue"=>"4", "first_page"=>"1149", "year"=>"2014", "publication_type"=>"full_text", "doi"=>"10.1007/s00429-013-0662-z", "fl_count"=>"22"}
• {"issn"=>"00223042", "journal_title"=>"Journal of Neurochemistry", "article_title"=>"Understanding the pathogenesis of Alzheimer’s disease: will RNA-Seq realize the promise of transcriptomics?", "contributors"=>{"contributor"=>[{"given_name"=>"Greg T.", "surname"=>"Sutherland", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Michal", "surname"=>"Janitz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jillian J.", "surname"=>"Kril", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"116", "issue"=>"6", "first_page"=>"937", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1111/j.1471-4159.2010.07157.x", "fl_count"=>"25"}
• {"issn"=>["0962-8436", "1471-2970"], "journal_title"=>"Philosophical Transactions of the Royal Society B: Biological Sciences", "journal_abbreviation"=>"Philosophical Transactions of the Royal Society B: Biological Sciences", "article_title"=>"Genetics and genomics of human ageing", "contributors"=>{"contributor"=>[{"given_name"=>"H. E.", "surname"=>"Wheeler", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"S. K.", "surname"=>"Kim", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"366", "issue"=>"1561", "first_page"=>"43", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1098/rstb.2010.0259", "fl_count"=>"28"}
• {"issn"=>"00068993", "journal_title"=>"Brain Research", "journal_abbreviation"=>"Brain Research", "article_title"=>"Gene profiling of pooled single neuronal cell bodies from laser capture microdissected vervet monkey lateral geniculate nucleus hybridized to the Rhesus Macaque Genome Array", "contributors"=>{"contributor"=>[{"given_name"=>"Pascal E.D.", "surname"=>"Lachance", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Avi", "surname"=>"Chaudhuri", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"1185", "first_page"=>"33", "year"=>"2007", "publication_type"=>"full_text", "doi"=>"10.1016/j.brainres.2007.09.080", "fl_count"=>"2"}
• {"issn"=>["0027-8424", "1091-6490"], "journal_title"=>"Proceedings of the National Academy of Sciences", "journal_abbreviation"=>"Proceedings of the National Academy of Sciences", "article_title"=>"Aging of the cerebral cortex differs between humans and chimpanzees", "contributors"=>{"contributor"=>[{"given_name"=>"C. C.", "surname"=>"Sherwood", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"A. D.", "surname"=>"Gordon", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J. S.", "surname"=>"Allen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"K. A.", "surname"=>"Phillips", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J. M.", "surname"=>"Erwin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"P. R.", "surname"=>"Hof", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"W. D.", "surname"=>"Hopkins", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"108", "issue"=>"32", "first_page"=>"13029", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1073/pnas.1016709108", "fl_count"=>"36"}
• {"issn"=>"2050-084X", "journal_title"=>"eLife", "article_title"=>"Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts", "contributors"=>{"contributor"=>[{"given_name"=>"Christine J", "surname"=>"Huh", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Bo", "surname"=>"Zhang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Matheus B", "surname"=>"Victor", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sonika", "surname"=>"Dahiya", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Luis FZ", "surname"=>"Batista", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Steve", "surname"=>"Horvath", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Andrew S", "surname"=>"Yoo", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"5", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.7554/eLife.18648", "fl_count"=>"10"}
• {"issn"=>["1389-5729", "1573-6768"], "journal_title"=>"Biogerontology", "journal_abbreviation"=>"Biogerontology", "article_title"=>"Activation of the immune response is a key feature of aging in mice", "contributors"=>{"contributor"=>[{"given_name"=>"Thore C.", "surname"=>"Brink", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Christian", "surname"=>"Regenbrecht", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Lloyd", "surname"=>"Demetrius", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Hans", "surname"=>"Lehrach", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"James", "surname"=>"Adjaye", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"10", "issue"=>"6", "first_page"=>"721", "year"=>"2009", "publication_type"=>"full_text", "doi"=>"10.1007/s10522-009-9219-1", "fl_count"=>"14"}
• {"issn"=>"15525260", "journal_title"=>"Alzheimer's & Dementia", "journal_abbreviation"=>"Alzheimer's & Dementia", "article_title"=>"Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease", "contributors"=>{"contributor"=>[{"given_name"=>"Diego", "surname"=>"Mastroeni", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Omar M.", "surname"=>"Khdour", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Elaine", "surname"=>"Delvaux", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jennifer", "surname"=>"Nolz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gary", "surname"=>"Olsen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Nicole", "surname"=>"Berchtold", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Carl", "surname"=>"Cotman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sidney M.", "surname"=>"Hecht", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Paul D.", "surname"=>"Coleman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"13", "issue"=>"5", "first_page"=>"510", "year"=>"2017", "publication_type"=>"full_text", "doi"=>"10.1016/j.jalz.2016.09.003", "fl_count"=>"4"}
• {"issn"=>["0962-8436", "1471-2970"], "journal_title"=>"Philosophical Transactions of the Royal Society B: Biological Sciences", "journal_abbreviation"=>"Philosophical Transactions of the Royal Society B: Biological Sciences", "article_title"=>"The endocannabinoid system in normal and pathological brain ageing", "contributors"=>{"contributor"=>{"given_name"=>"A.", "surname"=>"Bilkei-Gorzo", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"367", "issue"=>"1607", "first_page"=>"3326", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1098/rstb.2011.0388", "fl_count"=>"36"}
• {"issn"=>"01974580", "journal_title"=>"Neurobiology of Aging", "journal_abbreviation"=>"Neurobiology of Aging", "article_title"=>"Discovering novel microRNAs and age-related nonlinear changes in rat brains using deep sequencing", "contributors"=>{"contributor"=>[{"given_name"=>"Lanxuan", "surname"=>"Yin", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Yubai", "surname"=>"Sun", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jinfeng", "surname"=>"Wu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Siyu", "surname"=>"Yan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Zhenglu", "surname"=>"Deng", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jun", "surname"=>"Wang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Shenke", "surname"=>"Liao", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Dazhong", "surname"=>"Yin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Guolin", "surname"=>"Li", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"36", "issue"=>"2", "first_page"=>"1037", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1016/j.neurobiolaging.2014.11.001", "fl_count"=>"5"}
• {"issn"=>["1687-7063", "1687-7071"], "journal_title"=>"Current Gerontology and Geriatrics Research", "journal_abbreviation"=>"Current Gerontology and Geriatrics Research", "article_title"=>"The Impact of MicroRNAs on Brain Aging and Neurodegeneration", "contributors"=>{"contributor"=>[{"given_name"=>"Stephan P.", "surname"=>"Persengiev", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Ivanela I.", "surname"=>"Kondova", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ronald E.", "surname"=>"Bontrop", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"2012", "first_page"=>"1", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1155/2012/359369", "fl_count"=>"14"}
• {"issn"=>"1932-6203", "journal_title"=>"PLoS ONE", "journal_abbreviation"=>"PLoS ONE", "article_title"=>"Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain", "contributors"=>{"contributor"=>[{"given_name"=>"Sachi", "surname"=>"Inukai", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Alexandre", "surname"=>"de Lencastre", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Michael", "surname"=>"Turner", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Frank", "surname"=>"Slack", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Michael", "surname"=>"Watson", "sequence"=>"first", "contributor_role"=>"editor"}]}, "volume"=>"7", "issue"=>"7", "first_page"=>"e40028", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pone.0040028", "fl_count"=>"49"}
• {"issn"=>"1471-2164", "journal_title"=>"BMC Genomics", "journal_abbreviation"=>"BMC Genomics", "article_title"=>"Sixteen kiwi (Apteryx spp) transcriptomes provide a wealth of genetic markers and insight into sex chromosome evolution in birds", "contributors"=>{"contributor"=>[{"given_name"=>"Kristina M.", "surname"=>"Ramstad", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Hilary C.", "surname"=>"Miller", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gabriel", "surname"=>"Kolle", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"17", "issue"=>"1", "item_number"=>"410", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.1186/s12864-016-2714-2", "fl_count"=>"2"}
• {"issn"=>"1471-2164", "journal_title"=>"BMC Genomics", "journal_abbreviation"=>"BMC Genomics", "article_title"=>"Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia", "contributors"=>{"contributor"=>[{"given_name"=>"Beena M", "surname"=>"Kadakkuzha", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Komolitdin", "surname"=>"Akhmedov", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Tom R", "surname"=>"Capo", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Anthony C", "surname"=>"Carvalloza", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Mohammad", "surname"=>"Fallahi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sathyanarayanan V", "surname"=>"Puthanveettil", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"14", "issue"=>"1", "first_page"=>"880", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1186/1471-2164-14-880", "fl_count"=>"9"}
• {"issn"=>"13509462", "journal_title"=>"Progress in Retinal and Eye Research", "journal_abbreviation"=>"Progress in Retinal and Eye Research", "article_title"=>"Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases", "contributors"=>{"contributor"=>[{"given_name"=>"Melissa K.", "surname"=>"Jones", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Bin", "surname"=>"Lu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sergey", "surname"=>"Girman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Shaomei", "surname"=>"Wang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"58", "first_page"=>"1", "year"=>"2017", "publication_type"=>"full_text", "doi"=>"10.1016/j.preteyeres.2017.01.004", "fl_count"=>"9"}
• {"issn"=>["1471-0072", "1471-0080"], "journal_title"=>"Nature Reviews Molecular Cell Biology", "journal_abbreviation"=>"Nat Rev Mol Cell Biol", "article_title"=>"The role of nuclear architecture in genomic instability and ageing", "contributors"=>{"contributor"=>[{"given_name"=>"Philipp", "surname"=>"Oberdoerffer", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"David A.", "surname"=>"Sinclair", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"8", "issue"=>"9", "first_page"=>"692", "year"=>"2007", "publication_type"=>"full_text", "doi"=>"10.1038/nrm2238", "fl_count"=>"110"}
• {"issn"=>["0004-8674", "1440-1614"], "journal_title"=>"Australian & New Zealand Journal of Psychiatry", "journal_abbreviation"=>"Aust N Z J Psychiatry", "article_title"=>"Is Schizophrenia the Price of Human Central Nervous System Complexity?", "contributors"=>{"contributor"=>{"given_name"=>"Brian", "surname"=>"Dean", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"43", "issue"=>"1", "first_page"=>"13", "year"=>"2009", "publication_type"=>"full_text", "doi"=>"10.1080/00048670802534416", "fl_count"=>"20"}
• {"issn"=>"01664328", "journal_title"=>"Behavioural Brain Research", "journal_abbreviation"=>"Behavioural Brain Research", "article_title"=>"Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease", "contributors"=>{"contributor"=>[{"given_name"=>"Rikki", "surname"=>"Hullinger", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Luigi", "surname"=>"Puglielli", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"322", "first_page"=>"191", "year"=>"2017", "publication_type"=>"full_text", "doi"=>"10.1016/j.bbr.2016.05.008", "fl_count"=>"7"}
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• {"issn"=>["1094-8341", "1531-2267"], "journal_title"=>"Physiological Genomics", "journal_abbreviation"=>"Physiological Genomics", "article_title"=>"Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats", "contributors"=>{"contributor"=>[{"given_name"=>"Sivasai", "surname"=>"Balivada", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Chanran K.", "surname"=>"Ganta", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yongqing", "surname"=>"Zhang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Hitesh N.", "surname"=>"Pawar", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Richard J.", "surname"=>"Ortiz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Kevin G.", "surname"=>"Becker", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Arshad M.", "surname"=>"Khan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Michael J.", "surname"=>"Kenney", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"49", "issue"=>"8", "first_page"=>"400", "year"=>"2017", "publication_type"=>"full_text", "doi"=>"10.1152/physiolgenomics.00131.2016", "fl_count"=>"1"}
• {"issn"=>["0066-4278", "1545-1585"], "journal_title"=>"Annual Review of Physiology", "journal_abbreviation"=>"Annu. Rev. Physiol.", "article_title"=>"Insulin-Like Signaling, Nutrient Homeostasis, and Life Span", "contributors"=>{"contributor"=>[{"given_name"=>"Akiko", "surname"=>"Taguchi", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Morris F.", "surname"=>"White", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"70", "issue"=>"1", "first_page"=>"191", "year"=>"2008", "publication_type"=>"full_text", "doi"=>"10.1146/annurev.physiol.70.113006.100533", "fl_count"=>"147"}
• {"issn"=>"09581669", "journal_title"=>"Current Opinion in Biotechnology", "journal_abbreviation"=>"Current Opinion in Biotechnology", "article_title"=>"Systems biology of aging in four species", "contributors"=>{"contributor"=>[{"given_name"=>"Jacob M", "surname"=>"Zahn", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Stuart K", "surname"=>"Kim", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"18", "issue"=>"4", "first_page"=>"355", "year"=>"2007", "publication_type"=>"full_text", "doi"=>"10.1016/j.copbio.2007.07.004", "fl_count"=>"29"}
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• {"issn"=>"01974580", "journal_title"=>"Neurobiology of Aging", "journal_abbreviation"=>"Neurobiology of Aging", "article_title"=>"Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine", "contributors"=>{"contributor"=>[{"given_name"=>"Roy", "surname"=>"Lardenoije", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Daniël L.A.", "surname"=>"van den Hove", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Thomas S.J.", "surname"=>"Vaessen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Artemis", "surname"=>"Iatrou", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Koen P.V.", "surname"=>"Meuwissen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Britt T.J.", "surname"=>"van Hagen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gunter", "surname"=>"Kenis", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Harry W.M.", "surname"=>"Steinbusch", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Christoph", "surname"=>"Schmitz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Bart P.F.", "surname"=>"Rutten", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"36", "issue"=>"11", "first_page"=>"3079", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1016/j.neurobiolaging.2015.08.001", "fl_count"=>"3"}
• {"issn"=>"1932-6203", "journal_title"=>"PLoS ONE", "journal_abbreviation"=>"PLoS ONE", "article_title"=>"Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra", "contributors"=>{"contributor"=>[{"given_name"=>"Lin", "surname"=>"Gao", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"María", "surname"=>"Hidalgo-Figueroa", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Luis M.", "surname"=>"Escudero", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Juan", "surname"=>"Díaz-Martín", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"José", "surname"=>"López-Barneo", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Alberto", "surname"=>"Pascual", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Richard Jay", "surname"=>"Smeyne", "sequence"=>"first", "contributor_role"=>"editor"}]}, "volume"=>"8", "issue"=>"4", "first_page"=>"e62456", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pone.0062456", "fl_count"=>"6"}
• {"issn"=>"14749718", "journal_title"=>"Aging Cell", "journal_abbreviation"=>"Aging Cell", "article_title"=>"P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion", "contributors"=>{"contributor"=>[{"given_name"=>"Mariana", "surname"=>"Pehar", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Mi Hee", "surname"=>"Ko", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Mi", "surname"=>"Li", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Heidi", "surname"=>"Scrable", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Luigi", "surname"=>"Puglielli", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"13", "issue"=>"3", "first_page"=>"449", "year"=>"2014", "publication_type"=>"full_text", "doi"=>"10.1111/acel.12192", "fl_count"=>"6"}
• {"issn"=>"2045-2322", "journal_title"=>"Scientific Reports", "journal_abbreviation"=>"Sci Rep", "article_title"=>"Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans", "contributors"=>{"contributor"=>[{"given_name"=>"Frauke", "surname"=>"Adamla", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Zoya", "surname"=>"Ignatova", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"5", "issue"=>"1", "item_number"=>"10692", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1038/srep10692", "fl_count"=>"0"}
• {"issn"=>"2045-2322", "journal_title"=>"Scientific Reports", "journal_abbreviation"=>"Sci Rep", "article_title"=>"Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases", "contributors"=>{"contributor"=>[{"given_name"=>"Jialiang", "surname"=>"Yang", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Tao", "surname"=>"Huang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Francesca", "surname"=>"Petralia", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Quan", "surname"=>"Long", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Bin", "surname"=>"Zhang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Carmen", "surname"=>"Argmann", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yong", "surname"=>"Zhao", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Charles V.", "surname"=>"Mobbs", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Eric E.", "surname"=>"Schadt", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jun", "surname"=>"Zhu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Zhidong", "surname"=>"Tu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"5", "issue"=>"1", "item_number"=>"15145", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1038/srep15145", "fl_count"=>"23"}
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• {"issn"=>"14749718", "journal_title"=>"Aging Cell", "journal_abbreviation"=>"Aging Cell", "article_title"=>"Transcriptomics of aged Drosophila\n motor neurons reveals a matrix metalloproteinase that impairs motor function", "contributors"=>{"contributor"=>[{"given_name"=>"Jorge", "surname"=>"Azpurua", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Rebekah E.", "surname"=>"Mahoney", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Benjamin A.", "surname"=>"Eaton", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "first_page"=>"e12729", "year"=>"2018", "publication_type"=>"full_text", "doi"=>"10.1111/acel.12729", "fl_count"=>"0"}
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• {"issn"=>["2154-1264", "2154-1272"], "journal_title"=>"Transcription", "journal_abbreviation"=>"Transcription", "article_title"=>"Decoding human gene expression signatures in the brain", "contributors"=>{"contributor"=>[{"given_name"=>"Guang-Zhong", "surname"=>"Wang", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Genevieve", "surname"=>"Konopka", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"4", "issue"=>"3", "first_page"=>"102", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.4161/trns.24885", "fl_count"=>"2"}
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• {"issn"=>["0027-8424", "1091-6490"], "journal_title"=>"Proceedings of the National Academy of Sciences", "journal_abbreviation"=>"Proceedings of the National Academy of Sciences", "article_title"=>"Distinctive topology of age-associated epigenetic drift in the human interactome", "contributors"=>{"contributor"=>[{"given_name"=>"J.", "surname"=>"West", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"M.", "surname"=>"Widschwendter", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"A. E.", "surname"=>"Teschendorff", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"110", "issue"=>"35", "first_page"=>"14138", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1073/pnas.1307242110", "fl_count"=>"30"}
• {"issn"=>["1863-2653", "1863-2661"], "journal_title"=>"Brain Structure and Function", "journal_abbreviation"=>"Brain Struct Funct", "article_title"=>"A neuronal aging pattern unique to humans and common chimpanzees", "contributors"=>{"contributor"=>[{"given_name"=>"Emmanuel P.", "surname"=>"Gilissen", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Karelle", "surname"=>"Leroy", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Zehra", "surname"=>"Yilmaz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Enikö", "surname"=>"Kövari", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Constantin", "surname"=>"Bouras", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Alain", "surname"=>"Boom", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Luc", "surname"=>"Poncelet", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Joseph M.", "surname"=>"Erwin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Chet C.", "surname"=>"Sherwood", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Patrick R.", "surname"=>"Hof", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jean-Pierre", "surname"=>"Brion", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"221", "issue"=>"1", "first_page"=>"647", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.1007/s00429-014-0931-5", "fl_count"=>"5"}
• {"issn"=>"14749718", "journal_title"=>"Aging Cell", "article_title"=>"Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain", "contributors"=>{"contributor"=>[{"given_name"=>"Yixing", "surname"=>"Han", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Dali", "surname"=>"Han", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Zheng", "surname"=>"Yan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jerome D.", "surname"=>"Boyd-Kirkup", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Christopher D.", "surname"=>"Green", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Philipp", "surname"=>"Khaitovich", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jing-Dong J.", "surname"=>"Han", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"11", "issue"=>"6", "first_page"=>"1055", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1111/acel.12007", "fl_count"=>"17"}
• {"issn"=>"1932-6203", "journal_title"=>"PLoS ONE", "journal_abbreviation"=>"PLoS ONE", "article_title"=>"Evolution of the Aging Brain Transcriptome and Synaptic Regulation", "contributors"=>{"contributor"=>[{"given_name"=>"Patrick M.", "surname"=>"Loerch", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Tao", "surname"=>"Lu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Kelly A.", "surname"=>"Dakin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"James M.", "surname"=>"Vann", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Adrian", "surname"=>"Isaacs", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Chengiz", "surname"=>"Geula", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jianbin", "surname"=>"Wang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ying", "surname"=>"Pan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Dana H.", "surname"=>"Gabuzda", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Cheng", "surname"=>"Li", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Tomas A.", "surname"=>"Prolla", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Bruce A.", "surname"=>"Yankner", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Laszlo", "surname"=>"Orban", "sequence"=>"first", "contributor_role"=>"editor"}]}, "volume"=>"3", "issue"=>"10", "first_page"=>"e3329", "year"=>"2008", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pone.0003329", "fl_count"=>"131"}
• {"issn"=>"1545-7885", "journal_title"=>"PLoS Biology", "journal_abbreviation"=>"PLoS Biol", "article_title"=>"Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome", "contributors"=>{"contributor"=>[{"given_name"=>"Ingrid", "surname"=>"van der Pluijm", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"George A", "surname"=>"Garinis", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Renata M. C", "surname"=>"Brandt", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Theo G. M. F", "surname"=>"Gorgels", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Susan W", "surname"=>"Wijnhoven", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Karin E. M", "surname"=>"Diderich", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jan", "surname"=>"de Wit", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"James R", "surname"=>"Mitchell", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Conny", "surname"=>"van Oostrom", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Rudolf", "surname"=>"Beems", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Laura J", "surname"=>"Niedernhofer", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Susana", "surname"=>"Velasco", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Errol C", "surname"=>"Friedberg", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Kiyoji", "surname"=>"Tanaka", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Harry", "surname"=>"van Steeg", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jan H. J", "surname"=>"Hoeijmakers", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gijsbertus T. J", "surname"=>"van der Horst", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Priscilla", "surname"=>"Cooper", "sequence"=>"first", "contributor_role"=>"editor"}]}, "volume"=>"5", "issue"=>"1", "first_page"=>"e2", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pbio.0050002", "fl_count"=>"114"}
• {"issn"=>"01974580", "journal_title"=>"Neurobiology of Aging", "journal_abbreviation"=>"Neurobiology of Aging", "article_title"=>"Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis", "contributors"=>{"contributor"=>[{"given_name"=>"Stephan", "surname"=>"Persengiev", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Ivanela", "surname"=>"Kondova", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Nel", "surname"=>"Otting", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Arnulf H.", "surname"=>"Koeppen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ronald E.", "surname"=>"Bontrop", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"32", "issue"=>"12", "first_page"=>"2316.e17", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1016/j.neurobiolaging.2010.03.014", "fl_count"=>"40"}
• {"issn"=>["1474-9718", "1474-9726"], "journal_title"=>"Aging Cell", "journal_abbreviation"=>"Aging Cell", "article_title"=>"Modulated microRNA expression during adult lifespan in Caenorhabditis elegans", "contributors"=>{"contributor"=>[{"given_name"=>"Carolina", "surname"=>"Ibanez-Ventoso", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Maocheng", "surname"=>"Yang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Suzhen", "surname"=>"Guo", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Harlan", "surname"=>"Robins", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Richard W.", "surname"=>"Padgett", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Monica", "surname"=>"Driscoll", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"5", "issue"=>"3", "first_page"=>"235", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1111/j.1474-9726.2006.00210.x", "fl_count"=>"91"}
• {"issn"=>["0340-0727", "1430-2772"], "journal_title"=>"Psychological Research Psychologische Forschung", "journal_abbreviation"=>"Psychological Research", "article_title"=>"Adaptation to a direction-dependent visuomotor gain in the young and elderly", "contributors"=>{"contributor"=>[{"given_name"=>"Mathias", "surname"=>"Hegele", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Herbert", "surname"=>"Heuer", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"74", "issue"=>"1", "first_page"=>"21", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1007/s00426-008-0221-z", "fl_count"=>"17"}
• {"issn"=>"0006291X", "journal_title"=>"Biochemical and Biophysical Research Communications", "journal_abbreviation"=>"Biochemical and Biophysical Research Communications", "article_title"=>"Transcriptomic changes in developing kidney exposed to chronic hypoxia", "contributors"=>{"contributor"=>[{"given_name"=>"Dumitru A.", "surname"=>"Iacobas", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Chenhao", "surname"=>"Fan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sanda", "surname"=>"Iacobas", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"David C.", "surname"=>"Spray", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gabriel G.", "surname"=>"Haddad", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"349", "issue"=>"1", "first_page"=>"329", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1016/j.bbrc.2006.08.056", "fl_count"=>"14"}
• {"issn"=>"1932-6203", "journal_title"=>"PLoS ONE", "journal_abbreviation"=>"PLoS ONE", "article_title"=>"A Pipeline to Determine RT-QPCR Control Genes for Evolutionary Studies: Application to Primate Gene Expression across Multiple Tissues", "contributors"=>{"contributor"=>[{"given_name"=>"Olivier", "surname"=>"Fedrigo", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Lisa R.", "surname"=>"Warner", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Adam D.", "surname"=>"Pfefferle", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Courtney C.", "surname"=>"Babbitt", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Peter", "surname"=>"Cruz-Gordillo", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gregory A.", "surname"=>"Wray", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jeff", "surname"=>"Demuth", "sequence"=>"first", "contributor_role"=>"editor"}]}, "volume"=>"5", "issue"=>"9", "first_page"=>"e12545", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pone.0012545", "fl_count"=>"14"}
• {"issn"=>"2045-2322", "journal_title"=>"Scientific Reports", "journal_abbreviation"=>"Sci Rep", "article_title"=>"An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways", "contributors"=>{"contributor"=>[{"given_name"=>"James", "surname"=>"West", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Stephan", "surname"=>"Beck", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Xiangdong", "surname"=>"Wang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Andrew E.", "surname"=>"Teschendorff", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"3", "issue"=>"1", "item_number"=>"1630", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1038/srep01630", "fl_count"=>"47"}
• {"issn"=>"0254-5853", "journal_title"=>"Zoological Research", "journal_abbreviation"=>"Zoological Research", "article_title"=>"Research proceedings on primate comparative genomics", "contributors"=>{"contributor"=>[{"given_name"=>"Cheng-Hong", "surname"=>"LIAO", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Bing", "surname"=>"SU", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"33", "issue"=>"1", "first_page"=>"108", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.3724/SP.J.1141.2012.01108", "fl_count"=>"0"}
• {"issn"=>"03069877", "journal_title"=>"Medical Hypotheses", "journal_abbreviation"=>"Medical Hypotheses", "article_title"=>"Paleoneurology: Neurodegenerative diseases are age-related diseases of specific brain regions recently developed by homo sapiens", "contributors"=>{"contributor"=>{"given_name"=>"J.", "surname"=>"Ghika", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"71", "issue"=>"5", "first_page"=>"788", "year"=>"2008", "publication_type"=>"full_text", "doi"=>"10.1016/j.mehy.2008.05.034", "fl_count"=>"13"}
• {"issn"=>["1279-7707", "1760-4788"], "journal_title"=>"The journal of nutrition, health & aging", "journal_abbreviation"=>"J Nutr Health Aging", "article_title"=>"Oxidative stress, frailty and cognitive decline", "contributors"=>{"contributor"=>[{"given_name"=>"J.", "surname"=>"Mulero", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"P.", "surname"=>"Zafrilla", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"A.", "surname"=>"Martinez-Cacha", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"15", "issue"=>"9", "first_page"=>"756", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1007/s12603-011-0130-5", "fl_count"=>"43"}
• {"issn"=>"17406765", "journal_title"=>"Drug Discovery Today: Disease Mechanisms", "journal_abbreviation"=>"Drug Discovery Today: Disease Mechanisms", "article_title"=>"Using whole-genome transcriptional analyses to identify molecular mechanisms of aging", "contributors"=>{"contributor"=>{"given_name"=>"Coleen T.", "surname"=>"Murphy", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"3", "issue"=>"1", "first_page"=>"41", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1016/j.ddmec.2006.02.012", "fl_count"=>"8"}
• {"issn"=>"1465-6906", "journal_title"=>"Genome Biology", "journal_abbreviation"=>"Genome Biology", "article_title"=>"Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence", "contributors"=>{"contributor"=>[{"given_name"=>"Ian J", "surname"=>"Donaldson", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Berthold", "surname"=>"Göttgens", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"7", "issue"=>"6", "first_page"=>"R52", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1186/gb-2006-7-6-r52", "fl_count"=>"10"}
• {"issn"=>"10972765", "journal_title"=>"Molecular Cell", "journal_abbreviation"=>"Molecular Cell", "article_title"=>"Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates", "contributors"=>{"contributor"=>[{"given_name"=>"Gregory", "surname"=>"Hannum", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Justin", "surname"=>"Guinney", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ling", "surname"=>"Zhao", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Li", "surname"=>"Zhang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Guy", "surname"=>"Hughes", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"SriniVas", "surname"=>"Sadda", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Brandy", "surname"=>"Klotzle", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Marina", "surname"=>"Bibikova", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jian-Bing", "surname"=>"Fan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yuan", "surname"=>"Gao", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Rob", "surname"=>"Deconde", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Menzies", "surname"=>"Chen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Indika", "surname"=>"Rajapakse", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Stephen", "surname"=>"Friend", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Trey", "surname"=>"Ideker", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Kang", "surname"=>"Zhang", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"49", "issue"=>"2", "first_page"=>"359", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1016/j.molcel.2012.10.016", "fl_count"=>"442"}
• {"issn"=>["0027-8424", "1091-6490"], "journal_title"=>"Proceedings of the National Academy of Sciences", "journal_abbreviation"=>"Proceedings of the National Academy of Sciences", "article_title"=>"Gene expression changes in the course of normal brain aging are sexually dimorphic", "contributors"=>{"contributor"=>[{"given_name"=>"N. C.", "surname"=>"Berchtold", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"D. H.", "surname"=>"Cribbs", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"P. D.", "surname"=>"Coleman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J.", "surname"=>"Rogers", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"E.", "surname"=>"Head", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"R.", "surname"=>"Kim", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"T.", "surname"=>"Beach", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"C.", "surname"=>"Miller", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J.", "surname"=>"Troncoso", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J. Q.", "surname"=>"Trojanowski", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"H. R.", "surname"=>"Zielke", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"C. W.", "surname"=>"Cotman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"105", "issue"=>"40", "first_page"=>"15605", "year"=>"2008", "publication_type"=>"full_text", "doi"=>"10.1073/pnas.0806883105", "fl_count"=>"156"}
• {"issn"=>"1932-6203", "journal_title"=>"PLoS ONE", "journal_abbreviation"=>"PLoS ONE", "article_title"=>"Distinct Transcriptome Expression of the Temporal Cortex of the Primate Microcebus murinus during Brain Aging versus Alzheimer's Disease-Like Pathology", "contributors"=>{"contributor"=>[{"given_name"=>"Ronza", "surname"=>"Abdel Rassoul", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Sabine", "surname"=>"Alves", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Véronique", "surname"=>"Pantesco", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"John", "surname"=>"De Vos", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Bernard", "surname"=>"Michel", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Martine", "surname"=>"Perret", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Nadine", "surname"=>"Mestre-Francés", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jean-Michel", "surname"=>"Verdier", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gina", "surname"=>"Devau", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sérgio Teixeira", "surname"=>"Ferreira", "sequence"=>"first", "contributor_role"=>"editor"}]}, "volume"=>"5", "issue"=>"9", "first_page"=>"e12770", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pone.0012770", "fl_count"=>"8"}
• {"issn"=>["10597794", "10981004"], "journal_title"=>"Human Mutation", "journal_abbreviation"=>"Hum. Mutat.", "article_title"=>"Understanding the recent evolution of the human genome: insights from human-chimpanzee genome comparisons", "contributors"=>{"contributor"=>[{"given_name"=>"Hildegard", "surname"=>"Kehrer-Sawatzki", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"David N.", "surname"=>"Cooper", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"28", "issue"=>"2", "first_page"=>"99", "year"=>"2007", "publication_type"=>"full_text", "doi"=>"10.1002/humu.20420", "fl_count"=>"49"}
• {"issn"=>"08898529", "journal_title"=>"Endocrinology and Metabolism Clinics of North America", "journal_abbreviation"=>"Endocrinology and Metabolism Clinics of North America", "article_title"=>"Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling", "contributors"=>{"contributor"=>[{"given_name"=>"Marianna", "surname"=>"Sadagurski", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Morris F.", "surname"=>"White", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"42", "issue"=>"1", "first_page"=>"127", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1016/j.ecl.2012.11.008", "fl_count"=>"14"}
• {"issn"=>"1663-4365", "journal_title"=>"Frontiers in Aging Neuroscience", "journal_abbreviation"=>"Front. Aging Neurosci.", "article_title"=>"Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains", "contributors"=>{"contributor"=>[{"given_name"=>"Candice L.", "surname"=>"Brinkmeyer-Langford", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Jinting", "surname"=>"Guan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Guoli", "surname"=>"Ji", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"James J.", "surname"=>"Cai", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"8", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.3389/fnagi.2016.00183", "fl_count"=>"5"}
• {"issn"=>["0022-3042", "1471-4159"], "journal_title"=>"Journal of Neurochemistry", "journal_abbreviation"=>"J Neurochem", "article_title"=>"Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging", "contributors"=>{"contributor"=>[{"given_name"=>"Giridharan", "surname"=>"Gokulrangan", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Asma", "surname"=>"Zaidi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Mary L.", "surname"=>"Michaelis", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Christian", "surname"=>"Schöneich", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"0", "issue"=>"0", "first_page"=>"070209222715009", "year"=>"2007", "publication_type"=>"full_text", "doi"=>"10.1111/j.1471-4159.2006.04334.x", "fl_count"=>"3"}
• {"issn"=>["1742-206X", "1742-2051"], "journal_title"=>"Molecular BioSystems", "journal_abbreviation"=>"Mol. BioSyst.", "article_title"=>"Complex patterns of gene expression in human T cells during in vivo aging", "contributors"=>{"contributor"=>[{"given_name"=>"Daniel", "surname"=>"Remondini", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Stefano", "surname"=>"Salvioli", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Mirko", "surname"=>"Francesconi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Michela", "surname"=>"Pierini", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Dawn J.", "surname"=>"Mazzatti", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jonathan R.", "surname"=>"Powell", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Isabella", "surname"=>"Zironi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ferdinando", "surname"=>"Bersani", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gastone", "surname"=>"Castellani", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Claudio", "surname"=>"Franceschi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"6", "issue"=>"10", "first_page"=>"1983", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1039/c004635c", "fl_count"=>"11"}
• {"issn"=>"1663-4365", "journal_title"=>"Frontiers in Aging Neuroscience", "journal_abbreviation"=>"Front. Aging Neurosci.", "article_title"=>"Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex", "contributors"=>{"contributor"=>[{"given_name"=>"Lara", "surname"=>"Ianov", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Asha", "surname"=>"Rani", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Blanca S.", "surname"=>"Beas", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ashok", "surname"=>"Kumar", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Thomas C.", "surname"=>"Foster", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"8", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.3389/fnagi.2016.00113", "fl_count"=>"4"}
• {"issn"=>"01974580", "journal_title"=>"Neurobiology of Aging", "journal_abbreviation"=>"Neurobiology of Aging", "article_title"=>"Age-associated changes in gene expression in human brain and isolated neurons", "contributors"=>{"contributor"=>[{"given_name"=>"Azad", "surname"=>"Kumar", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"J. Raphael", "surname"=>"Gibbs", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Alexandra", "surname"=>"Beilina", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Allissa", "surname"=>"Dillman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ravindran", "surname"=>"Kumaran", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Daniah", "surname"=>"Trabzuni", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Mina", "surname"=>"Ryten", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Robert", "surname"=>"Walker", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Colin", "surname"=>"Smith", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Bryan J.", "surname"=>"Traynor", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"John", "surname"=>"Hardy", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Andrew B.", "surname"=>"Singleton", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Mark R.", "surname"=>"Cookson", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"34", "issue"=>"4", "first_page"=>"1199", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1016/j.neurobiolaging.2012.10.021", "fl_count"=>"21"}
• {"issn"=>"00223042", "journal_title"=>"Journal of Neurochemistry", "article_title"=>"Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition", "contributors"=>{"contributor"=>[{"given_name"=>"Michal", "surname"=>"Hetman", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Aruna", "surname"=>"Vashishta", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Grzegorz", "surname"=>"Rempala", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"114", "issue"=>"6", "first_page"=>"1537", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1111/j.1471-4159.2010.06859.x", "fl_count"=>"33"}
• {"issn"=>"0959437X", "journal_title"=>"Current Opinion in Genetics & Development", "journal_abbreviation"=>"Current Opinion in Genetics & Development", "article_title"=>"Focusing on comparative ape population genetics in the post-genomic age", "contributors"=>{"contributor"=>[{"given_name"=>"Anne C", "surname"=>"Stone", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Brian C", "surname"=>"Verrelli", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"16", "issue"=>"6", "first_page"=>"586", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1016/j.gde.2006.09.003", "fl_count"=>"5"}
• {"issn"=>"01974580", "journal_title"=>"Neurobiology of Aging", "journal_abbreviation"=>"Neurobiology of Aging", "article_title"=>"Neurotrophic signaling molecules associated with cholinergic damage in young and aged rats: Environmental enrichment as potential therapeutic agent", "contributors"=>{"contributor"=>[{"given_name"=>"Véronique", "surname"=>"Paban", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Caroline", "surname"=>"Chambon", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Christine", "surname"=>"Manrique", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Claude", "surname"=>"Touzet", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Béatrice", "surname"=>"Alescio-Lautier", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"32", "issue"=>"3", "first_page"=>"470", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1016/j.neurobiolaging.2009.03.010", "fl_count"=>"12"}
• {"issn"=>"19345909", "journal_title"=>"Cell Stem Cell", "journal_abbreviation"=>"Cell Stem Cell", "article_title"=>"Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects", "contributors"=>{"contributor"=>[{"given_name"=>"Jerome", "surname"=>"Mertens", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Apuã C.M.", "surname"=>"Paquola", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Manching", "surname"=>"Ku", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Emily", "surname"=>"Hatch", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Lena", "surname"=>"Böhnke", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Shauheen", "surname"=>"Ladjevardi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Sean", "surname"=>"McGrath", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Benjamin", "surname"=>"Campbell", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Hyungjun", "surname"=>"Lee", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Joseph R.", "surname"=>"Herdy", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J. Tiago", "surname"=>"Gonçalves", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Tomohisa", "surname"=>"Toda", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yongsung", "surname"=>"Kim", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jürgen", "surname"=>"Winkler", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jun", "surname"=>"Yao", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Martin W.", "surname"=>"Hetzer", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Fred H.", "surname"=>"Gage", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"17", "issue"=>"6", "first_page"=>"705", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1016/j.stem.2015.09.001", "fl_count"=>"91"}
• {"issn"=>"2045-2322", "journal_title"=>"Scientific Reports", "journal_abbreviation"=>"Sci Rep", "article_title"=>"Identification of a T cell gene expression clock obtained by exploiting a MZ twin design", "contributors"=>{"contributor"=>[{"given_name"=>"Daniel", "surname"=>"Remondini", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Nathan", "surname"=>"Intrator", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Claudia", "surname"=>"Sala", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Michela", "surname"=>"Pierini", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Paolo", "surname"=>"Garagnani", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Isabella", "surname"=>"Zironi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Claudio", "surname"=>"Franceschi", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Stefano", "surname"=>"Salvioli", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Gastone", "surname"=>"Castellani", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"7", "issue"=>"1", "item_number"=>"6005", "year"=>"2017", "publication_type"=>"full_text", "doi"=>"10.1038/s41598-017-05694-2", "fl_count"=>"0"}
• {"issn"=>["16159853", "16159861"], "journal_title"=>"PROTEOMICS", "journal_abbreviation"=>"Proteomics", "article_title"=>"Epigenetics to proteomics: From yeast to brain", "contributors"=>{"contributor"=>{"given_name"=>"Purnima", "surname"=>"Bhargava", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"10", "issue"=>"4", "first_page"=>"749", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1002/pmic.200900464", "fl_count"=>"6"}
• {"issn"=>"16720229", "journal_title"=>"Genomics, Proteomics & Bioinformatics", "journal_abbreviation"=>"Genomics, Proteomics & Bioinformatics", "article_title"=>"Microarray Analysis of Ageing-related Signatures and Their Expression in Tumors Based on a Computational Biology Approach", "contributors"=>{"contributor"=>{"given_name"=>"Xiaosheng", "surname"=>"Wang", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"10", "issue"=>"3", "first_page"=>"136", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1016/j.gpb.2012.01.001", "fl_count"=>"1"}
• {"issn"=>["0028-0836", "1476-4687"], "journal_title"=>"Nature", "journal_abbreviation"=>"Nature", "article_title"=>"Neural mechanisms of ageing and cognitive decline", "contributors"=>{"contributor"=>[{"given_name"=>"Nicholas A.", "surname"=>"Bishop", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Tao", "surname"=>"Lu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Bruce A.", "surname"=>"Yankner", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"464", "issue"=>"7288", "first_page"=>"529", "year"=>"2010", "publication_type"=>"full_text", "doi"=>"10.1038/nature08983", "fl_count"=>"427"}
• {"issn"=>["1553-7390", "1553-7404"], "journal_title"=>"PLoS Genetics", "journal_abbreviation"=>"PLoS Genet", "article_title"=>"Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature", "contributors"=>{"contributor"=>[{"given_name"=>"Jacob M.", "surname"=>"Zahn", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Rebecca", "surname"=>"Sonu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Hannes", "surname"=>"Vogel", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Emily", "surname"=>"Crane", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Krystyna", "surname"=>"Mazan-Mamczarz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ralph", "surname"=>"Rabkin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ronald W.", "surname"=>"Davis", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Kevin G.", "surname"=>"Becker", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Art B.", "surname"=>"Owen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Stuart K.", "surname"=>"Kim", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"2", "issue"=>"7", "first_page"=>"e115", "year"=>"2006", "publication_type"=>"full_text", "doi"=>"10.1371/journal.pgen.0020115", "fl_count"=>"171"}

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Scopus | Further Information

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• {"id"=>"665292853917188097", "text"=>"Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeFxIHdT", "created_at"=>"2015-11-13T22:19:11Z", "user"=>"neuroraf", "user_name"=>"Raphael Bene", "user_profile_image"=>"http://pbs.twimg.com/profile_images/447002839974281216/nevg65-F_normal.jpeg"}
• {"id"=>"665311576325382144", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-13T23:33:35Z", "user"=>"PLOSBiology", "user_name"=>"PLOS Biology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2432741784/7kk4r2cpabm7u2lqf17y_normal.jpeg"}
• {"id"=>"665312335544762368", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-13T23:36:36Z", "user"=>"bnborges", "user_name"=>"Bárbara Borges", "user_profile_image"=>"http://pbs.twimg.com/profile_images/611699838414159873/TDfG3_Hk_normal.jpg"}
• {"id"=>"665313224854601730", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-13T23:40:08Z", "user"=>"alfobioq", "user_name"=>"Ivan Alfaro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/503616955752800256/HYUCwMMN_normal.jpeg"}
• {"id"=>"665343469208993792", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-14T01:40:19Z", "user"=>"LDrogosPhD", "user_name"=>"Lauren Drogos", "user_profile_image"=>"http://pbs.twimg.com/profile_images/644248972102504448/WyInKUUz_normal.jpg"}
• {"id"=>"665405827407355906", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-14T05:48:06Z", "user"=>"neil_me", "user_name"=>"Neil Mennie", "user_profile_image"=>"http://pbs.twimg.com/profile_images/334281988/Photo_15_normal.jpg"}
• {"id"=>"665473646824157184", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-14T10:17:35Z", "user"=>"AleAliSousa", "user_name"=>"Alexandra A de Sousa", "user_profile_image"=>"http://pbs.twimg.com/profile_images/468722587652993025/cmIgfRV2_normal.jpeg"}
• {"id"=>"665583861225553920", "text"=>"RT @neuroraf: Aging and Gene Expression in the Primate Brain https://t.co/766tXsuNhD in @PLOSBiology by @mbeisen 's team https://t.co/H3LeF…", "created_at"=>"2015-11-14T17:35:33Z", "user"=>"icequeen146", "user_name"=>"Diana N.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/656281018723205120/wWcv8hyy_normal.jpg"}
• {"id"=>"734065790463381505", "text"=>"@thebyrdlab @GreeneScientist @amy_harmon reminds of an earlier paper on related topic, https://t.co/K0ZK7wxLJe", "created_at"=>"2016-05-21T16:58:17Z", "user"=>"jplotkin", "user_name"=>"Joshua B. Plotkin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1848769382/josh3_normal.jpg"}
• {"id"=>"734475809709260801", "text"=>"RT @jplotkin: @thebyrdlab @GreeneScientist @amy_harmon reminds of an earlier paper on related topic, https://t.co/K0ZK7wxLJe", "created_at"=>"2016-05-22T20:07:33Z", "user"=>"PLOSBiology", "user_name"=>"PLOS Biology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2432741784/7kk4r2cpabm7u2lqf17y_normal.jpeg"}
• {"id"=>"734476271187415040", "text"=>"RT @jplotkin: @thebyrdlab @GreeneScientist @amy_harmon reminds of an earlier paper on related topic, https://t.co/K0ZK7wxLJe", "created_at"=>"2016-05-22T20:09:23Z", "user"=>"saipathudut", "user_name"=>"saipathudu.t/vasan.t", "user_profile_image"=>"http://pbs.twimg.com/profile_images/729112639/what-goes-around-rifle-poster_normal.jpg"}
• {"id"=>"734680767184392192", "text"=>"Aging and Gene Expression in the Primate Brain @PLOSBiology https://t.co/hWBjEXyM1s #genomics #bioinformatics", "created_at"=>"2016-05-23T09:41:59Z", "user"=>"e_nios", "user_name"=>"e-nios", "user_profile_image"=>"http://pbs.twimg.com/profile_images/702983418443919361/O201hU2P_normal.jpg"}
• {"id"=>"734690551782465536", "text"=>"RT @e_nios: Aging and Gene Expression in the Primate Brain @PLOSBiology https://t.co/hWBjEXyM1s #genomics #bioinformatics", "created_at"=>"2016-05-23T10:20:52Z", "user"=>"PLOSBiology", "user_name"=>"PLOS Biology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2432741784/7kk4r2cpabm7u2lqf17y_normal.jpeg"}
• {"id"=>"734721625363337216", "text"=>"@RheeMor @BioinformatcsTp Very interesting study. Wish there were less typos. https://t.co/42IUqBxFpl", "created_at"=>"2016-05-23T12:24:20Z", "user"=>"amandab930", "user_name"=>"Amanda", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589508478965837824/dLCDNC13_normal.png"}
• {"id"=>"734722329628921860", "text"=>"Interesting read. Fewer typos would have been preceded as it was a bit distracting. https://t.co/42IUqBxFpl @RheeMor @BioinformatcsTp", "created_at"=>"2016-05-23T12:27:08Z", "user"=>"amandab930", "user_name"=>"Amanda", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589508478965837824/dLCDNC13_normal.png"}

Wikipedia | Further Information

• {"title"=>"Cerebellum", "url"=>"http://en.wikipedia.org/wiki/Cerebellum", "timestamp"=>"2018-04-06T17:34:38Z"}
• {"title"=>"Móżdżek", "url"=>"http://pl.wikipedia.org/wiki/Móżdżek", "timestamp"=>"2018-04-06T12:32:36Z"}
• {"title"=>"小脑", "url"=>"http://zh.wikipedia.org/wiki/小脑", "timestamp"=>"2018-01-12T14:19:24Z"}
• {"title"=>"Cerebel", "url"=>"http://ca.wikipedia.org/wiki/Cerebel", "timestamp"=>"2018-01-05T17:56:58Z"}
• {"title"=>"مخيخ", "url"=>"http://ar.wikipedia.org/wiki/مخيخ", "timestamp"=>"2018-03-10T13:43:25Z"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/961848"], "description"=>"<p>The seven regions—anterior cingulate cortex, Broca's area, caudate nucleus, cerebellum, frontal pole, prefrontal cortex, and primary visual cortex—are indicated in red.</p>", "links"=>[], "tags"=>["regions"], "article_id"=>631838, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g001", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Seven_Regions_of_the_Human_Brain_Analyzed_in_This_Work_/631838", "title"=>"The Seven Regions of the Human Brain Analyzed in This Work", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:00:04"}
• {"files"=>["https://ndownloader.figshare.com/files/962209"], "description"=>"<p>Average expression levels (base two logarithm expression intensity; error bars indicate plus or minus one standard error) in prefrontal cortex were calculated for four sets of genes in both young (two 45-y-old human, or five 7- to 12-y-old chimpanzee) and old (one 70-y-old human, or two older than 40-y-old chimpanzee) samples. Red indicates human genes; blue, chimpanzee genes; solid lines, genes (or orthologs of genes) down-regulated in human frontal pole; and dashed lines, genes (or orthologs) up-regulated in human frontal pole (connecting lines are not meant to imply linear changes in gene expression with age). The chimpanzee expression levels resemble young, but not old, human.</p>", "links"=>[], "tags"=>["chimpanzee"], "article_id"=>632201, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g005", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_Levels_in_Human_and_Chimpanzee_Cortex_/632201", "title"=>"Expression Levels in Human and Chimpanzee Cortex", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:02:47"}
• {"files"=>["https://ndownloader.figshare.com/files/962016"], "description"=>"<p>Average expression levels (base two logarithm expression intensity; error bars indicate plus or minus one standard error) in prefrontal cortex were calculated for four sets of genes in both young (two 45-y-old) and old (one 70-y-old) human samples. Red indicates cortex expression levels; blue, cerebellum expression levels; solid lines, genes down-regulated in frontal pole; and dashed lines, genes up-regulated in frontal pole (connecting lines are not meant to imply linear changes in gene expression with age). The genes up-regulated with age in cortex are somewhat up-regulated in cerebellum, whereas those down-regulated in cortex do not change at all with age in cerebellum.</p>", "links"=>[], "tags"=>["cortex"], "article_id"=>632007, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g003", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_Levels_in_Human_Cortex_and_Cerebellum_/632007", "title"=>"Expression Levels in Human Cortex and Cerebellum", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:01:21"}
• {"files"=>["https://ndownloader.figshare.com/files/962061"], "description"=>"<div><p>The abbreviations used are as follows: ACC, anterior cingulate cortex; C, cerebellum; PFC, prefrontal cortex.</p>\n <p>(A) Correlations of aging gene expression patterns between all three possible pairs of the three regions of the chimpanzee brain used in this work (from left to right, number of genes used are 1,343, 2,235, and 1,328). The strong correlation when comparing cortex regions indicates a reproducible pattern of aging in chimpanzee cortex.</p>\n <p>(B) Correlations of aging gene expression patterns between human frontal pole [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b07\" target=\"_blank\">7</a>] and each of the three regions of the chimpanzee brain used in this work (841 genes used in each comparison). The lack of any significant correlation suggests that human and chimpanzee brain aging patterns differ.</p></div>", "links"=>[], "tags"=>["chimpanzee"], "article_id"=>632052, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aging_in_the_Chimpanzee_Brain_/632052", "title"=>"Aging in the Chimpanzee Brain", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:01:42"}
• {"files"=>["https://ndownloader.figshare.com/files/474620", "https://ndownloader.figshare.com/files/474638"], "description"=>"<div><p>It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes in the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.</p> </div>", "links"=>[], "tags"=>["aging", "primate"], "article_id"=>153559, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.0030274.st001", "https://dx.doi.org/10.1371/journal.pbio.0030274.st002"], "stats"=>{"downloads"=>3, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Aging_and_Gene_Expression_in_the_Primate_Brain/153559", "title"=>"Aging and Gene Expression in the Primate Brain", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-20 13:37:09"}
• {"files"=>["https://ndownloader.figshare.com/files/961893"], "description"=>"<div><p>The abbreviations used are as follows: ACC, anterior cingulate cortex; BA, Broca's area; C, cerebellum; CN, caudate nucleus; PFC, prefrontal cortex; PVC, primary visual cortex.</p>\n <p>(A) Correlations of aging gene expression patterns between human frontal pole [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b07\" target=\"_blank\">7</a>] and each of the six regions of the human brain from [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b19\" target=\"_blank\">19</a>] (from left to right, number of genes used are 656, 733, 684, 710, 690, and 603). The strong correlation for all four cerebral cortex samples indicates a reproducible aging pattern across all tested regions of cortex; this pattern does not hold for caudate nucleus or cerebellum.</p>\n <p>(B) Correlations of aging gene expression patterns between human prefrontal cortex [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b20\" target=\"_blank\">20</a>] and each of the six regions of the human brain from [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b19\" target=\"_blank\">19</a>] (from left to right, number of genes used are 704, 832, 697, 784, 759, and 674). The strong correlations for all four cortex samples indicates a reproducible aging pattern across all tested regions of cortex but not caudate nucleus or cerebellum, confirming the result of (A).</p>\n <p>(C) Correlations of aging gene expression patterns between cerebellum [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b20\" target=\"_blank\">20</a>] and each of the six regions of the brain from [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0030274#pbio-0030274-b19\" target=\"_blank\">19</a>] (from left to right, number of genes used are 213, 241, 204, 241, 244, and 204). The lack of any significant correlation, even when comparing the two cerebellum aging patterns to each other, suggests that human cerebellum lacks a reproducible aging pattern.</p></div>", "links"=>[], "tags"=>["Computational biology", "neuroscience"], "article_id"=>631881, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Hunter B Fraser", "Philipp Khaitovich", "Joshua B Plotkin", "Svante Pääbo", "Michael B Eisen"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0030274.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aging_in_the_Human_Brain_/631881", "title"=>"Aging in the Human Brain", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:00:27"}

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Relative Metric

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F1000Prime | Further Information

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