Immunoglobulin Heavy Chain Exclusion in the Shark
Publication Date
June 24, 2008
Journal
PLOS Biology
Authors
Karolina Malecek, Victor Lee, Wendy Feng, Jing Li Huang, et al
Volume
6
Issue
6
Pages
e157
DOI
http://doi.org/10.1371/journal.pbio.0060157
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.0060157
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/18578572
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435157
Europe PMC
http://europepmc.org/abstract/MED/18578572
Web of Science
000257105500011
Scopus
45849107256
Mendeley
http://www.mendeley.com/research/immunoglobulin-heavy-chain-exclusion-shark
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Mendeley | Further Information

{"title"=>"Immunoglobulin heavy chain exclusion in the shark", "type"=>"journal", "authors"=>[{"first_name"=>"Karolina", "last_name"=>"Malecek", "scopus_author_id"=>"10039667100"}, {"first_name"=>"Victor", "last_name"=>"Lee", "scopus_author_id"=>"35088374700"}, {"first_name"=>"Wendy", "last_name"=>"Feng", "scopus_author_id"=>"24400863000"}, {"first_name"=>"Jing Li", "last_name"=>"Huang", "scopus_author_id"=>"24401288000"}, {"first_name"=>"Martin F.", "last_name"=>"Flajnik", "scopus_author_id"=>"35481841100"}, {"first_name"=>"Yuko", "last_name"=>"Ohta", "scopus_author_id"=>"35477875500"}, {"first_name"=>"Ellen", "last_name"=>"Hsu", "scopus_author_id"=>"7102911640"}], "year"=>2008, "source"=>"PLoS Biology", "identifiers"=>{"pui"=>"351888307", "sgr"=>"45849107256", "scopus"=>"2-s2.0-45849107256", "isbn"=>"10.1371/journal.pbio.0060157", "pmid"=>"18578572", "doi"=>"10.1371/journal.pbio.0060157", "issn"=>"15449173"}, "id"=>"6fb2be3a-74a7-3d49-bb9d-1531947c58a5", "abstract"=>"The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain locus. How allelic exclusion is regulated is unclear; we considered that sharks, the oldest vertebrates possessing the Ig/TCR-based immune system, would yield insights not previously approachable and reveal the primordial basis of the regulation of allelic exclusion. Sharks have an IgH locus organization consisting of 15-200 independently rearranging miniloci (VH-D1-D2-JH-Cmu), a gene organization that is considered ancestral to the tetrapod and bony fish IgH locus. We found that rearrangement takes place only within a minilocus, and the recombining gene segments are assembled simultaneously and randomly. Only one or few H chain genes were fully rearranged in each shark B cell, whereas the other loci retained their germline configuration. In contrast, most IgH were partially rearranged in every thymocyte (developing T cell) examined, but no IgH transcripts were detected. The distinction between B and T cells in their IgH configurations and transcription reveals a heretofore unsuspected chromatin state permissive for rearrangement in precursor lymphocytes, and suggests that controlled limitation of B cell lineage-specific factors mediate regulated rearrangement and allelic exclusion. This regulation may be shared by higher vertebrates in which additional mechanistic and regulatory elements have evolved with their structurally complex IgH locus.", "link"=>"http://www.mendeley.com/research/immunoglobulin-heavy-chain-exclusion-shark", "reader_count"=>19, "reader_count_by_academic_status"=>{"Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>15, "Medicine and Dentistry"=>2, "Physics and Astronomy"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1, "Brazil"=>1, "Russia"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/475738", "https://ndownloader.figshare.com/files/475816", "https://ndownloader.figshare.com/files/475867", "https://ndownloader.figshare.com/files/475917", "https://ndownloader.figshare.com/files/475964", "https://ndownloader.figshare.com/files/476006", "https://ndownloader.figshare.com/files/476049", "https://ndownloader.figshare.com/files/476091", "https://ndownloader.figshare.com/files/476113", "https://ndownloader.figshare.com/files/476142", "https://ndownloader.figshare.com/files/476169", "https://ndownloader.figshare.com/files/476196", "https://ndownloader.figshare.com/files/476215", "https://ndownloader.figshare.com/files/476233"], "description"=>"<div><p>The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain locus. How allelic exclusion is regulated is unclear; we considered that sharks, the oldest vertebrates possessing the Ig/TCR-based immune system, would yield insights not previously approachable and reveal the primordial basis of the regulation of allelic exclusion. Sharks have an IgH locus organization consisting of 15–200 independently rearranging miniloci (V<sub>H</sub>-D1-D2-J<sub>H</sub>-Cμ), a gene organization that is considered ancestral to the tetrapod and bony fish IgH locus. We found that rearrangement takes place only within a minilocus, and the recombining gene segments are assembled simultaneously and randomly. Only one or few H chain genes were fully rearranged in each shark B cell, whereas the other loci retained their germline configuration. In contrast, most IgH were partially rearranged in every thymocyte (developing T cell) examined, but no IgH transcripts were detected. The distinction between B and T cells in their IgH configurations and transcription reveals a heretofore unsuspected chromatin state permissive for rearrangement in precursor lymphocytes, and suggests that controlled limitation of B cell lineage-specific factors mediate regulated rearrangement and allelic exclusion. This regulation may be shared by higher vertebrates in which additional mechanistic and regulatory elements have evolved with their structurally complex IgH locus.</p> </div>", "links"=>[], "tags"=>["immunoglobulin", "exclusion"], "article_id"=>153746, "categories"=>["Genetics", "Immunology"], "users"=>["Karolina Malecek", "Victor Lee", "Wendy Feng", "Jing Li Huang", "Martin F Flajnik", "Yuko Ohta", "Ellen Hsu"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.0060157.sg001", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg002", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg003", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg004", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg005", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg006", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg007", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg008", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg009", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg010", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg011", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg012", "https://dx.doi.org/10.1371/journal.pbio.0060157.sg013", "https://dx.doi.org/10.1371/journal.pbio.0060157.sd001"], "stats"=>{"downloads"=>15, "page_views"=>98, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Immunoglobulin_Heavy_Chain_Exclusion_in_the_Shark/153746", "title"=>"Immunoglobulin Heavy Chain Exclusion in the Shark", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-06-24 01:02:26"}

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Relative Metric

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