Circadian and Social Cues Regulate Ion Channel Trafficking
Publication Date
September 29, 2009
Journal
PLOS Biology
Authors
Michael R. Markham, M. Lynne Mc Anelly, Philip K. Stoddard & Harold H. Zakon
Volume
7
Issue
9
Pages
e1000203
DOI
http://doi.org/10.1371/journal.pbio.1000203
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1000203
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/19787026
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741594
Europe PMC
http://europepmc.org/abstract/MED/19787026
Web of Science
000270820800016
Scopus
70349765704
Mendeley
http://www.mendeley.com/research/circadian-social-cues-regulate-ion-channel-trafficking
Events
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/881580"], "description"=>"<p>(A) Decrease in peak Na<sup>+</sup> current following 30 min exposure to Saline, CQ, NEM, and BFA. (B) Washing out CQ while maintaining ACTH in the bath saline led to increased INa magnitude (<i>n</i> = 4). (C) Washing out CQ with normal saline for 60 min did not produce recovery of INa, but subsequent addition of ACTH increased INa magnitude (<i>n</i> = 4).</p>", "links"=>[], "tags"=>["washout", "cq"], "article_id"=>552032, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g008", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rundown_of_sodium_current_and_washout_of_CQ_effect_/552032", "title"=>"Rundown of sodium current and washout of CQ effect.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:24:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/881687"], "description"=>"<p>(A,B) CQ and NEM prevented the ACTH-induced increase in IK<sub>IR</sub> magnitude. I-V curves depict normalized steady-state IK at baseline and after 30 min exposure to CQ or NEM, then 30 minutes after addition of ACTH. Potassium currents are isolated in all conditions by blocking INa with 1 µM TTX. The apparent increase in DR current with NEM treatment plus ACTH is not statistically significant when compared at individual membrane voltages. Insets: summary of peak IK<sub>IR</sub> at baseline and after 30 min exposure to CQ or NEM, then 30 min after addition of ACTH. Both compounds produced a decrease in current magnitude. Asterisks indicate conditions significantly different from baseline by Tukey's HSD following significant omnibus repeated measures ANOVA (for CQ <i>F</i><sub>[2,4,8]</sub> = 26.6, <i>p</i><0.001; NEM <i>F</i><sub>[2,5,10]</sub> = 6.00, <i>p</i><0.05). (C) The magnitude of IK<sub>DR</sub> at peak current is not changed by CQ or CQ with ACTH (<i>F</i><sub>[2,4,8]</sub> = 2.76, <i>p</i>>0.1). (D) The magnitude of IK<sub>DR</sub> at peak current was not changed in the presence of NEM or NEM with ACTH (<i>F</i><sub>[2,5,10]</sub> = 0.12, <i>p</i>>0.8).</p>", "links"=>[], "tags"=>["vesicular", "trafficking", "prevents", "acth-induced", "inward", "rectifier", "potassium", "delayed"], "article_id"=>552130, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g009", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disrupting_vesicular_trafficking_prevents_the_ACTH_induced_increase_in_the_inward_rectifier_potassium_current_IK_IR_but_has_no_effect_on_the_delayed_rectifier_current_IK_DR_/552130", "title"=>"Disrupting vesicular trafficking prevents the ACTH-induced increase in the inward rectifier potassium current (IK<sub>IR</sub>) but has no effect on the delayed rectifier current (IK<sub>DR</sub>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:24:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/881932"], "description"=>"<p>(A) Total Na<sup>+</sup> charge movement during peak INa recorded in voltage clamp increases by 43%±6% after treatment with ACTH but decreases by 28%±17% in control cells (<i>t</i> = 4.68, df = 9, <i>p</i><0.01). (B) Treatment with ACTH increases area under the AP by 61%±16%, compared to a 5%±5% decrease in controls (<i>t</i> = 4.20, df = 13, <i>p</i><0.001). (C) Area under the AP is greater in electrocytes harvested at night than in day-harvested electrocytes (<i>t</i> = 2.55, df = 10, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["influx", "enhanced", "electrocyte"], "article_id"=>552388, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g011", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_Na_influx_during_the_enhanced_electrocyte_AP_/552388", "title"=>"Increased Na<sup>+</sup> influx during the enhanced electrocyte AP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:26:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/881132"], "description"=>"<p>(A) AP amplitude (measured from resting potential to AP peak) is higher in electrocytes harvested at night than in those taken during the day (<i>t</i> = 3.39, df = 48, <i>p</i><0.01). (B) Night-harvested electrocytes have lower input resistances than those sampled during the day (<i>t</i> = 2.676, df = 43, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["ap", "amplitude", "higher"], "article_id"=>551590, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g003", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Electrocyte_AP_amplitude_is_higher_at_night_/551590", "title"=>"Electrocyte AP amplitude is higher at night.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:21:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/881038"], "description"=>"<p>(A) Experimental tank used to record calibrated EODs of free-swimming fish. EODs were digitized from nichrome recording electrodes at the ends of the tank only when circuitry detected that the fish was centered within an unglazed ceramic tube, equidistant from the recording electrodes at the ends of the tank. ADC, analog-to-digital-converter. (B) EOD amplitudes of a representative fish recorded approximately every 60 s over 3 d. Signal amplitude shows a clear day-night rhythm increasing to maximum during lights-out and decreasing to a minimum at midday. Inset: superimposed EOD waveforms taken from the same fish at nighttime maximum and daytime minimum. (C) EOD amplitudes were significantly higher at nighttime peak than at daytime minimum (<i>n</i> = 8, <i>t</i> = 3.91, df = 7, <i>p</i><0.01). Bars show means, and error bars indicate SEM. (D) Adding a second fish into the center compartment for 1 h at midday (arrowheads) caused transient increases in EOD amplitudes of four fish. All voltages are referenced to a point 10 cm from the center of a 5 cm calibration dipole <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000203#pbio.1000203-Franchina1\" target=\"_blank\">[38]</a>.</p>", "links"=>[], "tags"=>["cues", "eod"], "article_id"=>551495, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g002", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circadian_and_social_cues_increase_EOD_amplitude_/551495", "title"=>"Circadian and social cues increase EOD amplitude.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:21:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/881454"], "description"=>"<p>(A–C) CQ and NEM prevented the ACTH-induced increase in INa magnitude, whereas BFA did not prevent the ACTH-induced current enhancement. Potassium currents were blocked in all conditions with 60 mM TEA. I-V curves depict normalized INa at baseline and after 30 min exposure to CQ, NEM, or BFA, then 30 min after addition of ACTH. Insets: summary of peak INa at baseline and after 30 min exposure to CQ, NEM, or BFA, then 30 min after addition of ACTH. Asterisks indicate conditions significantly different from other conditions by Tukey's HSD following significant omnibus repeated measures ANOVA (for CQ <i>F</i><sub>[2,4,8]</sub> = 17.13, <i>p</i><0.01; NEM <i>F</i><sub>[2,4,8]</sub> = 17.28, <i>p</i><0.01; BFA <i>F</i><sub>[2,5,10]</sub> = 16.16, <i>p</i><0.001).</p>", "links"=>[], "tags"=>["vesicular", "trafficking", "prevents", "acth-induced"], "article_id"=>551906, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g007", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disrupting_vesicular_trafficking_prevents_the_ACTH_induced_increase_in_INa_/551906", "title"=>"Disrupting vesicular trafficking prevents the ACTH-induced increase in INa.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:23:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/881330"], "description"=>"<p>(A) Sodium currents recorded before and after 20 min exposure to saline or ACTH. Sodium currents were pharmacologically isolated by blocking potassium currents with 60 mM TEA. (B) Sodium current increases after 20 min exposure to ACTH. The PKA blocker H89 has no effect alone, but pretreatment with H89 blocked the ACTH-induced increase in Na<sup>+</sup> current magnitude (<i>n</i> = 5 per condition, ANOVA <i>F</i><sub>[3, 16]</sub> = 9.348, <i>p</i><0.001). (C) Normalized Na<sup>+</sup> I-V curves for cells before and after 20 min saline-control treatment. (D) Normalized Na<sup>+</sup> I-V curves for cells before and after 20 min exposure to ACTH. Voltage of peak INa was unchanged in both control and ACTH-treated cells (paired <i>t</i>-test, df = 4, <i>p</i>>0.3 for both saline and ACTH).</p>", "links"=>[], "tags"=>["increases", "ina"], "article_id"=>551789, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACTH_increases_INa_magnitude_via_the_cAMP_PKA_pathway_/551789", "title"=>"ACTH increases INa magnitude via the cAMP/PKA pathway.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:23:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/880964"], "description"=>"<p>(A) The EOD is produced by the coordinated APs of the electric organ cells, called electrocytes. A medullary pacemaker nucleus controls the electrocyte APs via spinal electromotor neurons which innervate the electrocytes. (B) Electrocytes are innervated on the posterior end of the cell, where the spinal nerve forms a large cholinergic synapse. The electrically excitable region of the cell membrane, populated by Na<sup>+</sup> and K<sup>+</sup> channels, is localized to the posterior most region of the cell, extending approximately 150 µm toward the anterior of the cell. The remainder of the cell membrane is electrically passive. APs in the electrocytes cause current to move along the rostral-caudal body axis and out into the surrounding water. (C) A section of electric organ from the tail, with skin removed to expose the electrocytes, which are densely packed within the electric organ. A single electrocyte is outlined in red. (D) The EOD waveform recorded from <i>S. macrurus</i> is a sinusoidal wave emitted at a steady frequency by each fish. The EOD frequency among fish has a range of approximately 70 to 150 Hz.</p>", "links"=>[], "tags"=>["biophysics", "neuroscience/neuronal signaling mechanisms", "physiology/cell signaling", "physiology/integrative physiology"], "article_id"=>551411, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Generation_of_the_EOD_/551411", "title"=>"Generation of the EOD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:20:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/881824"], "description"=>"<p>(A) Schematic experimental timeline indicating points of INa measurement represented in Panels B–E. Color-coded arrowheads correspond to the colors of representative traces shown in B–D. (B) Representative peak magnitude INa traces at baseline, after ATX-II saturation, and after washout of ATX-II followed by 20 min exposure to saline (top) or ACTH (bottom). Potassium currents were blocked in all conditions by addition of 60 mM TEA. (C) Same traces as in (B), but current amplitudes are normalized to baseline to facilitate direct comparison of the inactivation phase in each current. (D) Current traces following 20 min treatment with saline or ACTH treatment taken from Panel B. Black lines represent the best possible single exponential fit using the slow inactivation time-constant from the corresponding ATX-treated traces. The slow time-constant better accounts for inactivation in the saline treated cell. (E) After washout of ATX-II, τ<sub>fast</sub> accounts for approximately 25% of INa inactivation in all cells prior to 20 min exposure to saline or ACTH. After the 20 min experimental manipulation, the fast component of INa inactivation shows greater recovery in cells treated with ACTH than in saline controls (<i>F</i><sub>[3,12]</sub> = 7.612, <i>p</i><0.01; pairwise comparison significantly different <i>p</i><0.01 by Tukey's HSD).</p>", "links"=>[], "tags"=>["ina", "inactivation", "atx-ii"], "article_id"=>552278, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g010", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACTH_promotes_recovery_of_fast_INa_inactivation_following_ATX_II_treatment_/552278", "title"=>"ACTH promotes recovery of fast INa inactivation following ATX-II treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:25:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/881984"], "description"=>"<p>Ion channel proteins are synthesized in the endoplasmic reticulum and then further processed and inserted into vesicles in the Golgi apparatus. Delayed rectifier potassium channels undergo exocytosis to the cell surface without subsequent endocytosis. Inward rectifier channels and Na<sup>+</sup> channels are constitutively cycled into and out of the membrane. This process is accelerated when the melanocortin peptide hormone ACTH activates a G-protein coupled melanocortin receptor. The receptor initiates a signaling cascade that elevates cAMP and activates PKA. PKA then upregulates the exocytosis of channels into the membrane increasing the number of Na<sup>+</sup> and inward rectifier channels present in the electrocyte membrane, thereby increasing the magnitude of both conductances. For simplicity we have illustrated Na<sup>+</sup> and inward rectifier channels as being in the same vesicles, although we do not know whether they are in the same or different vesicles.</p>", "links"=>[], "tags"=>["controlling", "ion", "trafficking"], "article_id"=>552441, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g012", "stats"=>{"downloads"=>14, "page_views"=>163, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mechanisms_controlling_ion_channel_trafficking_in_S_macrurus_electrocytes_/552441", "title"=>"Mechanisms controlling ion channel trafficking in <i>S. macrurus</i> electrocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:26:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/881202"], "description"=>"<p>(A) Injections of ACTH increased EOD amplitude whereas saline injections have little or no effect. Plots show EODs recorded from two fish that received counterbalanced injections of saline or ACTH at midday. Inset: superimposed representative EOD waveforms taken at baseline and 1 h after ACTH injection. (B, C) Percentage increase in EOD amplitude and half width following injections of saline or ACTH injections. Bars show means, and error bars indicate SEM. (D) Representative traces of APs recorded at baseline and after 20 min exposure to saline (control) or ACTH. (E) In cells exposed to ACTH, AP amplitude and half width increased compared to saline controls. Both experimental and control cells showed slight but similar increases in input resistance (unpublished data). Asterisks indicate conditions different from saline control (unpaired <i>t</i> test, <i>p</i><0.05). (F) Time course of ACTH-induced increase in AP amplitude.</p>", "links"=>[], "tags"=>["increases", "eod", "amplitude", "vivo", "electrocyte", "ap"], "article_id"=>551650, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g004", "stats"=>{"downloads"=>2, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACTH_increases_EOD_amplitude_in_vivo_and_electrocyte_AP_amplitude_in_vitro_/551650", "title"=>"ACTH increases EOD amplitude in vivo and electrocyte AP amplitude in vitro.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:22:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/881391"], "description"=>"<p>(A) Representative family of electrocyte potassium currents recorded with INa blocked by 1 µM TTX. To generate the IV curves in Panel B, current amplitude was measured at steady state (open square in A). (B) Normalized IV curves at baseline and after 20 min exposure to saline (control) or ACTH. (C) Both ACTH and the cAMP analog 8-Br-cAMP increase the magnitude of IK<sub>IR</sub>. The PKA blocker H89 had no effect alone, but pretreatment with H89 blocked the ACTH- and 8-Br-cAMP-induced increase in IK<sub>IR</sub> magnitude. Asterisks indicate conditions different from saline controls (ANOVA <i>F</i><sub>[5, 34]</sub> = 16.22, <i>p</i><0.0001; pairwise comparisons by Tukey's HSD). (D) The delayed rectifier was stable across all experimental conditions (ANOVA <i>F</i><sub>[5, 34]</sub> <1, <i>p</i>>0.5).</p>", "links"=>[], "tags"=>["increases", "inward", "rectifier", "potassium", "delayed"], "article_id"=>551844, "categories"=>["Neuroscience", "Physiology", "Biophysics"], "users"=>["Michael R. Markham", "M. Lynne McAnelly", "Philip K. Stoddard", "Harold H. Zakon"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000203.g006", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACTH_increases_the_inward_rectifier_potassium_current_IK_IR_via_a_cAMP_PKA_pathway_the_delayed_rectifier_current_IK_DR_is_stable_across_all_conditions_/551844", "title"=>"ACTH increases the inward rectifier potassium current (IK<sub>IR</sub>) via a cAMP/PKA pathway; the delayed rectifier current (IK<sub>DR</sub>) is stable across all conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:23:21"}

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