Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification
Publication Date
July 27, 2010
Journal
PLOS Biology
Authors
Stein Aerts, Xiao Jiang Quan, Annelies Claeys, Marina Naval Sanchez, et al
Volume
8
Issue
7
Pages
e1000435
DOI
http://doi.org/10.1371/journal.pbio.1000435
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1000435
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20668662
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910651
Europe PMC
http://europepmc.org/abstract/MED/20668662
Web of Science
000280557100017
Events
Loading … Spinner

CrossRef

Scopus

{"@_fa"=>"true", "error"=>"Result set was empty"}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosbiology%2Farticle%3Fid%3D10.1371%252Fjournal.pbio.1000435", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"145", "xml_views"=>"22", "html_views"=>"409"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"289", "xml_views"=>"79", "html_views"=>"787"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"72", "xml_views"=>"5", "html_views"=>"275"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"55", "xml_views"=>"1", "html_views"=>"187"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"161"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"134"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"112"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"69"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"93"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"6", "html_views"=>"86"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"124"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"113"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"338"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"129"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"198"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"97"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"74"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"114"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"118"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"103"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"78"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}

Figshare

  • {"files"=>["http://files.figshare.com/838152/Figure_1.tif"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "users"=>["Bassem A. Hassan", "Xiao-Jiang Quan", "Annelies Claeys", "Marina Naval Sanchez", "Phillip Tate", "Stein Aerts", "Jiekun Yan"], "links"=>[], "tags"=>["predictions", "dorsal"], "title"=>"<p><i>cis</i>TargetX predictions of Dorsal target genes.</p>", "figshare_url"=>"http://figshare.com/articles/_cis_TargetX_predictions_of_Dorsal_target_genes_/508514", "defined_type"=>1, "doi"=>["http://dx.doi.org/10.1371/journal.pbio.1000435.g001"], "published_date"=>"2010-07-27 02:21:54", "article_id"=>508514, "categories"=>["Genetics", "Developmental Biology", "Computational Biology", "Molecular Biology", "Infectious Diseases", "Virology", "Medicine"], "description"=>"<p>(A) Example of scoring for homotypic clusters of binding sites with Cluster-Buster, using the Dorsal PWM and 1,980 other PWMs. (B) The scoring is applied to all 5-kb upstream sequences and introns (<i>k</i> = 1 to <i>k</i> = 93,330) of 13,667 genes across 12 <i>Drosophila</i> species (<i>i</i> = 1 to <i>i</i> = 12). (C) For each region <i>k</i> of species <i>i</i>, the highest score is retained and used to rank all regions in each species independently. The ranks <i>R</i><sub>k,i</sub> are integrated across the species into one ranking <i>R</i><sub>k</sub>. The highest ranking region for each gene is retained to yield a final ranking of all <i>D. melanogaster</i> genes. (D) Using a set of candidate coexpressed genes, a receiver operating characteristic (ROC) curve is drawn using the dl-PWM based ranking on the <i>x</i>-axis and the recovery of the candidate genes in the <i>y</i>-axis. In this example, a set of 80 genes expressed downstream of dl is used <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000435#pbio.1000435-Stathopoulos3\" target=\"_blank\">[26]</a>. The blue curve (using 12 species) shows significant enrichment of direct Dl targets within the set of 80 candidates. The optimal cut-off at position 220 yields a subset of 13 direct target predictions. (E) Histogram of AUC for all 1,981 PWMs tested, with the best performing PWMs being Dl PWMs, illustrating the use of motif discovery using ROC curves. (F) Predicted target regions are cloned in an enhancer reporter vector.</p>"}
  • {"files"=>["http://files.figshare.com/838238/Figure_2.tif"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "users"=>["Bassem A. Hassan", "Xiao-Jiang Quan", "Annelies Claeys", "Marina Naval Sanchez", "Phillip Tate", "Stein Aerts", "Jiekun Yan"], "links"=>[], "tags"=>["predictions", "ato"], "title"=>"<p><i>cis</i>TargetX predictions of Ato target genes.</p>", "figshare_url"=>"http://figshare.com/articles/_cis_TargetX_predictions_of_Ato_target_genes_/508611", "defined_type"=>1, "doi"=>["http://dx.doi.org/10.1371/journal.pbio.1000435.g002"], "published_date"=>"2010-07-27 02:23:31", "article_id"=>508611, "categories"=>["Genetics", "Developmental Biology", "Computational Biology", "Molecular Biology", "Infectious Diseases", "Virology", "Medicine"], "description"=>"<p >(A) Histogram of AUC values for all ROC curves generated from the rankings using 1,981 PWMs and 204 upregulated genes under Ato GOF conditions. The six best PWMs are all E-box motifs. (B) ROC curve for the best performing motif, RACASCTGY (blue) and the seventh best motif (M00234 for Su(H)). The arrow indicates the optimal cut-off for RACASCTGat position 674, yielding 36 direct Ato target predictions.</p>"}
  • {"files"=>["http://files.figshare.com/418266/Figure_S1.tif", "http://files.figshare.com/418278/Figure_S2.tif", "http://files.figshare.com/418287/Figure_S3.tif", "http://files.figshare.com/418293/Figure_S4.tif", "http://files.figshare.com/418306/Figure_S5.tif", "http://files.figshare.com/418314/Figure_S6.tif", "http://files.figshare.com/418325/Figure_S7.tif", "http://files.figshare.com/418338/Figure_S8.tif", "http://files.figshare.com/418343/Figure_S9.tif", "http://files.figshare.com/418351/Figure_S10.tif", "http://files.figshare.com/418363/Figure_S11.tif", "http://files.figshare.com/418379/Table_S1.pdf", "http://files.figshare.com/418382/Table_S2.pdf", "http://files.figshare.com/418393/Table_S3.pdf", "http://files.figshare.com/418402/Table_S4.pdf", "http://files.figshare.com/418417/Table_S5.pdf", "http://files.figshare.com/418427/Table_S6.pdf", "http://files.figshare.com/418435/Table_S7.pdf", "http://files.figshare.com/418446/Table_S8.pdf", "http://files.figshare.com/418464/Table_S9.pdf", "http://files.figshare.com/418470/Table_S10.pdf", "http://files.figshare.com/418476/Table_S11.pdf", "http://files.figshare.com/418489/Text_S1.pdf", "http://files.figshare.com/418494/Text_S2.pdf"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "users"=>["Bassem A. Hassan", "Xiao-Jiang Quan", "Annelies Claeys", "Marina Naval Sanchez", "Phillip Tate", "Stein Aerts", "Jiekun Yan"], "links"=>[], "tags"=>["specification", "predictions", "uncovers", "sensory", "transcriptome", "robust", "perturbations", "enhancer", "genome-wide"], "title"=>"Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in <em>Drosophila</em> Uncovers a Regulatory Basis for Sensory Specification", "figshare_url"=>"http://figshare.com/articles/Robust_Target_Gene_Discovery_through_Transcriptome_Perturbations_and_Genome_Wide_Enhancer_Predictions_in_Drosophila_Uncovers_a_Regulatory_Basis_for_Sensory_Specification/142582", "defined_type"=>4, "doi"=>["http://dx.doi.org/10.1371/journal.pbio.1000435.s001", "http://dx.doi.org/10.1371/journal.pbio.1000435.s002", "http://dx.doi.org/10.1371/journal.pbio.1000435.s003", "http://dx.doi.org/10.1371/journal.pbio.1000435.s004", "http://dx.doi.org/10.1371/journal.pbio.1000435.s005", "http://dx.doi.org/10.1371/journal.pbio.1000435.s006", "http://dx.doi.org/10.1371/journal.pbio.1000435.s007", "http://dx.doi.org/10.1371/journal.pbio.1000435.s008", "http://dx.doi.org/10.1371/journal.pbio.1000435.s009", "http://dx.doi.org/10.1371/journal.pbio.1000435.s010", "http://dx.doi.org/10.1371/journal.pbio.1000435.s011", "http://dx.doi.org/10.1371/journal.pbio.1000435.s012", "http://dx.doi.org/10.1371/journal.pbio.1000435.s013", "http://dx.doi.org/10.1371/journal.pbio.1000435.s014", "http://dx.doi.org/10.1371/journal.pbio.1000435.s015", "http://dx.doi.org/10.1371/journal.pbio.1000435.s016", "http://dx.doi.org/10.1371/journal.pbio.1000435.s017", "http://dx.doi.org/10.1371/journal.pbio.1000435.s018", "http://dx.doi.org/10.1371/journal.pbio.1000435.s019", "http://dx.doi.org/10.1371/journal.pbio.1000435.s020", "http://dx.doi.org/10.1371/journal.pbio.1000435.s021", "http://dx.doi.org/10.1371/journal.pbio.1000435.s022", "http://dx.doi.org/10.1371/journal.pbio.1000435.s023", "http://dx.doi.org/10.1371/journal.pbio.1000435.s024"], "published_date"=>"2010-07-27 00:43:02", "article_id"=>142582, "categories"=>["Genetics", "Developmental Biology", "Biological Sciences", "Molecular Biology", "Cancer", "Medicine"], "description"=>"<div><p>A comprehensive systems-level understanding of developmental programs requires the mapping of the underlying gene regulatory networks. While significant progress has been made in mapping a few such networks, almost all gene regulatory networks underlying cell-fate specification remain unknown and their discovery is significantly hampered by the paucity of generalized, in vivo validated tools of target gene and functional enhancer discovery. We combined genetic transcriptome perturbations and comprehensive computational analyses to identify a large cohort of target genes of the proneural and tumor suppressor factor Atonal, which specifies the switch from undifferentiated pluripotent cells to R8 photoreceptor neurons during larval development. Extensive in vivo validations of the predicted targets for the proneural factor Atonal demonstrate a 50% success rate of bona fide targets. Furthermore we show that these enhancers are functionally conserved by cloning orthologous enhancers from <em>Drosophila ananassae</em> and <em>D. virilis</em> in <em>D. melanogaster</em>. Finally, to investigate <em>cis</em>-regulatory cross-talk between Ato and other retinal differentiation transcription factors (TFs), we performed motif analyses and independent target predictions for Eyeless, Senseless, Suppressor of Hairless, Rough, and Glass. Our analyses show that <em>cis</em>TargetX identifies the correct motif from a set of coexpressed genes and accurately predicts target genes of individual TFs. The validated set of novel Ato targets exhibit functional enrichment of signaling molecules and a subset is predicted to be coregulated by other TFs within the retinal gene regulatory network.</p></div>"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "unique-ip"=>"4", "pdf"=>"1", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"60", "year"=>"2010", "pdf"=>"40", "unique-ip"=>"53", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"43", "unique-ip"=>"28", "pdf"=>"22", "year"=>"2010", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"32"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"28", "year"=>"2010", "pdf"=>"19", "unique-ip"=>"33", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"11"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"32", "unique-ip"=>"37", "pdf"=>"15", "year"=>"2010", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"10"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"31", "year"=>"2010", "pdf"=>"18", "unique-ip"=>"33", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"27", "pdf"=>"7", "year"=>"2011", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"23", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"20", "unique-ip"=>"28", "pdf"=>"7", "year"=>"2011", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"20", "year"=>"2011", "pdf"=>"9", "unique-ip"=>"26", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"17", "unique-ip"=>"18", "pdf"=>"8", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"27", "year"=>"2011", "pdf"=>"12", "unique-ip"=>"25", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"27", "unique-ip"=>"24", "pdf"=>"4", "year"=>"2011", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"16", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"14", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "unique-ip"=>"15", "pdf"=>"3", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"28", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"24", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"24", "pdf"=>"5", "year"=>"2011", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"13", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "unique-ip"=>"11", "pdf"=>"4", "year"=>"2012", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"17", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"22", "pdf"=>"7", "year"=>"2012", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"13", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"25", "unique-ip"=>"19", "pdf"=>"8", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"19", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"24", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"8", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"12", "pdf"=>"5", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"16", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"0", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[265, 560, 722, 863, 978, 1083, 1172, 1261, 1345, 1428, 1488, 1559, 1630, 1701, 1764, 1840, 1899, 1965, 2028, 2088, 2150, 2211, 2270, 2348, 2410, 2461, 2531, 2598, 2645, 2719, 2793, 2870, 2923, 2974, 3020, 3080, 3142, 3198, 3259, 3351, 3418, 3471, 3527, 3581, 3637, 3706, 3761, 3817, 3872]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 610, 768, 915, 1043, 1164, 1255, 1349, 1432, 1511, 1592, 1674, 1744, 1817, 1889, 1950, 2028, 2087, 2153, 2217, 2274, 2349, 2418, 2488, 2558, 2616, 2686, 2745, 2809, 2869, 2938, 3008, 3071, 3131, 3189, 3258, 3320, 3389, 3446, 3503, 3552, 3613, 3677, 3744, 3788, 3842, 3907, 3966, 4015]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[277, 558, 715, 845, 963, 1070, 1166, 1258, 1336, 1410, 1485, 1561, 1638, 1707, 1767, 1834, 1896, 1960, 2030, 2096, 2165, 2229, 2300, 2368, 2425, 2489, 2553, 2617, 2679, 2743, 2814, 2873, 2941, 2995, 3050, 3111, 3169, 3235, 3300, 3363, 3428, 3487, 3548, 3605, 3670, 3726, 3785, 3844]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[268, 527, 681, 804, 923, 1031, 1126, 1210, 1284, 1361, 1440, 1508, 1578, 1631, 1688, 1754, 1816, 1877, 1945, 2003, 2060, 2125, 2183, 2253, 2313, 2379, 2436, 2513, 2570, 2626, 2702, 2757, 2809, 2885, 2945, 3006, 3067, 3128, 3180, 3237, 3290, 3347, 3397, 3462, 3520, 3585, 3651, 3706, 3755]}]}
Loading … Spinner
There are currently no alerts