Bit by Bit: The Darwinian Basis of Life
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{"title"=>"Bit by bit: The darwinian basis of life", "type"=>"journal", "authors"=>[{"first_name"=>"Gerald F.", "last_name"=>"Joyce", "scopus_author_id"=>"46361343400"}], "year"=>2012, "source"=>"PLoS Biology", "identifiers"=>{"isbn"=>"1545-7885 (Electronic)\\r1544-9173 (Linking)", "scopus"=>"2-s2.0-84861548003", "pui"=>"364901035", "doi"=>"10.1371/journal.pbio.1001323", "sgr"=>"84861548003", "pmid"=>"22589698", "issn"=>"15449173"}, "id"=>"4183981a-723f-3d66-a83b-147c8bdbf377", "abstract"=>"All known examples of life belong to the same biology, but there is increasing enthusiasm among astronomers, astrobiologists, and synthetic biologists that other forms of life may soon be discovered or synthesized. This enthusiasm should be tempered by the fact that the probability for life to originate is not known. As a guiding principle in parsing potential examples of alternative life, one should ask: How many heritable \"bits\" of information are involved, and where did they come from? A genetic system that contains more bits than the number that were required to initiate its operation might reasonably be considered a new form of life.", "link"=>"http://www.mendeley.com/research/bit-bit-darwinian-basis-life", "reader_count"=>200, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>19, "Librarian"=>1, "Researcher"=>63, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>43, "Student > Postgraduate"=>6, "Student > Master"=>15, "Other"=>9, "Student > Bachelor"=>15, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>18}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>19, "Librarian"=>1, "Researcher"=>63, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>43, "Student > Postgraduate"=>6, "Student > Master"=>15, "Other"=>9, "Student > Bachelor"=>15, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>18}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>120, "Arts and Humanities"=>4, "Philosophy"=>1, "Chemistry"=>12, "Computer Science"=>8, "Earth and Planetary Sciences"=>4, "Engineering"=>4, "Environmental Science"=>6, "Biochemistry, Genetics and Molecular Biology"=>15, "Mathematics"=>2, "Medicine and Dentistry"=>4, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>10, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>10}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>4}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>12}, "Neuroscience"=>{"Neuroscience"=>3}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>120}, "Computer Science"=>{"Computer Science"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>15}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Hong Kong"=>1, "United States"=>10, "Portugal"=>2, "Austria"=>3, "Netherlands"=>2, "Sweden"=>1, "Serbia and Montenegro"=>1, "Brazil"=>1, "France"=>3, "Chile"=>2, "Hungary"=>1, "United Kingdom"=>7, "Switzerland"=>1, "Spain"=>4, "India"=>1, "Canada"=>4, "Venezuela"=>1, "Belgium"=>1, "Norway"=>1, "Finland"=>1, "Italy"=>1, "Mexico"=>3, "Australia"=>3, "Peru"=>1, "Germany"=>4}, "group_count"=>1}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/641396"], "description"=>"<p>The root of the tree is indicated by a horizontal line. The locations on the tree of <i>Halomonas</i> sp. (GFAJ-1) <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001323#pbio.1001323-WolfeSimon1\" target=\"_blank\">[2]</a> and <i>Mycoplasma mycoides</i> (JCVI-syn1.0) <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001323#pbio.1001323-Gibson1\" target=\"_blank\">[3]</a> are indicated by black circles adjacent to <i>Escherichia</i> and <i>Bacillus</i>, respectively.</p>", "links"=>[], "tags"=>["small-subunit", "ribosomal", "rna", "kingdoms"], "article_id"=>311890, "categories"=>["Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Gerald F. Joyce"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001323.g001", "stats"=>{"downloads"=>5, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_tree_of_life_based_on_small_subunit_ribosomal_RNA_sequences_showing_representative_species_from_each_of_the_three_kingdoms_compiled_by_Pace_11_/311890", "title"=>"Phylogenetic tree of life based on small-subunit ribosomal RNA sequences, showing representative species from each of the three kingdoms (compiled by Pace [<b>11</b>]).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:26:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/641523"], "description"=>"<p>(A) The replication cycle involves paired RNA enzymes (E in blue, E′ in orange) that catalyze each other's synthesis by joining two corresponding oligonucleotide substrates (A′ and B′ to form E′, A and B to form E). Each substrate contains six nucleotides of variable sequence that are recognized by Watson-Crick pairing to the enzyme. The tertiary structure is based on homology modeling to the crystal structure of the L1 ligase RNA enzyme <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001323#pbio.1001323-Robertson1\" target=\"_blank\">[13]</a>. (B) Sequence and secondary structure of the E·A′·B′ complex, with the two genetic regions (boxed) and two corresponding regions within the functional domain of the enzyme shown in color, and with the immutable nucleotides that are essential for replication shown in black. Curved arrow indicates the site of ligation of A′ and B′ to form E′. The E′·A·B complex has reciprocal composition.</p>", "links"=>[], "tags"=>["rna", "enzymes", "undergoing", "darwinian"], "article_id"=>312027, "categories"=>["Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Gerald F. Joyce"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001323.g003", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Self_replicating_RNA_enzymes_that_are_capable_of_undergoing_Darwinian_evolution_/312027", "title"=>"Self-replicating RNA enzymes that are capable of undergoing Darwinian evolution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:27:25"}

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