Stochastic assembly produces heterogeneous communities in the Caenorhabditis elegans intestine
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{"title"=>"Stochastic assembly produces heterogeneous communities in the Caenorhabditis elegans intestine", "type"=>"journal", "authors"=>[{"first_name"=>"Nicole M.", "last_name"=>"Vega", "scopus_author_id"=>"55190137300"}, {"first_name"=>"Jeff", "last_name"=>"Gore", "scopus_author_id"=>"7202240964"}], "year"=>2017, "source"=>"PLoS Biology", "identifiers"=>{"issn"=>"15457885", "sgr"=>"85016936424", "scopus"=>"2-s2.0-85016936424", "isbn"=>"1111111111", "doi"=>"10.1371/journal.pbio.2000633", "pmid"=>"28257456", "pui"=>"615124763"}, "id"=>"d1d66769-28ff-306f-95e8-396b5f67ee91", "abstract"=>"Author summary Host-associated bacterial communities—also known as microbiomes—vary extensively between individuals, even among clones exposed to the same environment. The sources of this variation are not entirely understood and can be very difficult to determine. In this manuscript, we demonstrate experimentally how randomness in bacterial colonization can result in large differences in the composition of host-associated bacterial communities, using the nematode worm Caenorhabditis elegans as a tractable host model. We find that the amount of variation between individual communities is a function of two rates relevant to how bacteria colonize the host intestine: the colonization rate and the birth rate. We can manipulate the degree of variation between communities by altering the colonization rate, using the amount of bacteria presented to the worms to control the rate at which migrants enter the intestine. When worms are fed with two neutrally competing, fluorescently labeled bacterial strains at low colonization rates, we are able to produce noise-induced bistability in this system, in which each community is dominated by bacteria of only one color. These results demonstrate the potential importance of noise and randomness as a driver of variation between communities and highlight the utility of the simple model organism C. elegans for studying questions relevant to host-associated microbial communities.", "link"=>"http://www.mendeley.com/research/stochastic-assembly-produces-heterogeneous-communities-caenorhabditis-elegans-intestine", "reader_count"=>40, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>18, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>18, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>19, "Medicine and Dentistry"=>1, "Physics and Astronomy"=>8, "Chemical Engineering"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>8}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>19}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"United States"=>2, "Mexico"=>1}, "group_count"=>1}

Scopus | Further Information

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