Astrocytes Optimize the Synaptic Transmission of Information
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{"title"=>"Astrocytes optimize the synaptic transmission of information", "type"=>"journal", "authors"=>[{"first_name"=>"Suhita", "last_name"=>"Nadkarni", "scopus_author_id"=>"8647379100"}, {"first_name"=>"Peter", "last_name"=>"Jung", "scopus_author_id"=>"57197726207"}, {"first_name"=>"Herbert", "last_name"=>"Levine", "scopus_author_id"=>"35399029700"}], "year"=>2008, "source"=>"PLoS Computational Biology", "identifiers"=>{"sgr"=>"44949143938", "doi"=>"10.1371/journal.pcbi.1000088", "pui"=>"351811544", "pmid"=>"18516277", "scopus"=>"2-s2.0-44949143938", "issn"=>"1553734X", "isbn"=>"1553-7358 (Electronic)"}, "id"=>"58fbf790-8356-39c9-b7b9-d42081f680eb", "abstract"=>"Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spontaneous release of vesicles limits the maximum degree of enhancement of synaptic transmission. This gives rise to an optimal tuning that depends on the number of active zones. There is strong experimental evidence that astrocytes that enwrap synapses can modulate the probabilities of vesicle release through bidirectional signaling and hence regulate synaptic transmission. For low-fidelity hippocampal synapses, which typically have only one or two active zones, the predicted optimal values lie close to those determined by experimentally measured astrocytic feedback, suggesting that astrocytes optimize synaptic transmission of information.", "link"=>"http://www.mendeley.com/research/astrocytes-optimize-synaptic-transmission-information", "reader_count"=>74, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>17, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>1, "Student > Master"=>16, "Student > Bachelor"=>8, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>17, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>1, "Student > Master"=>16, "Student > Bachelor"=>8, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Engineering"=>7, "Unspecified"=>3, "Environmental Science"=>1, "Materials Science"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>34, "Medicine and Dentistry"=>1, "Neuroscience"=>8, "Physics and Astronomy"=>5, "Psychology"=>3, "Chemistry"=>1, "Computer Science"=>9}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>7}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>8}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>5}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>34}, "Computer Science"=>{"Computer Science"=>9}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Iran"=>1, "United States"=>2, "Uruguay"=>1, "United Kingdom"=>1, "France"=>1, "Germany"=>3, "India"=>1}, "group_count"=>4}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/930347"], "description"=>"<p>Parameters for asynchronous release (Equation 1).</p>", "links"=>[], "tags"=>["asynchronous"], "article_id"=>600802, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parameters_for_asynchronous_release_Equation_1_/600802", "title"=>"Parameters for asynchronous release (Equation 1).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-05-30 00:13:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/930199"], "description"=>"<p>The vertical line denotes the value of α which corresponds to the experimental tripartite synapse.</p>", "links"=>[], "tags"=>["normalized", "presynaptic", "spiking", "astrocytic", "baseline", "synaptic", "probabilities"], "article_id"=>600644, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g008", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_information_transmission_not_normalized_here_but_at_a_fixed_presynaptic_spiking_frequency_of_5_Hz_is_shown_as_a_function_of_the_astrocytic_feedback_at_various_baseline_synaptic_transmission_probabilities_P_and_a_fixed_number_2_of_active_zones_/600644", "title"=>"The information transmission (not normalized here, but at a fixed presynaptic spiking frequency of 5 Hz) is shown as a function of the astrocytic feedback at various baseline synaptic transmission probabilities P and a fixed number (2) of active zones.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:10:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/930297"], "description"=>"<p>Parameters IP<sub>3</sub> production mediated by neuronal firing (Equation 5).</p>", "links"=>[], "tags"=>["mediated", "neuronal", "firing"], "article_id"=>600745, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parameters_IP_3_production_mediated_by_neuronal_firing_Equation_5_/600745", "title"=>"Parameters IP<sub>3</sub> production mediated by neuronal firing (Equation 5).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-05-30 00:12:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/930108"], "description"=>"<p>The baseline transmission probability is fixed P≈0.18, while the number of active zones varies. The vertical line denotes the value of α that yields the experimentally measured transmission probability of the tripartite synapse.</p>", "links"=>[], "tags"=>["normalized", "presynaptic", "spiking", "astrocytic"], "article_id"=>600554, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Synaptic_transmission_not_normalized_here_but_at_a_fixed_presynaptic_spiking_frequency_of_5_Hz_versus_astrocytic_feedback_/600554", "title"=>"Synaptic transmission (not normalized here, but at a fixed presynaptic spiking frequency of 5 Hz) versus astrocytic feedback.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:09:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/929948"], "description"=>"<p>The vertical line (inset) denotes the value of calcium that yields the experimentally measured transmission probability of the tripartite synapse. The calcium is normalized to the value that maximizes the transmission probability.</p>", "links"=>[], "tags"=>["spontaneous", "vesicle", "single-spike", "probability", "calcium"], "article_id"=>600398, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_signal_transmission_in_the_absence_of_spontaneous_vesicle_release_events_and_single_spike_transmission_probability_inset_as_a_function_of_relative_background_calcium_level_/600398", "title"=>"The signal transmission in the absence of spontaneous vesicle release events and single-spike transmission probability (inset) as a function of relative background calcium level.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:06:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/929899"], "description"=>"<p>The calcium is normalized to the value that maximizes synaptic transmission. The vertical line denotes the value of calcium that yields the experimentally measured transmission probability of the tripartite synapse. The inset shows the power spectrum of the postsynaptic current events at the value of calcium that maximized the signal transmission.</p>", "links"=>[], "tags"=>["presynaptic", "hz", "calcium"], "article_id"=>600350, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Synaptic_signal_transmission_at_a_presynaptic_action_potential_frequency_of_5_Hz_is_shown_as_a_function_of_the_relative_background_calcium_level_/600350", "title"=>"Synaptic signal transmission at a presynaptic action potential frequency of 5 Hz is shown as a function of the relative background calcium level.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:05:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/930150"], "description"=>"<p>The vertical line denotes the value of the feedback strength (α = 0.101 ms<sup>−1</sup>) that yields the experimentally measured transmission probability of the tripartite synapse.</p>", "links"=>[], "tags"=>["astrocyte", "synapse", "calibration", "vesicle"], "article_id"=>600597, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g007", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transmission_of_information_as_a_function_of_feedback_from_the_astrocyte_under_the_assumption_that_the_synapse_we_used_for_calibration_has_one_active_zone_for_vesicle_release_/600597", "title"=>"Transmission of information as a function of feedback from the astrocyte under the assumption that the synapse we used for calibration has one active zone for vesicle release.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:09:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/930277"], "description"=>"<p>Parameters of the modified Li-Rinzel model for astrocytic Ca<sup>2+</sup> oscillations (Equations 6–9).</p>", "links"=>[], "tags"=>["modified", "li-rinzel", "astrocytic", "oscillations"], "article_id"=>600726, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.t005", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parameters_of_the_modified_Li_Rinzel_model_for_astrocytic_Ca_2_oscillations_Equations_6_8211_9_/600726", "title"=>"Parameters of the modified Li-Rinzel model for astrocytic Ca<sup>2+</sup> oscillations (Equations 6–9).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-05-30 00:12:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/929787"], "description"=>"<p>Arrival of an action potential opens voltage gated Ca<sup>2+</sup> channels (white arrow), leading to a quick flux of calcium in the presynaptic terminal (1) that lasts between 1–2 ms. Glutamate (red circles) release in the synaptic cleft (4) takes place due to Ca<sup>2+</sup> binding to vesicle release machinery and initiates a small inward current in the postsynaptic terminal (2) by activating the ionotropic receptors (green and orange bars). For hippocampal synapses, the probability of vesicle (5) release is small, averaging at approximately 0.2. Activation of metabotropic glutamate receptors (indigo and orange bars) on the adjacent astrocytic process (3) due to glutamate binding initiates release of Ca<sup>2+</sup> from internal stores (6) in the astrocyte from IP<sub>3</sub> R-mediated Ca<sup>2+</sup> calcium channels causing an elevation in intracellular [Ca<sup>2+</sup>]. Intracellular [Ca<sup>2+</sup>]-dependent glutamate release from astrocytes triggers opening of Ca<sup>2+</sup> stores (6) in the presynaptic terminal. Availability of two distinct sources of Ca<sup>2+</sup> due to participation of the astrocyte increases neurotransmitter release rates. The astrocyte to neuron coupling parameter <i>α</i> governs the increase in presynaptic [Ca<sup>2+</sup>] and therefore the extent of potentiation.</p>", "links"=>[], "tags"=>["schematic", "synaptic", "glutamatergic", "tripartite"], "article_id"=>600234, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_schematic_of_synaptic_transmission_at_a_glutamatergic_tripartite_synapse_/600234", "title"=>"A schematic of synaptic transmission at a glutamatergic tripartite synapse.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:03:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/930240"], "description"=>"<p>Parameters for presynaptic calcium (Equation 10).</p>", "links"=>[], "tags"=>["presynaptic", "calcium"], "article_id"=>600696, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.t006", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parameters_for_presynaptic_calcium_Equation_10_/600696", "title"=>"Parameters for presynaptic calcium (Equation 10).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-05-30 00:11:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/930063"], "description"=>"<p>Due to the positive feedback from the astrocyte, the dynamical increase in release probability (total DP≈3) until it saturates at P≈5 is shown. When the feedback from the astrocyte is absent the release probability fluctuates around P≈0.2 (see inset).</p>", "links"=>[], "tags"=>["synapse", "functionally", "neurotransmitter", "triggers", "intracellular", "elevation", "consequential", "glutamate"], "article_id"=>600506, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_For_a_synapse_that_is_functionally_associated_with_an_astrocyte_the_initial_neurotransmitter_release_triggers_intracellular_Ca_2_elevation_and_a_consequential_glutamate_release_from_the_astrocyte_/600506", "title"=>"For a synapse that is functionally associated with an astrocyte, the initial neurotransmitter release triggers intracellular Ca<sup>2+</sup> elevation and a consequential glutamate release from the astrocyte.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:08:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/930375"], "description"=>"<p>Rate constants for the release model by Bertram, Sherman, and Stanley <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000088#pcbi.1000088-Bertram1\" target=\"_blank\">[26]</a>.</p>", "links"=>[], "tags"=>["constants", "stanley"], "article_id"=>600828, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rate_constants_for_the_release_model_by_Bertram_Sherman_and_Stanley_26_/600828", "title"=>"Rate constants for the release model by Bertram, Sherman, and Stanley [26].", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-05-30 00:13:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/929988"], "description"=>"<p>Opening of the voltage gated [Ca<sup>2+</sup>] channels due to an action potential gives rise to a [Ca<sup>2+</sup>] pulse that lasts 1.25 ms in our model. The <i>y</i>-axes have been normalized by [Ca<sup>2+</sup>] required to generate a release probability of P≈0.2 (300 µM for the Bertram, Sherman, and Stanley model <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000088#pcbi.1000088-Bertram1\" target=\"_blank\">[26]</a>). (Bottom panel) Intracellular astrocytic [Ca<sup>2+</sup>] response in the astrocyte to 20 Hz of neuronal firing.</p>", "links"=>[], "tags"=>["20", "hz"], "article_id"=>600445, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000088.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Presynaptic_Ca_2_in_response_to_20_Hz_stimulus_without_top_panel_and_with_center_panel_feedback_from_the_astrocyte_/600445", "title"=>"Presynaptic [Ca<sup>2+</sup>] in response to 20 Hz stimulus without (top panel) and with (center panel) feedback from the astrocyte.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-05-30 00:07:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/458683", "https://ndownloader.figshare.com/files/458897"], "description"=>"<div><p>Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spontaneous release of vesicles limits the maximum degree of enhancement of synaptic transmission. This gives rise to an optimal tuning that depends on the number of active zones. There is strong experimental evidence that astrocytes that enwrap synapses can modulate the probabilities of vesicle release through bidirectional signaling and hence regulate synaptic transmission. For low-fidelity hippocampal synapses, which typically have only one or two active zones, the predicted optimal values lie close to those determined by experimentally measured astrocytic feedback, suggesting that astrocytes optimize synaptic transmission of information.</p></div>", "links"=>[], "tags"=>["astrocytes", "optimize", "synaptic"], "article_id"=>150366, "categories"=>["Neuroscience"], "users"=>["Suhita Nadkarni", "Peter Jung", "Herbert Levine"], "doi"=>["https://dx.doi.org/10.1371/journal.pcbi.1000088.s001", "https://dx.doi.org/10.1371/journal.pcbi.1000088.s002"], "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Astrocytes_Optimize_the_Synaptic_Transmission_of_Information/150366", "title"=>"Astrocytes Optimize the Synaptic Transmission of Information", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-05-30 00:06:06"}

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  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}

Relative Metric

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