Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
Publication Date
November 21, 2008
Journal
PLOS Computational Biology
Authors
Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, et al
Volume
4
Issue
11
Pages
e1000225
DOI
http://doi.org/10.1371/journal.pcbi.1000225
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1000225
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/19023406
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579584
Europe PMC
http://europepmc.org/abstract/MED/19023406
Web of Science
000261480800017
Scopus
57149090493
Mendeley
http://www.mendeley.com/research/phylogenetic-dependency-networks-inferring-patterns-ctl-escape-codon-covariation-hiv1-gag
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Phylogenetic dependency networks: Inferring patterns of CTL escape and codon covariation in HIV-1 Gag", "type"=>"journal", "authors"=>[{"first_name"=>"Jonathan M.", "last_name"=>"Carlson", "scopus_author_id"=>"13807311800"}, {"first_name"=>"Zabrina L.", "last_name"=>"Brumme", "scopus_author_id"=>"6602495373"}, {"first_name"=>"Christine M.", "last_name"=>"Rousseau", "scopus_author_id"=>"7102137336"}, {"first_name"=>"Chanson J.", "last_name"=>"Brumme", "scopus_author_id"=>"9274829200"}, {"first_name"=>"Philippa", "last_name"=>"Matthews", "scopus_author_id"=>"56216352700"}, {"first_name"=>"Carl", "last_name"=>"Kadie", "scopus_author_id"=>"55892496800"}, {"first_name"=>"James I.", "last_name"=>"Mullins", "scopus_author_id"=>"35397850800"}, {"first_name"=>"Bruce D.", "last_name"=>"Walker", "scopus_author_id"=>"7402209193"}, {"first_name"=>"P. Richard", "last_name"=>"Harrigan", "scopus_author_id"=>"7004857656"}, {"first_name"=>"Philip J.R.", "last_name"=>"Goulder", "scopus_author_id"=>"7003741802"}, {"first_name"=>"David", "last_name"=>"Heckerman", "scopus_author_id"=>"7004273387"}], "year"=>2008, "source"=>"PLoS Computational Biology", "identifiers"=>{"pui"=>"352773632", "isbn"=>"1553-7358 (Electronic)", "pmid"=>"19023406", "doi"=>"10.1371/journal.pcbi.1000225", "sgr"=>"57149090493", "scopus"=>"2-s2.0-57149090493", "issn"=>"1553734X"}, "id"=>"49114cf5-0348-3043-bbeb-0ca4917bc191", "abstract"=>"HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) class I alleles, previous population-based studies have been limited by the inability to simultaneously account for HIV codon covariation, linkage disequilibrium among HLA alleles, and the confounding effects of HIV phylogeny when attempting to identify HLA-associated viral evolution. We have developed a statistical model of evolution, called a phylogenetic dependency network, that accounts for these three sources of confounding and identifies the primary sources of selection pressure acting on each HIV codon. Using synthetic data, we demonstrate the utility of this approach for identifying sites of HLA-mediated selection pressure and codon evolution as well as the deleterious effects of failing to account for all three sources of confounding. We then apply our approach to a large, clinically-derived dataset of Gag p17 and p24 sequences from a multicenter cohort of 1144 HIV-infected individuals from British Columbia, Canada (predominantly HIV-1 clade B) and Durban, South Africa (predominantly HIV-1 clade C). The resulting phylogenetic dependency network is dense, containing 149 associations between HLA alleles and HIV codons and 1386 associations among HIV codons. These associations include the complete reconstruction of several recently defined escape and compensatory mutation pathways and agree with emerging data on patterns of epitope targeting. The phylogenetic dependency network adds to the growing body of literature suggesting that sites of escape, order of escape, and compensatory mutations are largely consistent even across different clades, although we also identify several differences between clades. As recent case studies have demonstrated, understanding both the complexity and the consistency of immune escape has important implications for CTL-based vaccine design. Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes.", "link"=>"http://www.mendeley.com/research/phylogenetic-dependency-networks-inferring-patterns-ctl-escape-codon-covariation-hiv1-gag", "reader_count"=>109, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>7, "Researcher"=>34, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>34, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>3, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>7, "Researcher"=>34, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>34, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>3, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>67, "Philosophy"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Business, Management and Accounting"=>1, "Chemical Engineering"=>1, "Chemistry"=>1, "Computer Science"=>11, "Biochemistry, Genetics and Molecular Biology"=>5, "Mathematics"=>1, "Medicine and Dentistry"=>14, "Physics and Astronomy"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>67}, "Computer Science"=>{"Computer Science"=>11}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Hungary"=>1, "Belgium"=>1, "United States"=>8, "China"=>1, "South Africa"=>2, "United Kingdom"=>1, "Kenya"=>1, "Germany"=>1}, "group_count"=>5}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/57149090493"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/57149090493?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=57149090493&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=57149090493&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/57149090493", "dc:identifier"=>"SCOPUS_ID:57149090493", "eid"=>"2-s2.0-57149090493", "dc:title"=>"Phylogenetic dependency networks: Inferring patterns of CTL escape and codon covariation in HIV-1 Gag", "dc:creator"=>"Carlson J.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"4", "prism:issueIdentifier"=>"11", "prism:pageRange"=>nil, "prism:coverDate"=>"2008-11-01", "prism:coverDisplayDate"=>"November 2008", "prism:doi"=>"10.1371/journal.pcbi.1000225", "citedby-count"=>"79", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Microsoft Research", "affiliation-city"=>"Redmond", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"University of Washington, Seattle", "affiliation-city"=>"Seattle", "affiliation-country"=>"United States"}], "pubmed-id"=>"19023406", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1000225", "source-id"=>"4000151810"}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%252Fjournal.pcbi.1000225", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"118", "xml_views"=>"4", "html_views"=>"390"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"157", "xml_views"=>"16", "html_views"=>"504"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"39", "xml_views"=>"2", "html_views"=>"128"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"74"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"45"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"76"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"92"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"5", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"5", "html_views"=>"368"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"126"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"5", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"81"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"186"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"69"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"56"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"4", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"135"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/916243"], "description"=>"<p>Bold lines match optimal epitopes. X indicates no significant association.</p>", "links"=>[], "tags"=>["associations", "clade", "resistant"], "article_id"=>586688, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HLA_codon_associations_in_which_clade_B_and_or_clade_C_is_the_predicted_resistant_form_/586688", "title"=>"HLA-codon associations in which clade B and/or clade C is the predicted resistant form.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-11-21 01:51:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/915891"], "description"=>"<p>Precision-recall (A) and calibration curves (B) of the models with respect to HLA-codon associations; precision-recall (C) and calibration curves (D) of the models with respect to both HLA-codon and codon-codon associations. “PLC Strat” and “LC Strat” refer to running and , respectively, on data stratified by clade. The curves reflect the combined results from the two strata.</p>", "links"=>[], "tags"=>["generated", "mixed-clade"], "article_id"=>586334, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g010", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Performance_on_data_generated_from_the_mixed_clade_B_C_dataset_/586334", "title"=>"Performance on data generated from the mixed-clade B/C dataset.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:45:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/915535"], "description"=>"<p>Values correspond to −log<sub>10</sub>(<i>p</i>).</p>", "links"=>[], "tags"=>["clade"], "article_id"=>585979, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantile_Quantile_QQ_plot_of_p_values_on_the_mixed_clade_cohort_/585979", "title"=>"Quantile-Quantile (QQ) plot of <i>p</i>-values on the mixed clade cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:39:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/916184"], "description"=>"<p>Number of associations in optimal epitopes as a function of <i>q</i>-value rank.</p>", "links"=>[], "tags"=>["associations", "optimal", "epitopes"], "article_id"=>586631, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g013", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_associations_in_optimal_epitopes_as_a_function_of_q_value_rank_/586631", "title"=>"Number of associations in optimal epitopes as a function of <i>q</i>-value rank.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:50:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/916084"], "description"=>"<p>Gag p17 and p24 are drawn counterclockwise, with the N-terminus of p17 at the 3 o'clock position. Arcs indicate association between codons (inside the circle) or between HLA alleles and codons (outside the circle). Colors indicate <i>q</i>-values of the most significant association between the two attributes.</p>", "links"=>[], "tags"=>["phylogenetic", "dependency", "homer"], "article_id"=>586536, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g012", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gag_phylogenetic_dependency_network_for_combined_HOMER_and_Contract_cohorts_/586536", "title"=>"Gag phylogenetic dependency network for combined HOMER and Contract cohorts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:48:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/915399"], "description"=>"<p>Here, an amino acid evolves independently down the tree until is reaches an individual, where it is influenced by one or more predictor attributes.</p>", "links"=>[], "tags"=>["multivariate"], "article_id"=>585845, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_multivariate_model_/585845", "title"=>"The multivariate model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:37:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/915286"], "description"=>"<p>A PDN is a graphical model consisting of target attributes whose outcome is a probabilistic function of predictor attributes. Each of these probabilistic functions takes the phylogeny of the sequences into account. Here, the target attributes (green nodes) are binary and represent the presence or absence of amino acids at codons. These target attributes may have dependencies on other codons (codon covariation) and/or on HLA alleles (HLA-mediated escape), which are denoted by blue nodes. Arcs represent the learned dependencies between target and predictor attributes. All target attributes are assumed to be influenced by the phylogeny (red arcs). The probability components of a PDN are the local conditional probabilities, each of which relates a single target attribute to the phylogeny and a subset of the predictor attributes. These local conditional probabilities are learned independently for each target attribute. In the hypothetical example depicted here, B*57 and B*58 predict M1 and A*02 predicts A5. A5 predicts A3, and there is a cyclical dependency among M1, G2, A3 and R4, in which most of the arcs are bidirectional.</p>", "links"=>[], "tags"=>["dependency"], "article_id"=>585734, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_dependency_network_PDN_/585734", "title"=>"Phylogenetic dependency network (PDN).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/452490", "https://ndownloader.figshare.com/files/452496"], "description"=>"<div><p>HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) class I alleles, previous population-based studies have been limited by the inability to simultaneously account for HIV codon covariation, linkage disequilibrium among HLA alleles, and the confounding effects of HIV phylogeny when attempting to identify HLA-associated viral evolution. We have developed a statistical model of evolution, called a phylogenetic dependency network, that accounts for these three sources of confounding and identifies the primary sources of selection pressure acting on each HIV codon. Using synthetic data, we demonstrate the utility of this approach for identifying sites of HLA-mediated selection pressure and codon evolution as well as the deleterious effects of failing to account for all three sources of confounding. We then apply our approach to a large, clinically-derived dataset of Gag p17 and p24 sequences from a multicenter cohort of 1144 HIV-infected individuals from British Columbia, Canada (predominantly HIV-1 clade B) and Durban, South Africa (predominantly HIV-1 clade C). The resulting phylogenetic dependency network is dense, containing 149 associations between HLA alleles and HIV codons and 1386 associations among HIV codons. These associations include the complete reconstruction of several recently defined escape and compensatory mutation pathways and agree with emerging data on patterns of epitope targeting. The phylogenetic dependency network adds to the growing body of literature suggesting that sites of escape, order of escape, and compensatory mutations are largely consistent even across different clades, although we also identify several differences between clades. As recent case studies have demonstrated, understanding both the complexity and the consistency of immune escape has important implications for CTL-based vaccine design. Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes.</p></div>", "links"=>[], "tags"=>["phylogenetic", "dependency", "inferring", "patterns", "ctl", "codon", "covariation", "hiv-1", "gag"], "article_id"=>149123, "categories"=>["Genetics", "Cancer"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>["https://dx.doi.org/10.1371/journal.pcbi.1000225.s001", "https://dx.doi.org/10.1371/journal.pcbi.1000225.s002"], "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Phylogenetic_Dependency_Networks_Inferring_Patterns_of_CTL_Escape_and_Codon_Covariation_in_HIV_1_Gag/149123", "title"=>"Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-11-21 02:32:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/915346"], "description"=>"<p>(A) The null model, in which an amino acid evolves independently down the tree until it reaches a leaf. (B) The alternate model, in which an amino acid evolves independently down the tree until is reaches an individual, where it is influenced by selection pressure from the predictor. The variable <i>H<sub>i</sub></i> for the <i>i</i>th individual represents the variable <i>Y<sub>i</sub></i> had there been no influence from <i>X<sub>i</sub></i>. Only the <i>Y<sub>i</sub></i> and <i>X<sub>i</sub></i> are observed. Conditional probability distributions are not shown.</p>", "links"=>[], "tags"=>["univariate"], "article_id"=>585794, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g002", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_univariate_model_/585794", "title"=>"The univariate model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:36:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/915711"], "description"=>"<p>Precision-recall (A) and calibration curves (B) of the models with respect to HLA-codon associations; precision-recall (C) and calibration curves (D) of the models with respect to both HLA-codon and codon-codon associations. Better precision-recall curves are ones that tend toward the upper right of the plot. Curves with perfect calibration follow the diagonal.</p>", "links"=>[], "tags"=>["generated", "clade", "homer"], "article_id"=>586159, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g008", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Performance_on_data_generated_from_the_97_clade_B_HOMER_cohort_/586159", "title"=>"Performance on data generated from the 97% clade B HOMER cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:42:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/915464"], "description"=>"<p>Each path from root to leaf yields a distinct local probability distribution.</p>", "links"=>[], "tags"=>["computational biology/evolutionary modeling", "genetics and genomics/comparative genomics", "genetics and genomics/genetics of the immune system", "virology/immune evasion", "virology/immunodeficiency viruses", "virology/vaccines", "virology/virus evolution and symbiosis"], "article_id"=>585899, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decision_Tree_leaf_distribution_/585899", "title"=>"Decision Tree leaf distribution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:38:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/915641"], "description"=>"<p>Synthetic data were generated according to the Decision Tree model fit to real data (A) and the Noisy Add model fit to real data (B). On both datasets, the Noisy Add model performs at least as well as the Decision Tree model. In contrast, the Decision Tree model does poorly when applied to data generated from the Noisy Add model.</p>", "links"=>[], "tags"=>["represents"], "article_id"=>586091, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g007", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Noisy_Add_represents_real_data_better_than_Decision_Tree_/586091", "title"=>"Noisy Add represents real data better than Decision Tree.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:41:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/915820"], "description"=>"<p>In the text, “clade B” refers to the predominately red subtree and “clade C” refers to the predominantly blue subtree.</p>", "links"=>[], "tags"=>["built", "homer", "durban", "cohorts"], "article_id"=>586265, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g009", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tree_built_from_the_combined_HOMER_red_and_Durban_blue_cohorts_109_/586265", "title"=>"Tree built from the combined HOMER (red) and Durban (blue) cohorts [109].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:44:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/915596"], "description"=>"<p>(A) A generative process for the univariate leaf distribution. Here, the hidden variable <i>I</i> takes on a value of 0, 1 or −1 depending on whether selection pressure is absent, positive, or negative. (The subscript <i>i</i>, denoting a particular individual, is suppressed for simplicity.) The result is copied to Σ, which determines the result of the selection pressure. (B) The function that maps Σ and <i>H</i> to <i>Y</i>. (C) A generative process for the multivariate Noisy Add leaf distribution. (D) The grouping of the multivariate Noisy Add leaf distribution into a series of summations, grouped as Σ<sub>2</sub> = <i>I</i><sub>1</sub>+<i>I</i><sub>2</sub>, Σ<sub>3</sub> = Σ<sub>2</sub>+<i>I</i><sub>3</sub>, and so on. This grouping makes inference much faster.</p>", "links"=>[], "tags"=>["computational biology/evolutionary modeling", "genetics and genomics/comparative genomics", "genetics and genomics/genetics of the immune system", "virology/immune evasion", "virology/immunodeficiency viruses", "virology/vaccines", "virology/virus evolution and symbiosis"], "article_id"=>586035, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g006", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Noisy_Add_leaf_distribution_/586035", "title"=>"Noisy Add leaf distribution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:40:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/916012"], "description"=>"<p>The “PLC Half” curve plots the power of on synthetic data generated using only associations that were identified from a cohort one half the size of the full cohort. The curves show how power is affected by the strengths of the planted associations.</p>", "links"=>[], "tags"=>["hla-codon", "codon-codon", "associations", "mixed-clade", "cohort"], "article_id"=>586450, "categories"=>["Genetics", "Infectious Diseases", "Virology"], "users"=>["Jonathan M. Carlson", "Zabrina L. Brumme", "Christine M. Rousseau", "Chanson J. Brumme", "Philippa Matthews", "Carl Kadie", "James I. Mullins", "Bruce D. Walker", "P. Richard Harrigan", "Philip J. R. Goulder", "David Heckerman"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000225.g011", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Power_to_detect_both_HLA_codon_and_codon_codon_associations_A_or_just_HLA_codon_associations_B_in_the_mixed_clade_cohort_at_80_precision_/586450", "title"=>"Power to detect both HLA-codon and codon-codon associations (A) or just HLA-codon associations (B) in the mixed-clade cohort at 80% precision.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-21 01:47:30"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"26", "unique-ip"=>"28", "pdf"=>"7", "year"=>"2010", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"17", "year"=>"2010", "pdf"=>"6", "unique-ip"=>"21", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "unique-ip"=>"13", "pdf"=>"11", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"13", "year"=>"2010", "pdf"=>"8", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"3", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2010", "pdf"=>"8", "unique-ip"=>"11", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "unique-ip"=>"10", "pdf"=>"5", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"15", "year"=>"2010", "pdf"=>"16", "unique-ip"=>"20", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"11", "unique-ip"=>"15", "pdf"=>"3", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "year"=>"2010", "pdf"=>"4", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2010", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"9", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"5", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"12", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"14", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"3", "unique-ip"=>"11", "pdf"=>"9", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "unique-ip"=>"10", "pdf"=>"11", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"4", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"2", "full-text"=>"10", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"5", "pdf"=>"5", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"4", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "unique-ip"=>"9", "pdf"=>"3", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "year"=>"2008", "pdf"=>"7", "unique-ip"=>"9", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"45", "unique-ip"=>"42", "pdf"=>"27", "year"=>"2008", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"32", "year"=>"2009", "pdf"=>"22", "unique-ip"=>"31", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"28", "unique-ip"=>"30", "pdf"=>"14", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"38", "year"=>"2009", "pdf"=>"22", "unique-ip"=>"38", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"27", "unique-ip"=>"28", "pdf"=>"19", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"30", "year"=>"2009", "pdf"=>"19", "unique-ip"=>"29", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"22", "unique-ip"=>"22", "pdf"=>"14", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"16", "year"=>"2009", "pdf"=>"9", "unique-ip"=>"18", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"8", "full-text"=>"12", "unique-ip"=>"15", "pdf"=>"9", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"16", "year"=>"2009", "pdf"=>"15", "unique-ip"=>"17", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"14", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"18", "year"=>"2009", "pdf"=>"6", "unique-ip"=>"24", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"20", "unique-ip"=>"17", "pdf"=>"9", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"9", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"2", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}

Relative Metric

{"start_date"=>"2008-01-01T00:00:00Z", "end_date"=>"2008-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[322, 656, 839, 991, 1110, 1218, 1312, 1396, 1482, 1569, 1637, 1714, 1789, 1850, 1914, 1974, 2030, 2092, 2156, 2216, 2277, 2351, 2412, 2468, 2537, 2611, 2665, 2726, 2779, 2831, 2894, 2955, 3006, 3056, 3120, 3174, 3221, 3271, 3328, 3371, 3426, 3474, 3536, 3606, 3653, 3705, 3771, 3826, 3880, 3948, 4018, 4093, 4150, 4198, 4278, 4344, 4419, 4467, 4529, 4592, 4672, 4743, 4795, 4859, 4916, 4977, 5034, 5122, 5176, 5242, 5314, 5374, 5431]}, {"subject_area"=>"/Biology and life sciences/Zoology", "average_usage"=>[351, 717, 876, 1042, 1182, 1294, 1374, 1471, 1534, 1604, 1671, 1745, 1809, 1872, 1918, 1983, 2052, 2105, 2164, 2239, 2324, 2422, 2506, 2569, 2648, 2703, 2756, 2795, 2836, 2895, 2935, 2965, 3020, 3090, 3159, 3206, 3269, 3324, 3373, 3404, 3435, 3471, 3532, 3567, 3628, 3671, 3736, 3793, 3858, 3897, 3956, 4012, 4078, 4128, 4202, 4271, 4369, 4442, 4511, 4590, 4649, 4698, 4779, 4827, 4877, 4943, 5020, 5100, 5164, 5257, 5312, 5368, 5422, 5492]}, {"subject_area"=>"/Computer and information sciences", "average_usage"=>[339, 724, 899, 1082, 1207, 1287, 1387, 1492, 1620, 1704, 1778, 1868, 1917, 1973, 2046, 2095, 2185, 2232, 2275, 2327, 2363, 2404, 2469, 2530, 2615, 2652, 2721, 2770, 2845, 2897, 2939, 2975, 3033, 3084, 3137, 3194, 3256, 3322, 3364, 3419, 3462, 3512, 3586, 3639, 3696, 3760, 3830, 3897, 3962, 4036, 4086, 4124, 4170, 4220, 4272, 4331, 4406, 4478, 4536, 4577, 4639, 4707, 4750, 4795, 4850, 4935, 5033, 5113, 5169, 5210, 5264, 5315, 5356, 5403]}, {"subject_area"=>"/Computer and information sciences/Data management", "average_usage"=>[398, 861, 1090, 1224, 1349, 1476, 1685, 1820, 1922, 2031, 2116, 2192, 2248, 2287, 2330, 2420, 2530, 2659, 2751, 2852, 2953, 3077, 3155, 3255, 3358, 3476, 3581, 3662, 3735, 3793, 3873, 3929, 3971, 4013, 4081, 4159, 4222, 4263, 4298, 4348, 4422, 4483, 4558, 4661, 4770, 4870, 4962, 5042, 5127, 5197, 5262, 5331, 5394, 5463, 5524, 5609, 5669, 5714, 5754, 5816, 5895, 6001, 6077, 6139, 6251, 6373, 6426, 6494, 6553, 6602, 6658, 6712, 6759, 6797]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 661, 845, 1003, 1135, 1248, 1352, 1439, 1532, 1618, 1691, 1765, 1831, 1902, 1969, 2028, 2098, 2159, 2234, 2294, 2356, 2423, 2483, 2548, 2615, 2682, 2743, 2796, 2853, 2907, 2970, 3025, 3078, 3138, 3197, 3243, 3307, 3351, 3420, 3468, 3519, 3569, 3625, 3688, 3739, 3799, 3850, 3911, 3961, 4009, 4075, 4137, 4194, 4263, 4329, 4393, 4449, 4501, 4566, 4638, 4706, 4761, 4828, 4898, 4948, 4999, 5040, 5107, 5170, 5226, 5292, 5352, 5434]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[306, 629, 807, 954, 1065, 1186, 1291, 1390, 1486, 1554, 1623, 1692, 1755, 1817, 1881, 1955, 2001, 2057, 2132, 2209, 2264, 2323, 2404, 2464, 2526, 2602, 2661, 2705, 2770, 2834, 2884, 2942, 2987, 3043, 3097, 3144, 3176, 3234, 3263, 3316, 3368, 3445, 3512, 3578, 3632, 3669, 3729, 3763, 3809, 3859, 3909, 3986, 4088, 4176, 4215, 4263, 4367, 4455, 4503, 4556, 4617, 4668, 4722, 4774, 4830, 4895, 4955, 5022, 5086, 5119, 5158, 5239, 5299]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[363, 721, 930, 1104, 1255, 1348, 1433, 1534, 1606, 1669, 1762, 1803, 1875, 1942, 2013, 2068, 2149, 2213, 2280, 2351, 2390, 2439, 2507, 2579, 2644, 2680, 2723, 2786, 2845, 2899, 2943, 2969, 3021, 3084, 3131, 3180, 3220, 3244, 3268, 3333, 3370, 3438, 3491, 3529, 3575, 3618, 3677, 3718, 3807, 3851, 3957, 4082, 4144, 4197, 4231, 4279, 4340, 4383, 4461, 4505, 4555, 4643, 4686, 4771, 4827, 4886, 4932, 4997, 5051, 5123, 5188, 5243, 5314]}]}
Loading … Spinner
There are currently no alerts