CiteULike

Mendeley | Further Information

{"title"=>"Acute Effects of Sex Steroid Hormones on Susceptibility to Cardiac Arrhythmias: A Simulation Study", "type"=>"journal", "authors"=>[{"first_name"=>"Pei-Chi", "last_name"=>"Yang"}, {"first_name"=>"Junko", "last_name"=>"Kurokawa"}, {"first_name"=>"Tetsushi", "last_name"=>"Furukawa"}, {"first_name"=>"Colleen E.", "last_name"=>"Clancy"}], "year"=>2010, "source"=>"PLoS Computational Biology", "identifiers"=>{"pmid"=>"20126530", "isbn"=>"1553-7358 (Electronic)\\r1553-734X (Linking)", "issn"=>"1553-7358", "doi"=>"10.1371/journal.pcbi.1000658"}, "id"=>"9ed8d9df-aef1-38ba-8c25-fbf314ef8bdd", "abstract"=>"Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent males have shorter QT intervals than females. However, the specific role for hormones in modulating cardiac electrophysiological parameters and arrhythmia vulnerability is unclear. Here we use a computational modeling approach to incorporate experimentally measured effects of physiological concentrations of testosterone, estrogen and progesterone on cardiac ion channel targets. We then study the hormone effects on ventricular cell and tissue dynamics comprised of Faber-Rudy computational models. The \"female\" model predicts changes in action potential duration (APD) at different stages of the menstrual cycle that are consistent with clinically observed QT interval fluctuations. The \"male\" model predicts shortening of APD and QT interval at physiological testosterone concentrations. The model suggests increased susceptibility to drug-induced arrhythmia when estradiol levels are high, while testosterone and progesterone are apparently protective. Simulations predict the effects of sex steroid hormones on clinically observed QT intervals and reveal mechanisms of estrogen-mediated susceptibility to prolongation of QT interval. The simulations also indicate that acute effects of estrogen are not alone sufficient to cause arrhythmia triggers and explain the increased risk of females to Torsades de Pointes. Our results suggest that acute effects of sex steroid hormones on cardiac ion channels are sufficient to account for some aspects of gender specific susceptibility to long-QT linked arrhythmias.", "link"=>"http://www.mendeley.com/research/acute-effects-sex-steroid-hormones-susceptibility-cardiac-arrhythmias-simulation-study-5", "reader_count"=>9, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Chile"=>1}, "group_count"=>1}

ORCID

CrossRef

• {"issn"=>"16748301", "journal_title"=>"Journal of Biomedical Research", "journal_abbreviation"=>"Journal of Biomedical Research", "article_title"=>"Gender-based differences in cardiac disease", "contributors"=>{"contributor"=>[{"given_name"=>"Pei-Chi", "surname"=>"Yang", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Colleen E.", "surname"=>"Clancy", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"25", "issue"=>"2", "first_page"=>"81", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1016/S1674-8301(11)60010-9", "fl_count"=>"3"}
• {"issn"=>["0285-1660", "1884-2437"], "journal_title"=>"Japanese Journal of Electrocardiology", "journal_abbreviation"=>"JPN.J", "volume"=>"34", "issue"=>"3", "first_page"=>"297", "year"=>"2014", "publication_type"=>"full_text", "doi"=>"10.5105/jse.34.297", "fl_count"=>"0"}
• {"issn"=>"00063495", "journal_title"=>"Biophysical Journal", "journal_abbreviation"=>"Biophysical Journal", "article_title"=>"Synchronization of Early Afterdepolarizations and Arrhythmogenesis in Heterogeneous Cardiac Tissue Models", "contributors"=>{"contributor"=>[{"given_name"=>"Enno", "surname"=>"de Lange", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Yuanfang", "surname"=>"Xie", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Zhilin", "surname"=>"Qu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"103", "issue"=>"2", "first_page"=>"365", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1016/j.bpj.2012.06.007", "fl_count"=>"11"}
• {"issn"=>"01637258", "journal_title"=>"Pharmacology & Therapeutics", "journal_abbreviation"=>"Pharmacology & Therapeutics", "article_title"=>"Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes", "contributors"=>{"contributor"=>[{"given_name"=>"Junko", "surname"=>"Kurokawa", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Masami", "surname"=>"Kodama", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Colleen E.", "surname"=>"Clancy", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Tetsushi", "surname"=>"Furukawa", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.1016/j.pharmthera.2016.09.004", "fl_count"=>"0"}
• {"issn"=>"00063495", "journal_title"=>"Biophysical Journal", "journal_abbreviation"=>"Biophysical Journal", "article_title"=>"Models of HERG Gating", "contributors"=>{"contributor"=>[{"given_name"=>"Glenna C.L.", "surname"=>"Bett", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Qinlian", "surname"=>"Zhou", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Randall L.", "surname"=>"Rasmusson", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"101", "issue"=>"3", "first_page"=>"631", "year"=>"2011", "publication_type"=>"full_text", "doi"=>"10.1016/j.bpj.2011.06.050", "fl_count"=>"22"}
• {"issn"=>["0090-6964", "1573-9686"], "journal_title"=>"Annals of Biomedical Engineering", "journal_abbreviation"=>"Ann Biomed Eng", "article_title"=>"Multiscale Modeling in the Clinic: Drug Design and Development", "contributors"=>{"contributor"=>[{"given_name"=>"Colleen E.", "surname"=>"Clancy", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Gary", "surname"=>"An", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"William R.", "surname"=>"Cannon", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yaling", "surname"=>"Liu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Elebeoba E.", "surname"=>"May", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Peter", "surname"=>"Ortoleva", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Aleksander S.", "surname"=>"Popel", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"James P.", "surname"=>"Sluka", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jing", "surname"=>"Su", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Paolo", "surname"=>"Vicini", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Xiaobo", "surname"=>"Zhou", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"David M.", "surname"=>"Eckmann", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"44", "issue"=>"9", "first_page"=>"2591", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.1007/s10439-016-1563-0", "fl_count"=>"2"}
• {"issn"=>"1061-5377", "journal_title"=>"Cardiology in Review", "journal_abbreviation"=>"Cardiology in Review", "article_title"=>"Effect of Female Sex on Cardiac Arrhythmias", "contributors"=>{"contributor"=>[{"given_name"=>"B. M. Pampana", "surname"=>"Gowd", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Paul D.", "surname"=>"Thompson", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"20", "issue"=>"6", "first_page"=>"297", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1097/CRD.0b013e318259294b", "fl_count"=>"13"}
• {"issn"=>"15475271", "journal_title"=>"Heart Rhythm", "journal_abbreviation"=>"Heart Rhythm", "article_title"=>"Decreased repolarization reserve increases defibrillation threshold by favoring early afterdepolarizations in an in silico model of human ventricular tissue", "contributors"=>{"contributor"=>[{"given_name"=>"Nele", "surname"=>"Vandersickel", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Ivan V.", "surname"=>"Kazbanov", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Arne", "surname"=>"Defauw", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Daniël A.", "surname"=>"Pijnappels", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Alexander V.", "surname"=>"Panfilov", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"12", "issue"=>"5", "first_page"=>"1088", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1016/j.hrthm.2015.01.033", "fl_count"=>"1"}
• {"issn"=>["1759-5002", "1759-5010"], "journal_title"=>"Nature Reviews Cardiology", "journal_abbreviation"=>"Nat Rev Cardiol", "article_title"=>"Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis", "contributors"=>{"contributor"=>[{"given_name"=>"Darae", "surname"=>"Ko", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Faisal", "surname"=>"Rahman", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Renate B.", "surname"=>"Schnabel", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Xiaoyan", "surname"=>"Yin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Emelia J.", "surname"=>"Benjamin", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ingrid E.", "surname"=>"Christophersen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"13", "issue"=>"6", "first_page"=>"321", "year"=>"2016", "publication_type"=>"full_text", "doi"=>"10.1038/nrcardio.2016.45", "fl_count"=>"5"}
• {"issn"=>["0022-1295", "1540-7748"], "journal_title"=>"The Journal of General Physiology", "journal_abbreviation"=>"J Gen Physiol", "article_title"=>"Targeting the late component of the cardiac L-type Ca2+current to suppress early afterdepolarizations", "contributors"=>{"contributor"=>[{"given_name"=>"Roshni V.", "surname"=>"Madhvani", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Marina", "surname"=>"Angelini", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yuanfang", "surname"=>"Xie", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Antonios", "surname"=>"Pantazis", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Silvie", "surname"=>"Suriany", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Nils P.", "surname"=>"Borgstrom", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Alan", "surname"=>"Garfinkel", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Zhilin", "surname"=>"Qu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"James N.", "surname"=>"Weiss", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Riccardo", "surname"=>"Olcese", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"145", "issue"=>"5", "first_page"=>"395", "year"=>"2015", "publication_type"=>"full_text", "doi"=>"10.1085/jgp.201411288", "fl_count"=>"2"}
• {"issn"=>"00028703", "journal_title"=>"American Heart Journal", "journal_abbreviation"=>"American Heart Journal", "article_title"=>"Mechanisms of sex and age differences in ventricular repolarization in humans", "contributors"=>{"contributor"=>[{"given_name"=>"Jose", "surname"=>"Vicente", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Lars", "surname"=>"Johannesen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Loriano", "surname"=>"Galeotti", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"David G.", "surname"=>"Strauss", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"168", "issue"=>"5", "first_page"=>"749", "year"=>"2014", "publication_type"=>"full_text", "doi"=>"10.1016/j.ahj.2014.07.010", "fl_count"=>"8"}
• {"issn"=>"10453873", "journal_title"=>"Journal of Cardiovascular Electrophysiology", "journal_abbreviation"=>"J Cardiovasc Electrophysiol", "article_title"=>"Absence of Gender-Based Differences in the Atrial and Pulmonary Vein Substrate: A Detailed Electroanatomic Mapping Study", "contributors"=>{"contributor"=>[{"given_name"=>"TOMOS E.", "surname"=>"WALTERS", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"ANDREW W.", "surname"=>"TEH", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"STEVEN", "surname"=>"SPENCE", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"JOSEPH B.", "surname"=>"MORTON", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"PETER M.", "surname"=>"KISTLER", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"JONATHAN M.", "surname"=>"KALMAN", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"25", "issue"=>"10", "first_page"=>"1065", "year"=>"2014", "publication_type"=>"full_text", "doi"=>"10.1111/jce.12465", "fl_count"=>"4"}
• {"issn"=>["0741-238X", "1865-8652"], "journal_title"=>"Advances in Therapy", "journal_abbreviation"=>"Adv Ther", "article_title"=>"Drug-Induced Long QT Syndrome in Women", "contributors"=>{"contributor"=>[{"given_name"=>"Guoliang", "surname"=>"Li", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Gong", "surname"=>"Cheng", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Jine", "surname"=>"Wu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Xin", "surname"=>"Zhou", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Ping", "surname"=>"Liu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Chaofeng", "surname"=>"Sun", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"30", "issue"=>"9", "first_page"=>"793", "year"=>"2013", "publication_type"=>"full_text", "doi"=>"10.1007/s12325-013-0056-x", "fl_count"=>"5"}
• {"issn"=>"17406757", "journal_title"=>"Drug Discovery Today: Disease Models", "journal_abbreviation"=>"Drug Discovery Today: Disease Models", "article_title"=>"Computational models for predictive cardiac ion channel pharmacology", "contributors"=>{"contributor"=>[{"given_name"=>"Vladimir", "surname"=>"Yarov-Yarovoy", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Toby W.", "surname"=>"Allen", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Colleen E.", "surname"=>"Clancy", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"14", "first_page"=>"3", "year"=>"2014", "publication_type"=>"full_text", "doi"=>"10.1016/j.ddmod.2014.04.001", "fl_count"=>"0"}
• {"issn"=>["1099-5129", "1532-2092"], "journal_title"=>"Europace", "journal_abbreviation"=>"Europace", "article_title"=>"Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones", "contributors"=>{"contributor"=>[{"given_name"=>"N. A.", "surname"=>"Trayanova", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"T.", "surname"=>"O'Hara", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J. D.", "surname"=>"Bayer", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"P. M.", "surname"=>"Boyle", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"K. S.", "surname"=>"McDowell", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"J.", "surname"=>"Constantino", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"H. J.", "surname"=>"Arevalo", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Y.", "surname"=>"Hu", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"F.", "surname"=>"Vadakkumpadan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"14", "issue"=>"suppl 5", "first_page"=>"v82", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1093/europace/eus277", "fl_count"=>"16"}
• {"issn"=>"00071188", "journal_title"=>"British Journal of Pharmacology", "article_title"=>"17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl- current in rabbit articular chondrocytes", "contributors"=>{"contributor"=>[{"given_name"=>"Kousuke", "surname"=>"Kumagai", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Shinji", "surname"=>"Imai", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Futoshi", "surname"=>"Toyoda", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Noriaki", "surname"=>"Okumura", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Eiji", "surname"=>"Isoya", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Hiroshi", "surname"=>"Matsuura", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Yoshitaka", "surname"=>"Matsusue", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"166", "issue"=>"2", "first_page"=>"702", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1111/j.1476-5381.2011.01802.x", "fl_count"=>"10"}
• {"issn"=>"00223751", "journal_title"=>"The Journal of Physiology", "article_title"=>"Exploiting mathematical models to illuminate electrophysiological variability between individuals", "contributors"=>{"contributor"=>[{"given_name"=>"Amrita X.", "surname"=>"Sarkar", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"David J.", "surname"=>"Christini", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Eric A.", "surname"=>"Sobie", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"590", "issue"=>"11", "first_page"=>"2555", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1113/jphysiol.2011.223313", "fl_count"=>"30"}
• {"issn"=>["2160-5440", "2160-5629"], "journal_title"=>"Open Journal of Urology", "journal_abbreviation"=>"OJU", "article_title"=>"Changes in Electrocardiogram Findings during Treatment with Gonadotropin-Releasing Hormone Agonist and Surgical Castration for Prostate Carcinoma", "contributors"=>{"contributor"=>[{"given_name"=>"Hasan", "surname"=>"Sağlam", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"Akif", "surname"=>"Çakar", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Osman", "surname"=>"Köse", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Şükrü", "surname"=>"Kumsar", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Salih", "surname"=>"Budak", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Serbülent", "surname"=>"Gökhan Beyaz", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Öztuğ", "surname"=>"Adsan", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"02", "issue"=>"03", "first_page"=>"153", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.4236/oju.2012.223029", "fl_count"=>"1"}
• {"issn"=>["2090-6501", "2090-651X"], "journal_title"=>"Case Reports in Endocrinology", "journal_abbreviation"=>"Case Reports in Endocrinology", "article_title"=>"Feminizing Adrenal Carcinoma Presenting with Heart Failure and Ventricular Tachycardia", "contributors"=>{"contributor"=>[{"given_name"=>"Anjana", "surname"=>"Harnoor", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}, {"given_name"=>"R. Lee", "surname"=>"West", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}, {"given_name"=>"Fiona J.", "surname"=>"Cook", "first_author"=>"false", "sequence"=>"additional", "contributor_role"=>"author"}]}, "volume"=>"2012", "first_page"=>"1", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.1155/2012/760134", "fl_count"=>"0"}
• {"issn"=>"2090-5599", "journal_title"=>"ISRN Cardiology", "journal_abbreviation"=>"ISRN Cardiology", "article_title"=>"Computational Cardiology: The Heart of the Matter", "contributors"=>{"contributor"=>{"given_name"=>"Natalia A.", "surname"=>"Trayanova", "first_author"=>"true", "sequence"=>"first", "contributor_role"=>"author"}}, "volume"=>"2012", "first_page"=>"1", "year"=>"2012", "publication_type"=>"full_text", "doi"=>"10.5402/2012/269680", "fl_count"=>"12"}

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations

PubMed Central

• 3145286
• 3400768
• 3424714
• 3417499
• 4665638
• 3888406
• 4488347
• 4411259
• 3774200
• 3482619
• 3505657
• 3420512
• 3596698

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/76749160779"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/76749160779?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76749160779&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=76749160779&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/76749160779", "dc:identifier"=>"SCOPUS_ID:76749160779", "eid"=>"2-s2.0-76749160779", "dc:title"=>"Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: A simulation study", "dc:creator"=>"Yang P.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"6", "prism:issueIdentifier"=>"1", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-01-01", "prism:coverDisplayDate"=>"January 2010", "prism:doi"=>"10.1371/journal.pcbi.1000658", "citedby-count"=>"29", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of California, Davis", "affiliation-city"=>"Davis", "affiliation-country"=>"United States"}], "pubmed-id"=>"20126530", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1000658", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%252Fjournal.pcbi.1000658", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

Research Blogging

ScienceSeeker | Further Information

Twitter

Wikipedia

Wordpress.com | Further Information

Counter

• {"month"=>"1", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"118"}
• {"month"=>"2", "year"=>"2010", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"283"}
• {"month"=>"3", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"76"}
• {"month"=>"4", "year"=>"2010", "pdf_views"=>"16", "xml_views"=>"4", "html_views"=>"52"}
• {"month"=>"5", "year"=>"2010", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"91"}
• {"month"=>"6", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"51"}
• {"month"=>"7", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"44"}
• {"month"=>"8", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"64"}
• {"month"=>"9", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"50"}
• {"month"=>"10", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"48"}
• {"month"=>"11", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"50"}
• {"month"=>"12", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"30"}
• {"month"=>"1", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"28"}
• {"month"=>"2", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"35"}
• {"month"=>"3", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"46"}
• {"month"=>"4", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"5", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"17"}
• {"month"=>"6", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"19"}
• {"month"=>"7", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
• {"month"=>"8", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"9", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"46"}
• {"month"=>"10", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"11", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"55"}
• {"month"=>"12", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
• {"month"=>"1", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"44"}
• {"month"=>"2", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"3", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"49"}
• {"month"=>"4", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"53"}
• {"month"=>"5", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"59"}
• {"month"=>"6", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"56"}
• {"month"=>"7", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"50"}
• {"month"=>"8", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"5", "html_views"=>"34"}
• {"month"=>"9", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"49"}
• {"month"=>"10", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"51"}
• {"month"=>"11", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
• {"month"=>"12", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"1", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"49"}
• {"month"=>"2", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"357"}
• {"month"=>"3", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"59"}
• {"month"=>"4", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"48"}
• {"month"=>"5", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"61"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"3", "html_views"=>"69"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"77"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"64"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"104"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"96"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"73"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"72"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"104"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"84"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"65"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"20"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"33"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"41"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"23"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"39"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"21"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"44"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"45"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"56"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"13"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"21"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"27"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"20"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/429550", "https://ndownloader.figshare.com/files/429560", "https://ndownloader.figshare.com/files/429577", "https://ndownloader.figshare.com/files/429584", "https://ndownloader.figshare.com/files/429600", "https://ndownloader.figshare.com/files/429616", "https://ndownloader.figshare.com/files/429630"], "description"=>"<div><p>Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent males have shorter QT intervals than females. However, the specific role for hormones in modulating cardiac electrophysiological parameters and arrhythmia vulnerability is unclear. Here we use a computational modeling approach to incorporate experimentally measured effects of physiological concentrations of testosterone, estrogen and progesterone on cardiac ion channel targets. We then study the hormone effects on ventricular cell and tissue dynamics comprised of Faber-Rudy computational models. The “female” model predicts changes in action potential duration (APD) at different stages of the menstrual cycle that are consistent with clinically observed QT interval fluctuations. The “male” model predicts shortening of APD and QT interval at physiological testosterone concentrations. The model suggests increased susceptibility to drug-induced arrhythmia when estradiol levels are high, while testosterone and progesterone are apparently protective. Simulations predict the effects of sex steroid hormones on clinically observed QT intervals and reveal mechanisms of estrogen-mediated susceptibility to prolongation of QT interval. The simulations also indicate that acute effects of estrogen are not alone sufficient to cause arrhythmia triggers and explain the increased risk of females to Torsades de Pointes. Our results suggest that acute effects of sex steroid hormones on cardiac ion channels are sufficient to account for some aspects of gender specific susceptibility to long-QT linked arrhythmias.</p></div>", "links"=>[], "tags"=>["acute", "effects", "steroid", "hormones", "susceptibility", "cardiac", "simulation"], "article_id"=>144805, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>["https://dx.doi.org/10.1371/journal.pcbi.1000658.s001", "https://dx.doi.org/10.1371/journal.pcbi.1000658.s002", "https://dx.doi.org/10.1371/journal.pcbi.1000658.s003", "https://dx.doi.org/10.1371/journal.pcbi.1000658.s004", "https://dx.doi.org/10.1371/journal.pcbi.1000658.s005", "https://dx.doi.org/10.1371/journal.pcbi.1000658.s006", "https://dx.doi.org/10.1371/journal.pcbi.1000658.s007"], "stats"=>{"downloads"=>31, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Acute_Effects_of_Sex_Steroid_Hormones_on_Susceptibility_to_Cardiac_Arrhythmias_A_Simulation_Study/144805", "title"=>"Acute Effects of Sex Steroid Hormones on Susceptibility to Cardiac Arrhythmias: A Simulation Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-01-29 01:20:05"}
• {"files"=>["https://ndownloader.figshare.com/files/865491"], "description"=>"<p>Four snapshots following application of hormones and/or drug at indicated time points. Tissues were stimulated along one edge and propagated from endocardial to epicardial region followed by a point stimulus applied in the right corner of the endocardial region. Voltages are indicated by color gradient.</p>", "links"=>[], "tags"=>["increases", "vulnerability", "reentry", "short-long-short", "pacing"], "article_id"=>535944, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g007", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estrogen_increases_vulnerability_to_reentry_during_short_long_short_pacing_protocols_/535944", "title"=>"Estrogen increases vulnerability to reentry during short-long-short pacing protocols.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:39:04"}
• {"files"=>["https://ndownloader.figshare.com/files/865008"], "description"=>"<p>The APD for each concentration of sex-steroid hormone is indicated for the 50^th paced beat at a cycle length of 1000 ms in single M-cells. (A)–(B) Simulated APD in the presence of E2 (0.1 and 1 nM) and progesterone (2.5 and 40.6 nM) compared to control condition (0 nM). (C) Simulated APD with combined effects of E2 and progesterone at three physiological concentrations corresponding to different stages of the menstrual cycle: early follicular phase (estrogen: 0.1 nM and progesterone: 2.5 nM), late follicular phase (estrogen: 1 nM and progesterone: 2.5 nM) and luteal phase (estrogen: 0.7 nM and progesterone: 40.6 nM). (D) Simulated effects of two physiological concentrations of testosterone (10 and 35 nM) on APD. The corresponding APD at 90% repolarization (APD₉₀) is shown in horizontal bar graphs (right panels).</p>", "links"=>[], "tags"=>["hormones", "cardiac"], "article_id"=>535465, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Simulated_effects_of_sex_hormones_on_cardiac_action_potentials_/535465", "title"=>"Simulated effects of sex hormones on cardiac action potentials.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:31:05"}
• {"files"=>["https://ndownloader.figshare.com/files/864885"], "description"=>"<p>(A) Dose-dependence curves are shown for experimental (left traces) and simulated (right traces) inhibition of I_Kr current by E2. The simulated I_Kr tail currents (right) compared to experimentally measured I_Kr (left) at −40 mV following depolarization to a test potential = +20 mV in the absence (control) or presence of E2 (1 and 10 nM). (B) I_Ks was experimentally recorded at a test potential of +50 mV from a holding potential of −40 mV with 0 nM and 100 nM progesterone (top traces). Simulated (lower races) I_Ks are shown in the presence of 0 nM (control case), 2.5 nM (follicular phase), 40.6 nM (luteal phase) and 100 nM progesterone during a voltage pulse from −40 mV to +50 mV. (C) I_Ks (left panels) were elicited by 3.5-s test pulses to +50 mV from a holding potential of −40 mV (experiment — top traces and simulation — lower traces) in the absence and presence of testosterone (10 nM and 300 nM). The effect on I_Ca,L (right panels) from experimental data (top traces) and simulated results (lower traces) during a voltage step from −40 mV to 0 mV under control condition (0 nM), 10 nM and 300 nM testosterone.</p>", "links"=>[], "tags"=>["sex-steroid", "hormones", "testosterone", "cardiac", "ion"], "article_id"=>535338, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_sex_steroid_hormones_E2_progesterone_and_testosterone_on_cardiac_ion_channels_/535338", "title"=>"Effects of sex-steroid hormones E2, progesterone, and testosterone on cardiac ion channels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:28:58"}
• {"files"=>["https://ndownloader.figshare.com/files/865203"], "description"=>"<p>Shown is the 50^th paced beat at a cycle length of 1000 ms in 1D cables. (A) (i): Early follicular phase (ii): Late follicular phase (iii): Luteal phase. Simulated APD in the presence of two physiological concentrations (iv and v) of testosterone. (B) The computed virtual electrograms show QT intervals change during various stages of menstrual cycle and at two concentrations of testosterone (lower panels). The vertical bar graph shows the QT intervals under different circumstances (top panel).</p>", "links"=>[], "tags"=>["hormones", "menstrual", "cardiac"], "article_id"=>535662, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Simulated_combined_effects_of_female_hormones_during_the_menstrual_cycle_and_male_hormones_on_cardiac_action_potentials_/535662", "title"=>"Simulated combined effects of female hormones during the menstrual cycle and male hormones on cardiac action potentials.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:34:22"}
• {"files"=>["https://ndownloader.figshare.com/files/865551"], "description"=>"<p>(A) Comparison of 2D heterogeneous tissue dynamics in the absence or presence of E-4031 during the late follicular phase, and application of testosterone 3 nM with E-4031. (B) The same protocol as above was used, but the premature stimulus was applied during the vulnerable window in the middle of endocardial near the boundary between endocardial region and M cells. The late follicular phase with E-4031 is shown.</p>", "links"=>[], "tags"=>["drug-induced", "arrhythmias", "short-long-short", "pacing"], "article_id"=>536008, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g008", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Simulated_drug_induced_arrhythmias_during_short_long_short_pacing_protocols_/536008", "title"=>"Simulated drug-induced arrhythmias during short-long-short pacing protocols.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:40:08"}
• {"files"=>["https://ndownloader.figshare.com/files/865115"], "description"=>"<p>Action potential (50^th paced beat at 1000 ms pacing frequency) propagation from top (cell# 1) to bottom (cell# 100) in a 1 cm cardiac fiber is shown. Time is on the x-axis and voltage on the z-axis. (A) Application of E2 and progesterone (i): control case (no E2), (ii): 0.1 nM E2, (iii): 1 nM E2, (iv): 2.5 nM progesterone, and (v): 40.6 nM progesterone. (B) Comparison of QT intervals is shown in top panel. Lower panels are pseudo ECGs showing the effect of hormones on QT intervals for different cases. The corresponding T-waves are indicated.</p>", "links"=>[], "tags"=>["hormones", "cardiac"], "article_id"=>535574, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g003", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predicted_effects_of_sex_hormones_on_cardiac_tissue_and_QT_intervals_/535574", "title"=>"Predicted effects of sex hormones on cardiac tissue and QT-intervals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:32:54"}
• {"files"=>["https://ndownloader.figshare.com/files/865305"], "description"=>"<p>(A) Experimental (top) and simulated (bottom) dose-dependence curves for inhibition of hERG current by E4031 (control — black line), an I_Kr blocker, and after addition of estrogen (E2 — light gray line) and DHT (dark gray line). The curves for each concentration of E2 and DHT are indicated. (B) Simulated APD (50^th beat at a pacing rate of 1000 ms) with 10 nM E4031 in the presence of both E2 and progesterone (late follicular phase — i). (ii) Simulated effects of testosterone (3 nM) on APD with E4031 application. The computed ECG (low traces) shows that QT interval is substantially longer in case (i) than in case (ii).</p>", "links"=>[], "tags"=>["testosterone", "differentially"], "article_id"=>535769, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estrogen_and_testosterone_differentially_affect_sensitivity_of_I_Kr_to_drugs_/535769", "title"=>"Estrogen and testosterone differentially affect sensitivity of I_Kr to drugs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:36:09"}
• {"files"=>["https://ndownloader.figshare.com/files/865409"], "description"=>"<p>(A) The simulated cell was paced for 10 beats at BCL = 1000 ms (s1) followed by varying s1–s2 intervals and long pause intervals. The intervals between s1 and s2 are shown on the x-axis, pause intervals on y-axis and APD are indicated by color gradient. Simulated EAD formations under three conditions, late follicular phase (left panel), in the presence (middle) of testosterone 3 nM and E-4031 10 nM, and addition of E4031 in the absence of sex-steroid hormones (right). (B) Simulated APDs during the late follicular phase with E-4031 (10 nM) application at three basic cycle lengths (500 ms, 750 ms, and 1000 ms). The point indicated by an arrow (right panel) corresponding fiber and pseudo ECG (lower panels) under same conditions.</p>", "links"=>[], "tags"=>["ead", "susceptibility", "follicular", "menstrual"], "article_id"=>535867, "categories"=>["Medicine", "Physiology"], "users"=>["Pei-Chi Yang", "Junko Kurokawa", "Tetsushi Furukawa", "Colleen E. Clancy"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1000658.g006", "stats"=>{"downloads"=>2, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pause_induced_EAD_susceptibility_is_increased_in_the_late_follicular_phase_of_the_menstrual_cycle_/535867", "title"=>"Pause-induced EAD susceptibility is increased in the late follicular phase of the menstrual cycle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-01-29 01:37:47"}

PMC Usage Stats | Further Information

• {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"66", "unique-ip"=>"46", "pdf"=>"9", "year"=>"2010", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"49", "year"=>"2010", "pdf"=>"16", "unique-ip"=>"41", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"58", "unique-ip"=>"51", "pdf"=>"33", "year"=>"2010", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"45", "year"=>"2010", "pdf"=>"23", "unique-ip"=>"44", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"5"}
• {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"28", "unique-ip"=>"29", "pdf"=>"39", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"42", "year"=>"2010", "pdf"=>"40", "unique-ip"=>"40", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"36", "unique-ip"=>"39", "pdf"=>"31", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"23", "year"=>"2010", "pdf"=>"20", "unique-ip"=>"25", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"30", "unique-ip"=>"29", "pdf"=>"19", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2010", "pdf"=>"14", "unique-ip"=>"23", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"19", "pdf"=>"11", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"3"}
• {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "year"=>"2011", "pdf"=>"11", "unique-ip"=>"26", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"29", "unique-ip"=>"26", "pdf"=>"11", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"26", "year"=>"2011", "pdf"=>"19", "unique-ip"=>"29", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"21", "pdf"=>"15", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"28", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"13", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"17", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"17", "pdf"=>"6", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"22", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"22", "pdf"=>"11", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"20", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"21", "pdf"=>"13", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "unique-ip"=>"23", "pdf"=>"4", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"30", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"30", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"32", "unique-ip"=>"32", "pdf"=>"12", "year"=>"2012", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"33", "unique-ip"=>"30", "pdf"=>"9", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"19", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
• {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
• {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
• {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"9", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
• {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
• {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
• {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
• {"unique-ip"=>"17", "full-text"=>"22", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
• {"unique-ip"=>"34", "full-text"=>"36", "pdf"=>"18", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
• {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"29", "full-text"=>"32", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"25", "full-text"=>"36", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
• {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"34", "full-text"=>"30", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"30", "full-text"=>"30", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"24", "full-text"=>"20", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"27", "full-text"=>"32", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"17", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"31", "full-text"=>"29", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"39", "full-text"=>"39", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"32", "full-text"=>"37", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"37", "full-text"=>"41", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[288, 576, 733, 867, 984, 1087, 1182, 1267, 1346, 1424, 1501, 1577, 1646, 1711, 1778, 1841, 1908, 1970, 2034, 2102, 2162, 2227, 2296, 2359, 2422, 2482, 2550, 2610, 2679, 2747, 2820, 2887, 2955, 3009, 3067, 3130, 3200, 3257, 3322, 3379, 3443, 3507, 3571, 3632, 3683, 3753, 3822, 3877]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[276, 544, 702, 826, 936, 1045, 1140, 1222, 1305, 1377, 1453, 1528, 1584, 1661, 1725, 1783, 1848, 1913, 1977, 2038, 2103, 2158, 2223, 2290, 2346, 2406, 2467, 2529, 2588, 2652, 2722, 2779, 2835, 2892, 2943, 2999]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[290, 563, 717, 832, 936, 1036, 1112, 1185, 1252, 1329, 1409, 1471, 1534, 1591, 1646, 1708, 1776, 1840, 1903, 1953, 2006, 2073, 2139, 2193, 2247, 2308, 2370, 2440, 2489, 2546, 2600, 2659, 2705, 2764, 2843, 2917, 2963, 3003, 3062, 3126, 3188, 3253, 3294, 3346, 3402, 3467, 3538, 3593, 3642]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[275, 545, 699, 818, 931, 1035, 1128, 1212, 1291, 1366, 1439, 1514, 1580, 1649, 1708, 1765, 1826, 1877, 1940, 2009, 2076, 2150, 2215, 2266, 2335, 2395, 2459, 2521, 2596, 2669, 2724, 2787, 2840, 2890, 2961, 3025, 3081, 3142, 3195, 3261, 3314, 3377, 3442, 3491, 3538, 3583, 3649, 3699, 3747]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[270, 536, 692, 812, 932, 1037, 1128, 1210, 1293, 1367, 1439, 1514, 1580, 1646, 1711, 1766, 1834, 1902, 1969, 2036, 2106, 2165, 2221, 2285, 2337, 2403, 2459, 2517, 2586, 2644, 2716, 2782, 2842, 2895, 2958, 3017]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[279, 551, 699, 817, 930, 1027, 1124, 1209, 1287, 1362, 1438, 1512, 1582, 1650, 1717, 1772, 1831, 1888, 1948, 2002, 2070, 2138, 2203, 2267, 2331, 2395, 2467, 2523, 2592, 2656, 2718, 2785, 2839, 2892, 2960, 3034, 3087, 3144, 3194, 3254, 3313, 3373, 3446, 3496, 3551, 3607, 3660, 3712, 3773]}]}

F1000Prime