Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress
Publication Date
January 26, 2012
Journal
PLOS Computational Biology
Authors
Patrick D. Mc Mullen, Erin Z. Aprison, Peter B. Winter, Luis A. N. Amaral, et al
Volume
8
Issue
1
Pages
e1002338
DOI
http://doi.org/10.1371/journal.pcbi.1002338
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1002338
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22291584
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266876
Europe PMC
http://europepmc.org/abstract/MED/22291584
Web of Science
000300218100019
Scopus
84857496780
Mendeley
http://www.mendeley.com/research/macrolevel-modeling-response-c-elegans-reproduction-chronic-heat-stress
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/688714"], "description"=>"<p>Experiments performed to determine the dynamics of <i>C. elegans</i> reproductive behavior.</p>", "links"=>[], "tags"=>["performed", "reproductive"], "article_id"=>359203, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Experiments_performed_to_determine_the_dynamics_of_C_elegans_reproductive_behavior_/359203", "title"=>"Experiments performed to determine the dynamics of <i>C. elegans</i> reproductive behavior.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-01-26 02:33:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/688081"], "description"=>"<p>The average number of eggs laid by an individual hermaphrodite is substantially lower at 28°C (compared to ∼300 at 20°C), and is nearly zero at 30°C (A). In contrast, at 30°C, animals exhibit considerably milder effects on motility and viability (B).</p>", "links"=>[], "tags"=>["genetics and genomics", "chemistry", "Computational biology"], "article_id"=>358567, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reproduction_is_sensitive_to_chronic_temperature_changes_/358567", "title"=>"Reproduction is sensitive to chronic temperature changes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:22:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/688143"], "description"=>"<p>The brood sizes for animals reproducing at 20 (A) and 25°C (B) are normally distributed. However, at higher temperatures, 28 (C) and 29°C (D), the distribution of brood sizes reflects a heterogeneous population. At these temperatures, the brood size distributions (solid lines) can no longer be approximated as single normal distributions. Instead, each is better explained as a mixture of two distinct components (dashed lines), the relative weight of which is dependent on temperature. Red boxes in the left panels highlight the data shown in the right panels.</p>", "links"=>[], "tags"=>["exposes", "heterogeneous", "physiological", "reproductive"], "article_id"=>358627, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chronic_temperature_stress_exposes_heterogeneous_physiological_response_of_the_reproductive_system_in_C_elegans_/358627", "title"=>"Chronic temperature stress exposes heterogeneous physiological response of the reproductive system in <i>C. elegans</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:23:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/688385"], "description"=>"<p>Explicitly accounting for oocyte development (blue) is nearly indistinguishable from the quasi-steady-state approximation (red) (A). Including a discrete state for dead oocytes (B) complicates the model, but leads to a description (Equation 6) that is mathematically equivalent to the parsimonious model (Equation 4).</p>", "links"=>[], "tags"=>["models"], "article_id"=>358872, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_More_complicated_models_do_not_offer_an_improved_description_of_the_system_/358872", "title"=>"More complicated models do not offer an improved description of the system.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:27:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/688311"], "description"=>"<p>Because the reproductive dynamics are strongly temperature dependent, we let the three model parameters vary as exponential functions of temperature (A–C). As expected, all parameters increased with temperature. Red circles represent the estimated parameters values for the three temperatures used to train the model. Constraining model parameters yielded close fits to experimental observations, represented by dots ±1 standard deviation (D). Model predictions (solid lines) ±1 standard deviation (dashed lines) are shown for comparison.</p>", "links"=>[], "tags"=>["genetics and genomics", "chemistry", "Computational biology"], "article_id"=>358798, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fitting_the_model_to_experimental_data_/358798", "title"=>"Fitting the model to experimental data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:26:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/350795", "https://ndownloader.figshare.com/files/350829", "https://ndownloader.figshare.com/files/350859", "https://ndownloader.figshare.com/files/350894", "https://ndownloader.figshare.com/files/350940", "https://ndownloader.figshare.com/files/350997", "https://ndownloader.figshare.com/files/351031", "https://ndownloader.figshare.com/files/351064"], "description"=>"<div><p>A major goal of systems biology is to understand how organism-level behavior arises from a myriad of molecular interactions. Often this involves complex sets of rules describing interactions among a large number of components. As an alternative, we have developed a simple, macro-level model to describe how chronic temperature stress affects reproduction in <em>C. elegans</em>. Our approach uses fundamental engineering principles, together with a limited set of experimentally derived facts, and provides quantitatively accurate predictions of performance under a range of physiologically relevant conditions. We generated detailed time-resolved experimental data to evaluate the ability of our model to describe the dynamics of <em>C. elegans</em> reproduction. We find considerable heterogeneity in responses of individual animals to heat stress, which can be understood as modulation of a few processes and may represent a strategy for coping with the ever-changing environment. Our experimental results and model provide quantitative insight into the breakdown of a robust biological system under stress and suggest, surprisingly, that the behavior of complex biological systems may be determined by a small number of key components.</p> </div>", "links"=>[], "tags"=>["macro-level", "modeling", "reproduction"], "article_id"=>129340, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pcbi.1002338.s001", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s002", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s003", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s004", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s005", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s006", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s007", "https://dx.doi.org/10.1371/journal.pcbi.1002338.s008"], "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Macro_level_Modeling_of_the_Response_of_C_elegans_Reproduction_to_Chronic_Heat_Stress/129340", "title"=>"Macro-level Modeling of the Response of <em>C. elegans</em> Reproduction to Chronic Heat Stress", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-01-26 02:35:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/688690"], "description"=>"<p>Major assumptions of the model.</p>", "links"=>[], "tags"=>["assumptions"], "article_id"=>359178, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Major_assumptions_of_the_model_/359178", "title"=>"Major assumptions of the model.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-01-26 02:32:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/688509"], "description"=>"<p>The reproductive dynamics of <i>tra-3</i> and <i>cdc-48.1</i> mutants at 20°C (dots; ±1 standard deviation) are well described by the model (solid lines are median predictions; dashed lines are ±1 standard deviation) (A). At 25°C, <i>tra-3</i> animals produce fewer progeny than predicted (B). Embryos are arranged in an orderly fashion in N2 animals at 20 (C) and 25°C (E) and in <i>tra-3</i> mutants at 20°C (D), but not at 25°C (F). Consequently, <i>tra-3</i> mutants retain more embryos in the uterus than N2 animals (G; average number per worm is shown; ±1 standard deviation). Bagging phenotype of <i>tra-3</i> mutants is rescued by an egg-laying constitutive mutation <i>egl-19</i>(ad695) (H).</p>", "links"=>[], "tags"=>["reproductive"], "article_id"=>358999, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g007", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predicting_behavior_of_C_elegans_reproductive_mutants_/358999", "title"=>"Predicting behavior of <i>C. elegans</i> reproductive mutants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:29:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/688449"], "description"=>"<p>Predicted egg-laying trajectories (sold lines are median predictions; dashed lines are ±1 standard deviation) for animals shifted to 23, 28, and 30°C quantitatively capture the experimental data (dots; ±1 standard deviation).</p>", "links"=>[], "tags"=>["genetics and genomics", "chemistry", "Computational biology"], "article_id"=>358936, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predicting_the_dynamics_of_C_elegans_reproduction_/358936", "title"=>"Predicting the dynamics of <i>C. elegans</i> reproduction.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:28:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/688240"], "description"=>"<p>The reproductive system of a hermaphrodite consists principally of three compartments: the gonad, spermatheca, and uterus (A). The model tracks gametes through these compartments according to mass-action kinetics and parsimonious biological rules (B).</p>", "links"=>[], "tags"=>["genetics and genomics", "chemistry", "Computational biology"], "article_id"=>358724, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Modeling_the_dynamics_of_C_elegans_reproduction_/358724", "title"=>"Modeling the dynamics of <i>C. elegans</i> reproduction.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:25:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/688614"], "description"=>"<p>At permissive temperatures (≤25°C) brood sizes are well described as normal distributions (as shown in <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002338#pcbi-1002338-g002\" target=\"_blank\">Figure 2</a>). However, at higher temperatures (≥28°C), the brood size distributions diverge from normal, and a mixture of two distributions is required to describe the data. Two different combinations of distributions could account for the observations. In both cases a fraction of the overall population consists of worms reproducing robustly; these are described by a normal distribution (blue). An exponential distribution (red) could indicate that chronic stress causes random reproductive failure among individuals in the population (A). A normal distribution (red) would suggest that subpopulations of individuals deploy qualitatively distinct reproductive strategies (B). Regardless of the explanation, there is a dichotomy of reproductive behaviors among individuals within populations under temperature stress.</p>", "links"=>[], "tags"=>["interpretations", "heterogeneous"], "article_id"=>359103, "categories"=>["Biological Sciences", "Chemistry", "Genetics"], "users"=>["Patrick D. McMullen", "Erin Z. Aprison", "Peter B. Winter", "Luis A. N. Amaral", "Richard I. Morimoto", "Ilya Ruvinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002338.g008", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alternative_interpretations_of_the_heterogeneous_response_to_stress_by_individual_nematodes_/359103", "title"=>"Alternative interpretations of the heterogeneous response to stress by individual nematodes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-26 02:31:43"}

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Relative Metric

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