Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function
Publication Date
September 20, 2012
Journal
PLOS Computational Biology
Authors
Michael A. Jamros, Leandro C. Oliveira, Paul C. Whitford, José N. Onuchic, et al
Volume
8
Issue
9
Pages
e1002695
DOI
http://doi.org/10.1371/journal.pcbi.1002695
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1002695
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23028292
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447962
Europe PMC
http://europepmc.org/abstract/MED/23028292
Web of Science
000309510900031
Scopus
84866900603
Mendeley
http://www.mendeley.com/research/substratespecific-reorganization-conformational-ensemble-csk-implicates-novel-modes-kinase-function
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/572429"], "description"=>"<p>The best-fit ensemble for each state of Csk was fit to the experimental data for all other states of Csk.</p>", "links"=>[], "tags"=>["conformational"], "article_id"=>242920, "categories"=>["Biological Sciences", "Biochemistry", "Biophysics"], "users"=>["Michael A. Jamros", "Leandro C. Oliveira", "Paul C. Whitford", "José N. Onuchic", "Joseph A. Adams", "Patricia A. Jennings"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002695.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cross_calculation_of_conformational_ensembles_/242920", "title"=>"Cross-calculation of conformational ensembles.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 22:57:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/572174"], "description"=>"<p>Apo Csk appears in black, AMP-PNP bound Csk appears in red, and ADP bound Csk appears in blue. The three most prominent populations, from which representative conformations were selected for ensemble analysis, are highlighted for each state.</p>", "links"=>[], "tags"=>["probability", "conformations", "lowest", "sbm"], "article_id"=>242668, "categories"=>["Biological Sciences", "Biochemistry", "Biophysics"], "users"=>["Michael A. Jamros", "Leandro C. Oliveira", "Paul C. Whitford", "José N. Onuchic", "Joseph A. Adams", "Patricia A. Jennings"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002695.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_probability_of_R_g_P_R_g_of_the_5_of_conformations_with_the_lowest_967_2_values_from_the_SBM_simulations_/242668", "title"=>"The probability of R<sub>g</sub> (P(R<sub>g</sub>)) of the 5% of conformations with the lowest χ<sup>2</sup> values from the SBM simulations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:56:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/572094"], "description"=>"<p>A) Solution scattering data for apo Csk (black), AMP-PNP bound Csk (red), and ADP bound Csk (blue). B) Kratky plot of experimental solution scattering data colored in the same manner as A. Scattering data is normalized for ease of comparison in the plot.</p>", "links"=>[], "tags"=>["x-ray", "scattering", "curves", "kratky"], "article_id"=>242572, "categories"=>["Biological Sciences", "Biochemistry", "Biophysics"], "users"=>["Michael A. Jamros", "Leandro C. Oliveira", "Paul C. Whitford", "José N. Onuchic", "Joseph A. Adams", "Patricia A. Jennings"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002695.g001", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Small_angle_X_ray_scattering_curves_and_Kratky_plot_of_experimental_data_/242572", "title"=>"Small-angle X-ray scattering curves and Kratky plot of experimental data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:55:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/572260"], "description"=>"<p>Appearing next to the R<sub>g</sub> values of each conformation is the fraction of the best-fit ensemble made up by that conformation. For all conformations the SH3 domain appears in yellow, the SH2 domain appears in red, the N-lobe of the kinase domain appears in blue, the C-lobe of the kinase domain appears in orange, and the domain-domain linkers appear in cyan.</p>", "links"=>[], "tags"=>["conformations", "peaks"], "article_id"=>242757, "categories"=>["Biological Sciences", "Biochemistry", "Biophysics"], "users"=>["Michael A. Jamros", "Leandro C. Oliveira", "Paul C. Whitford", "José N. Onuchic", "Joseph A. Adams", "Patricia A. Jennings"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002695.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_conformations_from_the_peaks_of_the_P_R_g_plot_along_with_their_R_g_values_/242757", "title"=>"Representative conformations from the peaks of the P(R<sub>g</sub>) plot, along with their R<sub>g</sub> values.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:56:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/572352"], "description"=>"<p>The χ<sup>2</sup> value for the ensemble fit to the experimental data appears in the lower left corner of the plot for each curve. A comparison of the fit of the apo Csk ensemble (orange) and the ADP-bound ensemble (blue) to the ADP experimental data (black) appears in D.</p>", "links"=>[], "tags"=>["scattering", "curves", "best-fitting", "conformational", "ensembles", "fitted", "apo", "csk", "amp-pnp", "bound", "adp-bound"], "article_id"=>242823, "categories"=>["Biological Sciences", "Biochemistry", "Biophysics"], "users"=>["Michael A. Jamros", "Leandro C. Oliveira", "Paul C. Whitford", "José N. Onuchic", "Joseph A. Adams", "Patricia A. Jennings"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002695.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Theoretical_scattering_curves_of_the_best_fitting_conformational_ensembles_fitted_to_the_experimental_scattering_curves_black_for_apo_Csk_A_orange_AMP_PNP_bound_Csk_B_red_and_ADP_bound_Csk_C_blue_/242823", "title"=>"Theoretical scattering curves of the best-fitting conformational ensembles fitted to the experimental scattering curves (black) for apo Csk (A, orange), AMP-PNP bound Csk (B, red), and ADP-bound Csk (C, blue).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:56:57"}

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Relative Metric

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