Human Dominant Disease Genes Are Enriched in Paralogs Originating from Whole Genome Duplication
Publication Date
July 31, 2014
Journal
PLOS Computational Biology
Authors
Param Priya Singh, Séverine Affeldt, Giulia Malaguti & Hervé Isambert
Volume
10
Issue
7
Pages
e1003754
DOI
http://doi.org/10.1371/journal.pcbi.1003754
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1003754
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25080083
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117431
Europe PMC
http://europepmc.org/abstract/MED/25080083
Web of Science
000339890900056
Scopus
84905460407
Mendeley
http://www.mendeley.com/research/human-dominant-disease-genes-enriched-paralogs-originating-whole-genome-duplication
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1617047"], "description"=>"<p>(***) corresponds to highly significant deviations (p<10<sup>−6</sup>, FE test) and (**) to significant deviations (p<10<sup>−3</sup>, FE test) from the references in (A). Note that recessive MD genes (C) do not show any significant deviations in WGD, SSD, or singleton contents (p>0.3, FE test), although taking into account the age of SSD duplicates reveals a relative lack of recent SSD genes in MD genes (see text).</p>", "links"=>[], "tags"=>["singletons", "monogenic", "genes", "recessive", "md"], "article_id"=>1123559, "categories"=>["Biological Sciences"], "users"=>["Param Priya Singh", "Séverine Affeldt", "Giulia Malaguti", "Hervé Isambert"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003754.g001", "stats"=>{"downloads"=>4, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distributions_of_WGD_SSD_and_singletons_in_A_the_whole_human_genome_B_monogenic_disease_MD_genes_1_C_recessive_MD_genes_and_D_dominant_MD_genes_/1123559", "title"=>"Distributions of WGD, SSD, and singletons in (A) the whole human genome, (B) monogenic disease (MD) genes [1], (C) recessive MD genes, and (D) dominant MD genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-31 03:16:46"}

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  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[333]}]}
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