Adaptive Diversification in Genes That Regulate Resource Use in Escherichia coli
Publication Date
January 19, 2007
Journal
PLOS Genetics
Authors
Christine C Spencer, Melanie Bertrand, Michael Travisano & Michael Doebeli
Volume
3
Issue
1
Pages
e15
DOI
http://doi.org/10.1371/journal.pgen.0030015
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.0030015
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/17238290
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779306
Europe PMC
http://europepmc.org/abstract/MED/17238290
Web of Science
000243838600010
Scopus
34250013466
Mendeley
http://www.mendeley.com/research/adaptive-diversification-genes-regulate-resource-escherichia-coli
Events
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Mendeley | Further Information

{"title"=>"Adaptive diversification in genes that regulate resource use in Escherichia coli", "type"=>"journal", "authors"=>[{"first_name"=>"Christine C.", "last_name"=>"Spencer", "scopus_author_id"=>"55041458400"}, {"first_name"=>"Melanie", "last_name"=>"Bertrand", "scopus_author_id"=>"15830922100"}, {"first_name"=>"Michael", "last_name"=>"Travisano", "scopus_author_id"=>"6603764717"}, {"first_name"=>"Michael", "last_name"=>"Doebeli", "scopus_author_id"=>"7006077807"}], "year"=>2007, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "scopus"=>"2-s2.0-33846469818", "sgr"=>"33846469818", "pui"=>"46168835", "isbn"=>"1553-7390", "pmid"=>"17238290", "doi"=>"10.1371/journal.pgen.0030015"}, "id"=>"a3b7661a-c71f-3418-bab5-f8ff32ba7728", "abstract"=>"While there has been much recent focus on the ecological causes of adaptive diversification, we know less about the genetic nature of the trade-offs in resource use that create and maintain stable, diversified ecotypes. Here we show how a regulatory genetic change can contribute to sympatric diversification caused by differential resource use and maintained by negative frequency-dependent selection in Escherichia coli. During adaptation to sequential use of glucose and acetate, these bacteria differentiate into two ecotypes that differ in their growth profiles. The \"slow-switcher\" exhibits a long lag when switching to growth on acetate after depletion of glucose, whereas the \"fast-switcher\" exhibits a short switching lag. We show that the short switching time in the fast-switcher is associated with a failure to down-regulate potentially costly acetate metabolism during growth on glucose. While growing on glucose, the fast-switcher expresses malate synthase A (aceB), a critical gene for acetate metabolism that fails to be properly down-regulated because of a transposon insertion in one of its regulators. Swapping the mutant regulatory allele with the ancestral allele indicated that the transposon is in part responsible for the observed differentiation between ecological types. Our results provide a rare example of a mechanistic integration of diversifying processes at the genetic, physiological, and ecological levels.", "link"=>"http://www.mendeley.com/research/adaptive-diversification-genes-regulate-resource-escherichia-coli", "reader_count"=>98, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>11, "Researcher"=>28, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>4, "Student > Master"=>10, "Other"=>3, "Lecturer"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>11, "Researcher"=>28, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>4, "Student > Master"=>10, "Other"=>3, "Lecturer"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Engineering"=>1, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Mathematics"=>1, "Agricultural and Biological Sciences"=>77, "Physics and Astronomy"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>77}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "Sweden"=>1, "Belgium"=>2, "United States"=>7, "Australia"=>1, "France"=>1, "Chile"=>1, "Portugal"=>1, "Germany"=>1, "Spain"=>2}, "group_count"=>3}

CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/955130"], "description"=>"<div><p>(A) Three isolated genotypes (FS, SS, and Anc) consumed glucose (hours 0 to ∼4), then acetate (hours ∼4 until maximum OD), in a standard diauxic (two-stage) growth pattern. The SS (red) closely paralleled the ancestral (black) strain in growth patterns on acetate, while the FS (blue) exhibited a much faster diauxic switch from growth on glucose to growth on acetate and a higher growth rate on acetate (second stage of diauxie). Triangles on the horizontal axis indicate the switching points for each strain.</p><p>(B) All strains deplete glucose from the medium during the first phase of diauxie (from inoculation into batch culture to the time of diauxic switch).</p><p>(C) Change of acetate concentration in the medium during the first phase of diauxie. The ancestor and the SS ecotype accumulated acetate as they depleted glucose (Anc: <i>t</i> = 5.418, <i>p</i> = 0.003; SS: <i>t</i> = 11.342, <i>p</i> = 0.0002); however, the FS strain did not accumulate acetate during glucose depletion, indicating that acetate is consumed during growth on glucose (<i>t</i> = 2.769, <i>p</i> = 0.025 not significant at experimentwise α = 0.017). For panels B and C, data are averages ± 1 mean standard error for three replicates, except for a single preinoculation replicate (open square).</p></div>", "links"=>[], "tags"=>["profiles", "glucose", "acetate", "concentrations"], "article_id"=>625418, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Christine C Spencer", "Melanie Bertrand", "Michael Travisano", "Michael Doebeli"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.0030015.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_E_coli_Growth_Profiles_of_Each_Isolated_Strain_on_Glucose_Acetate_Mixture_and_the_Change_in_Glucose_and_Acetate_Concentrations_in_First_Phase_of_Diauxie_/625418", "title"=>"E. coli Growth Profiles of Each Isolated Strain on Glucose/Acetate Mixture and the Change in Glucose and Acetate Concentrations in First Phase of Diauxie", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:03:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/955228"], "description"=>"<div><p><i>aceB</i> mRNA expression was quantified using quantitative PCR and normalized against <i>23SrRNA-4</i> ribosomal mRNA expression.</p><p>RNA was isolated from cells in early log growth during the first phase of diauxie when glucose was present. In glucose-containing media, the FS has significantly higher <i>aceB</i> expression than the Anc and SS (<i>F<sub>8,18</sub></i> = 16.26, <i>p</i> < 0.0001; Tukey HSD<sub>FS,SS </sub><i>p</i> = 0.032). Symbols: Anc (black), SS (red), and FS (blue).</p></div>", "links"=>[], "tags"=>["mrna"], "article_id"=>625514, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Christine C Spencer", "Melanie Bertrand", "Michael Travisano", "Michael Doebeli"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.0030015.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_mRNA_Expression_from_the_aceB_Gene_/625514", "title"=>"Relative mRNA Expression from the <i>aceB</i> Gene", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:04:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/955181"], "description"=>"<p>Failure to negatively regulate <i>aceBAK</i> would result in constitutive expression of the operon.</p>", "links"=>[], "tags"=>["acetate", "operon", "iclr"], "article_id"=>625470, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Christine C Spencer", "Melanie Bertrand", "Michael Travisano", "Michael Doebeli"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.0030015.g002", "stats"=>{"downloads"=>15, "page_views"=>152, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_of_Negative_Regulation_of_the_Acetate_Operon_aceBAK_and_the_iclR_Gene_by_iclR_22_33_/625470", "title"=>"Schematic of Negative Regulation of the Acetate Operon <i>aceBAK</i> and the <i>iclR</i> Gene by iclR [22,33]", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:03:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/955290"], "description"=>"<p>The <i>iclR<sup>IS1</sup></i> allele (dark blue) alters switching lag relative to the <i>iclR<sup>Anc</sup></i> allele (light blue) in the genetic background of the FS ecotype (A and C) but not the ancestral genetic background with alleles shown in white and black, respectively (B and C; <i>F<sub>3,12</sub></i> = 32.0, <i>p</i> < 0.0001). Growth rates on glucose and acetate are not measurably affected by alleles at this locus (unpublished data; glucose: <i>F<sub>3,12</sub></i> = 28.0, <i>p</i> < 0.0001; acetate: <i>F<sub>3,11</sub></i> = 157.5, <i>p</i> < 0.0001).</p>", "links"=>[], "tags"=>["curves", "switching", "lags", "genetically", "derived"], "article_id"=>625578, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Christine C Spencer", "Melanie Bertrand", "Michael Travisano", "Michael Doebeli"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.0030015.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Growth_Curves_and_Switching_Lags_for_Genetically_Derived_Strains_/625578", "title"=>"Growth Curves and Switching Lags for Genetically Derived Strains", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:04:42"}

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