A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
Publication Date
December 11, 2009
Journal
PLOS Genetics
Authors
J. Brent Richards, Dawn Waterworth, Stephen O'rahilly, Marie France Hivert, et al
Volume
5
Issue
12
Pages
e1000768
DOI
http://doi.org/10.1371/journal.pgen.1000768
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1000768
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20011104
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781107
Europe PMC
http://europepmc.org/abstract/MED/20011104
Web of Science
000273469700019
Scopus
74249100913
Mendeley
http://www.mendeley.com/research/genomewide-association-study-reveals-variants-arl15-influence-adiponectin-levels
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Mendeley | Further Information

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Erich", "last_name"=>"Wichmann", "scopus_author_id"=>"7102574024"}, {"first_name"=>"Phil", "last_name"=>"Barter", "scopus_author_id"=>"7005927655"}, {"first_name"=>"Robert", "last_name"=>"Mahley", "scopus_author_id"=>"7101847176"}, {"first_name"=>"Y. Antero", "last_name"=>"Kesaniemi", "scopus_author_id"=>"55667210200"}, {"first_name"=>"Daniel J.", "last_name"=>"Rader", "scopus_author_id"=>"35378627400"}, {"first_name"=>"Muredach P.", "last_name"=>"Reilly", "scopus_author_id"=>"7202322545"}, {"first_name"=>"Stephen E.", "last_name"=>"Epstein", "scopus_author_id"=>"35405320800"}, {"first_name"=>"Alexandre F.R.", "last_name"=>"Stewart", "scopus_author_id"=>"56962727600"}, {"first_name"=>"Cornelia M.", "last_name"=>"Van Duijn", "scopus_author_id"=>"36037246700"}, {"first_name"=>"Heribert", "last_name"=>"Schunkert", "scopus_author_id"=>"7006507139"}, {"first_name"=>"Keith", "last_name"=>"Burling", "scopus_author_id"=>"15058551600"}, {"first_name"=>"Panos", "last_name"=>"Deloukas", "scopus_author_id"=>"7003287098"}, {"first_name"=>"Tomi", "last_name"=>"Pastinen", "scopus_author_id"=>"6601992219"}, {"first_name"=>"Nilesh J.", "last_name"=>"Samani", "scopus_author_id"=>"7004345054"}, {"first_name"=>"Ruth", "last_name"=>"McPherson", "scopus_author_id"=>"7102810960"}, {"first_name"=>"George Davey", "last_name"=>"Smith", "scopus_author_id"=>"35354080500"}, {"first_name"=>"Timothy M.", "last_name"=>"Frayling", "scopus_author_id"=>"7003962934"}, {"first_name"=>"Nicholas J.", "last_name"=>"Wareham", "scopus_author_id"=>"56754259200"}, {"first_name"=>"James B.", "last_name"=>"Meigs", "scopus_author_id"=>"7006125159"}, {"first_name"=>"Vincent", "last_name"=>"Mooser", "scopus_author_id"=>"7005808262"}, {"first_name"=>"Tim D.", "last_name"=>"Spector", "scopus_author_id"=>"35351391300"}], "year"=>2009, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"74249100913", "scopus"=>"2-s2.0-74249100913", "doi"=>"10.1371/journal.pgen.1000768", "isbn"=>"2200820186", "pui"=>"358116886", "issn"=>"15537390", "pmid"=>"20011104"}, "id"=>"4613ee0b-6971-3311-9583-e83ccf356c0f", "abstract"=>"The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P< or =5x10(-8)). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P< or =0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2x10(-19) for lead SNP, rs266717, n = 14,733). A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9x10(-8), n = 14,733). This same risk allele at ARL15 was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5x10(-6), n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2x10(-3), n = 10,128), and several metabolic traits. Expression studies in humans indicated that ARL15 is well-expressed in skeletal muscle. These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.", "link"=>"http://www.mendeley.com/research/genomewide-association-study-reveals-variants-arl15-influence-adiponectin-levels", "reader_count"=>92, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>5, "Researcher"=>28, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Other"=>8, "Student > Master"=>6, "Student > Bachelor"=>5, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>12}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>5, "Researcher"=>28, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Other"=>8, "Student > Master"=>6, "Student > Bachelor"=>5, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>12}, "reader_count_by_subject_area"=>{"Unspecified"=>13, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>27, "Agricultural and Biological Sciences"=>39, "Psychology"=>3, "Computer Science"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Psychology"=>{"Psychology"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>39}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>13}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>1, "China"=>1, "United Kingdom"=>3, "Mexico"=>1, "India"=>1}, "group_count"=>2}

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/872779"], "description"=>"<p>SNP: Single Nucleotide Polymorphism, CI: Confidence Interval.</p>", "links"=>[], "tags"=>["genome-wide", "snps", "mellitus", "coronary"], "article_id"=>543136, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.t003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_genome_wide_significant_SNPs_with_risk_of_type_2_diabetes_mellitus_T2D_and_coronary_heart_disease_CHD_n_8202_8202_10_128_for_T2D_n_8202_8202_22_421_for_CHD_/543136", "title"=>"Association of genome-wide significant SNPs with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD) (n = 10,128 for T2D; n = 22,421 for CHD).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-12-11 00:52:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/872362"], "description"=>"<p>HEK293 = untransfected HEK293 cells; ARL15 = HEK293 cells transiently expressing wild type human ARL15. SkM = skeletal muscle; WAT = white adipose tissue.</p>", "links"=>[], "tags"=>["blot", "arl15", "insulin-responsive", "tissues", "humans", "loading"], "article_id"=>542727, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.g004", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_showing_ARL15_expression_in_insulin_responsive_tissues_in_humans_with_945_tubulin_as_a_loading_control_/542727", "title"=>"Western blot showing ARL15 expression in insulin-responsive tissues in humans with α-tubulin as a loading control.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-12-11 00:45:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/871858"], "description"=>"<p>Overall study design.</p>", "links"=>[], "tags"=>["cardiovascular disorders/congenital heart disease", "diabetes and endocrinology/obesity", "diabetes and endocrinology/type 2 diabetes", "genetics and genomics/genetics of disease"], "article_id"=>542216, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_study_design_/542216", "title"=>"Overall study design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-12-11 00:36:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/872909"], "description"=>"*<p>Plasma.</p>†<p>Serum.</p><p>SD: Standard Deviation, GEMS: Genetic Etiology of Metabolic Syndrome, BLSA: Baltimore Longitudinal Study of Aging, EPIC-Norfolk: European Prospective Investigation of Cancer-Norfolk, ALSPAC: Avon Longitudinal Study of Parents and Children, ELISA: Enzyme-Linked Immunosorbent Assay, RIA: Radio-Immunoassay, BMI: Body Mass Index.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>543271, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Participant_characteristics_n_total_for_all_cohorts_8202_8202_14_733_/543271", "title"=>"Participant characteristics (n total for all cohorts = 14,733).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-12-11 00:54:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/432863", "https://ndownloader.figshare.com/files/432893", "https://ndownloader.figshare.com/files/432926", "https://ndownloader.figshare.com/files/432951", "https://ndownloader.figshare.com/files/432995", "https://ndownloader.figshare.com/files/433065", "https://ndownloader.figshare.com/files/433139", "https://ndownloader.figshare.com/files/433197"], "description"=>"<div><p>The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P≤5×10<sup>−8</sup>). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P≤0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding <em>ADIPOQ</em> locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2×10<sup>−19</sup> for lead SNP, rs266717, n = 14,733). A novel variant in the <em>ARL15</em> (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9×10<sup>−8</sup>, n = 14,733). This same risk allele at <em>ARL15</em> was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5×10<sup>−6</sup>, n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2×10<sup>−3</sup>, n = 10,128), and several metabolic traits. Expression studies in humans indicated that ARL15 is well-expressed in skeletal muscle. These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.</p></div>", "links"=>[], "tags"=>["genome-wide", "reveals", "variants", "adiponectin", "levels"], "article_id"=>145396, "categories"=>["Cancer", "Biological Sciences", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000768.s001", "https://dx.doi.org/10.1371/journal.pgen.1000768.s002", "https://dx.doi.org/10.1371/journal.pgen.1000768.s003", "https://dx.doi.org/10.1371/journal.pgen.1000768.s004", "https://dx.doi.org/10.1371/journal.pgen.1000768.s005", "https://dx.doi.org/10.1371/journal.pgen.1000768.s006", "https://dx.doi.org/10.1371/journal.pgen.1000768.s007", "https://dx.doi.org/10.1371/journal.pgen.1000768.s008"], "stats"=>{"downloads"=>25, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Genome_Wide_Association_Study_Reveals_Variants_in_ARL15_that_Influence_Adiponectin_Levels/145396", "title"=>"A Genome-Wide Association Study Reveals Variants in <em>ARL15</em> that Influence Adiponectin Levels", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-12-11 01:29:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/872056"], "description"=>"<p>(A) −Log(P-value) measures for association between single nucleotide polymorphisms (SNPs) and chromosomal position. (B) Linkage disequilibrium in GOLD heat map Haploview 4.0 color scheme, CEPH (Centre d'Étude du Polymorphisme Humain) population. The x axis represents genomic position in Mb (A) and in kb (B). All P-values are derived from the discovery meta-analysis of CoLaus, TwinsUK, and Genetic Etiology of Metabolic Syndrome (GEMS) cohorts, except that for the lead SNP, rs4311394 (in red), which is derived from the combined P-value from the CoLaus, TwinsUK, GEMS, Framingham, InCHIANTI, Baltimore Longitudinal Study of Aging (BLSA), Avon Longitudinal Study of Parents and Children (ALSPAC), and European Prospective Investigation of Cancer-Norfolk (EPIC-Norfolk) cohorts.</p>", "links"=>[], "tags"=>["snps", "adiponectin"], "article_id"=>542417, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SNPs_near_ARL15_and_adiponectin_levels_/542417", "title"=>"Association between SNPs near <i>ARL15</i> and adiponectin levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-12-11 00:40:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/872521"], "description"=>"<p>SNP: Single Nucleotide Polymorphism, CI: Confidence Interval, HOMA-IR: Homeostasis Model Assessment Insulin Resistance, HOMA-B: Homeostasis Model Assessment Beta-Cell Function.</p>", "links"=>[], "tags"=>["genome-wide", "snps", "indices", "insulin"], "article_id"=>542882, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.t004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_genome_wide_significant_SNPs_with_indices_of_insulin_homeostasis_/542882", "title"=>"Association of genome-wide significant SNPs with indices of insulin homeostasis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-12-11 00:48:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/872218"], "description"=>"<p>mRNA levels determined by quantitative real-time PCR in a panel of human tissues.</p>", "links"=>[], "tags"=>["arl15"], "article_id"=>542588, "categories"=>["Virology", "Computational Biology", "Medicine", "Genetics"], "users"=>["J. Brent Richards", "Dawn Waterworth", "Stephen O'Rahilly", "Marie-France Hivert", "Ruth J. F. Loos", "John R. B. Perry", "Toshiko Tanaka", "Nicholas John Timpson", "Robert K. Semple", "Nicole Soranzo", "Kijoung Song", "Nuno Rocha", "Elin Grundberg", "Josée Dupuis", "Jose C. Florez", "Claudia Langenberg", "Inga Prokopenko", "Richa Saxena", "Robert Sladek", "Yurii Aulchenko", "David Evans", "Gérard Waeber", "Jeanette Erdmann", "Mary-Susan Burnett", "Naveed Sattar", "Joseph Devaney", "Christina Willenborg", "Aroon Hingorani", "Jaquelin C. M. Witteman", "Peter Vollenweider", "Beate Glaser", "Christian Hengstenberg", "Luigi Ferrucci", "David Melzer", "Klaus Stark", "John Deanfield", "Janina Winogradow", "Martina Grassl", "Alistair S. Hall", "Josephine M. Egan", "John R. Thompson", "Sally L. Ricketts", "Inke R. König", "Wibke Reinhard", "Scott Grundy", "H-Erich Wichmann", "Phil Barter", "Robert Mahley", "Y. Antero Kesäniemi", "Daniel J. Rader", "Muredach P. Reilly", "Stephen E. Epstein", "Alexandre F. R. Stewart", "Cornelia M. van Duijn", "Heribert Schunkert", "Keith Burling", "Panos Deloukas", "Tomi Pastinen", "Nilesh J. Samani", "Ruth McPherson", "George Davey Smith", "Timothy M. Frayling", "Nicholas J. Wareham", "James B. Meigs", "Vincent Mooser", "Tim D. Spector"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000768.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_distribution_of_ARL15_expression_/542588", "title"=>"Tissue distribution of ARL15 expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-12-11 00:43:08"}
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PMC Usage Stats | Further Information

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Relative Metric

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