Variation in Genes Related to Cochlear Biology Is Strongly Associated with Adult-Onset Deafness in Border Collies
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Variation in Genes Related to Cochlear Biology Is Strongly Associated with Adult-Onset Deafness in Border Collies", "type"=>"journal", "authors"=>[{"first_name"=>"Jennifer S.", "last_name"=>"Yokoyama", "scopus_author_id"=>"26649290800"}, {"first_name"=>"Ernest T.", "last_name"=>"Lam", "scopus_author_id"=>"25959136700"}, {"first_name"=>"Alison L.", "last_name"=>"Ruhe", "scopus_author_id"=>"35727882400"}, {"first_name"=>"Carolyn A.", "last_name"=>"Erdman", "scopus_author_id"=>"55955414700"}, {"first_name"=>"Kathryn R.", "last_name"=>"Robertson", "scopus_author_id"=>"35565594900"}, {"first_name"=>"Aubrey A.", "last_name"=>"Webb", "scopus_author_id"=>"7402883394"}, {"first_name"=>"D. Colette", "last_name"=>"Williams", "scopus_author_id"=>"56801182800"}, {"first_name"=>"Melanie L.", "last_name"=>"Chang", "scopus_author_id"=>"55370476400"}, {"first_name"=>"Marjo K.", "last_name"=>"Hytönen", "scopus_author_id"=>"7003691505"}, {"first_name"=>"Hannes", "last_name"=>"Lohi", "scopus_author_id"=>"6602309083"}, {"first_name"=>"Steven P.", "last_name"=>"Hamilton", "scopus_author_id"=>"7402244945"}, {"first_name"=>"Mark W.", "last_name"=>"Neff", "scopus_author_id"=>"7005745217"}], "year"=>2012, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"84866908419", "scopus"=>"2-s2.0-84866908419", "doi"=>"10.1371/journal.pgen.1002898", "isbn"=>"1553-7390", "pui"=>"365755966", "issn"=>"15537390", "pmid"=>"23028339"}, "id"=>"6af8f3f3-3c9b-334f-b818-e1a10fe01c0c", "abstract"=>"Domestic dogs can suffer from hearing losses that can have profound impacts on working ability and quality of life. We have identified a type of adult-onset hearing loss in Border Collies that appears to have a genetic cause, with an earlier age of onset (3-5 years) than typically expected for aging dogs (8-10 years). Studying this complex trait within pure breeds of dog may greatly increase our ability to identify genomic regions associated with risk of hearing impairment in dogs and in humans. We performed a genome-wide association study (GWAS) to detect loci underlying adult-onset deafness in a sample of 20 affected and 28 control Border Collies. We identified a region on canine chromosome 6 that demonstrates extended support for association surrounding SNP Chr6.25819273 (p-value = 1.09 × 10(-13)). To further localize disease-associated variants, targeted next-generation sequencing (NGS) of one affected and two unaffected dogs was performed. Through additional validation based on targeted genotyping of additional cases (n = 23 total) and controls (n = 101 total) and an independent replication cohort of 16 cases and 265 controls, we identified variants in USP31 that were strongly associated with adult-onset deafness in Border Collies, suggesting the involvement of the NF-κB pathway. We found additional support for involvement of RBBP6, which is critical for cochlear development. These findings highlight the utility of GWAS-guided fine-mapping of genetic loci using targeted NGS to study hereditary disorders of the domestic dog that may be analogous to human disorders.", "link"=>"http://www.mendeley.com/research/variation-genes-related-cochlear-biology-strongly-associated-adultonset-deafness-border-collies", "reader_count"=>14, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>7, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Student > Ph. D. Student"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>7, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Student > Ph. D. Student"=>2}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>3, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84866908419"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84866908419?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866908419&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84866908419&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84866908419", "dc:identifier"=>"SCOPUS_ID:84866908419", "eid"=>"2-s2.0-84866908419", "dc:title"=>"Variation in Genes Related to Cochlear Biology Is Strongly Associated with Adult-Onset Deafness in Border Collies", "dc:creator"=>"Yokoyama J.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"8", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-09-01", "prism:coverDisplayDate"=>"September 2012", "prism:doi"=>"10.1371/journal.pgen.1002898", "citedby-count"=>"5", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of California, San Francisco", "affiliation-city"=>"San Francisco", "affiliation-country"=>"United States"}], "pubmed-id"=>"23028339", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1002898", "source-id"=>"4000151808"}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1002898", "share_count"=>3, "like_count"=>1, "comment_count"=>0, "click_count"=>0, "total_count"=>4}

Counter

  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"100", "xml_views"=>"16", "html_views"=>"1486"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"51", "xml_views"=>"1", "html_views"=>"680"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"132"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"205"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"226"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"84"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"224"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"93"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"123"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"52"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"126"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"254"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"198"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"310"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"417"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"178"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"209"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"198"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"194"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"109"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"28"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/304294", "https://ndownloader.figshare.com/files/304345", "https://ndownloader.figshare.com/files/304413", "https://ndownloader.figshare.com/files/304463", "https://ndownloader.figshare.com/files/304521", "https://ndownloader.figshare.com/files/304564", "https://ndownloader.figshare.com/files/304612", "https://ndownloader.figshare.com/files/304659", "https://ndownloader.figshare.com/files/304713", "https://ndownloader.figshare.com/files/304753", "https://ndownloader.figshare.com/files/304840"], "description"=>"<div><p>Domestic dogs can suffer from hearing losses that can have profound impacts on working ability and quality of life. We have identified a type of adult-onset hearing loss in Border Collies that appears to have a genetic cause, with an earlier age of onset (3–5 years) than typically expected for aging dogs (8–10 years). Studying this complex trait within pure breeds of dog may greatly increase our ability to identify genomic regions associated with risk of hearing impairment in dogs and in humans. We performed a genome-wide association study (GWAS) to detect loci underlying adult-onset deafness in a sample of 20 affected and 28 control Border Collies. We identified a region on canine chromosome 6 that demonstrates extended support for association surrounding SNP Chr6.25819273 (p-value = 1.09×10<sup>−13</sup>). To further localize disease-associated variants, targeted next-generation sequencing (NGS) of one affected and two unaffected dogs was performed. Through additional validation based on targeted genotyping of additional cases (n = 23 total) and controls (n = 101 total) and an independent replication cohort of 16 cases and 265 controls, we identified variants in <em>USP31</em> that were strongly associated with adult-onset deafness in Border Collies, suggesting the involvement of the NF-κB pathway. We found additional support for involvement of <em>RBBP6</em>, which is critical for cochlear development. These findings highlight the utility of GWAS–guided fine-mapping of genetic loci using targeted NGS to study hereditary disorders of the domestic dog that may be analogous to human disorders.</p> </div>", "links"=>[], "tags"=>["genes", "cochlear", "adult-onset", "deafness", "collies"], "article_id"=>120016, "categories"=>["Genetics"], "users"=>["Jennifer S. Yokoyama", "Ernest T. Lam", "Alison L. Ruhe", "Carolyn A. Erdman", "Kathryn R. Robertson", "Aubrey A. Webb", "D. Colette Williams", "Melanie L. Chang", "Marjo K. Hytönen", "Hannes Lohi", "Steven P. Hamilton", "Mark W. Neff"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002898.s001", "https://dx.doi.org/10.1371/journal.pgen.1002898.s002", "https://dx.doi.org/10.1371/journal.pgen.1002898.s003", "https://dx.doi.org/10.1371/journal.pgen.1002898.s004", "https://dx.doi.org/10.1371/journal.pgen.1002898.s005", "https://dx.doi.org/10.1371/journal.pgen.1002898.s006", "https://dx.doi.org/10.1371/journal.pgen.1002898.s007", "https://dx.doi.org/10.1371/journal.pgen.1002898.s008", "https://dx.doi.org/10.1371/journal.pgen.1002898.s009", "https://dx.doi.org/10.1371/journal.pgen.1002898.s010", "https://dx.doi.org/10.1371/journal.pgen.1002898.s011"], "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Variation_in_Genes_Related_to_Cochlear_Biology_Is_Strongly_Associated_with_Adult_Onset_Deafness_in_Border_Collies/120016", "title"=>"Variation in Genes Related to Cochlear Biology Is Strongly Associated with Adult-Onset Deafness in Border Collies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-09-13 00:00:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/576943"], "description"=>"a<p>SNP: marker name (location information); A1: risk allele; A2: reference allele; Freq<sub>Case</sub>: allele frequency of A1 in cases; Freq<sub>Control</sub>: allele frequency of A1 in controls; P<sub>EMMAX</sub>: p-values from EMMAX primary GWAS; P<sub>Allelic</sub>: p-values from allelic association analysis; P<sub>Perm</sub>: genome-wide (EMP2) permuted p-values from PLINK; OR (95% CI): odds ratio with 95% confidence interval as calculated with logistic regression.</p><p>All top 25 hits from the EMMAX analysis reached statistical significance at the Bonferroni-corrected level, and all but one are on CFA6. All top 25 findings also reached genome-wide significance after empirical significance testing with permutation. Odds ratios calculated in PLINK demonstrate strong effects for all top hits.</p>", "links"=>[], "tags"=>["25", "ranked", "findings", "presbycusis"], "article_id"=>247425, "categories"=>["Genetics"], "users"=>["Jennifer S. Yokoyama", "Ernest T. Lam", "Alison L. Ruhe", "Carolyn A. Erdman", "Kathryn R. Robertson", "Aubrey A. Webb", "D. Colette Williams", "Melanie L. Chang", "Marjo K. Hytönen", "Hannes Lohi", "Steven P. Hamilton", "Mark W. Neff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002898.t001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_25_ranked_findings_from_analysis_for_presbycusis_in_Border_Collies_a_/247425", "title"=>"Top 25 ranked findings from analysis for presbycusis in Border Collies.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-13 02:03:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/576893"], "description"=>"a<p>SNP: marker name (location information); A1: risk allele; A2: reference allele; Fr<sub>Case</sub>: allele frequency of A1 in cases; Fr<sub>Cont</sub>: allele frequency of A1 in controls; P: p-values from allelic association analysis; OR: odds ratio with 95% confidence interval; Comb. P: combined p-value from meta-analysis.</p><p>The strength of association of the three variants is shown. Chr6.24500625 in <i>RBBP6</i> and Chr6.25681850 in <i>USP31</i> remain highly significant after inclusion of more cases and controls.</p>", "links"=>[], "tags"=>["stages"], "article_id"=>247380, "categories"=>["Genetics"], "users"=>["Jennifer S. Yokoyama", "Ernest T. Lam", "Alison L. Ruhe", "Carolyn A. Erdman", "Kathryn R. Robertson", "Aubrey A. Webb", "D. Colette Williams", "Melanie L. Chang", "Marjo K. Hytönen", "Hannes Lohi", "Steven P. Hamilton", "Mark W. Neff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002898.t002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_association_results_with_combined_data_from_all_stages_of_study_a_/247380", "title"=>"Summary of association results with combined data from all stages of study.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-13 02:03:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/576696"], "description"=>"<p>Chromosome markers are plotted on the x-axis in order and alternately shaded. The -log<sub>10</sub>(p-value) is plotted on the y-axis. The red line indicates significance at the Bonferroni-corrected level for 30,000 SNPs. There is extensive regional support for an association on CFA6. The inset shows an enlargement of the 25-Mb association region, including genes of interest. The raw GWAS and permuted p-values (P<sub>perm-gw</sub>) for the top SNP are also given.</p>", "links"=>[], "tags"=>["GWAS", "adult-onset"], "article_id"=>247181, "categories"=>["Genetics"], "users"=>["Jennifer S. Yokoyama", "Ernest T. Lam", "Alison L. Ruhe", "Carolyn A. Erdman", "Kathryn R. Robertson", "Aubrey A. Webb", "D. Colette Williams", "Melanie L. Chang", "Marjo K. Hytönen", "Hannes Lohi", "Steven P. Hamilton", "Mark W. Neff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002898.g001", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Manhattan_plot_of_GWAS_for_adult_onset_deafness_/247181", "title"=>"Manhattan plot of GWAS for adult-onset deafness.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-13 01:59:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/576815"], "description"=>"<p>Each box color represents a different genotype, as indicated by the key; dogs are listed in rows and SNPs in columns. Case dogs are all homozygous for a single haplotype spanning 7 markers, and all but one case also share an 11-SNP haplotype (for which the single dog is heterozygous). One sample used as a control (marked with *) also carries the 11-SNP risk haplotype.</p>", "links"=>[], "tags"=>["cfa6", "25"], "article_id"=>247295, "categories"=>["Genetics"], "users"=>["Jennifer S. Yokoyama", "Ernest T. Lam", "Alison L. Ruhe", "Carolyn A. Erdman", "Kathryn R. Robertson", "Aubrey A. Webb", "D. Colette Williams", "Melanie L. Chang", "Marjo K. Hytönen", "Hannes Lohi", "Steven P. Hamilton", "Mark W. Neff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002898.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Haplotypes_in_CFA6_region_25_Mb_/247295", "title"=>"Haplotypes in CFA6 region 25 Mb.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-13 02:01:35"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"44", "full-text"=>"41", "pdf"=>"25", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"10", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"36", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"23", "full-text"=>"39", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"35", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"38", "full-text"=>"60", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"31", "full-text"=>"38", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"22", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"30", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"26", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"26", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"28", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"29", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"32", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"27", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"24", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"25", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"29", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"17", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"14", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"22", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[375, 629, 760, 889, 1000, 1110, 1203, 1298, 1399, 1492, 1603, 1699, 1774, 1855, 1918, 1998, 2062, 2152, 2227, 2312, 2378, 2461, 2528, 2600, 2664]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[333, 576, 707, 814, 908, 1004, 1104, 1197, 1280, 1370, 1449, 1531, 1603, 1673, 1742, 1817, 1886, 1954, 2025, 2098, 2171, 2234, 2304, 2365, 2431]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Otorhinolaryngology", "average_usage"=>[301, 529, 662, 747, 833, 932, 1022, 1100, 1176, 1259, 1318, 1389, 1472, 1531, 1582, 1651, 1714, 1788, 1840, 1921, 2004, 2090, 2189, 2255, 2309]}]}
Loading … Spinner
There are currently no alerts