Revisiting the Design of Phase III Clinical Trials of Antimalarial Drugs for Uncomplicated Plasmodium falciparum Malaria
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{"title"=>"Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria", "type"=>"generic", "authors"=>[{"first_name"=>"Steffen", "last_name"=>"Borrmann", "scopus_author_id"=>"7005941216"}, {"first_name"=>"Tim", "last_name"=>"Peto", "scopus_author_id"=>"7005772816"}, {"first_name"=>"Robert W.", "last_name"=>"Snow", "scopus_author_id"=>"56771582900"}, {"first_name"=>"Win", "last_name"=>"Gutteridge", "scopus_author_id"=>"24760440100"}, {"first_name"=>"Nicholas J.", "last_name"=>"White", "scopus_author_id"=>"7401767314"}], "year"=>2008, "source"=>"PLoS Medicine", "identifiers"=>{"doi"=>"10.1371/journal.pmed.0050227", "pui"=>"352744029", "issn"=>"15491277", "scopus"=>"2-s2.0-56749176780", "sgr"=>"56749176780", "pmid"=>"19018658"}, "id"=>"bed849fa-4fe7-3062-a891-acb77e122941", "abstract"=>"Steffen Borrmann and colleagues discuss appropriate endpoints and their measurement during phase III trials of new antimalarial drugs.", "link"=>"http://www.mendeley.com/research/revisiting-design-phase-iii-clinical-trials-antimalarial-drugs-uncomplicated-plasmodium-falciparum-m-1", "reader_count"=>27, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>1, "Other"=>9, "Student > Master"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>1, "Other"=>9, "Student > Master"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>2, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>4, "Business, Management and Accounting"=>2, "Chemistry"=>6, "Immunology and Microbiology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Chemistry"=>{"Chemistry"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>2}}, "reader_count_by_country"=>{"Belgium"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/915177"], "description"=>"<p>The solid line represents recrudescent infections with a cumulative failure rate of 5% by day 42. Dashed lines represent different rates of re-infections corresponding to entomological inoculation rates of two (yellow), four (orange), and six (red) infective mosquito bites/year, respectively. Trailing plasma drug concentrations delay both detectable recrudescent primary and secondary blood stage infections—however, both effects are fading until day 42. <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0050227#pmed-0050227-g001\" target=\"_blank\">Figure 1A</a> illustrates that most recrudescent primary infections are captured by day 42. Extension of follow-up beyond day 28 results in increased ratios of new versus recrudescent infections and hence, elevated risk of outcome misclassifications due to intrinsic limitations of current molecular techniques used to discriminate between primary and secondary infections. The assessment of the total number of recurrent infections as a composite outcome (often denoted the PCR “uncorrected cure rate”) requires some time limits as re-infection occurs eventually in almost everyone after blood concentrations of the drug(s) fall below the MIC (<a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0050227#pmed-0050227-g001\" target=\"_blank\">Figure 1B</a>).</p>", "links"=>[], "tags"=>["plots", "incidence", "rates", "cumulative", "proportions", "recrudescent", "infections", "re-infections", "uncomplicated", "malaria", "eliminated"], "article_id"=>585618, "categories"=>["Microbiology", "Infectious Diseases", "Pharmacology"], "users"=>["Steffen Borrmann", "Tim Peto", "Robert W Snow", "Win Gutteridge", "Nicholas J White"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.0050227.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Simulated_Plots_of_Weekly_Incidence_Rates_and_Cumulative_Proportions_for_Recrudescent_Primary_Infections_and_Re_Infections_Following_Treatment_of_Uncomplicated_P_falciparum_Malaria_with_a_Slowly_Eliminated_Partner_Drug_Half_Life_of_1_Week_/585618", "title"=>"Simulated Plots of Weekly Incidence Rates and Cumulative Proportions for Recrudescent Primary Infections and Re-Infections Following Treatment of Uncomplicated P. falciparum Malaria with a Slowly Eliminated (Partner) Drug (Half-Life of ~1 Week)", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:31:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/915334"], "description"=>"<p>Phase III trials are designed to provide pivotal efficacy and safety data for obtaining regulatory approval. The indicated numbers of study participants are approximations of the magnitude of required total sample sizes in different transmission settings.</p>", "links"=>[], "tags"=>["iterative", "antimalarial", "drugs"], "article_id"=>585790, "categories"=>["Microbiology", "Infectious Diseases", "Pharmacology"], "users"=>["Steffen Borrmann", "Tim Peto", "Robert W Snow", "Win Gutteridge", "Nicholas J White"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.0050227.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Simplified_Outline_of_the_Iterative_Process_of_the_Clinical_Development_of_New_Antimalarial_Candidate_Drugs_or_Drug_Combinations_/585790", "title"=>"Simplified Outline of the Iterative Process of the Clinical Development of New Antimalarial Candidate Drugs or Drug Combinations", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:32:33"}

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Relative Metric

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