Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies
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{"title"=>"Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: A collaborative analysis of data for 10,159 cases from 12 studies", "type"=>"journal", "authors"=>[{"first_name"=>"Fiona M.", "last_name"=>"Blows", "scopus_author_id"=>"57192872316"}, {"first_name"=>"Kristy E.", "last_name"=>"Driver", "scopus_author_id"=>"23972332600"}, {"first_name"=>"Marjanka K.", "last_name"=>"Schmidt", "scopus_author_id"=>"55312657600"}, {"first_name"=>"Annegien", "last_name"=>"Broeks", "scopus_author_id"=>"6603423682"}, {"first_name"=>"Flora E.", "last_name"=>"van Leeuwen", "scopus_author_id"=>"7103402884"}, {"first_name"=>"Jelle", "last_name"=>"Wesseling", "scopus_author_id"=>"7005190231"}, {"first_name"=>"Maggie C.", "last_name"=>"Cheang", "scopus_author_id"=>"8587225200"}, {"first_name"=>"Karen", "last_name"=>"Gelmon", "scopus_author_id"=>"7005225389"}, {"first_name"=>"Torsten O.", "last_name"=>"Nielsen", "scopus_author_id"=>"7201759696"}, {"first_name"=>"Carl", "last_name"=>"Blomqvist", "scopus_author_id"=>"35373975300"}, {"first_name"=>"Päivi", "last_name"=>"Heikkila", "scopus_author_id"=>"7006489628"}, {"first_name"=>"Tuomas", "last_name"=>"Heikkinen", "scopus_author_id"=>"56856581200"}, {"first_name"=>"Heli", "last_name"=>"Nevanlinna", "scopus_author_id"=>"7004551802"}, {"first_name"=>"Lars A.", "last_name"=>"Akslen", "scopus_author_id"=>"7007046494"}, {"first_name"=>"Louis R.", "last_name"=>"Bégin", "scopus_author_id"=>"7005267727"}, {"first_name"=>"William D.", "last_name"=>"Foulkes", "scopus_author_id"=>"7101673318"}, {"first_name"=>"Fergus J.", "last_name"=>"Couch", "scopus_author_id"=>"7005841005"}, {"first_name"=>"Xianshu", "last_name"=>"Wang", "scopus_author_id"=>"57193400915"}, {"first_name"=>"Vicky", "last_name"=>"Cafourek", "scopus_author_id"=>"36102330400"}, {"first_name"=>"Janet E.", "last_name"=>"Olson", "scopus_author_id"=>"7402883190"}, {"first_name"=>"Laura", "last_name"=>"Baglietto", "scopus_author_id"=>"57190511196"}, {"first_name"=>"Graham G.", "last_name"=>"Giles", "scopus_author_id"=>"57193910834"}, {"first_name"=>"Gianluca", "last_name"=>"Severi", "scopus_author_id"=>"7004042887"}, {"first_name"=>"Catriona A.", "last_name"=>"McLean", "scopus_author_id"=>"7103396821"}, {"first_name"=>"Melissa C.", "last_name"=>"Southey", "scopus_author_id"=>"7003842049"}, {"first_name"=>"Emad", "last_name"=>"Rakha", "scopus_author_id"=>"6507328020"}, {"first_name"=>"Andrew R.", "last_name"=>"Green", "scopus_author_id"=>"56293864500"}, {"first_name"=>"Ian O.", "last_name"=>"Ellis", "scopus_author_id"=>"36039440700"}, {"first_name"=>"Mark E.", "last_name"=>"Sherman", "scopus_author_id"=>"35374273000"}, {"first_name"=>"Jolanta", "last_name"=>"Lissowska", "scopus_author_id"=>"6602685552"}, {"first_name"=>"William F.", "last_name"=>"Anderson", "scopus_author_id"=>"7403926823"}, {"first_name"=>"Angela", "last_name"=>"Cox", "scopus_author_id"=>"7402563876"}, {"first_name"=>"Simon S.", "last_name"=>"Cross", "scopus_author_id"=>"35993775100"}, {"first_name"=>"Malcolm W.R.", "last_name"=>"Reed", "scopus_author_id"=>"7401800418"}, {"first_name"=>"Elena", "last_name"=>"Provenzano", "scopus_author_id"=>"15765938100"}, {"first_name"=>"Sarah Jane", "last_name"=>"Dawson", "scopus_author_id"=>"56839845600"}, {"first_name"=>"Alison M.", "last_name"=>"Dunning", "scopus_author_id"=>"26643422500"}, {"first_name"=>"Manjeet", "last_name"=>"Humphreys", "scopus_author_id"=>"18339637300"}, {"first_name"=>"Douglas F.", "last_name"=>"Easton", "scopus_author_id"=>"16471950000"}, {"first_name"=>"Montserrat", "last_name"=>"García-Closas", "scopus_author_id"=>"6603897426"}, {"first_name"=>"Carlos", "last_name"=>"Caldas", "scopus_author_id"=>"7006688992"}, {"first_name"=>"Paul D.", "last_name"=>"Pharoah", "scopus_author_id"=>"7102929844"}, {"first_name"=>"David", "last_name"=>"Huntsman", "scopus_author_id"=>"7003437964"}], "year"=>2010, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491277", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "arxiv"=>"e1000279", "doi"=>"10.1371/journal.pmed.1000279", "pui"=>"358974500", "sgr"=>"77953248475", "pmid"=>"20520800", "scopus"=>"2-s2.0-77953248475"}, "id"=>"b7156430-8d23-32d3-820c-b511b59deca0", "abstract"=>"BACKGROUND: Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the major subtypes of breast cancer as classified using five immunohistochemical markers, to investigate patterns of mortality over time, and to test for heterogeneity by subtype. METHODS AND FINDINGS: We pooled data from more than 10,000 cases of invasive breast cancer from 12 studies that had collected information on hormone receptor status, human epidermal growth factor receptor-2 (HER2) status, and at least one basal marker (cytokeratin [CK]5/6 or epidermal growth factor receptor [EGFR]) together with survival time data. Tumours were classified as luminal and nonluminal tumours according to hormone receptor expression. These two groups were further subdivided according to expression of HER2, and finally, the luminal and nonluminal HER2-negative tumours were categorised according to expression of basal markers. Changes in mortality rates over time differed by subtype. In women with luminal HER2-negative subtypes, mortality rates were constant over time, whereas mortality rates associated with the luminal HER2-positive and nonluminal subtypes tended to peak within 5 y of diagnosis and then decline over time. In the first 5 y after diagnosis the nonluminal tumours were associated with a poorer prognosis, but over longer follow-up times the prognosis was poorer in the luminal subtypes, with the worst prognosis at 15 y being in the luminal HER2-positive tumours. Basal marker expression distinguished the HER2-negative luminal and nonluminal tumours into different subtypes. These patterns were independent of any systemic adjuvant therapy. CONCLUSIONS: The six subtypes of breast cancer defined by expression of five markers show distinct behaviours with important differences in short term and long term prognosis. Application of these markers in the clinical setting could have the potential to improve the targeting of adjuvant chemotherapy to those most likely to benefit. The different patterns of mortality over time also suggest important biological differences between the subtypes that may result in differences in response to specific therapies, and that stratification of breast cancers by clinically relevant subtypes in clinical trials is urgently required.", "link"=>"http://www.mendeley.com/research/subtyping-breast-cancer-immunohistochemistry-investigate-relationship-between-subtype-short-long-ter", "reader_count"=>319, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>25, "Librarian"=>2, "Student > Doctoral Student"=>18, "Researcher"=>53, "Student > Ph. D. 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  • {"files"=>["https://ndownloader.figshare.com/files/4965058"], "description"=>"<p>All curves are adjusted for age at diagnosis, tumour grade, tumour size, node status, and study.</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518368, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_and_B_Kaplan_Meier_cumulative_survival_all_cause_mortality_in_luminal_and_nonluminal_tumours_by_subtype_/518368", "title"=>"(A and B) Kaplan-Meier cumulative survival (all-cause mortality) in luminal and nonluminal tumours by subtype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-25 02:19:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/4965088"], "description"=>"<p>Multivariate period-specific all-cause mortality hazard ratios (95% CI).</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518690, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_period_specific_all_cause_mortality_hazard_ratios_95_CI_/518690", "title"=>"Multivariate period-specific all-cause mortality hazard ratios (95% CI).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 02:24:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4965100"], "description"=>"<p>Number of tumours by subtype and study.</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518596, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.t003", "stats"=>{"downloads"=>6, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_tumours_by_subtype_and_study_/518596", "title"=>"Number of tumours by subtype and study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 02:23:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/4965109"], "description"=>"<p>Characteristics of breast cancer subtypes by age at diagnosis, tumour grade, tumour size, and node status.</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518505, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.t004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_breast_cancer_subtypes_by_age_at_diagnosis_tumour_grade_tumour_size_and_node_status_/518505", "title"=>"Characteristics of breast cancer subtypes by age at diagnosis, tumour grade, tumour size, and node status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 02:21:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/4965046"], "description"=>"<p>All hazard ratios are stratified by study and adjusted for tumour grade, tumour size, and node status.</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518221, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Period_specific_hazard_ratios_all_cause_mortality_for_major_breast_cancer_subtypes_/518221", "title"=>"Period-specific hazard ratios (all-cause mortality) for major breast cancer subtypes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-25 02:17:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/4964953", "https://ndownloader.figshare.com/files/4965019", "https://ndownloader.figshare.com/files/4965013", "https://ndownloader.figshare.com/files/4965007", "https://ndownloader.figshare.com/files/4965001", "https://ndownloader.figshare.com/files/4964992", "https://ndownloader.figshare.com/files/4964986", "https://ndownloader.figshare.com/files/4964977", "https://ndownloader.figshare.com/files/4964971", "https://ndownloader.figshare.com/files/4964968", "https://ndownloader.figshare.com/files/4965022"], "description"=>"<div><p>Background</p><p>Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the major subtypes of breast cancer as classified using five immunohistochemical markers, to investigate patterns of mortality over time, and to test for heterogeneity by subtype.</p><p>Methods and Findings</p><p>We pooled data from more than 10,000 cases of invasive breast cancer from 12 studies that had collected information on hormone receptor status, human epidermal growth factor receptor-2 (HER2) status, and at least one basal marker (cytokeratin [CK]5/6 or epidermal growth factor receptor [EGFR]) together with survival time data. Tumours were classified as luminal and nonluminal tumours according to hormone receptor expression. These two groups were further subdivided according to expression of HER2, and finally, the luminal and nonluminal HER2-negative tumours were categorised according to expression of basal markers. Changes in mortality rates over time differed by subtype. In women with luminal HER2-negative subtypes, mortality rates were constant over time, whereas mortality rates associated with the luminal HER2-positive and nonluminal subtypes tended to peak within 5 y of diagnosis and then decline over time. In the first 5 y after diagnosis the nonluminal tumours were associated with a poorer prognosis, but over longer follow-up times the prognosis was poorer in the luminal subtypes, with the worst prognosis at 15 y being in the luminal HER2-positive tumours. Basal marker expression distinguished the HER2-negative luminal and nonluminal tumours into different subtypes. These patterns were independent of any systemic adjuvant therapy.</p><p>Conclusions</p><p>The six subtypes of breast cancer defined by expression of five markers show distinct behaviours with important differences in short term and long term prognosis. Application of these markers in the clinical setting could have the potential to improve the targeting of adjuvant chemotherapy to those most likely to benefit. The different patterns of mortality over time also suggest important biological differences between the subtypes that may result in differences in response to specific therapies, and that stratification of breast cancers by clinically relevant subtypes in clinical trials is urgently required.</p><p> </p><p><i>Please see later in the article for the Editors' Summary</i></p></div>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>143344, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1000279.s001", "https://dx.doi.org/10.1371/journal.pmed.1000279.s010", "https://dx.doi.org/10.1371/journal.pmed.1000279.s009", "https://dx.doi.org/10.1371/journal.pmed.1000279.s008", "https://dx.doi.org/10.1371/journal.pmed.1000279.s007", "https://dx.doi.org/10.1371/journal.pmed.1000279.s006", "https://dx.doi.org/10.1371/journal.pmed.1000279.s005", "https://dx.doi.org/10.1371/journal.pmed.1000279.s004", "https://dx.doi.org/10.1371/journal.pmed.1000279.s003", "https://dx.doi.org/10.1371/journal.pmed.1000279.s002", "https://dx.doi.org/10.1371/journal.pmed.1000279.s011"], "stats"=>{"downloads"=>95, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Subtyping_of_Breast_Cancer_by_Immunohistochemistry_to_Investigate_a_Relationship_between_Subtype_and_Short_and_Long_Term_Survival_A_Collaborative_Analysis_of_Data_for_10_159_Cases_from_12_Studies/143344", "title"=>"Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-12 17:44:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/4965031"], "description"=>"<p>Classification of breast cancer subtypes according to IHC marker profile.</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518103, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.g001", "stats"=>{"downloads"=>1, "page_views"=>90, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Classification_of_breast_cancer_subtypes_according_to_IHC_marker_profile_/518103", "title"=>"Classification of breast cancer subtypes according to IHC marker profile.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-25 02:15:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/4965076"], "description"=>"<p>Description of participating studies.</p>", "links"=>[], "tags"=>["12 Studies Background Immunohistochemical markers", "subtype", "Long Term Survival", "survival time data", "epidermal growth factor receptor", "hormone receptor status", "mortality rates", "breast cancer", "CK", "HER", "5 y", "EGFR", "prognosis", "hormone receptor expression", "nonluminal tumours", "Basal marker expression"], "article_id"=>518776, "categories"=>["Cell Biology", "Biotechnology", "Biological Sciences not elsewhere classified", "Cancer"], "users"=>["Fiona M. Blows", "Kristy E. Driver", "Marjanka K. Schmidt", "Annegien Broeks", "Flora E. van Leeuwen", "Jelle Wesseling", "Maggie C. Cheang", "Karen Gelmon", "Torsten O. Nielsen", "Carl Blomqvist", "Päivi Heikkilä", "Tuomas Heikkinen", "Heli Nevanlinna", "Lars A. Akslen", "Louis R. Bégin", "William D. Foulkes", "Fergus J. Couch", "Xianshu Wang", "Vicky Cafourek", "Janet E. Olson", "Laura Baglietto", "Graham G. Giles", "Gianluca Severi", "Catriona A. McLean", "Melissa C. Southey", "Emad Rakha", "Andrew R. Green", "Ian O. Ellis", "Mark E. Sherman", "Jolanta Lissowska", "William F. Anderson", "Angela Cox", "Simon S. Cross", "Malcolm W. R. Reed", "Elena Provenzano", "Sarah-Jane Dawson", "Alison M. Dunning", "Manjeet Humphreys", "Douglas F. Easton", "Montserrat García-Closas", "Carlos Caldas", "Paul D. Pharoah", "David Huntsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000279.t001", "stats"=>{"downloads"=>9, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Description_of_participating_studies_/518776", "title"=>"Description of participating studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 02:26:16"}

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  • {"unique-ip"=>"33", "full-text"=>"35", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}

Relative Metric

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