Closing the Policy-Practice Gap in the Management of Child Contacts of Tuberculosis Cases in Developing Countries
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{"title"=>"Closing the policy-practice gap in the management of child contacts of Tuberculosis cases in developing countries", "type"=>"journal", "authors"=>[{"first_name"=>"Philip C.", "last_name"=>"Hill", "scopus_author_id"=>"12779383000"}, {"first_name"=>"Merrin E.", "last_name"=>"Rutherford", "scopus_author_id"=>"26029643800"}, {"first_name"=>"Rick", "last_name"=>"Audas", "scopus_author_id"=>"6603247574"}, {"first_name"=>"Reinout", "last_name"=>"van Crevel", "scopus_author_id"=>"6603956378"}, {"first_name"=>"Stephen M.", "last_name"=>"Graham", "scopus_author_id"=>"55627579200"}], "year"=>2011, "source"=>"PLoS Medicine", "identifiers"=>{"sgr"=>"80055035315", "issn"=>"15491277", "isbn"=>"1549-1676 (Electronic) 1549-1277 (Linking)", "pmid"=>"22022234", "doi"=>"10.1371/journal.pmed.1001105", "pui"=>"362826629", "scopus"=>"2-s2.0-80055035315"}, "id"=>"353cf49c-7476-3c83-92e8-0babd6ad2c1f", "abstract"=>"Child contacts of an adult with sputum smear-positive tuberculosis (TB) are at high risk of infection with Mycobacterium tuberculosis and subsequent early progression to TB. Therefore, the World Health Organization (WHO) recommends that all children aged <5 years who are a household contact of a sputum smear-positive case should receive preventive treatment, once TB disease has been ruled out. However, this WHO recommendation is rarely implemented, despite being incorporated widely into National TB Control Program (NTP) guidelines. It is clear that there is a policy-practice gap that needs to be addressed. In this article, the authors propose an evidence-based approach to close this gap and show how this can lead to the management of child contacts of TB cases being properly incorporated into NTP activities, applied in the community and clinic, and formally evaluated.", "link"=>"http://www.mendeley.com/research/closing-policypractice-gap-management-child-contacts-tuberculosis-cases-developing-countries", "reader_count"=>41, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>17, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>4, "Other"=>3, "Student > Master"=>8, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>17, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>4, "Other"=>3, "Student > Master"=>8, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>30, "Agricultural and Biological Sciences"=>3, "Business, Management and Accounting"=>1, "Social Sciences"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>30}, "Social Sciences"=>{"Social Sciences"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Cambodia"=>1, "United States"=>1, "Rwanda"=>1, "Brazil"=>1, "Kenya"=>1, "India"=>1, "Indonesia"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/725105"], "description"=>"a<p>Index cases interviewed at diagnosis to identify case, contact, and household factors associated with non-attendance. A study of 500 contacts is advised, assuming non-attendance of at least 20%.</p>b<p>Cohort study of 500 enables evaluation of risk factors for non-adherence (taking <80% of doses) and temporary defaulting (not taking medicine for at least one week), assuming at least 20% non-adherence; enlarged to 1,000 assuming permanent default rate is at least 10%.</p>c<p><i>n</i> = 2,000 is estimated to identify “secondary cases” on the basis of 60%–90% efficacy of preventive therapy, an assumption of >80% adherence and a natural progression off treatment of up to 20% over one year <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001105#pmed.1001105-Marais1\" target=\"_blank\">[2]</a>.</p>d<p>Cohort of 200 is based on an expected incidence of symptomatic hepatotoxicity due to IPT of <10% over a treatment course in children <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001105#pmed.1001105-Devrim1\" target=\"_blank\">[25]</a>.</p>", "links"=>[], "tags"=>["tb"], "article_id"=>395468, "categories"=>["Biotechnology", "Infectious Diseases"], "users"=>["Philip C. Hill", "Merrin E. Rutherford", "Rick Audas", "Reinout van Crevel", "Stephen M. Graham"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001105.t001", "stats"=>{"downloads"=>5, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indicators_of_system_performance_in_child_TB_case_contact_management_/395468", "title"=>"Indicators of system performance in child TB case contact management.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 13:50:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/725045"], "description"=>"<p>A health needs assessment framework for addressing the policy-practice gap in the management of child contacts of TB cases.</p>", "links"=>[], "tags"=>["needs", "addressing", "policy-practice", "contacts", "tb"], "article_id"=>395396, "categories"=>["Biotechnology", "Infectious Diseases"], "users"=>["Philip C. Hill", "Merrin E. Rutherford", "Rick Audas", "Reinout van Crevel", "Stephen M. Graham"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001105.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_health_needs_assessment_framework_for_addressing_the_policy_practice_gap_in_the_management_of_child_contacts_of_TB_cases_/395396", "title"=>"A health needs assessment framework for addressing the policy-practice gap in the management of child contacts of TB cases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 13:50:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/725143"], "description"=>"a<p>Targets for adherence to screening and treatment suggested here are broadly in line with WHO targets for the identification and management of tuberculosis cases.</p>", "links"=>[], "tags"=>["examples", "gaps", "ipt", "site-specific", "factors", "situational"], "article_id"=>395493, "categories"=>["Biotechnology", "Infectious Diseases"], "users"=>["Philip C. Hill", "Merrin E. Rutherford", "Rick Audas", "Reinout van Crevel", "Stephen M. Graham"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001105.t002", "stats"=>{"downloads"=>7, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Possible_examples_of_identification_of_gaps_with_respect_to_IPT_and_possible_relevant_site_specific_risk_factors_identified_from_the_situational_analysis_/395493", "title"=>"Possible examples of identification of gaps with respect to IPT and possible relevant site-specific risk factors identified from the situational analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 13:51:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/725179"], "description"=>"<p>DOT, directly observed therapy; INH, Isoniazid; RIF, rifampicin.</p>", "links"=>[], "tags"=>["options", "analyses", "recommendations", "gaps", "contacts", "tb"], "article_id"=>395526, "categories"=>["Biotechnology", "Infectious Diseases"], "users"=>["Philip C. Hill", "Merrin E. Rutherford", "Rick Audas", "Reinout van Crevel", "Stephen M. Graham"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001105.t003", "stats"=>{"downloads"=>5, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_possible_options_analyses_and_recommendations_to_address_gaps_that_are_identified_in_the_management_of_child_contacts_of_adult_TB_cases_/395526", "title"=>"Examples of possible options analyses and recommendations to address gaps that are identified in the management of child contacts of adult TB cases.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 13:51:19"}

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Relative Metric

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