HIV Treatment as Prevention: Optimising the Impact of Expanded HIV Treatment Programmes
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{"title"=>"HIV treatment as prevention: Optimising the impact of expanded HIV treatment programmes", "type"=>"generic", "authors"=>[{"first_name"=>"Wim", "last_name"=>"Delva", "scopus_author_id"=>"8938472000"}, {"first_name"=>"Jeffrey W.", "last_name"=>"Eaton", "scopus_author_id"=>"36055866100"}, {"first_name"=>"Fei", "last_name"=>"Meng", "scopus_author_id"=>"55324779900"}, {"first_name"=>"Christophe", "last_name"=>"Fraser", "scopus_author_id"=>"35460815100"}, {"first_name"=>"Richard G.", "last_name"=>"White", "scopus_author_id"=>"8781712900"}, {"first_name"=>"Peter", "last_name"=>"Vickerman", "scopus_author_id"=>"6505889496"}, {"first_name"=>"Marie Claude", "last_name"=>"Boily", "scopus_author_id"=>"7003395873"}, {"first_name"=>"Timothy B.", "last_name"=>"Hallett", "scopus_author_id"=>"35614255000"}], "year"=>2012, "source"=>"PLoS Medicine", "identifiers"=>{"isbn"=>"1549-1277", "scopus"=>"2-s2.0-84864485996", "pui"=>"365352076", "doi"=>"10.1371/journal.pmed.1001258", "sgr"=>"84864485996", "pmid"=>"22802738", "issn"=>"15491277"}, "id"=>"4aa3460b-e51d-3dd4-b319-f699914ddf45", "abstract"=>"Until now, decisions about how to allocate ART have largely been based on maximising the therapeutic benefit of ART for patients. Since the results of the HPTN 052 study showed efficacy of antiretroviral therapy (ART) in preventing HIV transmission, there has been increased interest in the benefits of ART not only as treatment, but also in prevention. Resources for expanding ART in the short term may be limited, so the question is how to generate the most prevention benefit from realistic potential increases in the availability of ART. Although not a formal systematic review, here we review different ways in which access to ART could be expanded by prioritising access to particular groups based on clinical or behavioural factors. For each group we consider (i) the clinical and epidemiological benefits, (ii) the potential feasibility, acceptability, and equity, and (iii) the affordability and cost-effectiveness of prioritising ART access for that group. In re-evaluating the allocation of ART in light of the new data about ART preventing transmission, the goal should be to create policies that maximise epidemiological and clinical benefit while still being feasible, affordable, acceptable, and equitable.", "link"=>"http://www.mendeley.com/research/hiv-treatment-prevention-optimising-impact-expanded-hiv-treatment-programmes", "reader_count"=>52, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>4, "Student > Master"=>11, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>9}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>4, "Student > Master"=>11, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>9}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Nursing and Health Professions"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>23, "Business, Management and Accounting"=>2, "Social Sciences"=>10, "Decision Sciences"=>1, "Immunology and Microbiology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>23}, "Social Sciences"=>{"Social Sciences"=>10}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Nigeria"=>1, "Portugal"=>1}, "group_count"=>1}

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  • {"files"=>["https://ndownloader.figshare.com/files/611172"], "description"=>"<p>?, insufficient evidence to warrant definitive decision; +, available evidence suggests this is a beneficial option, compared to the other expansion options; −, available evidence suggests this is an unfavourable option, compared to the other expansion options; •, available evidence supports neither that this is a beneficial option nor that it is an unfavourable option.</p>", "links"=>[], "tags"=>["acceptability", "options"], "article_id"=>281659, "categories"=>["Biotechnology", "Infectious Diseases"], "users"=>["Wim Delva", "Jeffrey W. Eaton", "Fei Meng", "Christophe Fraser", "Richard G. White", "Peter Vickerman", "Marie-Claude Boily", "Timothy B. Hallett"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001258.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Likely_profile_of_prevention_and_clinical_impact_affordability_feasibility_and_acceptability_of_alternative_options_for_ART_expansion_beyond_current_guidelines_/281659", "title"=>"Likely profile of prevention and clinical impact, affordability, feasibility, and acceptability of alternative options for ART expansion beyond current guidelines.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 02:40:37"}
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  • {"files"=>["https://ndownloader.figshare.com/files/610990"], "description"=>"<p>(A) HIV transmission rate per 100 person-years (PYs) by CD4 count for the infected partner in discordant couples enrolled in a randomized controlled trial of acyclovir <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001258#pmed.1001258-Donnell1\" target=\"_blank\">[11]</a>. (B) Mortality rate by CD4 category in ART-naïve HIV-positive individuals enrolled in research cohorts in West Africa <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001258#pmed.1001258-Lewden1\" target=\"_blank\">[132]</a>. In both panels, the width of the bars represents the proportion of ART-naïve HIV-positive 15- to 64-year-olds by CD4 count in a nationally representative household survey in Kenya <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001258#pmed.1001258-Stover1\" target=\"_blank\">[15]</a>.</p>", "links"=>[], "tags"=>["cd4"], "article_id"=>281479, "categories"=>["Biotechnology", "Infectious Diseases"], "users"=>["Wim Delva", "Jeffrey W. Eaton", "Fei Meng", "Christophe Fraser", "Richard G. White", "Peter Vickerman", "Marie-Claude Boily", "Timothy B. Hallett"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001258.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIV_transmission_and_mortality_by_CD4_count_/281479", "title"=>"HIV transmission and mortality by CD4 count.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:39:28"}

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Relative Metric

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