Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases
Publication Date
April 26, 2011
Journal
PLOS Neglected Tropical Diseases
Authors
Penelope A. Hancock, Steven P. Sinkins & H. Charles J. Godfray
Volume
5
Issue
4
Pages
e1024
DOI
http://doi.org/10.1371/journal.pntd.0001024
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001024
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21541357
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082501
Europe PMC
http://europepmc.org/abstract/MED/21541357
Web of Science
000289937400004
Scopus
79955840474
Mendeley
http://www.mendeley.com/research/strategies-introducing-wolbachia-reduce-transmission-mosquitoborne-diseases
Events
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/391241", "https://ndownloader.figshare.com/files/391350", "https://ndownloader.figshare.com/files/391417", "https://ndownloader.figshare.com/files/391450", "https://ndownloader.figshare.com/files/391502", "https://ndownloader.figshare.com/files/391551", "https://ndownloader.figshare.com/files/391580", "https://ndownloader.figshare.com/files/391601"], "description"=>"<div><p>Certain strains of the endosymbiont <em>Wolbachia</em> have the potential to lower the vectorial capacity of mosquito populations and assist in controlling a number of mosquito-borne diseases. An important consideration when introducing <em>Wolbachia-</em>carrying mosquitoes into natural populations is the minimisation of any transient increase in disease risk or biting nuisance. This may be achieved by predominantly releasing male mosquitoes. To explore this, we use a sex-structured model of <em>Wolbachia-</em>mosquito interactions. We first show that <em>Wolbachia</em> spread can be initiated with very few infected females provided the infection frequency in males exceeds a threshold. We then consider realistic introduction scenarios involving the release of batches of infected mosquitoes, incorporating seasonal fluctuations in population size. For a range of assumptions about mosquito population dynamics we find that male-biased releases allow the infection to spread after the introduction of low numbers of females, many fewer than with equal sex-ratio releases. We extend the model to estimate the transmission rate of a mosquito-borne pathogen over the course of <em>Wolbachia</em> establishment. For a range of release strategies we demonstrate that male-biased release of <em>Wolbachia</em>-infected mosquitoes can cause substantial transmission reductions without transiently increasing disease risk. The results show the importance of including mosquito population dynamics in studying <em>Wolbachia</em> spread and that male-biased releases can be an effective and safe way of rapidly establishing the symbiont in mosquito populations.</p> </div>", "links"=>[], "tags"=>["strategies", "introducing", "mosquito-borne", "diseases"], "article_id"=>137266, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.s001", "https://dx.doi.org/10.1371/journal.pntd.0001024.s002", "https://dx.doi.org/10.1371/journal.pntd.0001024.s003", "https://dx.doi.org/10.1371/journal.pntd.0001024.s004", "https://dx.doi.org/10.1371/journal.pntd.0001024.s005", "https://dx.doi.org/10.1371/journal.pntd.0001024.s006", "https://dx.doi.org/10.1371/journal.pntd.0001024.s007", "https://dx.doi.org/10.1371/journal.pntd.0001024.s008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Strategies_for_Introducing_Wolbachia_to_Reduce_Transmission_of_Mosquito_Borne_Diseases/137266", "title"=>"Strategies for Introducing <em>Wolbachia</em> to Reduce Transmission of Mosquito-Borne Diseases", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-26 02:01:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/780923"], "description"=>"<p>Grey-shaded boxes represent mosquito stages infected with <i>Wolbachia.</i> Females have fecundity , larval development time is <i>T<sub>L</sub></i> days, and adult mosquitoes experience mortality at a rate which depends on adult age <i>a.</i> Subscripts <i>W</i> and <i>U</i> denote mosquitoes infected and uninfected with <i>Wolbachia.</i> Infected females fail to transmit <i>Wolbachia</i> to their offspring with probability .</p>", "links"=>[], "tags"=>["ecology"], "article_id"=>451296, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diagram_showing_the_model_structure_/451296", "title"=>"Diagram showing the model structure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:21:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/780980"], "description"=>"<p>Solid lines show the frequency in males and dashed lines show the frequency in females. Introduction is assumed to occur at a constant rate and the rate of female introduction is 1% of the rate of male introduction. Lines A show introduction at the minimum rate required for <i>Wolbachia</i> to spread (<i>I<sub>M</sub></i>  =  0.39 day<sup>−1</sup>) and lines B show an introduction rate twice as high as the minimum rate. The dotted line shows the unstable equilibrium male infection frequency. Other parameters are as in <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001024#pntd-0001024-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["adults", "infected"], "article_id"=>451351, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Wolbachia_infection_frequency_in_male_and_female_adults_following_the_introduction_of_infected_mosquitoes_/451351", "title"=>"The <i>Wolbachia</i> infection frequency in male and female adults following the introduction of infected mosquitoes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:22:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/781015"], "description"=>"<p>Solid lines show the mosquito abundance and dashed lines with crosses show the minimum total number of released mosquitoes required for <i>Wolbachia</i> to spread. The sex-ratio of the releases is 95% male and 30 equal-sized daily releases are made. Panels A and B show the seasonal mosquito abundance patterns described in the text. Panel A also shows the minimum total number of introduced insects required to cause spread for equal sex-ratio releases (dashed lines, open squares), and the number of females introduced for the 95% male strategy (dotted lines, crosses) and for the equal sex-ratio strategy (dotted lines, open squares). Other parameters are as in <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001024#pntd-0001024-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["released", "mosquitoes"], "article_id"=>451394, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_number_of_released_mosquitoes_required_for_Wolbachia_to_spread_at_different_release_times_/451394", "title"=>"The number of released mosquitoes required for <i>Wolbachia</i> to spread at different release times.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:23:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/781069"], "description"=>"<p>A strategy of 30 daily 95% male releases of the minimum number of <i>Wolbachia-</i>infected mosquitoes required for spread is shown. Releases begin in the second year in the second month of the high-abundance season. Seasonal dynamics follow pattern A. The solid line shows the male infection frequency and the shaded area shows the period during which releases occur. Other parameters are as in <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001024#pntd-0001024-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["eir", "male-biased"], "article_id"=>451445, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_daily_EIR_dashed_line_and_female_population_size_dotted_line_following_male_biased_Wolbachia_releases_/451445", "title"=>"The daily EIR (dashed line) and female population size (dotted line) following male-biased <i>Wolbachia</i> releases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:24:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/781112"], "description"=>"<p>A strategy of 90 daily releases of 95% male, <i>Wolbachia-</i>infected mosquitoes is shown. The solid line shows the male infection frequency and the shaded area shows the period during which releases occur. Panels show different effects of <i>Wolbachia</i> on adult longevity: A. a 16% reduction in average adult lifespan (<i>s<sub>g</sub></i> = 0.16), B. a 5% reduction in average adult lifespan (<i>s<sub>g</sub></i> = 0.05, <i>r<sub>w</sub></i> = 0.03). Insets show the same results for the third year only, and also include lines showing the EIR for different effects of <i>Wolbachia</i> on pathogen development; lines labelled 1,2 and 3 show <i>c<sub>w</sub></i> = 0, <i>c<sub>w</sub></i> = 0.5 and <i>c<sub>w</sub></i> = 0.8 respectively. Other parameters are as in <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001024#pntd-0001024-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["eir"], "article_id"=>451492, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Daily_EIR_dashed_line_and_female_population_size_dotted_line_following_extended_Wolbachia_releases_/451492", "title"=>"Daily EIR (dashed line) and female population size (dotted line) following extended <i>Wolbachia</i> releases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:24:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/781172"], "description"=>"<p>The parameters used in the model and their default values.</p>", "links"=>[], "tags"=>["parameters", "default"], "article_id"=>451550, "categories"=>["Ecology"], "users"=>["Penelope A. Hancock", "Steven P. Sinkins", "H. Charles J. Godfray"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001024.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_parameters_used_in_the_model_and_their_default_values_/451550", "title"=>"The parameters used in the model and their default values.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-04-26 00:25:50"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"36", "full-text"=>"43", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"42", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"44", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"24", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Ecology", "average_usage"=>[328, 524, 638, 721, 822, 922, 1007, 1090, 1169, 1236, 1294, 1369, 1443, 1516, 1581, 1642, 1713, 1795, 1860, 1934, 1983, 2054, 2125, 2211, 2268, 2328, 2388, 2472, 2549, 2605, 2675, 2735, 2819, 2887, 2957, 3027, 3086]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[323, 535, 656, 759, 849, 938, 1016, 1092, 1160, 1209, 1271, 1328, 1396, 1463, 1520, 1587, 1666, 1725, 1797, 1864, 1912, 1974, 2027, 2096, 2144, 2221, 2277, 2332, 2394, 2431, 2479, 2553, 2630, 2668, 2734, 2770, 2821]}, {"subject_area"=>"/Ecology and environmental sciences", "average_usage"=>[331, 535, 647, 744, 844, 946, 1026, 1107, 1176, 1235, 1292, 1362, 1432, 1501, 1565, 1632, 1688, 1764, 1827, 1880, 1949, 2007, 2080, 2146, 2214, 2260, 2337, 2405, 2464, 2520, 2575, 2661, 2717, 2785, 2835, 2892, 2961]}, {"subject_area"=>"/Ecology and environmental sciences/Ecological metrics", "average_usage"=>[359, 499, 586, 699, 803, 885, 967, 1025, 1076, 1150, 1200, 1262, 1320, 1382, 1447, 1514, 1595, 1643, 1720, 1784, 1832, 1885, 1951, 2001, 2071]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[335, 648, 777, 906, 1018, 1131, 1224, 1307, 1396, 1462, 1541, 1619, 1695, 1764, 1821, 1892, 1959, 2029, 2095, 2155, 2218, 2270, 2329, 2395, 2457, 2528, 2590, 2638, 2708, 2759, 2823, 2882, 2930, 2990, 3041, 3099, 3150]}, {"subject_area"=>"/People and places/Demography", "average_usage"=>[352, 584, 703, 791, 903, 987, 1078, 1163, 1237, 1318, 1379, 1447, 1507, 1584, 1660, 1717, 1793, 1863, 1922, 1967, 2039, 2098, 2152, 2219, 2285, 2341, 2392, 2466, 2528, 2581, 2623, 2670, 2731, 2787, 2856, 2901, 2953]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[344, 630, 756, 876, 981, 1083, 1179, 1272, 1346, 1421, 1508, 1583, 1659, 1744, 1809, 1891, 1954, 2030, 2105, 2174, 2247, 2324, 2386, 2441, 2502, 2557, 2621, 2685, 2753, 2825, 2882, 2935, 2989, 3052, 3117, 3181, 3242]}]}
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