Analysis of Neglected Tropical Disease Drug and Vaccine Development Pipelines to Predict Issuance of FDA Priority Review Vouchers over the Next Decade
Publication Date
October 25, 2012
Journal
PLOS Neglected Tropical Diseases
Authors
Rianna Stefanakis, Andrew S. Robertson, Elizabeth L. Ponder & Melinda Moree
Volume
6
Issue
10
Pages
e1803
DOI
http://doi.org/10.1371/journal.pntd.0001803
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001803
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23145186
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493373
Europe PMC
http://europepmc.org/abstract/MED/23145186
Web of Science
000310527200002
Scopus
84869029528
Mendeley
http://www.mendeley.com/research/analysis-neglected-tropical-disease-drug-vaccine-development-pipelines-predict-issuance-fda-priority
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Analysis of Neglected Tropical Disease Drug and Vaccine Development Pipelines to Predict Issuance of FDA Priority Review Vouchers over the Next Decade", "type"=>"journal", "authors"=>[{"first_name"=>"Rianna", "last_name"=>"Stefanakis", "scopus_author_id"=>"36629419800"}, {"first_name"=>"Andrew S.", "last_name"=>"Robertson", "scopus_author_id"=>"55354176700"}, {"first_name"=>"Elizabeth L.", "last_name"=>"Ponder", "scopus_author_id"=>"55480385900"}, {"first_name"=>"Melinda", "last_name"=>"Moree", "scopus_author_id"=>"6507065526"}], "year"=>2012, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352727", "sgr"=>"84869029528", "doi"=>"10.1371/journal.pntd.0001803", "scopus"=>"2-s2.0-84869029528", "pui"=>"366040801", "pmid"=>"23145186"}, "id"=>"6ae2e1b1-1745-3a94-ad64-652528acde15", "abstract"=>"http://dx.plos.org/10.1371/journal.pntd.0001803", "link"=>"http://www.mendeley.com/research/analysis-neglected-tropical-disease-drug-vaccine-development-pipelines-predict-issuance-fda-priority", "reader_count"=>29, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>8, "Chemistry"=>1, "Psychology"=>1, "Social Sciences"=>3, "Economics, Econometrics and Finance"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "United States"=>1, "Brazil"=>1}, "group_count"=>0}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84869029528"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84869029528?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84869029528&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84869029528&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84869029528", "dc:identifier"=>"SCOPUS_ID:84869029528", "eid"=>"2-s2.0-84869029528", "dc:title"=>"Analysis of Neglected Tropical Disease Drug and Vaccine Development Pipelines to Predict Issuance of FDA Priority Review Vouchers over the Next Decade", "dc:creator"=>"Stefanakis R.", "prism:publicationName"=>"PLoS Neglected Tropical Diseases", "prism:issn"=>"19352727", "prism:eIssn"=>"19352735", "prism:volume"=>"6", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-10-01", "prism:coverDisplayDate"=>"October 2012", "prism:doi"=>"10.1371/journal.pntd.0001803", "citedby-count"=>"11", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"BIO Ventures for Global Health", "affiliation-city"=>"San Francisco", "affiliation-country"=>"United States"}], "pubmed-id"=>"23145186", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1803", "source-id"=>"11900154404"}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosntds%2Farticle%3Fid%3D10.1371%252Fjournal.pntd.0001803", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Twitter

Counter

  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"56", "xml_views"=>"10", "html_views"=>"708"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"104", "xml_views"=>"4", "html_views"=>"1868"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"121"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"3", "html_views"=>"70"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"32", "xml_views"=>"3", "html_views"=>"146"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"4", "html_views"=>"142"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"14", "html_views"=>"57"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"13", "html_views"=>"65"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"11", "html_views"=>"89"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"106"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"150"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"10", "html_views"=>"109"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"27", "html_views"=>"130"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"8", "html_views"=>"135"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"12", "html_views"=>"152"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"15", "html_views"=>"134"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"17", "html_views"=>"105"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"20", "html_views"=>"102"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"24", "html_views"=>"98"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"18", "html_views"=>"109"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"19", "html_views"=>"110"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"15", "html_views"=>"95"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"21", "html_views"=>"153"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"22", "html_views"=>"96"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"11", "html_views"=>"71"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"18", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"15", "html_views"=>"106"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"37", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"25", "html_views"=>"59"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"17", "html_views"=>"49"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"30", "html_views"=>"49"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"14", "html_views"=>"54"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"41", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"23", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"22", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"16", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"20", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"3", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"17", "html_views"=>"69"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"4", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"55"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/552818"], "description"=>"<p>Criteria are based on the <i>FDA Draft Guidance for Industry: Tropical Disease Priority Review Vouchers.</i></p>", "links"=>[], "tags"=>["fda"], "article_id"=>223316, "categories"=>["Science Policy"], "users"=>["Rianna Stefanakis", "Andrew S. Robertson", "Elizabeth L. Ponder", "Melinda Moree"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001803.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Eligibility_decision_tree_for_a_US_FDA_priority_review_voucher_/223316", "title"=>"Eligibility decision tree for a US FDA priority review voucher.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:11:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/552894"], "description"=>"<p>Drugs and vaccines from the pre-clinical phase of development, through phases I, II, and III were evaluated for PRV eligibility (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001803#pntd-0001803-g001\" target=\"_blank\">Figure 1</a>). A total of 17 drugs in clinical development could earn a PRV, if approved by the FDA; two more are already approved abroad and would be eligible to earn a voucher if submitted to the FDA (six in phase I; eight in phase II; three in phase III). Forty-five vaccines are currently undergoing clinical development (16 in phase I; 24 in phase II; five in phase III); three additional vaccines are already approved abroad and would be eligible to earn a PRV if submitted to the FDA. The analysis excluded programs that are “on hold”.</p>", "links"=>[], "tags"=>["prv-eligible", "drugs", "vaccines", "pipeline"], "article_id"=>223386, "categories"=>["Science Policy"], "users"=>["Rianna Stefanakis", "Andrew S. Robertson", "Elizabeth L. Ponder", "Melinda Moree"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001803.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_PRV_eligible_drugs_and_vaccines_in_the_pipeline_by_phase_of_clinical_development_/223386", "title"=>"Number of PRV-eligible drugs and vaccines in the pipeline by phase of clinical development.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:12:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/552957"], "description"=>"<p>Prediction model used to calculate the total number of expected PRVs, as well as the average annual rate of how many PRVs will be awarded. The model assumes a 100% success rate for approval by FDA of products already approved abroad. (The analysis adjusted for situations where one product approval would deem another ineligible. For example, SM14, a recombinant/purified protein vaccine, is currently under development for both schistosomiasis and fascioliasis. If it were to be approved for schistosomiasis, it would make approval for the indication of use against fascioliasis ineligible. Therefore, SM14 was counted as one product for the purposes of predicting the number of PRVs.) Similarly, the model assumes each individual product in development will yield one product. For malaria vaccines, for example, this may not be the case as many believe that these parts would be combined into one product before licensure. See study limitations for further explanation.</p>", "links"=>[], "tags"=>["approvals", "fda", "drugs", "vaccines"], "article_id"=>223452, "categories"=>["Science Policy"], "users"=>["Rianna Stefanakis", "Andrew S. Robertson", "Elizabeth L. Ponder", "Melinda Moree"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001803.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimated_approvals_of_FDA_drugs_and_vaccines_for_NTDs_/223452", "title"=>"Estimated approvals of FDA drugs and vaccines for NTDs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:12:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/553000"], "description"=>"<p>Values represent the average number of months it takes to complete a phase of clinical development.</p><p>MVI, Malaria Vaccine Initiative; PATH, Program for Appropriate Technology in Health.</p>", "links"=>[], "tags"=>["timelines", "sources"], "article_id"=>223497, "categories"=>["Science Policy"], "users"=>["Rianna Stefanakis", "Andrew S. Robertson", "Elizabeth L. Ponder", "Melinda Moree"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001803.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_timelines_for_development_from_various_sources_in_months_/223497", "title"=>"Average timelines for development from various sources (in months).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:12:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/553028"], "description"=>"a<p>Except for bedaquiline and PXVX-0200, it is unknown whether all developers plan to submit these products for approval from FDA. These are estimates based on the individual product meeting eligibility criteria. These predictions are not supported by any statements made by the FDA.</p><p>GSK, GlaxoSmithKline; IND, investigational new drug; MMV, Medicines for Malaria Venture; NDA, new drug application.</p>", "links"=>[], "tags"=>["products", "fda"], "article_id"=>223533, "categories"=>["Science Policy"], "users"=>["Rianna Stefanakis", "Andrew S. Robertson", "Elizabeth L. Ponder", "Melinda Moree"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001803.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NTD_products_expected_to_seek_FDA_approval_in_the_next_5_years_a_/223533", "title"=>"NTD products expected to seek FDA approval in the next 5 years.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:13:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/553064"], "description"=>"<p>Values represent the probability of success (POS) that a product will move to the next stage of development.</p>a<p>Kola and Landis rates represent those for the infectious disease therapeutic area.</p>", "links"=>[], "tags"=>["probability", "rates"], "article_id"=>223560, "categories"=>["Science Policy"], "users"=>["Rianna Stefanakis", "Andrew S. Robertson", "Elizabeth L. Ponder", "Melinda Moree"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001803.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_probability_of_success_POS_rates_from_various_sources_/223560", "title"=>"Average probability of success (POS) rates from various sources.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:13:11"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"26", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Clinical medicine", "average_usage"=>[320, 556, 672, 767, 863, 963, 1059, 1140, 1221, 1310, 1393, 1465, 1536, 1600, 1652, 1705, 1767, 1838, 1912, 1952, 2007, 2056, 2116, 2159, 2205]}, {"subject_area"=>"/Medicine and health sciences/Parasitic diseases", "average_usage"=>[357, 723, 872, 1005, 1118, 1230, 1343, 1452, 1559, 1664, 1758, 1833, 1919, 1999, 2076, 2152, 2223, 2295, 2359, 2437, 2528, 2600, 2688, 2743, 2789]}, {"subject_area"=>"/Medicine and health sciences/Pharmaceutics", "average_usage"=>[305, 566, 705, 814, 911, 1028, 1121, 1228, 1325, 1435, 1532, 1608, 1690, 1769, 1843, 1921, 1997, 2089, 2155, 2225, 2285, 2361, 2433, 2496, 2560]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[314, 554, 687, 796, 891, 983, 1075, 1170, 1261, 1340, 1422, 1504, 1574, 1647, 1715, 1786, 1848, 1919, 1990, 2053, 2115, 2197, 2258, 2333, 2395]}, {"subject_area"=>"/Medicine and health sciences/Public and occupational health", "average_usage"=>[327, 554, 673, 780, 874, 968, 1060, 1133, 1222, 1304, 1376, 1463, 1536, 1602, 1663, 1742, 1796, 1853, 1931, 1985, 2044, 2108, 2170, 2248, 2305]}]}
Loading … Spinner
There are currently no alerts