Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study
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{"title"=>"Lack of association between measles virus vaccine and autism with enteropathy: A case-control study", "type"=>"journal", "authors"=>[{"first_name"=>"Mady", "last_name"=>"Hornig", "scopus_author_id"=>"6701704785"}, {"first_name"=>"Thomas", "last_name"=>"Briese", "scopus_author_id"=>"7003898074"}, {"first_name"=>"Timothy", "last_name"=>"Buie", "scopus_author_id"=>"55574192626"}, {"first_name"=>"Margaret L.", "last_name"=>"Bauman", "scopus_author_id"=>"7007019448"}, {"first_name"=>"Gregory", "last_name"=>"Lauwers", "scopus_author_id"=>"35391239300"}, {"first_name"=>"Ulrike", "last_name"=>"Siemetzki", "scopus_author_id"=>"24832166400"}, {"first_name"=>"Kimberly", "last_name"=>"Hummel", "scopus_author_id"=>"7101642342"}, {"first_name"=>"Paul A.", "last_name"=>"Rota", "scopus_author_id"=>"7005808979"}, {"first_name"=>"William J.", "last_name"=>"Bellini", "scopus_author_id"=>"7005204113"}, {"first_name"=>"John J.", "last_name"=>"O'Leary", "scopus_author_id"=>"7202225810"}, {"first_name"=>"Orla", "last_name"=>"Sheils", "scopus_author_id"=>"6701770039"}, {"first_name"=>"Errol", "last_name"=>"Alden", "scopus_author_id"=>"57078415600"}, {"first_name"=>"Larry", "last_name"=>"Pickering", "scopus_author_id"=>"7101687464"}, {"first_name"=>"W. Ian", "last_name"=>"Lipkin", "scopus_author_id"=>"7005714572"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-52149120139", "pui"=>"352385260", "sgr"=>"52149120139", "pmid"=>"18769550", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0003140", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)"}, "id"=>"cb4234a8-1a9b-340b-8543-88f09d146b53", "abstract"=>"BACKGROUND: The presence of measles virus (MV) RNA in bowel tissue from children with autism spectrum disorders (ASD) and gastrointestinal (GI) disturbances was reported in 1998. Subsequent investigations found no associations between MV exposure and ASD but did not test for the presence of MV RNA in bowel or focus on children with ASD and GI disturbances. Failure to replicate the original study design may contribute to continued public concern with respect to the safety of the measles, mumps, and rubella (MMR) vaccine. METHODOLOGY/PRINCIPAL FINDINGS: The objective of this case-control study was to determine whether children with GI disturbances and autism are more likely than children with GI disturbances alone to have MV RNA and/or inflammation in bowel tissues and if autism and/or GI episode onset relate temporally to receipt of MMR. The sample was an age-matched group of US children undergoing clinically-indicated ileocolonoscopy. Ileal and cecal tissues from 25 children with autism and GI disturbances and 13 children with GI disturbances alone (controls) were evaluated by real-time reverse transcription (RT)-PCR for presence of MV RNA in three laboratories blinded to diagnosis, including one wherein the original findings suggesting a link between MV and ASD were reported. The temporal order of onset of GI episodes and autism relative to timing of MMR administration was examined. We found no differences between case and control groups in the presence of MV RNA in ileum and cecum. Results were consistent across the three laboratory sites. GI symptom and autism onset were unrelated to MMR timing. Eighty-eight percent of ASD cases had behavioral regression. CONCLUSIONS/SIGNIFICANCE: This study provides strong evidence against association of autism with persistent MV RNA in the GI tract or MMR exposure. Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD.", "link"=>"http://www.mendeley.com/research/lack-association-between-measles-virus-vaccine-autism-enteropathy-casecontrol-study", "reader_count"=>138, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>12, "Librarian"=>2, "Student > Doctoral Student"=>12, "Researcher"=>22, "Student > Ph. D. 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  • {"files"=>["https://ndownloader.figshare.com/files/921449"], "description"=>"a<p>Mann-Whitney U, one-tailed, <i>P</i> = 0.67.</p>b<p>Mann-Whitney U, one-tailed, <i>P</i> = 0.15.</p>c<p>Mann-Whitney U, one-tailed, <i>P</i> = 0.50.</p>d<p><i>X<sup>2</sup></i>, Fisher’s exact test, one-tailed, <i>P</i> = 0.36.</p>*<p>Mann-Whitney U, one-tailed, <i>P</i> = 0.04.</p>", "links"=>[], "tags"=>["mental health/child and adolescent psychiatry", "neurological disorders/developmental and pediatric neurology", "public health and epidemiology/immunization", "public health and epidemiology/infectious diseases"], "article_id"=>591879, "categories"=>["Medicine", "Computational Biology", "Neuroscience", "Mental Health"], "users"=>["Mady Hornig", "Thomas Briese", "Timothy Buie", "Margaret L. Bauman", "Gregory Lauwers", "Ulrike Siemetzki", "Kimberly Hummel", "Paul A. Rota", "William J. Bellini", "John J. O'Leary", "Orla Sheils", "Errol Alden", "Larry Pickering", "W. Ian Lipkin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003140.t001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_characteristics_/591879", "title"=>"Subject characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-04 00:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/921345"], "description"=>"†<p><i>X<sup>2</sup></i>, Fisher’s exact test, one-tailed, <i>p</i> = 0.03.</p>", "links"=>[], "tags"=>["subjects", "mmr", "gi", "onset"], "article_id"=>591765, "categories"=>["Medicine", "Computational Biology", "Neuroscience", "Mental Health"], "users"=>["Mady Hornig", "Thomas Briese", "Timothy Buie", "Margaret L. Bauman", "Gregory Lauwers", "Ulrike Siemetzki", "Kimberly Hummel", "Paul A. Rota", "William J. Bellini", "John J. O'Leary", "Orla Sheils", "Errol Alden", "Larry Pickering", "W. Ian Lipkin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003140.t004", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_and_frequency_of_AUT_GI_subjects_receiving_MMR_before_or_after_GI_onset_and_with_index_GI_episode_before_or_after_ASD_/591765", "title"=>"Number and frequency of AUT/GI subjects receiving MMR before or after GI onset and with index GI episode before or after ASD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-04 00:29:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/921540"], "description"=>"*<p>Represents number of cDNA molecules per PCR reaction; each PCR reaction represents 100 ng total RNA from one sample.</p><p>Key:</p><p><i>Dub</i>, Trinity College Dublin (Coombe Women's Hospital), Dublin.</p><p><i>CU</i>, Columbia University, New York.</p><p><i>CDC</i>, Centers for Disease Control and Prevention, Atlanta.</p><p><i>MeF</i>, <i>MeH</i>, measles primer sets specific for F and H gene regions of MV, respectively (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003140#pone.0003140.s001\" target=\"_blank\"><i>Appendix S1</i></a>).</p><p><i>OLF</i>, <i>OLH</i>, measles primer sets specific for F and H gene regions of MV, respectively <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003140#pone.0003140-Uhlmann1\" target=\"_blank\">[10]</a> (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003140#pone.0003140.s001\" target=\"_blank\"><i>Appendix S1</i></a>).</p>", "links"=>[], "tags"=>["rna", "Real-time"], "article_id"=>591974, "categories"=>["Medicine", "Computational Biology", "Neuroscience", "Mental Health"], "users"=>["Mady Hornig", "Thomas Briese", "Timothy Buie", "Margaret L. Bauman", "Gregory Lauwers", "Ulrike Siemetzki", "Kimberly Hummel", "Paul A. Rota", "William J. Bellini", "John J. O'Leary", "Orla Sheils", "Errol Alden", "Larry Pickering", "W. Ian Lipkin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003140.t003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MV_RNA_detected_by_real_time_RT_PCR_/591974", "title"=>"MV RNA detected by real-time RT-PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-04 00:32:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/454882", "https://ndownloader.figshare.com/files/455011"], "description"=>"<div><h3>Background</h3><p>The presence of measles virus (MV) RNA in bowel tissue from children with autism spectrum disorders (ASD) and gastrointestinal (GI) disturbances was reported in 1998. Subsequent investigations found no associations between MV exposure and ASD but did not test for the presence of MV RNA in bowel or focus on children with ASD and GI disturbances. Failure to replicate the original study design may contribute to continued public concern with respect to the safety of the measles, mumps, and rubella (MMR) vaccine.</p><h3>Methodology/Principal Findings</h3><p>The objective of this case-control study was to determine whether children with GI disturbances and autism are more likely than children with GI disturbances alone to have MV RNA and/or inflammation in bowel tissues and if autism and/or GI episode onset relate temporally to receipt of MMR. The sample was an age-matched group of US children undergoing clinically-indicated ileocolonoscopy. Ileal and cecal tissues from 25 children with autism and GI disturbances and 13 children with GI disturbances alone (controls) were evaluated by real-time reverse transcription (RT)-PCR for presence of MV RNA in three laboratories blinded to diagnosis, including one wherein the original findings suggesting a link between MV and ASD were reported. The temporal order of onset of GI episodes and autism relative to timing of MMR administration was examined. We found no differences between case and control groups in the presence of MV RNA in ileum and cecum. Results were consistent across the three laboratory sites. GI symptom and autism onset were unrelated to MMR timing. Eighty-eight percent of ASD cases had behavioral regression.</p><h3>Conclusions/Significance</h3><p>This study provides strong evidence against association of autism with persistent MV RNA in the GI tract or MMR exposure. Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD.</p></div>", "links"=>[], "tags"=>["measles", "autism", "case-control"], "article_id"=>149615, "categories"=>["Medicine", "Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Mady Hornig", "Thomas Briese", "Timothy Buie", "Margaret L. Bauman", "Gregory Lauwers", "Ulrike Siemetzki", "Kimberly Hummel", "Paul A. Rota", "William J. Bellini", "John J. O'Leary", "Orla Sheils", "Errol Alden", "Larry Pickering", "W. Ian Lipkin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003140.s001", "https://dx.doi.org/10.1371/journal.pone.0003140.s002"], "stats"=>{"downloads"=>14, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Lack_of_Association_between_Measles_Virus_Vaccine_and_Autism_with_Enteropathy_A_Case_Control_Study/149615", "title"=>"Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-09-04 02:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/921499"], "description"=>"<p>Key: <i>MMR</i>, Measles-Mumps-Rubella vaccine.</p>a<p>Mann-Whitney U, one-tailed, <i>p</i> = 0.15.</p>b<p>Mann-Whitney U, one-tailed, <i>p</i> = 0.29.</p>c<p><i>X<sup>2</sup></i>, Fisher’s exact test, one-tailed, <i>p</i> = 0.13.</p>", "links"=>[], "tags"=>["gi", "episodes", "autism", "mmr"], "article_id"=>591932, "categories"=>["Medicine", "Computational Biology", "Neuroscience", "Mental Health"], "users"=>["Mady Hornig", "Thomas Briese", "Timothy Buie", "Margaret L. Bauman", "Gregory Lauwers", "Ulrike Siemetzki", "Kimberly Hummel", "Paul A. Rota", "William J. Bellini", "John J. O'Leary", "Orla Sheils", "Errol Alden", "Larry Pickering", "W. Ian Lipkin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003140.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Onset_of_GI_episodes_and_autism_relative_to_MMR_administration_/591932", "title"=>"Onset of GI episodes and autism relative to MMR administration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-04 00:32:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/921399"], "description"=>"**<p>Mann-Whitney U, one-tailed, p<0.0001.</p>*<p>Mann-Whitney U, one-tailed, p = 0.001.</p>", "links"=>[], "tags"=>["subjects", "mmr", "gi", "onset"], "article_id"=>591827, "categories"=>["Medicine", "Computational Biology", "Neuroscience", "Mental Health"], "users"=>["Mady Hornig", "Thomas Briese", "Timothy Buie", "Margaret L. Bauman", "Gregory Lauwers", "Ulrike Siemetzki", "Kimberly Hummel", "Paul A. Rota", "William J. Bellini", "John J. O'Leary", "Orla Sheils", "Errol Alden", "Larry Pickering", "W. Ian Lipkin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003140.t005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ages_of_AUT_GI_subjects_receiving_MMR_before_or_after_GI_onset_and_with_index_GI_episode_before_or_after_ASD_/591827", "title"=>"Ages of AUT/GI subjects receiving MMR before or after GI onset and with index GI episode before or after ASD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-09-04 00:30:27"}

PMC Usage Stats | Further Information

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Relative Metric

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