Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria: A Prospective Multi-Centre Individual Patient Data Analysis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: A prospective multi-centre individual patient data analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Julien", "last_name"=>"Zwang", "scopus_author_id"=>"12809052800"}, {"first_name"=>"Elizabeth A.", "last_name"=>"Ashley", "scopus_author_id"=>"7004338928"}, {"first_name"=>"Corine", "last_name"=>"Karema", "scopus_author_id"=>"57196395925"}, {"first_name"=>"Umberto", "last_name"=>"D'Alessandro", "scopus_author_id"=>"7005042050"}, {"first_name"=>"Frank", "last_name"=>"Smithuis", "scopus_author_id"=>"6602715002"}, {"first_name"=>"Grant", "last_name"=>"Dorsey", "scopus_author_id"=>"7004468886"}, {"first_name"=>"Bart", "last_name"=>"Janssens", "scopus_author_id"=>"55910498800"}, {"first_name"=>"Mayfong", "last_name"=>"Mayxay", "scopus_author_id"=>"6603556481"}, {"first_name"=>"Paul", "last_name"=>"Newton", "scopus_author_id"=>"7103312945"}, {"first_name"=>"Pratap", "last_name"=>"Singhasivanon", "scopus_author_id"=>"7003665904"}, {"first_name"=>"Kasia", "last_name"=>"Stepniewska", "scopus_author_id"=>"6701362958"}, {"first_name"=>"Nicholas J.", "last_name"=>"White", "scopus_author_id"=>"7401767314"}, {"first_name"=>"François", "last_name"=>"Nosten", "scopus_author_id"=>"7007076815"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-68149158508", "doi"=>"10.1371/journal.pone.0006358", "sgr"=>"68149158508", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pmid"=>"19649267", "issn"=>"19326203", "pui"=>"355036411"}, "id"=>"703750a8-b976-3ed9-9c69-aab0d9b8172a", "abstract"=>"BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patient data analysis of efficacy and tolerability in acute uncomplicated falciparum malaria, from seven published randomized clinical trials conducted in Africa and South East Asia using a predefined in-vivo protocol. Comparator drugs were mefloquine-artesunate (MAS3) in Thailand, Myanmar, Laos and Cambodia; artemether-lumefantrine in Uganda; and amodiaquine+sulfadoxine-pyrimethamine and artesunate+amodiaquine in Rwanda.\\n\\nMETHODS AND FINDINGS: In total 3,547 patients were enrolled: 1,814 patients (32% children under five years) received DP and 1,733 received a comparator antimalarial at 12 different sites and were followed for 28-63 days. There was no significant heterogeneity between trials. DP was well tolerated with 1.7% early vomiting. There were less adverse events with DP in children and adults compared to MAS3 except for diarrhea; ORs (95%CI) 2.74 (2.13 to 3.51) and 3.11 (2.31 to 4.18), respectively. DP treatment resulted in a rapid clearance of fever and parasitaemia. The PCR genotype corrected efficacy at Day 28 of DP assessed by survival analysis was 98.7% (95%CI 97.6-99.8). DP was superior to the comparator drugs in protecting against both P.falciparum recurrence and recrudescence (P = 0.001, weighted by site). There was no difference between DP and MAS3 in treating P. vivax co-infections and in suppressing the first relapse (median interval to P. vivax recurrence: 6 weeks). Children under 5 y were at higher risk of recurrence for both infections. The proportion of patients developing gametocytaemia (P = 0.002, weighted by site) and the subsequent gametocyte carriage rates were higher with DP (11/1000 person gametocyte week, PGW) than MAS3 (6/1000 PGW, P = 0.001, weighted by site).\\n\\nCONCLUSIONS: DP proved a safe, well tolerated, and highly effective treatment of P.falciparum malaria in Asia and Africa, but the effect on gametocyte carriage was inferior to that of MAS3.", "link"=>"http://www.mendeley.com/research/safety-efficacy-dihydroartemisininpiperaquine-falciparum-malaria-prospective-multicentre-individual", "reader_count"=>63, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>21, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>21, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>8, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1, "Computer Science"=>2, "Economics, Econometrics and Finance"=>2, "Environmental Science"=>1, "Nursing and Health Professions"=>1, "Mathematics"=>3, "Medicine and Dentistry"=>33, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Social Sciences"=>3, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>33}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>2}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Burkina Faso"=>1, "Rwanda"=>2, "Brazil"=>1, "United Kingdom"=>1, "Thailand"=>1, "Spain"=>1}, "group_count"=>5}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68149158508"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68149158508?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68149158508&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=68149158508&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/68149158508", "dc:identifier"=>"SCOPUS_ID:68149158508", "eid"=>"2-s2.0-68149158508", "dc:title"=>"Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: A prospective multi-centre individual patient data analysis", "dc:creator"=>"Zwang J.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"4", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2009-07-29", "prism:coverDisplayDate"=>"29 July 2009", "prism:doi"=>"10.1371/journal.pone.0006358", "citedby-count"=>"72", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Shoklo Malaria Research Unit", "affiliation-city"=>"Mae Sod", "affiliation-country"=>"Thailand"}], "pubmed-id"=>"19649267", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e6358", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0006358", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"171"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"114", "xml_views"=>"7", "html_views"=>"493"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"161"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"182"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"184"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"178"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"164"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"161"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"142"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"151"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"118"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"115"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"133"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"152"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"158"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"39", "xml_views"=>"2", "html_views"=>"152"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"140"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"151"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"5", "html_views"=>"109"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"168"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"151"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"133"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"149"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"142"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"161"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"132"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"147"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"141"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"68"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"81"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"79"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"65"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"92"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"110"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"73"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/889775"], "description"=>"<p>IQR; interquartile range.</p><p>n-a: no observation.</p>", "links"=>[], "tags"=>["baseline", "patients", "receiving"], "article_id"=>560222, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trials_baseline_characteristics_patients_receiving_dihydroartemisinin_piperaquine_/560222", "title"=>"Trials baseline characteristics, patients receiving dihydroartemisinin-piperaquine.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-29 00:03:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/889616"], "description"=>"<p>Patients receiving DP in Cambodia, Laos, Myanmar, and Thailand who had <i>P. vivax</i> parasitaemia detected during the follow-up.</p>", "links"=>[], "tags"=>["cumulative", "incidence", "dyhydroartemisinin-piperaquine"], "article_id"=>560059, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.g006", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_vivax_cumulative_incidence_density_dyhydroartemisinin_piperaquine_treatment_groups_/560059", "title"=>"P.vivax cumulative incidence density, dyhydroartemisinin-piperaquine treatment groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-29 00:00:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/889913"], "description"=>"<p>Early vomiting (</p>", "links"=>[], "tags"=>["vomiting", "dihydroartemisinin-piperaquine"], "article_id"=>560359, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.t005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Early_vomiting_lt_one_hour_after_treatment_administration_dihydroartemisinin_piperaquine_groups_/560359", "title"=>"Early vomiting (", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-29 00:05:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/889732"], "description"=>"*<p>Pooled efficacy based on randomised trials was assessed by intent to treat analysis for recurrent and recrudescent cases. The Kaplan-Meier analysis was computed for an hypothetical cohort of 100 persons (the population free of disease per 100 is equivalent to efficacy expressed per 100). CI = confidence interval.</p>**<p>Quotients adjusted for indeterminate cases.</p>***<p>Endpoint Rwanda.</p>****<p>Endpoint Laos, Uganda, Myanmar.</p>*****<p>Endpoint Cambodia, Thailand.</p>", "links"=>[], "tags"=>["efficacy", "dihydroartemisinin-piperaquine", "falciparum", "malaria", "randomised", "trials", "assessed"], "article_id"=>560168, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.t003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pooled_efficacy_of_dihydroartemisinin_piperaquine_against_falciparum_malaria_based_on_randomised_trials_assessed_by_survival_analysis_Kaplan_Meier_/560168", "title"=>"Pooled efficacy of dihydroartemisinin-piperaquine against falciparum malaria based on randomised trials assessed by survival analysis (Kaplan-Meier).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-29 00:02:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/889115"], "description"=>"<p>Note: DP; dihydroartemisinin-piperaquine, MAS3; mefloquine-artesunate, AQ+SP; amodiaquine+sulfadoxine-pyrimethamine, AL; artemether-lumefantrine, AS+AQ; artesunate+amodiaquine, Pf; <i>P. falciparum</i>, loss; loss to follow-up, ACR; adequate clinical response, ACT; artemisinin combination therapy.</p>", "links"=>[], "tags"=>["artemisinin"], "article_id"=>559558, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Note_DP_dihydroartemisinin_piperaquine_MAS3_mefloquine_artesunate_AQ_SP_amodiaquine_sulfadoxine_pyrimethamine_AL_artemether_lumefantrine_AS_AQ_artesunate_amodiaquine_Pf_P_falciparum_loss_loss_to_follow_up_ACR_adequate_clinical_response_ACT_artemisinin_co/559558", "title"=>"Note: DP; dihydroartemisinin-piperaquine, MAS3; mefloquine-artesunate, AQ+SP; amodiaquine+sulfadoxine-pyrimethamine, AL; artemether-lumefantrine, AS+AQ; artesunate+amodiaquine, Pf; <i>P. falciparum</i>, loss; loss to follow-up, ACR; adequate clinical response, ACT; artemisinin combination therapy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-29 02:39:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/889684"], "description"=>"*<p>Efficacy based on randomised trials was assessed by modified intent to treat analysis for recurrent and recrudescent cases. The Kaplan-Meier results were expressed as percentages.</p>", "links"=>[], "tags"=>["efficacy"], "article_id"=>560131, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.t002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dihydroartemisinin_piperaquine_efficacy_by_country_and_site_Day_28_survival_analysis_Kaplan_Meier_/560131", "title"=>"Dihydroartemisinin-piperaquine efficacy by country and site, Day 28, survival analysis (Kaplan-Meier).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-29 00:02:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/889381"], "description"=>"<p>Note: DP; Dihydroartemisinin-piperaquine, MAS3; mefloquine-artesunate.</p>", "links"=>[], "tags"=>["pediatrics and child health", "infectious diseases/neglected tropical diseases", "public health and epidemiology/global health"], "article_id"=>559828, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Note_DP_Dihydroartemisinin_piperaquine_MAS3_mefloquine_artesunate_/559828", "title"=>"Note: DP; Dihydroartemisinin-piperaquine, MAS3; mefloquine-artesunate.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-29 02:43:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/889482"], "description"=>"<p>The size of boxes is proportional to the number of patients included. 95% confidence intervals (CI) are calculated for the odds ratio (OR).</p>", "links"=>[], "tags"=>["represents", "adverse", "dihydroartemisinin-piperaquine", "children", "adults", "did", "comparators", "comparative"], "article_id"=>559919, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.g005", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Note_the_forest_plot_represents_the_risk_of_adverse_event_appearance_after_the_start_of_dihydroartemisinin_piperaquine_treatment_in_children_lt_15_y_and_adults_who_did_not_present_this_symptom_on_admission_versus_comparators_in_comparative_studies_/559919", "title"=>"Note: the forest plot represents the risk of adverse event appearance after the start of dihydroartemisinin-piperaquine treatment in children (<15 y) and adults who did not present this symptom on admission versus comparators in comparative studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-29 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/889221"], "description"=>"<p>DP; dihydroartemisinin-piperaquine, MAS3; mefloquine-artesunate, AQ+SP; amodiaquine+sulfadoxine-pyrimethamine, AL; artemether-lumefantrine, AS+AQ; artesunate+amodiaquine. NC: not computable because of no recrudescent cases. *Overall number of failures does not add up because two comparators were used in Rwanda. Note: the forest plot represents the risk of parasite reappearance (PCR corrected; i.e. recrudescence, and not corrected i.e. recrudescence+new infection) of DP versus comparators in comparative studies. Groups size are equivalent except in Thailand where the DP group was twice as large (N = 686). Endpoints were assessed on Day 28 in Rwanda, Day 42 in Laos, Myanmar, and Uganda, and Day 63 in Cambodia, and Thailand. Overall results were stratified by site, and drugs. The size of the boxes is proportional to the number of patients included and thus to the overall effect. The diamond represents the overall hazard ratio and 95% CI.</p>", "links"=>[], "tags"=>["pediatrics and child health", "infectious diseases/neglected tropical diseases", "public health and epidemiology/global health"], "article_id"=>559664, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Note_HR_hazard_ratio_CI_confidence_interval_/559664", "title"=>"Note: HR; hazard ratio, CI; confidence interval.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-29 02:41:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/889826"], "description"=>"<p>CI; confidence interval.</p>*<p>The incidence within the first week is the proportion of cases occurring in the first week divided by the total number of cases within 28 days for each adverse event.</p>", "links"=>[], "tags"=>["incidence", "prevalence", "dihydroartemisinin-piperaquine"], "article_id"=>560270, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.t006", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adverse_event_incidence_density_and_prevalence_rates_dihydroartemisinin_piperaquine_groups_/560270", "title"=>"Adverse event incidence density and prevalence rates, dihydroartemisinin-piperaquine groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-29 00:04:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/889297"], "description"=>"<p>The endpoint was assessed at Day 14. Overall result was stratified by site. The size of boxes is proportional to the number of patients included and thus to the overall effect. The diamond represents the overall hazard ratio and 95% CI.</p>", "links"=>[], "tags"=>["represents", "clearing", "gametocytes", "comparing", "dp", "comparator", "drugs", "randomised"], "article_id"=>559739, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.g003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Note_the_forest_plot_represents_the_risk_of_clearing_gametocytes_comparing_DP_versus_comparator_drugs_in_randomised_studies_/559739", "title"=>"Note: the forest plot represents the risk of clearing gametocytes comparing DP versus comparator drugs in randomised studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-29 02:42:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/440677", "https://ndownloader.figshare.com/files/440715", "https://ndownloader.figshare.com/files/440752"], "description"=>"<div><h3>Background</h3><p>The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patient data analysis of efficacy and tolerability in acute uncomplicated falciparum malaria, from seven published randomized clinical trials conducted in Africa and South East Asia using a predefined in-vivo protocol. Comparator drugs were mefloquine-artesunate (MAS3) in Thailand, Myanmar, Laos and Cambodia; artemether-lumefantrine in Uganda; and amodiaquine+sulfadoxine-pyrimethamine and artesunate+amodiaquine in Rwanda.</p><h3>Methods and Findings</h3><p>In total 3,547 patients were enrolled: 1,814 patients (32% children under five years) received DP and 1,733 received a comparator antimalarial at 12 different sites and were followed for 28–63 days. There was no significant heterogeneity between trials. DP was well tolerated with 1.7% early vomiting. There were less adverse events with DP in children and adults compared to MAS3 except for diarrhea; ORs (95%CI) 2.74 (2.13 to 3.51) and 3.11 (2.31 to 4.18), respectively. DP treatment resulted in a rapid clearance of fever and parasitaemia. The PCR genotype corrected efficacy at Day 28 of DP assessed by survival analysis was 98.7% (95%CI 97.6–99.8). DP was superior to the comparator drugs in protecting against both P.falciparum recurrence and recrudescence (P = 0.001, weighted by site). There was no difference between DP and MAS3 in treating P. vivax co-infections and in suppressing the first relapse (median interval to P. vivax recurrence: 6 weeks). Children under 5 y were at higher risk of recurrence for both infections. The proportion of patients developing gametocytaemia (P = 0.002, weighted by site) and the subsequent gametocyte carriage rates were higher with DP (11/1000 person gametocyte week, PGW) than MAS3 (6/1000 PGW, P = 0.001, weighted by site).</p><h3>Conclusions</h3><p>DP proved a safe, well tolerated, and highly effective treatment of P.falciparum malaria in Asia and Africa, but the effect on gametocyte carriage was inferior to that of MAS3.</p></div>", "links"=>[], "tags"=>["efficacy", "dihydroartemisinin-piperaquine", "falciparum", "prospective", "multi-centre"], "article_id"=>146873, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006358.s001", "https://dx.doi.org/10.1371/journal.pone.0006358.s002", "https://dx.doi.org/10.1371/journal.pone.0006358.s003"], "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Safety_and_Efficacy_of_Dihydroartemisinin_Piperaquine_in_Falciparum_Malaria_A_Prospective_Multi_Centre_Individual_Patient_Data_Analysis/146873", "title"=>"Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria: A Prospective Multi-Centre Individual Patient Data Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-07-29 01:54:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/889862"], "description"=>"<p>Note: Age was per 1 year increase in age, and parasite count was per 1 unit increase in the log transformed parasite density. AOR; adjusted odds ratio. AHR; adjusted hazard ratio. CI; confidence interval.</p>", "links"=>[], "tags"=>["gametocyte", "dihydroartemisinin-piperaquine"], "article_id"=>560310, "categories"=>["Medicine", "Cancer"], "users"=>["Julien Zwang", "Elizabeth A. Ashley", "Corine Karema", "Umberto D'Alessandro", "Frank Smithuis", "Grant Dorsey", "Bart Janssens", "Mayfong Mayxay", "Paul Newton", "Pratap Singhasivanon", "Kasia Stepniewska", "Nicholas J. White", "François Nosten"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006358.t004", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predictors_of_patent_gametocytaemia_and_gametocyte_appearance_dihydroartemisinin_piperaquine_groups_/560310", "title"=>"Predictors of patent gametocytaemia, and gametocyte appearance, dihydroartemisinin-piperaquine groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-29 00:05:10"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "year"=>"2010", "pdf"=>"12", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"21", "pdf"=>"11", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"35", "year"=>"2010", "pdf"=>"18", "unique-ip"=>"29", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"16", "pdf"=>"6", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "year"=>"2010", "pdf"=>"15", "unique-ip"=>"20", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "unique-ip"=>"16", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2010", "pdf"=>"14", "unique-ip"=>"14", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"10", "pdf"=>"7", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"10", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"10", "unique-ip"=>"14", "pdf"=>"8", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2010", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"13", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"11", "pdf"=>"7", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"2", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"3", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"14", "pdf"=>"9", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"7", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"14", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"9", "pdf"=>"2", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"12", "pdf"=>"6", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"13", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"65", "unique-ip"=>"65", "pdf"=>"53", "year"=>"2009", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"39", "year"=>"2009", "pdf"=>"23", "unique-ip"=>"34", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"11", "pdf"=>"8", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"27", "year"=>"2009", "pdf"=>"13", "unique-ip"=>"23", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"16", "unique-ip"=>"16", "pdf"=>"6", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2012", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"41", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"36", "full-text"=>"38", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"19", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"36", "full-text"=>"39", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"37", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"45", "full-text"=>"51", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"30", "full-text"=>"35", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}

Relative Metric

{"start_date"=>"2009-01-01T00:00:00Z", "end_date"=>"2009-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Parasitology", "average_usage"=>[333, 557, 666, 769, 870, 981, 1073, 1139, 1199, 1269, 1375, 1438, 1505, 1553, 1632, 1680, 1736, 1808, 1874, 1941, 1996, 2052, 2096, 2145, 2173, 2204, 2257, 2304, 2346, 2426, 2472, 2508, 2551, 2615, 2668, 2696, 2761, 2814, 2861, 2928, 3033, 3082, 3181, 3261, 3320, 3367, 3445, 3502, 3610, 3671, 3724, 3766, 3819, 3858, 3936, 4038, 4100, 4152, 4198, 4244, 4305, 4363]}, {"subject_area"=>"/Engineering and technology/Electronics", "average_usage"=>[361, 646, 737, 857, 972, 1056, 1166, 1281, 1390, 1478, 1590, 1707, 1834, 1930, 2023, 2095, 2142, 2290, 2388, 2471, 2513, 2535, 2559, 2606, 2656, 2717, 2769, 2825, 2876, 2974, 3024, 3089, 3169, 3234, 3299, 3367, 3478, 3547, 3643, 3724, 3812, 3916, 4008, 4095, 4183, 4262, 4339, 4420, 4526, 4596, 4673, 4752, 4802, 4888, 4963, 5027, 5104, 5176, 5236, 5320, 5417, 5527, 5591]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[332, 584, 719, 824, 927, 1030, 1139, 1233, 1322, 1402, 1483, 1570, 1649, 1730, 1806, 1873, 1939, 2003, 2068, 2130, 2191, 2248, 2302, 2362, 2427, 2485, 2544, 2599, 2653, 2709, 2778, 2840, 2896, 2950, 3013, 3073, 3137, 3189, 3253, 3305, 3364, 3423, 3489, 3557, 3606, 3668, 3742, 3797, 3852, 3907, 3962, 4027, 4072, 4132, 4193, 4256, 4308, 4366, 4427, 4493, 4556]}, {"subject_area"=>"/Medicine and health sciences/Parasitic diseases", "average_usage"=>[253, 507, 616, 727, 835, 909, 985, 1060, 1132, 1194, 1253, 1340, 1410, 1474, 1548, 1610, 1675, 1733, 1776, 1841, 1911, 1981, 2012, 2061, 2114, 2171, 2207, 2266, 2318, 2380, 2425, 2479, 2539, 2586, 2667, 2736, 2791, 2835, 2896, 2955, 3027, 3088, 3165, 3242, 3310, 3364, 3437, 3497, 3564, 3652, 3708, 3761, 3809, 3866, 3960, 4061, 4113, 4168, 4258, 4325, 4383, 4487]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[302, 565, 710, 814, 921, 1026, 1126, 1222, 1311, 1409, 1491, 1580, 1659, 1736, 1809, 1874, 1947, 2004, 2061, 2133, 2186, 2236, 2302, 2362, 2441, 2494, 2550, 2603, 2651, 2711, 2785, 2840, 2904, 2962, 3018, 3066, 3133, 3181, 3253, 3300, 3357, 3409, 3459, 3556, 3621, 3657, 3709, 3784, 3856, 3886, 3958, 4027, 4081, 4124, 4183, 4241, 4297, 4338, 4391, 4437, 4488]}, {"subject_area"=>"/Medicine and health sciences/Tropical diseases", "average_usage"=>[262, 539, 658, 749, 834, 916, 1020, 1108, 1196, 1250, 1338, 1408, 1481, 1549, 1611, 1671, 1721, 1786, 1854, 1904, 1968, 2031, 2101, 2158, 2205, 2271, 2326, 2381, 2440, 2488, 2544, 2603, 2658, 2726, 2786, 2839, 2896, 2954, 3019, 3067, 3126, 3181, 3241, 3294, 3367, 3446, 3538, 3634, 3677, 3736, 3785, 3816, 3867, 3946, 4032, 4083, 4121, 4191, 4278, 4344, 4399, 4438]}]}
Loading … Spinner
There are currently no alerts