Molecular, Biochemical and Genetic Characteristics of BSE in Canada
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{"title"=>"Molecular, biochemical and genetic characteristics of BSE in Canada", "type"=>"journal", "authors"=>[{"first_name"=>"Sandor", "last_name"=>"Dudas", "scopus_author_id"=>"14041598500"}, {"first_name"=>"Jianmin", "last_name"=>"Yang", "scopus_author_id"=>"57192451830"}, {"first_name"=>"Catherine", "last_name"=>"Graham", "scopus_author_id"=>"36847902800"}, {"first_name"=>"Markus", "last_name"=>"Czub", "scopus_author_id"=>"7003543241"}, {"first_name"=>"Tim A.", "last_name"=>"Mcallister", "scopus_author_id"=>"7102068695"}, {"first_name"=>"Michael B.", "last_name"=>"Coulthart", "scopus_author_id"=>"6701732556"}, {"first_name"=>"Stefanie", "last_name"=>"Czub", "scopus_author_id"=>"7003367168"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"359515464", "doi"=>"10.1371/journal.pone.0010638", "scopus"=>"2-s2.0-77956288686", "issn"=>"19326203", "pmid"=>"20498835", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "sgr"=>"77956288686"}, "id"=>"88daac14-21ef-3209-9278-aaee81ce235d", "abstract"=>"The epidemiology and possibly the etiology of bovine spongiform encephalopathy (BSE) have recently been recognized to be heterogeneous. In particular, three types [classical (C) and two atypical (H, L)] have been identified, largely on the basis of characteristics of the proteinase K (PK)-resistant core of the misfolded prion protein associated with the disease (PrP(res)). The present study was conducted to characterize the 17 Canadian BSE cases which occurred prior to November 2009 based on the molecular and biochemical properties of their PrP(res), including immunoreactivity, molecular weight, glycoform profile and relative PK sensitivity. Two cases exhibited molecular weight and glycoform profiles similar to those of previously reported atypical cases, one corresponding to H-type BSE (case 6) and the other to L-type BSE (case 11). All other cases were classified as C-type. PK digestion under mild and stringent conditions revealed a reduced protease resistance in both of these cases compared to the C-type cases. With Western immunoblotting, N-terminal-specific antibodies bound to PrP(res) from case 6 but not to that from case 11 or C-type cases. C-terminal-specific antibodies revealed a shift in the glycoform profile and detected a fourth protein fragment in case 6, indicative of two PrP(res) subpopulations in H-type BSE. No mutations suggesting a genetic etiology were found in any of the 17 animals by sequencing the full PrP-coding sequence in exon 3 of the PRNP gene. Thus, each of the three known BSE types have been confirmed in Canadian cattle and show molecular characteristics highly similar to those of classical and atypical BSE cases described from Europe, Japan and the USA. The occurrence of atypical cases of BSE in countries such as Canada with low BSE prevalence and transmission risk argues for the occurrence of sporadic forms of BSE worldwide.", "link"=>"http://www.mendeley.com/research/molecular-biochemical-genetic-characteristics-bse-canada", "reader_count"=>12, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/848710"], "description"=>"<p>L- (case 11, lanes 1 and 2), C- (case 12, lanes 3 and 4) and H- (case 6, lanes 5 and 6) type BSE after PK digestions with (+) and without (−) PNGase F deglycosylation. Core antibody 6H4 detection demonstrates the size differences between classical and atypical BSE and also a slight size shift between the unglycosylated and deglycosylated bands within each individual type of BSE. The lane labelled as M contains the molecular weight marker and weights are in kilodaltons.</p>", "links"=>[], "tags"=>["blot", "canadian", "bse", "pk", "digestion", "pngase"], "article_id"=>519147, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_analysis_of_Canadian_BSE_after_PK_digestion_and_PNGase_F_treatment_/519147", "title"=>"Western blot analysis of Canadian BSE after PK digestion and PNGase F treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/848803"], "description"=>"<p>L- (case 11, lanes 1 and 2), C- (case 12, lanes 3 and 4) and H- (case 6, lanes 5 and 6) type BSE after PK digestions at 37°C for one hour under mild (Mild: pH 6.5, PK 50 µg/ml) and stringent (Str.: pH 8.0, PK 500 µg/ml) conditions. Core antibody 6H4 detection demonstrates little change in the amount of PrP<sup>res</sup> surviving the stringent digestion in C-type BSE and a significant degradation of L-type PrP<sup>res</sup> and almost complete degradation of H-type PrP<sup>res</sup> under the stringent conditions. The lane labelled as M contains the molecular weight marker and weights are in kilodaltons.</p>", "links"=>[], "tags"=>["blot", "canadian", "bse", "stringent", "pk"], "article_id"=>519250, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_analysis_of_Canadian_BSE_after_mild_and_stringent_PK_digestion_/519250", "title"=>"Western blot analysis of Canadian BSE after mild and stringent PK digestion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:20:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/848878"], "description"=>"<p>The antibodies used can be organized into three groups based on their target epitope. The N-terminal-specific antibodies include 12B2, P4, and SAF32, core-specific antibodies are 9A2, 6H4, and L42, and the C-terminal-specific antibodies are 94B4 and SAF84.</p>", "links"=>[], "tags"=>["differential"], "article_id"=>519332, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibodies_used_to_determine_differential_immunoreactivity_/519332", "title"=>"Antibodies used to determine differential immunoreactivity.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:20:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/848909"], "description"=>"<p>The proportion of PrP<sup>res</sup> detected as diglycosylated is approximately 60% for the C- and H-type. In comparison, the L-type had a much lower proportion of the diglycosylated PrP<sup>res</sup> at approximately 40%. The L-type case also had a ratio of di- to monoglycosylated (D/M) PrP<sup>res</sup> well below 2 (1.1), whereas the ratios of intensity of D/M from all other cases were above or equal to 2 when using core specific antibodies for detection. Profiles were determined by analyzing western blot reactivity using the BioRad Quantity One software (BioRad, Canada).</p><p><b><i>D</i></b>  =  Diglycosylated PrP<sup>res</sup>; <b><i>M</i></b>  =  Monoglycosylated PrP<sup>res</sup>; <b><i>Un</i></b>  =  Unglycosylated PrP<sup>res</sup>; <b><i>D/M</i></b>  =  Diglycosylated PrP<sup>res</sup>/Monoglycosylated PrP<sup>res</sup>.</p>", "links"=>[], "tags"=>["quantification", "canadian", "bse", "cases", "antibody"], "article_id"=>519361, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glycoform_quantification_of_PrP_res_from_the_Canadian_BSE_cases_using_core_antibody_6H4_/519361", "title"=>"Glycoform quantification of PrP<sup>res</sup> from the Canadian BSE cases using core antibody 6H4.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:20:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/848951"], "description"=>"<p>Animal information for the 17 Canadian BSE cases.</p>", "links"=>[], "tags"=>["17", "canadian", "bse"], "article_id"=>519405, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Animal_information_for_the_17_Canadian_BSE_cases_/519405", "title"=>"Animal information for the 17 Canadian BSE cases.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:20:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/848988"], "description"=>"<p>Determination of these five characteristics provides valuable information in typing BSE cases. Each of the Canadian cases were definitively place it into one of the three know types of BSE after reviewing the results generated when determining these five characteristics.</p><p><b>Ab  = </b> Antibody, <b>D/M</b>  =  Diglycosylated PrP<sup>res</sup>/Monoglycosylated PrP<sup>res</sup>, <b>S/M</b>  =  stringent digest immunoreactivity/mild digest immunoreactivity.</p>", "links"=>[], "tags"=>["properties", "discriminate", "bse"], "article_id"=>519440, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.t006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_molecular_biochemical_properties_of_PrP_res_used_to_discriminate_between_the_three_BSE_types_/519440", "title"=>"Summary of the molecular/biochemical properties of PrP<sup>res</sup> used to discriminate between the three BSE types.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:21:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/849030"], "description"=>"<p>When using N-terminal-specific, C-terminal-specific and core-specific antibodies to compare their affinity to the different types of BSE, N-terminal-specific antibodies P4, 12B2 and SAF32 bound to all three bands of PrP<sup>res</sup> in H-type, but not to the PrP<sup>res</sup> bands of the C- or L-type cases. The core- and C-terminal-specific antibodies 9A2, L42, 6H4, 94B4, SAF84 bound to all three bands of the PrP<sup>res</sup> of the H-, L-, and C-types.</p><p>****All three bands of PrP<sup>res</sup> were visible and strongly reactive;</p><p>***All three bands of PrP<sup>res</sup> were visible;</p><p>**Two of the three bands of PrP<sup>res</sup> were visible;</p><p>*One of the three bands of PrP<sup>res</sup> was visible; - None of the PrP<sup>res</sup> bands were visible; Ab  =  Primary antibody.</p>", "links"=>[], "tags"=>["blot", "immunoreactivity", "profiles", "canadian", "bse"], "article_id"=>519480, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_PrP_res_immunoreactivity_profiles_for_the_Canadian_BSE_cases_/519480", "title"=>"Western blot PrP<sup>res</sup> immunoreactivity profiles for the Canadian BSE cases.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:21:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/849073"], "description"=>"<p>AJ298878  =  GenBank reference sequence; OPR  =  octapeptide repeat; ..  =  homozygous for AJ298878 sequence; –  =  codon 78 missing on 5-OPR allele.</p>", "links"=>[], "tags"=>["canadian", "bse-affected", "polymorphic", "positions", "protein-coding"], "article_id"=>519523, "categories"=>["Molecular Biology", "Neuroscience", "Medicine"], "users"=>["Sandor Dudas", "Jianmin Yang", "Catherine Graham", "Markus Czub", "Tim A. McAllister", "Michael B. Coulthart", "Stefanie Czub"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010638.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotypes_of_Canadian_BSE_affected_cattle_at_polymorphic_positions_in_the_protein_coding_sequence_of_PRNP_/519523", "title"=>"Genotypes of Canadian BSE-affected cattle at polymorphic positions in the protein-coding sequence of <i>PRNP</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:21:34"}

PMC Usage Stats | Further Information

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  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "year"=>"2010", "pdf"=>"10", "unique-ip"=>"25", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"16", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
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  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"30", "full-text"=>"41", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
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Relative Metric

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