Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells
Publication Date
January 28, 2011
Journal
PLOS ONE
Authors
Caterina Mammi, Donatella Pastore, Marco F. Lombardo, Francesca Ferrelli, et al
Volume
6
Issue
1
Pages
e14542
DOI
http://doi.org/10.1371/journal.pone.0014542
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0014542
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21297971
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030559
Europe PMC
http://europepmc.org/abstract/MED/21297971
Web of Science
000286664100001
Scopus
79551522184
Mendeley
http://www.mendeley.com/research/sildenafil-reduces-insulinresistance-human-endothelial-cells
Events
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/802276"], "description"=>"<p><b>A</b>: Western Blot analysis of eNOS Ser<sup>1177</sup> phosphorylation. Means ± S.E. (n = 4). * <i>p</i><0.05 vs Ctrl; ° <i>p</i><0.05 vs insulin; **<i>p</i><0.01 vs sildenafil; °°<i>p</i><0.05 vs sildenafil+insulin. <b>B</b>: Sildenafil treatment (1 µM/5 h) induces NO production that is partially inhibited from LY. Means ± S.E. (n = 6). *<i>p</i><0.05 <i>vs</i> Ctrl; **<i>p</i><0.01 <i>vs</i> Ctrl; ‡ <i>p</i><0.05 <i>vs</i> insulin; ¶ <i>p</i><0.05 <i>vs</i> LY; ¶¶ <i>p</i><0.05 <i>vs</i> LY+insulin; # <i>p</i><0.05 and ## <i>p</i><0.01 <i>vs</i> sildenafil; ∥ <i>p</i><0.05 <i>vs</i> sildenafil+insulin. <b>C</b>: L-NAME effects on NO production induced by sildenafil treatment. L-NAME reduces NO production induced by acute treatment with sildenafil. Means ± S.E. (n = 6). *p<0.05 <i>vs</i> Ctrl; # <i>p</i><0.05 <i>vs</i> sildenafil. Full bar represent conditions without sildenafil, dashed bars represent sildenafil treatment.</p>", "links"=>[], "tags"=>["phosphorylation", "induced", "acute"], "article_id"=>472627, "categories"=>["Chemistry", "Computational Biology", "Virology"], "users"=>["Caterina Mammi", "Donatella Pastore", "Marco F. Lombardo", "Francesca Ferrelli", "Massimiliano Caprio", "Claudia Consoli", "Manfredi Tesauro", "Lucia Gatta", "Massimo Fini", "Massimo Federici", "Paolo Sbraccia", "Giulia Donadel", "Alfonso Bellia", "Giuseppe M. Rosano", "Andrea Fabbri", "Davide Lauro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014542.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_eNOS_Ser_1177_phosphorylation_and_NO_production_induced_by_acute_treatment_with_sildenafil_/472627", "title"=>"eNOS Ser<sup>1177</sup> phosphorylation and NO production induced by acute treatment with sildenafil.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:55:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/802194"], "description"=>"<p>Sildenafil chronic treatment (1 µM/72 h) enhances eNOS phosphorylation in basal condition and after HG treatment, but not significantly after Gluc-N treatment. Full bars represent conditions without sildenafil, dashed bars represent sildenafil treatment. Ctrl was expressed as 100%. Means ± S.E. (n = 5). *<i>p</i><0.05 <i>vs</i> Ctrl, ‡ <i>p</i><0.05 <i>vs</i> insulin; † <i>p</i><0.05 <i>vs</i> HG; †† <i>p</i><0.05 <i>vs</i> HG + insulin.</p>", "links"=>[], "tags"=>["phosphorylation", "sildenafil"], "article_id"=>472547, "categories"=>["Chemistry", "Computational Biology", "Virology"], "users"=>["Caterina Mammi", "Donatella Pastore", "Marco F. Lombardo", "Francesca Ferrelli", "Massimiliano Caprio", "Claudia Consoli", "Manfredi Tesauro", "Lucia Gatta", "Massimo Fini", "Massimo Federici", "Paolo Sbraccia", "Giulia Donadel", "Alfonso Bellia", "Giuseppe M. Rosano", "Andrea Fabbri", "Davide Lauro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014542.g003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_eNOS_Ser_1177_phosphorylation_after_sildenafil_treatment_/472547", "title"=>"eNOS Ser<sup>1177</sup> phosphorylation after sildenafil treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:54:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/802429"], "description"=>"<p>Sildenafil treatment induces NO production in insulin resistance condition (HG and Gluc-N) in HUVEC (panel A) and HAEC (panel B). Full bars represent conditions without sildenafil, dashed bars represent sildenafil treatment. Means ± S.E. (n = 6). *<i>p</i><0.05 and **<i>p</i><0.01 <i>vs</i> Ctrl; ‡ <i>p</i><0.05 and ‡‡ <i>p</i><0.01 <i>vs</i> insulin; † <i>p</i><0.05 <i>vs</i> HG; $ <i>p<</i>0.05 <i>vs</i> sildenafil; # <i>p</i><0.05 <i>vs</i> sildenafil+HG; <b>∞ </b><i>p</i><0.05 <i>vs</i> Gluc-N.</p>", "links"=>[], "tags"=>["insulin-resistance", "conditions", "sildenafil"], "article_id"=>472773, "categories"=>["Chemistry", "Computational Biology", "Virology"], "users"=>["Caterina Mammi", "Donatella Pastore", "Marco F. Lombardo", "Francesca Ferrelli", "Massimiliano Caprio", "Claudia Consoli", "Manfredi Tesauro", "Lucia Gatta", "Massimo Fini", "Massimo Federici", "Paolo Sbraccia", "Giulia Donadel", "Alfonso Bellia", "Giuseppe M. Rosano", "Andrea Fabbri", "Davide Lauro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014542.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NO_production_in_insulin_resistance_conditions_after_sildenafil_treatment_/472773", "title"=>"NO production in insulin-resistance conditions after sildenafil treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:55:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/802552"], "description"=>"<p>Schematic summary of sildenafil action in endothelial cells.</p>", "links"=>[], "tags"=>["sildenafil", "endothelial"], "article_id"=>472902, "categories"=>["Chemistry", "Computational Biology", "Virology"], "users"=>["Caterina Mammi", "Donatella Pastore", "Marco F. Lombardo", "Francesca Ferrelli", "Massimiliano Caprio", "Claudia Consoli", "Manfredi Tesauro", "Lucia Gatta", "Massimo Fini", "Massimo Federici", "Paolo Sbraccia", "Giulia Donadel", "Alfonso Bellia", "Giuseppe M. Rosano", "Andrea Fabbri", "Davide Lauro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014542.g006", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_summary_of_sildenafil_action_in_endothelial_cells_/472902", "title"=>"Schematic summary of sildenafil action in endothelial cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:56:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/801952"], "description"=>"<p><b>A</b>: PDE5 mRNA expression in HUVEC and hfCC cells: RT-PCR shows that HUVEC express detectable levels of PDE-5 mRNA. Actin was used as control. <b>B</b>: Western Blot analysis for PDE5 protein expression. <b>C</b>: Real time PCR shows that insulin (30 min) and/or sildenafil (5 h) treatments induce PDE5 and eNOS but not iNOS expression *<i>p</i><0.05 <i>vs</i> Ctrl, **<i>p</i><0.01 <i>vs</i> Ctrl; † <i>p</i><0.05 <i>vs</i> sildenafil. <b>D</b>: A representative Western Blot shows that insulin (30 min) and/or sildenafil (5 h) treatments do not alter iNOS protein levels.</p>", "links"=>[], "tags"=>["inos", "endothelial"], "article_id"=>472281, "categories"=>["Chemistry", "Computational Biology", "Virology"], "users"=>["Caterina Mammi", "Donatella Pastore", "Marco F. Lombardo", "Francesca Ferrelli", "Massimiliano Caprio", "Claudia Consoli", "Manfredi Tesauro", "Lucia Gatta", "Massimo Fini", "Massimo Federici", "Paolo Sbraccia", "Giulia Donadel", "Alfonso Bellia", "Giuseppe M. Rosano", "Andrea Fabbri", "Davide Lauro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014542.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PDE5_and_iNOS_expression_in_human_endothelial_cells_/472281", "title"=>"PDE5 and iNOS expression in human endothelial cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:53:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/802053"], "description"=>"<p>Insulin plus sildenafil treatment (1 µM/72 h) enhances Akt-1 phosphorylation in insulin resistance condition respect to the same conditions without sildenafil. Full bars represent conditions without sildenafil, dashed bars represent sildenafil treatment. Ctrl was expressed as 100%. Means ± S.E. (n = 5). ‡ <i>p</i><0.05 <i>vs</i> insulin; †<i>p</i><0.05 <i>vs</i> HG+insulin; § <i>p</i><0.05 <i>vs</i> Gluc-N+insulin.</p>", "links"=>[], "tags"=>["phosphorylation", "sildenafil"], "article_id"=>472405, "categories"=>["Chemistry", "Computational Biology", "Virology"], "users"=>["Caterina Mammi", "Donatella Pastore", "Marco F. Lombardo", "Francesca Ferrelli", "Massimiliano Caprio", "Claudia Consoli", "Manfredi Tesauro", "Lucia Gatta", "Massimo Fini", "Massimo Federici", "Paolo Sbraccia", "Giulia Donadel", "Alfonso Bellia", "Giuseppe M. Rosano", "Andrea Fabbri", "Davide Lauro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014542.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Akt_1_phosphorylation_after_sildenafil_treatment_/472405", "title"=>"Akt-1 phosphorylation after sildenafil treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:54:00"}

PMC Usage Stats | Further Information

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Relative Metric

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