The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The natural product domain seeker NaPDoS: A phylogeny based bioinformatic tool to classify secondary metabolite gene diversity", "type"=>"journal", "authors"=>[{"first_name"=>"Nadine", "last_name"=>"Ziemert", "scopus_author_id"=>"23979136400"}, {"first_name"=>"Sheila", "last_name"=>"Podell", "scopus_author_id"=>"6601930561"}, {"first_name"=>"Kevin", "last_name"=>"Penn", "scopus_author_id"=>"12544524800"}, {"first_name"=>"Jonathan H.", "last_name"=>"Badger", "scopus_author_id"=>"35232327400"}, {"first_name"=>"Eric", "last_name"=>"Allen", "scopus_author_id"=>"7202717583"}, {"first_name"=>"Paul R.", "last_name"=>"Jensen", "scopus_author_id"=>"13309855300"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0034064", "sgr"=>"84859078407", "issn"=>"19326203", "scopus"=>"2-s2.0-84859078407", "pui"=>"364529162", "pmid"=>"22479523"}, "id"=>"dc1bbf2e-2638-3fc0-8eb3-0e9667c29559", "abstract"=>"New bioinformatic tools are needed to analyze the growing volume of DNA sequence data. This is especially true in the case of secondary metabolite biosynthesis, where the highly repetitive nature of the associated genes creates major challenges for accurate sequence assembly and analysis. Here we introduce the web tool Natural Product Domain Seeker (NaPDoS), which provides an automated method to assess the secondary metabolite biosynthetic gene diversity and novelty of strains or environments. NaPDoS analyses are based on the phylogenetic relationships of sequence tags derived from polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) genes, respectively. The sequence tags correspond to PKS-derived ketosynthase domains and NRPS-derived condensation domains and are compared to an internal database of experimentally characterized biosynthetic genes. NaPDoS provides a rapid mechanism to extract and classify ketosynthase and condensation domains from PCR products, genomes, and metagenomic datasets. Close database matches provide a mechanism to infer the generalized structures of secondary metabolites while new phylogenetic lineages provide targets for the discovery of new enzyme architectures or mechanisms of secondary metabolite assembly. Here we outline the main features of NaPDoS and test it on four draft genome sequences and two metagenomic datasets. The results provide a rapid method to assess secondary metabolite biosynthetic gene diversity and richness in organisms or environments and a mechanism to identify genes that may be associated with uncharacterized biochemistry.", "link"=>"http://www.mendeley.com/research/natural-product-domain-seeker-napdos-phylogeny-based-bioinformatic-tool-classify-secondary-metabolit", "reader_count"=>180, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>8, "Researcher"=>41, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>65, "Student > Postgraduate"=>6, "Student > Master"=>22, "Other"=>5, "Student > Bachelor"=>15, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>8, "Researcher"=>41, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>65, "Student > Postgraduate"=>6, "Student > Master"=>22, "Other"=>5, "Student > Bachelor"=>15, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Environmental Science"=>5, "Biochemistry, Genetics and Molecular Biology"=>14, "Materials Science"=>1, "Agricultural and Biological Sciences"=>122, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemical Engineering"=>1, "Chemistry"=>19, "Computer Science"=>2, "Immunology and Microbiology"=>6, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>19}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>6}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>122}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>14}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Colombia"=>1, "Czech Republic"=>1, "United States"=>14, "Denmark"=>7, "Brazil"=>2, "Australia"=>1, "Chile"=>3, "Germany"=>2, "Spain"=>1}, "group_count"=>9}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84859078407"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84859078407?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859078407&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84859078407&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84859078407", "dc:identifier"=>"SCOPUS_ID:84859078407", "eid"=>"2-s2.0-84859078407", "dc:title"=>"The natural product domain seeker NaPDoS: A phylogeny based bioinformatic tool to classify secondary metabolite gene diversity", "dc:creator"=>"Ziemert N.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-03-29", "prism:coverDisplayDate"=>"29 March 2012", "prism:doi"=>"10.1371/journal.pone.0034064", "citedby-count"=>"102", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Scripps Institution of Oceanography", "affiliation-city"=>"San Diego", "affiliation-country"=>"United States"}], "pubmed-id"=>"22479523", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e34064", "source-id"=>"10600153309"}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0034064", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"7", "html_views"=>"264"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"134", "xml_views"=>"17", "html_views"=>"298"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"63", "xml_views"=>"1", "html_views"=>"142"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"5", "html_views"=>"77"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"59", "xml_views"=>"1", "html_views"=>"121"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"82"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"89"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"84"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"103"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"124"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"89"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"117"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"112"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"106"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"28", "xml_views"=>"3", "html_views"=>"148"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"169"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"42", "xml_views"=>"1", "html_views"=>"149"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"140"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"7", "html_views"=>"107"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"142"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"129"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"131"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"117"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"87"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"79", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"57", "xml_views"=>"3", "html_views"=>"64"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"58", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"91", "xml_views"=>"3", "html_views"=>"81"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"82", "xml_views"=>"3", "html_views"=>"113"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"80", "xml_views"=>"1", "html_views"=>"69"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"64", "xml_views"=>"4", "html_views"=>"75"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"47"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/661662"], "description"=>"<p>A) KS domain phylogeny. Polyphyletic groups are distinguished by letters. B) C domain phylogeny.</p>", "links"=>[], "tags"=>["genetics and genomics", "chemistry", "biotechnology"], "article_id"=>332149, "categories"=>["Biotechnology", "Chemistry", "Genetics"], "users"=>["Nadine Ziemert", "Sheila Podell", "Kevin Penn", "Jonathan H. Badger", "Eric Allen", "Paul R. Jensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034064.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogeny_based_domain_classification_/332149", "title"=>"Phylogeny based domain classification.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-29 00:35:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/661786"], "description"=>"<p>KS domain classification.</p>", "links"=>[], "tags"=>["genetics and genomics", "chemistry", "biotechnology"], "article_id"=>332271, "categories"=>["Biotechnology", "Chemistry", "Genetics"], "users"=>["Nadine Ziemert", "Sheila Podell", "Kevin Penn", "Jonathan H. Badger", "Eric Allen", "Paul R. Jensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034064.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_KS_domain_classification_/332271", "title"=>"KS domain classification.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-29 00:37:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/661495"], "description"=>"<p>Screen shot of the NaPDoS webpage.</p>", "links"=>[], "tags"=>["napdos"], "article_id"=>331983, "categories"=>["Biotechnology", "Chemistry", "Genetics"], "users"=>["Nadine Ziemert", "Sheila Podell", "Kevin Penn", "Jonathan H. Badger", "Eric Allen", "Paul R. Jensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034064.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Screen_shot_of_the_NaPDoS_webpage_/331983", "title"=>"Screen shot of the NaPDoS webpage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-29 00:33:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/339038", "https://ndownloader.figshare.com/files/339050", "https://ndownloader.figshare.com/files/339056", "https://ndownloader.figshare.com/files/339063", "https://ndownloader.figshare.com/files/339078", "https://ndownloader.figshare.com/files/339087", "https://ndownloader.figshare.com/files/339098"], "description"=>"<div><p>New bioinformatic tools are needed to analyze the growing volume of DNA sequence data. This is especially true in the case of secondary metabolite biosynthesis, where the highly repetitive nature of the associated genes creates major challenges for accurate sequence assembly and analysis. Here we introduce the web tool Natural Product Domain Seeker (NaPDoS), which provides an automated method to assess the secondary metabolite biosynthetic gene diversity and novelty of strains or environments. NaPDoS analyses are based on the phylogenetic relationships of sequence tags derived from polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) genes, respectively. The sequence tags correspond to PKS-derived ketosynthase domains and NRPS-derived condensation domains and are compared to an internal database of experimentally characterized biosynthetic genes. NaPDoS provides a rapid mechanism to extract and classify ketosynthase and condensation domains from PCR products, genomes, and metagenomic datasets. Close database matches provide a mechanism to infer the generalized structures of secondary metabolites while new phylogenetic lineages provide targets for the discovery of new enzyme architectures or mechanisms of secondary metabolite assembly. Here we outline the main features of NaPDoS and test it on four draft genome sequences and two metagenomic datasets. The results provide a rapid method to assess secondary metabolite biosynthetic gene diversity and richness in organisms or environments and a mechanism to identify genes that may be associated with uncharacterized biochemistry.</p> </div>", "links"=>[], "tags"=>["seeker", "phylogeny", "based", "bioinformatic", "metabolite"], "article_id"=>127025, "categories"=>["Biotechnology", "Chemistry", "Genetics"], "users"=>["Nadine Ziemert", "Sheila Podell", "Kevin Penn", "Jonathan H. Badger", "Eric Allen", "Paul R. Jensen"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0034064.s001", "https://dx.doi.org/10.1371/journal.pone.0034064.s002", "https://dx.doi.org/10.1371/journal.pone.0034064.s003", "https://dx.doi.org/10.1371/journal.pone.0034064.s004", "https://dx.doi.org/10.1371/journal.pone.0034064.s005", "https://dx.doi.org/10.1371/journal.pone.0034064.s006", "https://dx.doi.org/10.1371/journal.pone.0034064.s007"], "stats"=>{"downloads"=>23, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Natural_Product_Domain_Seeker_NaPDoS_A_Phylogeny_Based_Bioinformatic_Tool_to_Classify_Secondary_Metabolite_Gene_Diversity/127025", "title"=>"The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-03-29 01:57:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/661385"], "description"=>"<p>The web interface to this pipeline is divided 3 consecutive steps. Nucleic acid sequences are translated into predicted amino acids and genomic sequences are screened using Hidden Markov Models (HMM). For protein and small nucleic acid sequences a BLAST search is performed against curated reference database examples to identify matches to known PKS/NRPS pathways. Selected candidate sequences plus the BLAST results are trimmed and inserted into a manually curated reference alignment, keeping the original reference alignment intact. This alignment is used to build a tree.</p>", "links"=>[], "tags"=>["bioinformatic"], "article_id"=>331871, "categories"=>["Biotechnology", "Chemistry", "Genetics"], "users"=>["Nadine Ziemert", "Sheila Podell", "Kevin Penn", "Jonathan H. Badger", "Eric Allen", "Paul R. Jensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034064.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NaPDoS_bioinformatic_pipeline_/331871", "title"=>"NaPDoS bioinformatic pipeline.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-29 00:31:11"}

PMC Usage Stats | Further Information

  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"53", "year"=>"2012", "pdf"=>"29", "unique-ip"=>"53", "figure"=>"23", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"75", "unique-ip"=>"59", "pdf"=>"21", "year"=>"2012", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"36", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"26", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"45", "full-text"=>"39", "pdf"=>"27", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"65", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"33", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"13", "cited-by"=>"3", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[366, 574, 695, 795, 885, 973, 1063, 1148, 1233, 1319, 1389, 1459, 1533, 1611, 1685, 1754, 1820, 1882, 1937, 2001, 2071, 2129, 2219, 2273, 2335]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[333, 576, 707, 814, 908, 1004, 1104, 1197, 1280, 1370, 1449, 1531, 1603, 1673, 1742, 1817, 1886, 1954, 2025, 2098, 2171, 2234, 2304, 2365, 2431]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[324, 551, 679, 782, 879, 971, 1064, 1154, 1245, 1328, 1406, 1476, 1541, 1617, 1683, 1754, 1818, 1893, 1962, 2025, 2092, 2164, 2227, 2294, 2355]}, {"subject_area"=>"/Computer and information sciences", "average_usage"=>[352, 587, 696, 809, 901, 989, 1072, 1156, 1257, 1334, 1422, 1486, 1555, 1647, 1714, 1780, 1844, 1919, 1997, 2051, 2138, 2198, 2267, 2324, 2391]}]}
Loading … Spinner
There are currently no alerts