Home-Based Aerobic Interval Training Improves Peak Oxygen Uptake Equal to Residential Cardiac Rehabilitation: A Randomized, Controlled Trial
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{"title"=>"Home-based aerobic interval training improves peak oxygen uptake equal to residential cardiac rehabilitation: A randomized, controlled trial", "type"=>"journal", "authors"=>[{"first_name"=>"Trine", "last_name"=>"Moholdt", "scopus_author_id"=>"23485745300"}, {"first_name"=>"Mona", "last_name"=>"Bekken Vold", "scopus_author_id"=>"55316926300"}, {"first_name"=>"Jostein", "last_name"=>"Grimsmo", "scopus_author_id"=>"35362033400"}, {"first_name"=>"Stig Arild", "last_name"=>"Slørdahl", "scopus_author_id"=>"7006793359"}, {"first_name"=>"Ulrik", "last_name"=>"Wisløff", "scopus_author_id"=>"55931365800"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84864010847", "scopus"=>"2-s2.0-84864010847", "doi"=>"10.1371/journal.pone.0041199", "isbn"=>"1932-6203", "pui"=>"365274700", "issn"=>"19326203", "pmid"=>"22815970"}, "id"=>"8bd0c603-29bd-3cd0-ac08-b2a316a88c0a", "abstract"=>"Aerobic capacity, measured as the peak oxygen uptake, is a strong predictor of survival in cardiac patients. Aerobic interval training (AIT), walking/running four times four minutes at 85-95% of peak heart rate, has proven to be effective in increasing peak oxygen uptake in coronary heart disease patients. As some patients do not attend organized rehabilitation programs, home-based exercise should be an alternative. We investigated whether AIT could be performed effectively at home, and compared the effects on peak oxygen uptake with that observed after a standard care, four-week residential rehabilitation. Thirty patients undergoing coronary artery bypass surgery were randomized to residential rehabilitation or home-based AIT. At six months follow-up, peak oxygen uptake increased 4.6 (±2.7) and 3.9 (±3.6) mL·kg(-1) min(-1) (both p<0.005, non-significant between-group difference) after residential rehabilitation and AIT, respectively. Quality of life increased significantly in both groups, with no statistical significant difference between groups. We found no evidence for a different treatment effect between patients randomized to home-based AIT compared to patients attending organized rehabilitation (95% confidence interval -1.8, 3.5). AIT patients reported good adherence to exercise training. Even though these first data indicate positive effects of home-based AIT in patients undergoing coronary artery bypass surgery, more studies are needed to provide supporting evidence for the application of this rehabilitation strategy. Trial registration: ClinicalTrials.gov NCT00363922.", "link"=>"http://www.mendeley.com/research/homebased-aerobic-interval-training-improves-peak-oxygen-uptake-equal-residential-cardiac-rehabilita-8", "reader_count"=>41, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>13, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>13, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>23, "Sports and Recreations"=>7, "Chemistry"=>1, "Psychology"=>2, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>23}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>7}, "Psychology"=>{"Psychology"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Netherlands"=>2, "Brazil"=>3, "United Kingdom"=>1, "Chile"=>1}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/607354"], "description"=>"<p>Data presented is mean value ± standard deviation if not otherwise stated.</p><p>There were no baseline differences between groups in age, gender, weeks after coronary artery bypass surgery at inclusion, body mass index, or initial peak oxygen uptake. More patients in the residential group were taking beta blockers at baseline.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>277848, "categories"=>["Medicine", "Biotechnology"], "users"=>["Trine Moholdt", "Mona Bekken Vold", "Jostein Grimsmo", "Stig Arild Slørdahl", "Ulrik Wisløff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041199.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_characteristics_at_baseline_/277848", "title"=>"Patient characteristics at baseline.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-18 02:10:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/607434"], "description"=>"<p>Number of patients. AIT  =  Aerobic interval training.</p>", "links"=>[], "tags"=>["discharge", "centre", "follow-up", "months", "patients", "home-based", "aerobic"], "article_id"=>277915, "categories"=>["Medicine", "Biotechnology"], "users"=>["Trine Moholdt", "Mona Bekken Vold", "Jostein Grimsmo", "Stig Arild Slørdahl", "Ulrik Wisløff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041199.t003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reported_exercise_training_between_discharge_from_the_rehabilitation_centre_and_follow_up_testing_at_6_months_for_patients_in_home_based_aerobic_interval_training_group_/277915", "title"=>"Reported exercise training between discharge from the rehabilitation centre and follow-up testing at 6 months for patients in home-based aerobic interval training group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-18 02:11:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/607293"], "description"=>"<p>Flow-chart of participants in the study.</p>", "links"=>[], "tags"=>["public health and epidemiology", "geriatrics", "respiratory medicine", "Non-clinical medicine"], "article_id"=>277780, "categories"=>["Medicine", "Biotechnology"], "users"=>["Trine Moholdt", "Mona Bekken Vold", "Jostein Grimsmo", "Stig Arild Slørdahl", "Ulrik Wisløff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041199.g001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_participants_in_the_study_/277780", "title"=>"Flow-chart of participants in the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-18 02:09:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/317355", "https://ndownloader.figshare.com/files/317420"], "description"=>"<div><p>Aerobic capacity, measured as the peak oxygen uptake, is a strong predictor of survival in cardiac patients. Aerobic interval training (AIT), walking/running four times four minutes at 85–95% of peak heart rate, has proven to be effective in increasing peak oxygen uptake in coronary heart disease patients. As some patients do not attend organized rehabilitation programs, home-based exercise should be an alternative. We investigated whether AIT could be performed effectively at home, and compared the effects on peak oxygen uptake with that observed after a standard care, four-week residential rehabilitation. Thirty patients undergoing coronary artery bypass surgery were randomized to residential rehabilitation or home-based AIT. At six months follow-up, peak oxygen uptake increased 4.6 (±2.7) and 3.9 (±3.6) mL·kg<sup>−1</sup> min<sup>−1</sup> (both p<0.005, non-significant between-group difference) after residential rehabilitation and AIT, respectively. Quality of life increased significantly in both groups, with no statistical significant difference between groups. We found no evidence for a different treatment effect between patients randomized to home-based AIT compared to patients attending organized rehabilitation (95% confidence interval −1.8, 3.5). AIT patients reported good adherence to exercise training. Even though these first data indicate positive effects of home-based AIT in patients undergoing coronary artery bypass surgery, more studies are needed to provide supporting evidence for the application of this rehabilitation strategy.</p> <h3>Trial Registration</h3><p>ClinicalTrials.gov <a href=\"http://clinicaltrials.gov/ct2/show/NCT00363922?term=NCT00363922\">NCT00363922</a></p> </div>", "links"=>[], "tags"=>["home-based", "aerobic", "improves", "uptake", "cardiac", "controlled"], "article_id"=>122650, "categories"=>["Medicine", "Biotechnology"], "users"=>["Trine Moholdt", "Mona Bekken Vold", "Jostein Grimsmo", "Stig Arild Slørdahl", "Ulrik Wisløff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041199.s001", "https://dx.doi.org/10.1371/journal.pone.0041199.s002"], "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Home_Based_Aerobic_Interval_Training_Improves_Peak_Oxygen_Uptake_Equal_to_Residential_Cardiac_Rehabilitation_A_Randomized_Controlled_Trial/122650", "title"=>"Home-Based Aerobic Interval Training Improves Peak Oxygen Uptake Equal to Residential Cardiac Rehabilitation: A Randomized, Controlled Trial", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-07-18 00:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/607396"], "description"=>"<p>For the residential group, results of exercise tests at 4 weeks are shown. Change scores are between baseline and six months follow-up. If not otherwise stated, values are average ± standard deviation. Quality of life and blood markers were not measured at 4 weeks.</p><p>EMM  =  Estimated Marginal Means, 95% CI = 95% Confidence Interval, VO<sub>2peak</sub>  =  Peak oxygen uptake, Perceived exertion is according to the 6–20 Borg scale, RER  =  respiratory exchange ratio, HRR, 1 min  =  heart rate recovery the first minute after ending an exercise test, HDL  =  high density lipoprotein cholesterol. HbA1c  =  glycated haemoglobin.</p>*<p>Significant change from baseline (within-group difference, <i>p</i><0.05).</p>†<p>Significantly different change from baseline (between-group difference p<0.05).</p>", "links"=>[], "tags"=>["variables", "baseline", "months", "follow-up", "patients", "completing"], "article_id"=>277887, "categories"=>["Medicine", "Biotechnology"], "users"=>["Trine Moholdt", "Mona Bekken Vold", "Jostein Grimsmo", "Stig Arild Slørdahl", "Ulrik Wisløff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041199.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Outcome_variables_at_baseline_and_six_months_follow_up_for_patients_completing_follow_up_testing_/277887", "title"=>"Outcome variables at baseline and six months follow-up for patients completing follow-up testing.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-18 02:11:27"}

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