Time to Pregnancy: A Computational Method for Using the Duration of Non-Conception for Predicting Conception
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{"title"=>"Time to Pregnancy: A Computational Method for Using the Duration of Non-Conception for Predicting Conception", "type"=>"journal", "authors"=>[{"first_name"=>"Peter D.", "last_name"=>"Sozou", "scopus_author_id"=>"56960916700"}, {"first_name"=>"Geraldine M.", "last_name"=>"Hartshorne", "scopus_author_id"=>"7004589921"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84867126571", "pui"=>"365784408", "doi"=>"10.1371/journal.pone.0046544", "pmid"=>"23056338", "scopus"=>"2-s2.0-84867126571", "issn"=>"19326203"}, "id"=>"ed22521f-7767-38b8-9811-95c0972167a8", "abstract"=>"An important problem in reproductive medicine is deciding when people who have failed to become pregnant without medical assistance should begin investigation and treatment. This study describes a computational approach to determining what can be deduced about a couple's future chances of pregnancy from the number of menstrual cycles over which they have been trying to conceive. The starting point is that a couple's fertility is inherently uncertain. This uncertainty is modelled as a probability distribution for the chance of conceiving in each menstrual cycle. We have developed a general numerical computational method, which uses Bayes' theorem to generate a posterior distribution for a couple's chance of conceiving in each cycle, conditional on the number of previous cycles of attempted conception. When various metrics of a couple's expected chances of pregnancy were computed as a function of the number of cycles over which they had been trying to conceive, we found good fits to observed data on time to pregnancy for different populations. The commonly-used standard of 12 cycles of non-conception as an indicator of subfertility was found to be reasonably robust, though a larger or smaller number of cycles may be more appropriate depending on the population from which a couple is drawn and the precise subfertility metric which is most relevant, for example the probability of conception in the next cycle or the next 12 cycles. We have also applied our computational method to model the impact of female reproductive ageing. Results indicate that, for women over the age of 35, it may be appropriate to start investigation and treatment more quickly than for younger women. Ignoring reproductive decline during the period of attempted conception added up to two cycles to the computed number of cycles before reaching a metric of subfertility.", "link"=>"http://www.mendeley.com/research/time-pregnancy-computational-method-using-duration-nonconception-predicting-conception", "reader_count"=>19, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Student > Doctoral Student"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Student > Doctoral Student"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>2, "Social Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Japan"=>1, "France"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/300728"], "description"=>"<div><p>An important problem in reproductive medicine is deciding when people who have failed to become pregnant without medical assistance should begin investigation and treatment. This study describes a computational approach to determining what can be deduced about a couple's future chances of pregnancy from the number of menstrual cycles over which they have been trying to conceive. The starting point is that a couple's fertility is inherently uncertain. This uncertainty is modelled as a probability distribution for the chance of conceiving in each menstrual cycle. We have developed a general numerical computational method, which uses Bayes' theorem to generate a posterior distribution for a couple's chance of conceiving in each cycle, conditional on the number of previous cycles of attempted conception. When various metrics of a couple's expected chances of pregnancy were computed as a function of the number of cycles over which they had been trying to conceive, we found good fits to observed data on time to pregnancy for different populations. The commonly-used standard of 12 cycles of non-conception as an indicator of subfertility was found to be reasonably robust, though a larger or smaller number of cycles may be more appropriate depending on the population from which a couple is drawn and the precise subfertility metric which is most relevant, for example the probability of conception in the next cycle or the next 12 cycles. We have also applied our computational method to model the impact of female reproductive ageing. Results indicate that, for women over the age of 35, it may be appropriate to start investigation and treatment more quickly than for younger women. Ignoring reproductive decline during the period of attempted conception added up to two cycles to the computed number of cycles before reaching a metric of subfertility.</p> </div>", "links"=>[], "tags"=>["computational", "duration", "non-conception", "predicting"], "article_id"=>119295, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Time_to_Pregnancy_A_Computational_Method_for_Using_the_Duration_of_Non_Conception_for_Predicting_Conception/119295", "title"=>"Time to Pregnancy: A Computational Method for Using the Duration of Non-Conception for Predicting Conception", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 02:34:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/564237"], "description"=>"<p>Plots showing the cumulative probability of conception P, i.e. the probability of conception within <i>n</i> cycles, for different values of the intrinsic conception rate <i>y</i>.</p>", "links"=>[], "tags"=>["cumulative", "probability", "intrinsic"], "article_id"=>234733, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plots_showing_the_cumulative_probability_of_conception_P_i_e_the_probability_of_conception_within_n_cycles_for_different_values_of_the_intrinsic_conception_rate_y_/234733", "title"=>"Plots showing the cumulative probability of conception P, i.e. the probability of conception within <i>n</i> cycles, for different values of the intrinsic conception rate <i>y</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-04 01:18:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/564296"], "description"=>"<p>In each panel the plot labelled I shows the initial (prior) distribution. The other plots show the distribution conditional on non-conception after 6, 12, 18 and 24 cycles. A thick line represents the finite proportion of the population with an intrinsic conception rate of zero. (This is intended as a schematic representation: the thickness of the line is not proportional to the proportion of couples who are sterile.) The total area underneath each curve corresponds to the proportion of the remaining population which is not sterile: this decreases with the number of cycles as the proportion of the remaining population who are sterile increases (see first column of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t002\" target=\"_blank\">tables 2</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t003\" target=\"_blank\">3</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t004\" target=\"_blank\">4</a>, and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t005\" target=\"_blank\">5</a>). For example 4, the part of the distribution representing the low fertility segment of the population (i.e. with an intrinsic conception rate below about 0.12) changes little as the number of cycles of non-conception increases from 12 to 24, while the proportion of the remaining population in the higher fertility segment (i.e. with an intrinsic conception rate above about 0.12) is very low after 18 cycles and negligible after 24 cycles.</p>", "links"=>[], "tags"=>["intrinsic", "examples"], "article_id"=>234790, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_the_intrinsic_conception_rate_for_examples_1_to_4_A_example_1_B_example_2_C_example_3_D_example_4_/234790", "title"=>"Distribution of the intrinsic conception rate for examples 1 to 4: (A) example 1, (B) example 2, (C) example 3, (D) example 4.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-04 01:19:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/564467"], "description"=>"<p>They are plotted as a function of the number of cycles of attempted conception.</p>", "links"=>[], "tags"=>["examples", "probability", "conceiving", "cumulative"], "article_id"=>234959, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_For_examples_1_to_4_this_shows_A_the_probability_of_conceiving_on_the_next_cycle_for_a_couple_who_have_not_yet_conceived_and_B_the_cumulative_conception_probability_/234959", "title"=>"For examples 1 to 4 this shows: (A) the probability of conceiving on the next cycle for a couple who have not yet conceived, and (B) the cumulative conception probability.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-04 01:22:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/564567"], "description"=>"<p>In each panel the plot labelled I shows the initial (prior) distribution. The other plots show the distribution conditional on non-conception after 6, 12, 18 and 24 cycles. A thick line represents the finite proportion of the population with an intrinsic conception rate of zero. The total area underneath each curve corresponds to the proportion of the remaining population which is not sterile.</p>", "links"=>[], "tags"=>["intrinsic", "ages"], "article_id"=>235063, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_the_intrinsic_conception_rate_at_4_different_female_ages_at_the_start_of_the_attempt_to_conceive_for_example_5_A_age_25_B_age_30_C_age_35_D_age_40_/235063", "title"=>"Distribution of the intrinsic conception rate at 4 different female ages at the start of the attempt to conceive, for example 5: (A) age 25, (B) age 30, (C) age 35, (D) age 40.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-04 01:24:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/564725"], "description"=>"<p>They are plotted as a function of the number of cycles of attempted conception.</p>", "links"=>[], "tags"=>["ages", "35", "probability", "conceiving", "cumulative"], "article_id"=>235216, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_For_example_5_this_shows_for_female_ages_at_the_start_of_the_attempt_to_conceive_of_25_30_35_and_40_A_the_probability_of_conceiving_on_the_next_cycle_for_a_couple_who_have_not_yet_conceived_and_B_the_cumulative_conception_probability_/235216", "title"=>"For example 5 this shows, for female ages at the start of the attempt to conceive, of 25, 30, 35 and 40: (A) the probability of conceiving on the next cycle for a couple who have not yet conceived, and (B) the cumulative conception probability.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-04 01:26:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/564825"], "description"=>"<p>Intrinsic conception rates corresponding to probability <i>P</i> of conceiving within 12 or 24 cycles.</p>", "links"=>[], "tags"=>["rates", "corresponding", "probability", "conceiving", "12", "24"], "article_id"=>235315, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intrinsic_conception_rates_corresponding_to_probability_P_of_conceiving_within_12_or_24_cycles_/235315", "title"=>"Intrinsic conception rates corresponding to probability <i>P</i> of conceiving within 12 or 24 cycles.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:28:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/564860"], "description"=>"<p>The model of how fertility declines with age for example 5 is described in the text, with details of the computational implementation given in the supporting information (text S1).</p>", "links"=>[], "tags"=>["computed", "cycles", "attempted", "indicators", "subfertility", "reproductive", "ageing", "switched"], "article_id"=>235350, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t012"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Change_in_the_computed_number_of_cycles_of_attempted_conception_required_for_various_indicators_of_subfertility_to_be_attained_as_a_result_of_reproductive_ageing_during_the_conception_process_being_switched_off_for_example_5_/235350", "title"=>"Change in the computed number of cycles of attempted conception required for various indicators of subfertility to be attained, as a result of reproductive ageing during the conception process being switched off, for example 5.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:29:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/564889"], "description"=>"<p>In example 2, 5% of couples are assumed to have a zero probability of conceiving. The remaining 95% are assumed to have intrinsic conception rates described by a beta distribution, with α = 1.8 and β = 4.2. This population is systematically less fertile than that in example 1.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235385, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_2_/235385", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 2.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:29:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/564918"], "description"=>"<p>In example 1: 5% of couples are assumed to be sterile (intrinsic conception rate = 0). The remaining 95% are assumed to have intrinsic conception rates described by a beta distribution with parameters α = 2.3 and β = 3.7.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235420, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_1_/235420", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 1.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:30:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/564956"], "description"=>"<p>In example 4, 5% of couples are assumed to have an intrinsic conception rate of zero; 85% have intrinsic conception rates drawn from a beta distribution with α = 11 and β = 22; and 10% have intrinsic conception rates drawn from a beta distribution with α = 4 and β = 76.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235456, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_4_/235456", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 4.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:30:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/564988"], "description"=>"<p>In example 3, 1% of couples are assumed to have an intrinsic conception rate of zero. The remaining 99.5% of the population are assumed to have intrinsic conception rates described by a beta distribution, with α = 11 and β = 22.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235484, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_3_/235484", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 3.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:31:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/565027"], "description"=>"<p>In example 5, couples are assumed to have peak intrinsic conception rates drawn from a beta distribution with α = 3 and β = 10; the distribution of female ages at which couples become sterile is as given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone.0046544-Leridon3\" target=\"_blank\">[24]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t002\" target=\"_blank\">Table 2</a>; a couple's intrinsic conception rate declines linearly for 12.5 years prior to sterility.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235523, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_5_at_a_female_age_of_25_/235523", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 5, at a female age of 25.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:32:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/565071"], "description"=>"<p>The characteristics of the populations for examples 1, 2, 3 and 4 are described in the legends of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t002\" target=\"_blank\">Tables 2</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t003\" target=\"_blank\">3</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t004\" target=\"_blank\">4</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t005\" target=\"_blank\">5</a>, and in the text.</p>", "links"=>[], "tags"=>["cycles", "attempted", "indicators", "subfertility", "examples"], "article_id"=>235560, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_cycles_of_attempted_conception_required_for_various_indicators_of_subfertility_to_be_attained_for_examples_1_2_3_and_4_/235560", "title"=>"Number of cycles of attempted conception required for various indicators of subfertility to be attained, for examples 1, 2, 3 and 4.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:32:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/565109"], "description"=>"<p>In example 5, couples are assumed to have peak intrinsic conception rates drawn from a beta distribution with α = 3 and β = 10; the distribution of female ages at which couples become sterile is as given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone.0046544-Leridon3\" target=\"_blank\">[24]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t002\" target=\"_blank\">Table 2</a>; a couple's intrinsic conception rate declines linearly for 12.5 years prior to sterility.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235601, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_5_at_a_female_age_of_35_/235601", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 5, at a female age of 35.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:33:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/565143"], "description"=>"<p>In example 5, couples are assumed to have peak intrinsic conception rates drawn from a beta distribution with α = 3 and β = 10; the distribution of female ages at which couples become sterile is as given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone.0046544-Leridon3\" target=\"_blank\">[24]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t002\" target=\"_blank\">Table 2</a>; a couple's intrinsic conception rate declines linearly for 12.5 years prior to sterility.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235640, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_5_at_a_female_age_of_30_/235640", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 5, at a female age of 30.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:34:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/231578", "https://ndownloader.figshare.com/files/565180"], "description"=>"<p>In example 5, couples are assumed to have peak intrinsic conception rates drawn from a beta distribution with α = 3 and β = 10; the distribution of female ages at which couples become sterile is as given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone.0046544-Leridon3\" target=\"_blank\">[24]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046544#pone-0046544-t002\" target=\"_blank\">Table 2</a>; a couple's intrinsic conception rate declines linearly for 12.5 years prior to sterility.</p>", "links"=>[], "tags"=>["metrics", "cycles", "attempted"], "article_id"=>235673, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/235673"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fertility_metrics_as_a_function_of_the_number_of_cycles_of_attempted_conception_for_example_5_at_a_female_age_of_40_/235673", "title"=>"Fertility metrics as a function of the number of cycles of attempted conception for example 5, at a female age of 40.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:34:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/565216"], "description"=>"<p>The model of how fertility declines with age for example 5 is described in the text, with details of the computational implementation given in the supporting information (text S1).</p>", "links"=>[], "tags"=>["cycles", "attempted", "ages", "indicators", "subfertility"], "article_id"=>235712, "categories"=>["Mathematics", "Medicine", "Biotechnology"], "users"=>["Peter D. Sozou", "Geraldine M. Hartshorne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0046544.t011"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_cycles_of_attempted_conception_required_at_different_ages_for_various_indicators_of_subfertility_to_be_attained_for_example_5_/235712", "title"=>"Number of cycles of attempted conception required at different ages for various indicators of subfertility to be attained, for example 5.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-04 01:35:12"}

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Relative Metric

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