Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography
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{"title"=>"Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography", "type"=>"journal", "authors"=>[{"first_name"=>"Linbo", "last_name"=>"Liu", "scopus_author_id"=>"55597087617"}, {"first_name"=>"Kengyeh K.", "last_name"=>"Chu", "scopus_author_id"=>"14015267100"}, {"first_name"=>"Grace H.", "last_name"=>"Houser", "scopus_author_id"=>"24402491000"}, {"first_name"=>"Bradford J.", "last_name"=>"Diephuis", "scopus_author_id"=>"42761085000"}, {"first_name"=>"Yao", "last_name"=>"Li", "scopus_author_id"=>"36519127700"}, {"first_name"=>"Eric J.", "last_name"=>"Wilsterman", "scopus_author_id"=>"55889486500"}, {"first_name"=>"Suresh", "last_name"=>"Shastry", "scopus_author_id"=>"7003614942"}, {"first_name"=>"Gregory", "last_name"=>"Dierksen", "scopus_author_id"=>"36622269000"}, {"first_name"=>"Susan E.", "last_name"=>"Birket", "scopus_author_id"=>"11439067100"}, {"first_name"=>"Marina", "last_name"=>"Mazur", "scopus_author_id"=>"7102655432"}, {"first_name"=>"Suzanne", "last_name"=>"Byan-Parker", "scopus_author_id"=>"55221866600"}, {"first_name"=>"William E.", "last_name"=>"Grizzle", "scopus_author_id"=>"7006493765"}, {"first_name"=>"Eric J.", "last_name"=>"Sorscher", "scopus_author_id"=>"7005699295"}, {"first_name"=>"Steven M.", "last_name"=>"Rowe", "scopus_author_id"=>"8385101500"}, {"first_name"=>"Guillermo J.", "last_name"=>"Tearney", "scopus_author_id"=>"7006907866"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0054473", "pui"=>"368176370", "pmid"=>"23372732", "scopus"=>"2-s2.0-84872780985", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84872780985", "issn"=>"19326203"}, "id"=>"a46975ee-60b9-3415-b846-55b343638d87", "abstract"=>"We demonstrate the use of a high resolution form of optical coherence tomography, termed micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia. μOCT captures several key parameters governing the function of the airway surface (airway surface liquid depth, periciliary liquid depth, ciliary function including beat frequency, and mucociliary transport rate) from the same series of images and without exogenous particles or labels, enabling non-invasive study of dynamic phenomena. Additionally, the high resolution of μOCT reveals distinguishable phases of the ciliary stroke pattern and glandular extrusion. Images and functional measurements from primary human bronchial epithelial cell cultures and excised tissue are presented and compared with measurements using existing gold standard methods. Active secretion from mucus glands in tissue, a key parameter of epithelial function, was also observed and quantified.", "link"=>"http://www.mendeley.com/research/method-quantitative-study-airway-functional-microanatomy-using-microoptical-coherence-tomography", "reader_count"=>72, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Student > Doctoral Student"=>6, "Researcher"=>18, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>3, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Student > Doctoral Student"=>6, "Researcher"=>18, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>3, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>5}, "reader_count_by_subject_area"=>{"Engineering"=>24, "Unspecified"=>2, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>15, "Arts and Humanities"=>1, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Physics and Astronomy"=>10, "Chemistry"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>24}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>10}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Republic of Singapore"=>1, "United States"=>3}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/503472"], "description"=>"<p>Number of samples <i>n</i> refers to separate measurements from a single tissue sample.</p>", "links"=>[], "tags"=>["parameters", "swine", "trachea"], "article_id"=>173978, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OCT_measured_parameters_from_swine_trachea_ex_vivo_/173978", "title"=>"μOCT measured parameters from swine trachea <i>ex vivo</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-23 01:06:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/502669"], "description"=>"<p>A. A time-averaged (2 s) μOCT image of fully differentiated primary human bronchial epithelial cells derived from a normal subject. From top to bottom, air, mucus layer (mu), PCL layer (pcl; red bar), cilia (green arrows), and epithelial monolayer (ep) are readily seen. ASL depth is defined as the distance between the air-mucus interface and the apical surface of the epithelium (ep). PCL depth is defined by the distance between the ventral surface of the mucus layer and the apical surface of the epithelium. B. H&E stained histology of HBE cells. Scale bar: 10 µm.</p>", "links"=>[], "tags"=>["hbe"], "article_id"=>173173, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_956_OCT_image_of_primary_HBE_culture_/173173", "title"=>"Representative μOCT image of primary HBE culture.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 00:52:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/502937"], "description"=>"<p>A. A time-averaged (1 s) μOCT image of human tracheal tissue shows epithelium (ep), lamina propria (lp), gland duct (gd), mucus (m), cilia (ci) and goblet cells (gc). Yellow bar indicates airway surface liquid (ASL) depth and Red bar indicates PCL depth. B. Orthogonal view at the position indicated by the dashed blue line shows the whole gland duct and the goblet cell in A. Ciliary beat pattern and possible goblet cell nucleus are clearly seen in the inset. Scale bars: 20 µm.</p>", "links"=>[], "tags"=>["anatomy"], "article_id"=>173443, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_956_OCT_functional_anatomy_of_human_trachea_/173443", "title"=>"μOCT functional anatomy of human trachea.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 00:57:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/503144"], "description"=>"<p>A. A representative frame from a μOCT video of trachea dissected from a swine shows mucus (yellow arrow) extrusion from a gland duct (gd) in lamina propria (lp). B. Three-dimensional reconstructed en face view allows estimation of luminal area of the duct. In swine trachea, mucus extrusion rate is 0.095 nL/min (N = 3, ±SEM = ±0.006) at room temperature.</p>", "links"=>[], "tags"=>["extrusion", "gland"], "article_id"=>173646, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g006", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mucus_extrusion_from_single_gland_duct_/173646", "title"=>"Mucus extrusion from single gland duct.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 01:00:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/503252"], "description"=>"<p>A. (Top panel) 6-stage schematic of ciliary motion during the recovery stroke; (bottom panel) a μOCT image of fully differentiated primary HBE cells derived from a normal subject shows cilia tips (green) 3–5 µm from the apical cell surface, indicating the recovery stroke. Cilia and mucus are presented in pseudo-colors: green and purple respectively. B. (top panel) 4-stage schematic of ciliary motion during the effective stroke; (bottom panel) μOCT signal of the same cilia after 250 ms that subtend an angle of 114°, delineating an arc with radius of approximately 7 µm during the effective stroke. C. (top panel) 10-stage schematic of ciliary motion during the full ciliary beat cycle; A time-averaged (4 s) image (bottom panel) shows an arc indicating the effective strokes (yellow arrows) and bilobular pattern of the recovery stroke (orange arrows). D. A time-averaged (1 s) image of normal swine trachea shows arcs indicating the effective strokes (yellow arrows) and bilobular pattern suggesting the recovery stroke (orange arrows) in the ciliary motion pattern. Scale bars: 10 µm.</p>", "links"=>[], "tags"=>["images", "ciliary", "hbe", "swine"], "article_id"=>173756, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g007", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_956_OCT_images_of_ciliary_motion_pattern_in_HBE_culture_and_swine_trachea_/173756", "title"=>"μOCT images of ciliary motion pattern in HBE culture and swine trachea.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 01:02:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/502803"], "description"=>"<p>A. μOCT image. Yellow bar indicates airway surface liquid (ASL) depth and Red bar indicates PCL depth. Epithelium (ep) and lamina propria (lp) are also visible. B. H&E stained histology image illustrating cilia (c), epithelium (ep) and lamina propria (lp). Scale bar of both images: 10 µm.</p>", "links"=>[], "tags"=>["anatomy", "excised", "swine"], "article_id"=>173305, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_anatomy_of_excised_swine_trachea_/173305", "title"=>"Functional anatomy of excised swine trachea.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 00:55:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/503362"], "description"=>"<p>Time-lapsed ciliary motion pattern can be easily identified in the M-mode image (top) of the active epithelial area shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054473#pone-0054473-g007\" target=\"_blank\">Figs. 7 A–C</a> and also <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054473#pone.0054473.s005\" target=\"_blank\">Movie S5</a>. The continuity of the sinusoidal pattern in the M-mode image indicates that the entire beat cycle was captured. Corresponding time-lapse intensity analysis (bottom) reveals triphasic pattern of the ciliary beat cycle: the recovery stroke (blue line), the effective stroke (orange line) and the rest phase in between the effective stroke and next effective stroke.</p>", "links"=>[], "tags"=>["cultured", "hbe"], "article_id"=>173866, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g008", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cilia_motion_pattern_in_cultured_HBE_cells_/173866", "title"=>"Cilia motion pattern in cultured HBE cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 01:04:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/477732", "https://ndownloader.figshare.com/files/477733", "https://ndownloader.figshare.com/files/477734", "https://ndownloader.figshare.com/files/477735", "https://ndownloader.figshare.com/files/477736"], "description"=>"<div><p>We demonstrate the use of a high resolution form of optical coherence tomography, termed micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia. μOCT captures several key parameters governing the function of the airway surface (airway surface liquid depth, periciliary liquid depth, ciliary function including beat frequency, and mucociliary transport rate) from the same series of images and without exogenous particles or labels, enabling non-invasive study of dynamic phenomena. Additionally, the high resolution of μOCT reveals distinguishable phases of the ciliary stroke pattern and glandular extrusion. Images and functional measurements from primary human bronchial epithelial cell cultures and excised tissue are presented and compared with measurements using existing gold standard methods. Active secretion from mucus glands in tissue, a key parameter of epithelial function, was also observed and quantified.</p> </div>", "links"=>[], "tags"=>["quantitative", "airway", "microanatomy", "micro-optical", "coherence", "tomography"], "article_id"=>154104, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0054473.s001", "https://dx.doi.org/10.1371/journal.pone.0054473.s002", "https://dx.doi.org/10.1371/journal.pone.0054473.s003", "https://dx.doi.org/10.1371/journal.pone.0054473.s004", "https://dx.doi.org/10.1371/journal.pone.0054473.s005"], "stats"=>{"downloads"=>6, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Method_for_Quantitative_Study_of_Airway_Functional_Microanatomy_Using_Micro_Optical_Coherence_Tomography__/154104", "title"=>"Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-23 01:08:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/502575"], "description"=>"<p>A. System diagram. RM: reference mirror. OL. objective lens. EC: environmental chamber. AO: analog output board. G: grating. IMAQ: image acquisition board. L: camera lens. LSC: line scan camera. SMF: single mode fiber. PC: personal computer. RAID: redundant array of independent disks. CL: Camera Link cable. B. Depth profile of mirror surface, indicating axial full-width half maximum of 1.3 µm.</p>", "links"=>[], "tags"=>["instrumentation", "schematic", "axial"], "article_id"=>173078, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_956_OCT_instrumentation_schematic_and_axial_resolution_/173078", "title"=>"μOCT instrumentation schematic and axial resolution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 00:51:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/503049"], "description"=>"<p>All error bars represent SEM. A. ASL depth measured with μOCT (7.40±1.82 µm, n = 5) and confocal microscopy (7.76±0.87 µm, n = 6). B. CBF measured with μOCT (9.32±0.27 Hz, n = 4) and Hoffman contrast microscopy (10.17±0.56 Hz, n = 4). C. MCT velocity measured with μOCT (24.22±14.88 µm/sec, n = 6) and particle-tracking fluorescence microscopy (1.91±0.62 µm/sec, n = 11). Number of measurements n refers to separate wells analyzed.</p>", "links"=>[], "tags"=>["hbe"], "article_id"=>173554, "categories"=>["Medicine", "Biophysics", "Physiology", "Biotechnology", "Cell Biology"], "users"=>["Linbo Liu", "Kengyeh K. Chu", "Grace H. Houser", "Bradford J. Diephuis", "Yao Li", "Eric J. Wilsterman", "Suresh Shastry", "Gregory Dierksen", "Susan E. Birket", "Marina Mazur", "Suzanne Byan-Parker", "William E. Grizzle", "Eric J. Sorscher", "Steven M. Rowe", "Guillermo J. Tearney"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054473.g005", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_956_OCT_and_gold_standard_measurements_in_HBE_cells_/173554", "title"=>"Comparison of μOCT and gold standard measurements in HBE cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-23 00:59:14"}

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Relative Metric

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