Identification of Unique Gene Expression Profile in Children with Regressive Autism Spectrum Disorder (ASD) and Ileocolitis
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{"title"=>"Identification of Unique Gene Expression Profile in Children with Regressive Autism Spectrum Disorder (ASD) and Ileocolitis", "type"=>"journal", "authors"=>[{"first_name"=>"Stephen J.", "last_name"=>"Walker", "scopus_author_id"=>"7403745200"}, {"first_name"=>"John", "last_name"=>"Fortunato", "scopus_author_id"=>"36100891600"}, {"first_name"=>"Lenny G.", "last_name"=>"Gonzalez", "scopus_author_id"=>"36598154600"}, {"first_name"=>"Arthur", "last_name"=>"Krigsman", "scopus_author_id"=>"55245886600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368490083", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0058058", "sgr"=>"84874767708", "scopus"=>"2-s2.0-84874767708", "pmid"=>"23520485"}, "id"=>"0ad94bd9-b2df-3de6-83e1-db5ddaf48690", "abstract"=>"Gastrointestinal symptoms are common in children with autism spectrum disorder (ASD) and are often associated with mucosal inflammatory infiltrates of the small and large intestine. Although distinct histologic and immunohistochemical properties of this inflammatory infiltrate have been previously described in this ASD(GI) group, molecular characterization of these lesions has not been reported. In this study we utilize transcriptome profiling of gastrointestinal mucosal biopsy tissue from ASD(GI) children and three non-ASD control groups (Crohn's disease, ulcerative colitis, and histologically normal) in an effort to determine if there is a gene expression profile unique to the ASD(GI) group. Comparison of differentially expressed transcripts between the groups demonstrated that non-pathologic (normal) tissue segregated almost completely from inflamed tissue in all cases. Gene expression profiles in intestinal biopsy tissue from patients with Crohn's disease, ulcerative colitis, and ASD(GI), while having significant overlap with each other, also showed distinctive features for each group. Taken together, these results demonstrate that ASD(GI) children have a gastrointestinal mucosal molecular profile that overlaps significantly with known inflammatory bowel disease (IBD), yet has distinctive features that further supports the presence of an ASD-associated IBD variant, or, alternatively, a prodromal phase of typical inflammatory bowel disease. Although we report qPCR confirmation of representative differentially expressed transcripts determined initially by microarray, these findings may be considered preliminary to the extent that they require further confirmation in a validation cohort.", "link"=>"http://www.mendeley.com/research/identification-unique-gene-expression-profile-children-regressive-autism-spectrum-disorder-asd-ileoc-1", "reader_count"=>38, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>6, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>6, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>16, "Agricultural and Biological Sciences"=>8, "Neuroscience"=>1, "Psychology"=>4, "Computer Science"=>2, "Immunology and Microbiology"=>1, "Nursing and Health Professions"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Panama"=>1, "Brazil"=>1, "France"=>1}, "group_count"=>2}

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  • {"files"=>["https://ndownloader.figshare.com/files/982967", "https://ndownloader.figshare.com/files/982968", "https://ndownloader.figshare.com/files/982969", "https://ndownloader.figshare.com/files/982970"], "description"=>"<div><p>Gastrointestinal symptoms are common in children with autism spectrum disorder (ASD) and are often associated with mucosal inflammatory infiltrates of the small and large intestine. Although distinct histologic and immunohistochemical properties of this inflammatory infiltrate have been previously described in this ASD<sup>GI</sup> group, molecular characterization of these lesions has not been reported. In this study we utilize transcriptome profiling of gastrointestinal mucosal biopsy tissue from ASD<sup>GI</sup> children and three non-ASD control groups (Crohn's disease, ulcerative colitis, and histologically normal) in an effort to determine if there is a gene expression profile unique to the ASD<sup>GI</sup> group. Comparison of differentially expressed transcripts between the groups demonstrated that non-pathologic (normal) tissue segregated almost completely from inflamed tissue in all cases. Gene expression profiles in intestinal biopsy tissue from patients with Crohn's disease, ulcerative colitis, and ASD<sup>GI</sup>, while having significant overlap with each other, also showed distinctive features for each group. Taken together, these results demonstrate that ASD<sup>GI</sup> children have a gastrointestinal mucosal molecular profile that overlaps significantly with known inflammatory bowel disease (IBD), yet has distinctive features that further supports the presence of an ASD-associated IBD variant, or, alternatively, a prodromal phase of typical inflammatory bowel disease. Although we report qPCR confirmation of representative differentially expressed transcripts determined initially by microarray, these findings may be considered preliminary to the extent that they require further confirmation in a validation cohort.</p> </div>", "links"=>[], "tags"=>["children", "regressive", "autism", "ileocolitis"], "article_id"=>648962, "categories"=>["Chemistry", "Genetics", "Medicine", "Neuroscience"], "users"=>["Stephen J. Walker", "John Fortunato", "Lenny G. Gonzalez", "Arthur Krigsman"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0058058.s001", "https://dx.doi.org/10.1371/journal.pone.0058058.s002", "https://dx.doi.org/10.1371/journal.pone.0058058.s003", "https://dx.doi.org/10.1371/journal.pone.0058058.s004"], "stats"=>{"downloads"=>4, "page_views"=>82, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Identification_of_Unique_Gene_Expression_Profile_in_Children_with_Regressive_Autism_Spectrum_Disorder_ASD_and_Ileocolitis__/648962", "title"=>"Identification of Unique Gene Expression Profile in Children with Regressive Autism Spectrum Disorder (ASD) and Ileocolitis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-09 12:47:39"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1006674"], "description"=>"<p>Characteristics of Study Population.</p>", "links"=>[], "tags"=>["genetics and genomics", "pediatrics and child health", "Gastroenterology and hepatology", "neurological disorders"], "article_id"=>667301, "categories"=>["Chemistry", "Genetics", "Medicine", "Neuroscience"], "users"=>["Stephen J. Walker", "John Fortunato", "Lenny G. Gonzalez", "Arthur Krigsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058058.t001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_Study_Population_/667301", "title"=>"Characteristics of Study Population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-08 02:01:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/982954"], "description"=>"<p>Each circle represents the cumulative gene expression profile for an individual sample. Samples with similar profiles cluster together in the three-dimensional space.</p>", "links"=>[], "tags"=>["scatterplot", "53", "microarray", "datasets", "terminal", "ileum"], "article_id"=>648950, "categories"=>["Chemistry", "Genetics", "Medicine", "Neuroscience"], "users"=>["Stephen J. Walker", "John Fortunato", "Lenny G. Gonzalez", "Arthur Krigsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058058.g001", "stats"=>{"downloads"=>7, "page_views"=>300, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_Component_Analysis_PCA_scatterplot_representing_53_individual_microarray_datasets_from_terminal_ileum_tissues_/648950", "title"=>"Principal Component Analysis (PCA) scatterplot representing 53 individual microarray datasets from terminal ileum tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 12:45:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/982964"], "description"=>"<p>Pair-wise comparisons were performed between each of the disease groups (ASD<sup>GI</sup>, CD and UC) and the control (non-histopathologic tissue) samples. <b>A.</b> There were 1409 unique DETs (differentially-expressed transcripts) in the ASD<sup>GI</sup> versus control comparison in TI mucosa. <b>B</b>. There were 1189 unique DETs in the ASD<sup>GI</sup> versus control comparison in colonic mucosa. <b>C.</b> The overlap between those two lists is displayed in this Venn diagram. There are a total of 178 DETs shared in ASD<sup>GI</sup> tissues (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058058#pone.0058058.s004\" target=\"_blank\">Table <b>S4</b></a>). This list of 178 DETs was imported into Ingenuity Pathway Analysis software for further analysis.</p>", "links"=>[], "tags"=>["ti"], "article_id"=>648959, "categories"=>["Chemistry", "Genetics", "Medicine", "Neuroscience"], "users"=>["Stephen J. Walker", "John Fortunato", "Lenny G. Gonzalez", "Arthur Krigsman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0058058.g004", "stats"=>{"downloads"=>1, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overlapping_unique_ASD_GI_gene_expression_from_TI_and_colon_/648959", "title"=>"Overlapping unique ASD<sup>GI</sup> gene expression from TI and colon.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-09 12:47:14"}

PMC Usage Stats | Further Information

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Relative Metric

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