MicroRNA Profiling of Primary Cutaneous Large B-Cell Lymphomas
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"MicroRNA profiling of primary cutaneous large B-cell lymphomas", "type"=>"journal", "authors"=>[{"first_name"=>"Lianne", "last_name"=>"Koens", "scopus_author_id"=>"35220324500"}, {"first_name"=>"Yongjun", "last_name"=>"Qin", "scopus_author_id"=>"24576993200"}, {"first_name"=>"Wai Y.", "last_name"=>"Leung", "scopus_author_id"=>"56002215000"}, {"first_name"=>"Willem E.", "last_name"=>"Corver", "scopus_author_id"=>"6603933852"}, {"first_name"=>"Patty M.", "last_name"=>"Jansen", "scopus_author_id"=>"55648565800"}, {"first_name"=>"Rein", "last_name"=>"Willemze", "scopus_author_id"=>"7101785262"}, {"first_name"=>"Maarten H.", "last_name"=>"Vermeer", "scopus_author_id"=>"7005437498"}, {"first_name"=>"Cornelis P.", "last_name"=>"Tensen", "scopus_author_id"=>"35502616300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84892693761", "pmid"=>"24358187", "issn"=>"19326203", "sgr"=>"84892693761", "doi"=>"10.1371/journal.pone.0082471", "pui"=>"372169949"}, "id"=>"1c1a8a1a-b6a4-3b6b-9eca-2d092177df6c", "abstract"=>"Aberrant expression of microRNAs is widely accepted to be pathogenetically involved in nodal diffuse large B-cell lymphomas (DLBCLs). However, the microRNAs profiles of primary cutaneous large B-cell lymphomas (PCLBCLs) are not yet described. Its two main subtypes, i.e., primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT) and primary cutaneous follicle center lymphoma (PCFCL) are characterized by an activated B-cell (ABC)-genotype and a germinal center B-cell (GCB)-genotype, respectively. We performed high-throughput sequencing analysis on frozen tumor biopsies from 19 cases of PCFCL and PCLBCL-LT to establish microRNA profiles. Cluster analysis of the complete microRNome could not distinguish between the two subtypes, but 16 single microRNAs were found to be differentially expressed. Single microRNA RT-qPCR was conducted on formalin-fixed paraffin-embedded tumor biopsies of 20 additional cases, confirming higher expression of miR-9-5p, miR-31-5p, miR-129-2-3p and miR-214-3p in PCFCL as compared to PCLBCL-LT. MicroRNAs previously described to be higher expressed in ABC-type as compared to GCB-type nodal DLBCL were not differentially expressed between PCFCL and PCLBCL-LT. In conclusion, PCFCL and PCLBCL-LT differ in their microRNA profiles. In contrast to their gene expression profile, they only show slight resemblance with the microRNA profiles found in GCB- and ABC-type nodal DLBCL.", "link"=>"http://www.mendeley.com/research/microrna-profiling-primary-cutaneous-large-bcell-lymphomas-2", "reader_count"=>19, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>4, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>4, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>7}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84892693761"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84892693761?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892693761&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84892693761&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84892693761", "dc:identifier"=>"SCOPUS_ID:84892693761", "eid"=>"2-s2.0-84892693761", "dc:title"=>"MicroRNA profiling of primary cutaneous large B-cell lymphomas", "dc:creator"=>"Koens L.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-12-16", "prism:coverDisplayDate"=>"16 December 2013", "prism:doi"=>"10.1371/journal.pone.0082471", "citedby-count"=>"8", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Leiden University Medical Center - LUMC", "affiliation-city"=>"Leiden", "affiliation-country"=>"Netherlands"}], "pubmed-id"=>"24358187", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e82471", "source-id"=>"10600153309"}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0082471", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"31", "xml_views"=>"4", "html_views"=>"129"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1316703"], "description"=>"<p>The expression of the 4 microRNAs that are repeatedly reported in previous studies to be more abundantly expressed in ABC-type than GCB-type nodal DLBCL are represented in dot plots. ΔΔCq was calculated with miR-148b-3p, let-7e-5p and miR-25-3p as stably expressed reference microRNAs. *P-value < 0.05; ** P-value  =  0.05 (Mann Whitney U test).</p>", "links"=>[], "tags"=>["ffpe", "samples"], "article_id"=>879168, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.g004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RT_qPCR_expression_in_FFPE_samples_2_/879168", "title"=>"RT-qPCR expression in FFPE samples (2).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316701"], "description"=>"<p>PCFCL and PCLBCL-LT tend to cluster together in two subgroups, with only 2 cases of PCLBCL-LT clustering together with the PCFCL cases.</p>", "links"=>[], "tags"=>["hierarchical", "clustering", "pclbcl", "samples", "high-throughput", "16", "differentially"], "article_id"=>879166, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Unsupervised_hierarchical_clustering_analysis_in_PCLBCL_samples_of_high_throughput_sequencing_using_16_differentially_expressed_microRNAs_/879166", "title"=>"Unsupervised hierarchical clustering analysis in PCLBCL samples of high-throughput sequencing, using 16 differentially expressed microRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316716", "https://ndownloader.figshare.com/files/1316717", "https://ndownloader.figshare.com/files/1316718", "https://ndownloader.figshare.com/files/1316719", "https://ndownloader.figshare.com/files/1316720"], "description"=>"<div><p>Aberrant expression of microRNAs is widely accepted to be pathogenetically involved in nodal diffuse large B-cell lymphomas (DLBCLs). However, the microRNAs profiles of primary cutaneous large B-cell lymphomas (PCLBCLs) are not yet described. Its two main subtypes, i.e., primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT) and primary cutaneous follicle center lymphoma (PCFCL) are characterized by an activated B-cell (ABC)-genotype and a germinal center B-cell (GCB)-genotype, respectively. We performed high-throughput sequencing analysis on frozen tumor biopsies from 19 cases of PCFCL and PCLBCL-LT to establish microRNA profiles. Cluster analysis of the complete microRNome could not distinguish between the two subtypes, but 16 single microRNAs were found to be differentially expressed. Single microRNA RT-qPCR was conducted on formalin-fixed paraffin-embedded tumor biopsies of 20 additional cases, confirming higher expression of miR-9-5p, miR-31-5p, miR-129-2-3p and miR-214-3p in PCFCL as compared to PCLBCL-LT. MicroRNAs previously described to be higher expressed in ABC-type as compared to GCB-type nodal DLBCL were not differentially expressed between PCFCL and PCLBCL-LT. In conclusion, PCFCL and PCLBCL-LT differ in their microRNA profiles. In contrast to their gene expression profile, they only show slight resemblance with the microRNA profiles found in GCB- and ABC-type nodal DLBCL.</p></div>", "links"=>[], "tags"=>["profiling", "cutaneous", "B-cell"], "article_id"=>879174, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0082471.s001", "https://dx.doi.org/10.1371/journal.pone.0082471.s002", "https://dx.doi.org/10.1371/journal.pone.0082471.s003", "https://dx.doi.org/10.1371/journal.pone.0082471.s004", "https://dx.doi.org/10.1371/journal.pone.0082471.s005"], "stats"=>{"downloads"=>22, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MicroRNA_Profiling_of_Primary_Cutaneous_Large_B_Cell_Lymphomas_/879174", "title"=>"MicroRNA Profiling of Primary Cutaneous Large B-Cell Lymphomas", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316706"], "description"=>"<p><i>NA</i>: not assessed; RT: radio-therapy; PCT: polychemotherapy; A<sup>+</sup>: alive with disease; A<sup>0</sup>: alive without disease; D<sup>+</sup>: death with disease; D<sup>0</sup>: death without disease; <sup>a</sup> heavy chains not assessed.<sup></sup> BCR: B-cell receptor; PFS: progression-free survival; HTS: high-throughput sequencing; RT-PCR: Real Time polymerase chain reaction; </p>", "links"=>[], "tags"=>[], "article_id"=>879171, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_characteristics_/879171", "title"=>"Patient characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316705"], "description"=>"a<p>higher expression in subgroup of PCLBCL.</p><p>PCFCL: primary cutaneous follicle center lymphoma; PCLBCL-LT: primary cutaneous diffuse large B-cell lymphoma, leg type.</p>", "links"=>[], "tags"=>["rt-qpcr"], "article_id"=>879170, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.t003", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MicroRNAs_in_RT_qPCR_validation_predicted_targets_/879170", "title"=>"MicroRNAs in RT-qPCR validation: predicted targets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316700"], "description"=>"<p>From left to right the mean of the top microRNAs expressed in PCLBCL-LT are listed and compared to the other subgroups.</p>", "links"=>[], "tags"=>["abundantly"], "article_id"=>879165, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Most_abundantly_expressed_microRNAs_/879165", "title"=>"Most abundantly expressed microRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316704"], "description"=>"<p><i>p</i>-values Benjamini-Hochberg corrected.<sup>a</sup></p>b<p>microRNA included in RT-qPCR validation.</p><p>PCFCL: primary cutaneous follicle center lymphoma, PCLBCL-LT: primary cutaneous large B-cell lymphoma, leg type.</p>", "links"=>[], "tags"=>["differential", "micrornas", "pcfcl"], "article_id"=>879169, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_High_throughput_sequencing_differential_expression_of_microRNAs_between_PCFCL_and_PCLBCL_LT_/879169", "title"=>"High-throughput sequencing: differential expression of microRNAs between PCFCL and PCLBCL-LT.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-16 03:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/1316702"], "description"=>"<p>The expression of the 4 microRNAs showing statistically significantly higher expression in PCFCL as compared to PCLBCL-LT are represented in dot plots. ΔΔCq was calculated with miR-148b-3p, let-7e-5p and miR-25-3p as stably expressed reference microRNAs. *P-value < 0.05 (Mann Whitney U test).</p>", "links"=>[], "tags"=>["ffpe", "samples"], "article_id"=>879167, "categories"=>["Biological Sciences"], "users"=>["Lianne Koens", "Yongjun Qin", "Wai Y. Leung", "Willem E. Corver", "Patty M. Jansen", "Rein Willemze", "Maarten H. Vermeer", "Cornelis P. Tensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0082471.g003", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RT_qPCR_expression_in_FFPE_samples_1_/879167", "title"=>"RT-qPCR expression in FFPE samples (1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-16 03:37:24"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"34", "full-text"=>"42", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"51", "full-text"=>"45", "pdf"=>"20", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"29", "pdf"=>"17", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"20", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"23", "full-text"=>"18", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"22", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"28", "full-text"=>"22", "pdf"=>"12", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"37", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}]}
Loading … Spinner
There are currently no alerts