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{"title"=>"Micronutrients in HIV: A bayesian meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"George M.", "last_name"=>"Carter", "scopus_author_id"=>"7402525156"}, {"first_name"=>"Debbie", "last_name"=>"Indyk", "scopus_author_id"=>"6506722673"}, {"first_name"=>"Matthew", "last_name"=>"Johnson", "scopus_author_id"=>"56134845600"}, {"first_name"=>"Michael", "last_name"=>"Andreae", "scopus_author_id"=>"14324265100"}, {"first_name"=>"Kathryn", "last_name"=>"Suslov", "scopus_author_id"=>"55175279600"}, {"first_name"=>"Sudharani", "last_name"=>"Busani", "scopus_author_id"=>"56533921600"}, {"first_name"=>"Aryan", "last_name"=>"Esmaeili", "scopus_author_id"=>"56583833000"}, {"first_name"=>"Henry S.", "last_name"=>"Sacks", "scopus_author_id"=>"35399574100"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84926442506", "scopus"=>"2-s2.0-84926442506", "doi"=>"10.1371/journal.pone.0120113", "isbn"=>"1932-6203", "pui"=>"603600301", "issn"=>"19326203", "pmid"=>"25830916"}, "id"=>"836b14ba-cd40-32fa-97b4-d0d9ffca0f24", "abstract"=>"BACKGROUND: Approximately 28.5 million people living with HIV are eligible for treatment (CD4<500), but currently have no access to antiretroviral therapy. Reduced serum level of micronutrients is common in HIV disease. Micronutrient supplementation (MNS) may mitigate disease progression and mortality.\\n\\nOBJECTIVES: We synthesized evidence on the effect of micronutrient supplementation on mortality and rate of disease progression in HIV disease.\\n\\nMETHODS: We searched MEDLINE, EMBASE, the Cochrane Central, AMED and CINAHL databases through December 2014, without language restriction, for studies of greater than 3 micronutrients versus any or no comparator. We built a hierarchical Bayesian random effects model to synthesize results. Inferences are based on the posterior distribution of the population effects; posterior distributions were approximated by Markov chain Monte Carlo in OpenBugs.\\n\\nPRINCIPAL FINDINGS: From 2166 initial references, we selected 49 studies for full review and identified eight reporting on disease progression and/or mortality. Bayesian synthesis of data from 2,249 adults in three studies estimated the relative risk of disease progression in subjects on MNS vs. control as 0.62 (95% credible interval, 0.37, 0.96). Median number needed to treat is 8.4 (4.8, 29.9) and the Bayes Factor 53.4. Based on data reporting on 4,095 adults reporting mortality in 7 randomized controlled studies, the RR was 0.84 (0.38, 1.85), NNT is 25 (4.3, ∞).\\n\\nCONCLUSIONS: MNS significantly and substantially slows disease progression in HIV+ adults not on ARV, and possibly reduces mortality. Micronutrient supplements are effective in reducing progression with a posterior probability of 97.9%. Considering MNS low cost and lack of adverse effects, MNS should be standard of care for HIV+ adults not yet on ARV.", "link"=>"http://www.mendeley.com/research/micronutrients-hiv-bayesian-metaanalysis", "reader_count"=>23, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>5, "Chemistry"=>1, "Social Sciences"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>2, "Brazil"=>1, "United Kingdom"=>1}, "group_count"=>7}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2001224", "https://ndownloader.figshare.com/files/2001225", "https://ndownloader.figshare.com/files/2001226", "https://ndownloader.figshare.com/files/2001227", "https://ndownloader.figshare.com/files/2001228", "https://ndownloader.figshare.com/files/2001229"], "description"=>"<div><p>Background</p><p>Approximately 28.5 million people living with HIV are eligible for treatment (CD4<500), but currently have no access to antiretroviral therapy. Reduced serum level of micronutrients is common in HIV disease. Micronutrient supplementation (MNS) may mitigate disease progression and mortality.</p><p>Objectives</p><p>We synthesized evidence on the effect of micronutrient supplementation on mortality and rate of disease progression in HIV disease.</p><p>Methods</p><p>We searched MEDLINE, EMBASE, the Cochrane Central, AMED and CINAHL databases through December 2014, without language restriction, for studies of greater than 3 micronutrients versus any or no comparator. We built a hierarchical Bayesian random effects model to synthesize results. Inferences are based on the posterior distribution of the population effects; posterior distributions were approximated by Markov chain Monte Carlo in OpenBugs.</p><p>Principal Findings</p><p>From 2166 initial references, we selected 49 studies for full review and identified eight reporting on disease progression and/or mortality. Bayesian synthesis of data from 2,249 adults in three studies estimated the relative risk of disease progression in subjects on MNS vs. control as 0.62 (95% credible interval, 0.37, 0.96). Median number needed to treat is 8.4 (4.8, 29.9) and the Bayes Factor 53.4. Based on data reporting on 4,095 adults reporting mortality in 7 randomized controlled studies, the RR was 0.84 (0.38, 1.85), NNT is 25 (4.3, ∞).</p><p>Conclusions</p><p>MNS significantly and substantially slows disease progression in HIV+ adults not on ARV, and possibly reduces mortality. Micronutrient supplements are effective in reducing progression with a posterior probability of 97.9%. Considering MNS low cost and lack of adverse effects, MNS should be standard of care for HIV+ adults not yet on ARV.</p></div>", "links"=>[], "tags"=>["rr", "nnt", "mortality", "medline", "OpenBugs.Principal FindingsFrom 2166", "embase", "mns", "Bayes Factor 53.4.", "Reduced serum level", "micronutrient", "CINAHL", "AMED", "Markov chain Monte Carlo", "hiv", "bayesian", "arv", "disease progression"], "article_id"=>1364100, "categories"=>["Biological Sciences"], "users"=>["George M. Carter", "Debbie Indyk", "Matthew Johnson", "Michael Andreae", "Kathryn Suslov", "Sudharani Busani", "Aryan Esmaeili", "Henry S. Sacks"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0120113.s001", "https://dx.doi.org/10.1371/journal.pone.0120113.s002", "https://dx.doi.org/10.1371/journal.pone.0120113.s003", "https://dx.doi.org/10.1371/journal.pone.0120113.s004", "https://dx.doi.org/10.1371/journal.pone.0120113.s005", "https://dx.doi.org/10.1371/journal.pone.0120113.s006"], "stats"=>{"downloads"=>4, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Micronutrients_in_HIV_A_Bayesian_Meta_Analysis_/1364100", "title"=>"Micronutrients in HIV: A Bayesian Meta-Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-01 03:01:30"}
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  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"37", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2017", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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