A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK
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{"title"=>"A naturally occurring bovine tauopathy is geographically widespread in the UK", "type"=>"journal", "authors"=>[{"first_name"=>"Martin", "last_name"=>"Jeffrey", "scopus_author_id"=>"26643251800"}, {"first_name"=>"Pedro", "last_name"=>"Piccardo", "scopus_author_id"=>"7004382184"}, {"first_name"=>"Diane L.", "last_name"=>"Ritchie", "scopus_author_id"=>"7201711082"}, {"first_name"=>"James W.", "last_name"=>"Ironside", "scopus_author_id"=>"56597627200"}, {"first_name"=>"Alison J.E.", "last_name"=>"Green", "scopus_author_id"=>"7404025048"}, {"first_name"=>"Gillian", "last_name"=>"McGovern", "scopus_author_id"=>"6602822908"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84939223582", "doi"=>"10.1371/journal.pone.0129499", "pmid"=>"26091261", "pui"=>"605586092", "issn"=>"19326203", "scopus"=>"2-s2.0-84939223582"}, "id"=>"383b6ba0-8a24-3713-b1ee-ee6e92f7001a", "abstract"=>"Many human neurodegenerative diseases are associated with hyperphosphorylation and widespread intra-neuronal and glial associated aggregation of the microtubule associated protein tau. In contrast, animal tauopathies are not reported with only senescent animals showing inconspicuous tau labelling of fine processes albeit significant tau aggregation may occur in some experimental animal disease. Since 1986, an idiopathic neurological condition of adult cattle has been recognised in the UK as a sub-set of cattle slaughtered as suspect bovine spongiform encephalopathy cases. This disorder is characterised by brainstem neuronal chromatolysis and degeneration with variable hippocampal sclerosis and spongiform change. Selected cases of idiopathic brainstem neuronal chromatolysis (IBNC) were identified from archive material and characterised using antibodies specific to several tau hyperphosphorylation sites or different isoforms of the tau microtubule binding region. Labelling was also carried out for alpha synuclein, ubiquitin, TDP43, Aβ 1-42, Aβ 1-40. Widespread tau labelling was identified in all IBNC brains examined and with each of seven tau antibodies recognising different hyperphosphorylated sites. Labelling with each antibody was associated with dendrites, neuronal perikarya and glia. Thus IBNC is a sporadic, progressive neurological disease predominantly affecting aged cattle that occurs throughout the UK and is associated with hyperphosphorylation of tau, a rare example of a naturally-occurring tauopathy in a non-primate species. Secondary accumulation of alpha synuclein and ubiquitin was also present. The neuropathology does not precisely correspond with any human tauopathy. The cause of IBNC remains undetermined but environmental factors and exposure to agrochemicals needs to be considered in future aetiological investigations.", "link"=>"http://www.mendeley.com/research/naturally-occurring-bovine-tauopathy-geographically-widespread-uk", "reader_count"=>6, "reader_count_by_academic_status"=>{"Researcher"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Researcher"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Italy"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2126795"], "description"=>"<p>(a) Parallel punctuate labelling along dendrites (arrows) and around the perikarya of two neurons in the hypoglossal nucleus. (b) Punctuate neuronal perikaryonal land dendritic labelling in the thalamus. Note vacuolation of some affected neurons. (c) No ubiquitin labelling of neurons or neuropil in the thalamus of a control cow brain. Bars: a = 20μm; b = 100μm; c = 50 μm.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454882, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ubiquitin_immunohistochemistry_/1454882", "title"=>"Ubiquitin immunohistochemistry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126797"], "description"=>"<p>Western blot analysis of tau isoforms within the thalamus (Th), cerebellum (Cb) and hippocampus (H) from a single case of IBNC. Tau isoforms in the brains of animals in which no P-tau was detected (control A and control B) following immunohistochemistry are shown on the blot for comparison.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454884, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.g006", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_Blot_for_tau_on_IBNC_brains_and_controls_/1454884", "title"=>"Western Blot for tau on IBNC brains and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126799"], "description"=>"<p>* data from Defra website</p><p>** data from personal hand–written notes</p><p>*** peak of the UK BSE epidemic</p><p>NA data not available.</p><p>Table showing annual frequency of IBNC cases relative to negative subset and confirmed cases of BSE in Scotland.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454886, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.t001", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Table_showing_annual_frequency_of_IBNC_cases_relative_to_negative_subset_and_confirmed_cases_of_BSE_in_Scotland_/1454886", "title"=>"Table showing annual frequency of IBNC cases relative to negative subset and confirmed cases of BSE in Scotland.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126800"], "description"=>"<p>*variable Western blot immune-phenotypes are reported in Argyrophilic grain disease [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129499#pone.0129499.ref028\" target=\"_blank\">28</a>].</p><p>Table showing characteristics of some human tauopathies compared with IBNC.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454887, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.t002", "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Table_showing_characteristics_of_some_human_tauopathies_compared_with_IBNC_/1454887", "title"=>"Table showing characteristics of some human tauopathies compared with IBNC.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126773"], "description"=>"<p>Presence or absence of labelling of dendrites of the CA1 sector of hippocampus from a single case of IBNC following labelling with multiple tau specific antibodies. Panels show labelling with antibodies specific to hyperphosphorylated threonine or serine residues: a, threonine 205; b, threonine 212; c, serine 214; d, threonine 231; e, serine 396; f, serine 404. Labelling is also shown for antibodies specific to 3 repeat (g) or 4 repeat (h) isoforms. Bars = 100μm.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454864, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hippocampal_tau_and_P_tau_labelling_with_8_antibodies_/1454864", "title"=>"Hippocampal tau and P-tau labelling with 8 antibodies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126778"], "description"=>"<p>Glial associated patterns of immunohistochemical labelling with AT8 antibody. (a) Striatum showing white and grey matter labelling of glial cells. (b) Detail of glial cells in hippocampus showing stellate morphology. (c) Further detail of glia labelling showing stellate pattern and loss of glial cytoplasm with maintained peripheral rim of labelling. (d) Control cow brain with encephalic listeriosis. No labelling for P-tau is present. Bars: a = 200μm; b = 100μm; c = 20μm; d = 200μm.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454868, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.g002", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glial_P_tau_labelling_/1454868", "title"=>"Glial P-tau labelling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126783"], "description"=>"<p>Dendrite and peri-neuronal tau immunohistochemical labelling patterns with AT8 antibody. (a) Detail of dendritic labelling of CA1 dendrites in hippocampus. Parallel rows of puncta suggest labelling is at or adjacent to the plasma-membrane. (b) Labelling around the perikarya and processes of neurons in the thalamus. (c) Some dendrites that are labelled with AT8 also appear to be the origins of loculated vacuoles. Bars: 100μm.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454873, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.g003", "stats"=>{"downloads"=>3, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neuronal_and_dendritic_P_tau_labelling_/1454873", "title"=>"Neuronal and dendritic P-tau labelling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-19 03:06:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/2126789"], "description"=>"<p>(a) Generalised punctuate pattern of neuropil labelling in the dorso-lateral geniculate nucleus of the midbrain sparing neuronal perikarya. (b) Punctuate pattern labelling of dendrites in the substantia nigra. (c) Punctuate labelling of neuropil associated with dentate gyrus of hippocampus. (d) No labelling for alpha synuclein in the dentate gyrus of a control cow. Bars: 100μm.</p>", "links"=>[], "tags"=>["tau antibodies recognising", "future aetiological investigations", "uk", "antibody", "spongiform encephalopathy cases", "tau labelling", "tdp", "tau microtubule binding region", "Occurring Bovine Tauopathy", "tau hyperphosphorylation sites", "IBNC"], "article_id"=>1454879, "categories"=>["Biological Sciences"], "users"=>["Martin Jeffrey", "Pedro Piccardo", "Diane L. Ritchie", "James W. Ironside", "Alison J. E. Green", "Gillian McGovern"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0129499.g004", "stats"=>{"downloads"=>2, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alpha_synuclein_immunohistochemistry_/1454879", "title"=>"Alpha synuclein immunohistochemistry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-19 03:06:20"}

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  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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