Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells
Publication Date
September 12, 2017
Journal
PLOS ONE
Authors
Jing Chang, Yuefeng Xia, Karla Wasserloos, Meihong Deng, et al
Volume
12
Issue
9
Pages
e0184770
DOI
http://doi.org/10.1371/journal.pone.0184770
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0184770
Scopus
85029454834
Mendeley
http://www.mendeley.com/research/cyclic-stretch-induced-il33-production-through-hmgb1tlr4-signaling-pathway-murine-respiratory-epithe
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Mendeley | Further Information

{"title"=>"Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells", "type"=>"journal", "authors"=>[{"first_name"=>"Jing", "last_name"=>"Chang", "scopus_author_id"=>"57195639186"}, {"first_name"=>"Yuefeng", "last_name"=>"Xia", "scopus_author_id"=>"57195640006"}, {"first_name"=>"Karla", "last_name"=>"Wasserloos", "scopus_author_id"=>"6602919622"}, {"first_name"=>"Meihong", "last_name"=>"Deng", "scopus_author_id"=>"56496218400"}, {"first_name"=>"Kory J.", "last_name"=>"Blose", "scopus_author_id"=>"56222144800"}, {"first_name"=>"David A.", "last_name"=>"Vorp", "scopus_author_id"=>"7005301469"}, {"first_name"=>"Heth R.", "last_name"=>"Turnquist", "scopus_author_id"=>"6601989181"}, {"first_name"=>"Timothy R.", "last_name"=>"Billiar", "scopus_author_id"=>"57188781831"}, {"first_name"=>"Bruce A.", "last_name"=>"Pitt", "scopus_author_id"=>"57190002392"}, {"first_name"=>"Ma Zhong", "last_name"=>"Zhang", "scopus_author_id"=>"23026382800"}, {"first_name"=>"Li Ming", "last_name"=>"Zhang", "scopus_author_id"=>"57190003884"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1111111111", "pmid"=>"28898270", "scopus"=>"2-s2.0-85029454834", "pui"=>"618254120", "doi"=>"10.1371/journal.pone.0184770", "sgr"=>"85029454834"}, "id"=>"f074a3a5-ae96-31a3-9c65-b3800d0e7662", "abstract"=>"Interleukin 33 (IL-33), an inflammatory and mechanically responsive cytokine, is an important component of a TLR4-dependent innate immune process in mucosal epithelium. Although TLR4 also plays a role in sensing biomechanical stretch, a pathway of stretch-induced TLR4-dependent IL-33 biosynthesis has not been revealed. In the current study, we show that short term (6 h) cyclic stretch (CS) of cultured murine respiratory epithelial cells (MLE-12) increased intracellular IL-33 expression in a TLR4 dependent fashion. There was no detectable IL-33 in conditioned media in this interval. CS, however, increased release of the notable alarmin, HMGB1, and a neutralizing antibody (2G7) to HMGB1 completely abolished the CS mediated increase in IL-33. rHMGB1 increased IL-33 synthesis and this was partially abrogated by silencing TLR4 suggesting additional receptors for HMGB1 are involved in its regulation of IL-33. Collectively, these data reveal a HMGB1/TLR4/IL-33 pathway in the response of respiratory epithelium to mechanical stretch.", "link"=>"http://www.mendeley.com/research/cyclic-stretch-induced-il33-production-through-hmgb1tlr4-signaling-pathway-murine-respiratory-epithe", "reader_count"=>2, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}}, "group_count"=>0}

Scopus | Further Information

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