Salivary Gland NK Cells Are Phenotypically and Functionally Unique
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{"title"=>"Salivary gland NK cells are phenotypically and functionally unique", "type"=>"journal", "authors"=>[{"first_name"=>"Marlowe S.", "last_name"=>"Tessmer", "scopus_author_id"=>"8234954700"}, {"first_name"=>"Emma C.", "last_name"=>"Reilly", "scopus_author_id"=>"36070080700"}, {"first_name"=>"Laurent", "last_name"=>"Brossay", "scopus_author_id"=>"6603788390"}], "year"=>2011, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-79551521491", "doi"=>"10.1371/journal.ppat.1001254", "pui"=>"361204774", "issn"=>"15537366", "pmid"=>"21249177", "sgr"=>"79551521491"}, "id"=>"842b6329-099f-3c72-830d-332d512833c0", "abstract"=>"Natural killer (NK) cells and CD8(+) T cells play vital roles in containing and eliminating systemic cytomegalovirus (CMV). However, CMV has a tropism for the salivary gland acinar epithelial cells and persists in this organ for several weeks after primary infection. Here we characterize a distinct NK cell population that resides in the salivary gland, uncommon to any described to date, expressing both mature and immature NK cell markers. Using RORγt reporter mice and nude mice, we also show that the salivary gland NK cells are not lymphoid tissue inducer NK-like cells and are not thymic derived. During the course of murine cytomegalovirus (MCMV) infection, we found that salivary gland NK cells detect the infection and acquire activation markers, but have limited capacity to produce IFN-γ and degranulate. Salivary gland NK cell effector functions are not regulated by iNKT or T(reg) cells, which are mostly absent in the salivary gland. Additionally, we demonstrate that peripheral NK cells are not recruited to this organ even after the systemic infection has been controlled. Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells.", "link"=>"http://www.mendeley.com/research/salivary-gland-nk-cells-phenotypically-functionally-unique", "reader_count"=>36, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>23, "Medicine and Dentistry"=>7, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>4, "Energy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Energy"=>{"Energy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "United Kingdom"=>1, "France"=>2}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/806846"], "description"=>"<p><i>(A)</i> B6 mice were infected with 5×10<sup>4</sup> pfu/mouse MCMV and sacrificed on D0, D7, 14 or 21 p.i. NK1.1<sup>+</sup>CD3<sup>−</sup> cells of the SMG were compared to spleen and liver for expression of KLRG1. <i>(B)</i> The graph represents the percentage of B6 NK cells and CD8<sup>+</sup> T cells in the SMG during MCMV infection at D0, 7, 14 and 21. 3–5 experiments of 2–3 mice per group is shown.</p>", "links"=>[], "tags"=>["nk", "cells", "activated", "induce", "klrg1", "mcmv"], "article_id"=>477214, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g003", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SMG_NK_cells_become_activated_and_induce_the_expression_of_KLRG1_during_MCMV_infection_/477214", "title"=>"SMG NK cells become activated and induce the expression of KLRG1 during MCMV infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 02:00:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/402775", "https://ndownloader.figshare.com/files/402799", "https://ndownloader.figshare.com/files/402823", "https://ndownloader.figshare.com/files/402847", "https://ndownloader.figshare.com/files/402873", "https://ndownloader.figshare.com/files/402887"], "description"=>"<div><p>Natural killer (NK) cells and CD8<sup>+</sup> T cells play vital roles in containing and eliminating systemic cytomegalovirus (CMV). However, CMV has a tropism for the salivary gland acinar epithelial cells and persists in this organ for several weeks after primary infection. Here we characterize a distinct NK cell population that resides in the salivary gland, uncommon to any described to date, expressing both mature and immature NK cell markers. Using RORγt reporter mice and nude mice, we also show that the salivary gland NK cells are not lymphoid tissue inducer NK-like cells and are not thymic derived. During the course of murine cytomegalovirus (MCMV) infection, we found that salivary gland NK cells detect the infection and acquire activation markers, but have limited capacity to produce IFN-γ and degranulate. Salivary gland NK cell effector functions are not regulated by <em>i</em>NKT or T<sub>reg</sub> cells, which are mostly absent in the salivary gland. Additionally, we demonstrate that peripheral NK cells are not recruited to this organ even after the systemic infection has been controlled. Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells.</p></div>", "links"=>[], "tags"=>["salivary", "gland", "nk", "cells", "are", "phenotypically", "functionally"], "article_id"=>139587, "categories"=>["Immunology", "Cancer"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>["https://dx.doi.org/10.1371/journal.ppat.1001254.s001", "https://dx.doi.org/10.1371/journal.ppat.1001254.s002", "https://dx.doi.org/10.1371/journal.ppat.1001254.s003", "https://dx.doi.org/10.1371/journal.ppat.1001254.s004", "https://dx.doi.org/10.1371/journal.ppat.1001254.s005", "https://dx.doi.org/10.1371/journal.ppat.1001254.s006"], "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Salivary_Gland_NK_Cells_Are_Phenotypically_and_Functionally_Unique/139587", "title"=>"Salivary Gland NK Cells Are Phenotypically and Functionally Unique", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-01-13 02:39:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/806789"], "description"=>"<p><i>(A)</i> Organs from naïve Rag<sup>−/−</sup> mice were examined to confirm the presence of NK cells in the SMG vs. spleen, liver, and blood. NK cells from the SMG were comparably lacking cell surface KLRG1, but expressed increased levels of CD69. <i>(B)</i> Organs from naïve nude mice were examined to confirm the presence of NK cells in the SMG and spleen. <i>(C)</i> NKp46<sup>+</sup>CD3<sup>−</sup> cells from the SMG and gut lamina propria of naïve or D14 MCMV infected RORcγt<sup>+/GFP</sup> reporter mice were examined for GFP expression.</p>", "links"=>[], "tags"=>["nk", "cells", "mice", "thymic", "lti"], "article_id"=>477155, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g002", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SMG_NK_cells_are_present_in_Rag_8722_8722_mice_and_are_not_thymic_or_LTi_derived_/477155", "title"=>"SMG NK cells are present in Rag<sup>−/−</sup> mice and are not thymic or LTi derived.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 01:59:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/807044"], "description"=>"<p>Lymphoid cells from the SMG and spleens were isolated from 24 hour Poly(I∶C) treated mice. Both organs were processed and incubated for 6 hours with no treatment, crosslinked with anti-NKG2D or anti-Ly49H, or stimulated with IL-12/IL-18. Cells were treated with Monensin and stained for IFN-γ <i>(A)</i> and CD107α <i>(B)</i> and analyzed by flow cytometry. The bar graph shows a compilation of 3 experiments with 9 mice pooled for each experiment. *p = 0.004−0.003 **p = <0.003.</p>", "links"=>[], "tags"=>["primed", "smg", "nk", "cells", "impaired", "degranulation", "compared", "splenic"], "article_id"=>477406, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Poly_I_8758_C_primed_SMG_NK_cells_have_impaired_IFN_947_and_degranulation_compared_with_splenic_NK_cells_/477406", "title"=>"Poly(I∶C) primed SMG NK cells have impaired IFN-γ and degranulation compared with splenic NK cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 02:03:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/806721"], "description"=>"<p><i>(A)</i> Naïve NK cells represent a significant population of lymphocytes within the SMG and display reduced levels of KLRG1 and CD27 compared to the spleen and liver. <i>(B)</i> Naïve NK1.1<sup>+</sup>CD3<sup>−</sup> cells from the SMG of B6 mice were examined for other NK cell markers.</p>", "links"=>[], "tags"=>["cells"], "article_id"=>477090, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotype_of_NK1_1_CD3_8722_cells_in_the_SMG_/477090", "title"=>"Phenotype of NK1.1<sup>+</sup>CD3<sup>−</sup> cells in the SMG.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 01:58:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/807193"], "description"=>"<p><i>(A)</i> Mice expressing a GFP-Foxp3 fusion-protein reporter were infected with MCMV for the time points shown and analyzed for accumulation of T<sub>regs</sub> in the spleen, liver, blood and SMG as shown by CD4<sup>+</sup>GFP<sup>+</sup> T cells. Representative of 3 separate experiments with 3–4 mice per group. <i>(B)</i> Splenic, hepatic and SMG leukocytes were isolated from naïve B6 and Jα18 deficient mice. The <i>i</i>NKT cell compartment was analyzed by staining with TCR-β and α-GalCer-loaded CD1d tetramer. Representative of 3 separate experiments with 2–3 mice per group.</p>", "links"=>[], "tags"=>["cells", "absent", "mcmv", "infected"], "article_id"=>477561, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g008", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T_regs_and_i_NKT_cells_are_absent_from_na_ve_and_MCMV_infected_SMG_/477561", "title"=>"T-regs and <i>i</i>NKT cells are absent from naïve and MCMV infected SMG.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 02:06:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/807134"], "description"=>"<p>Lymphoid cells from the SMG and spleens were isolated from D10 and D2 MCMV infected mice, respectively. Both organs were processed and incubated for 6 hours as described in <a href=\"http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1001254#ppat-1001254-g006\" target=\"_blank\">Figure 6</a>. Cells were treated with Monensin and stained for IFN-γ <i>(A)</i> and CD107α <i>(B)</i> and analyzed by flow cytometry. The bar graph shows a compilation of 4 experiments with 3 mice pooled for each experiment. *p = 0.03−0.003 **p = <0.003.</p>", "links"=>[], "tags"=>["activated", "smg", "nk", "cells", "impaired", "degranulation", "compared", "splenic"], "article_id"=>477496, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g007", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MCMV_activated_SMG_NK_cells_have_impaired_IFN_947_and_degranulation_compared_with_splenic_NK_cells_/477496", "title"=>"MCMV activated SMG NK cells have impaired IFN-γ and degranulation compared with splenic NK cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 02:04:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/806935"], "description"=>"<p>B6 splenic lymphocytes were depleted of CD19<sup>+</sup> and CD5<sup>+</sup> cells to enrich for NK cells. Remaining cells were stained with non-reducing amounts of NK1.1 and CD3 and sorted using a FACSAria. NK1.1<sup>+</sup>CD3<sup>−</sup> cells were of > 98% purity before i.v. injection into congenic B6 mice at 2×10<sup>6</sup> cells/mouse. Recipient congenic B6 mice were either infected with 5×10<sup>4</sup> pfu/mouse MCMV two hours or ten days prior to adoptive transfer. On D7 post-NK cell transfer, mice were analyzed for CD45.2<sup>+</sup> NK cell trafficking. The figures represent 1 of 2 separate experiments with 2 mice per group.</p>", "links"=>[], "tags"=>["cells", "periphery", "recruited", "smg", "mcmv"], "article_id"=>477302, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NK_cells_from_the_periphery_are_not_recruited_to_the_SMG_during_MCMV_infection_/477302", "title"=>"NK cells from the periphery are not recruited to the SMG during MCMV infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 02:01:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/806980"], "description"=>"<p>B6 mice were infected with 5×10<sup>4</sup> pfu/mouse MCMV and sacrificed on D2, 7, 10 or 14 p.i. IFN-γ production from NK1.1<sup>+</sup>CD3<sup>−</sup> cells was determined by intracellular staining. Representative of 5 separate experiments with 2–4 mice pooled per group.</p>", "links"=>[], "tags"=>["nk", "cells", "hyporesponsive", "mcmv"], "article_id"=>477348, "categories"=>["Immunology", "Infectious Diseases"], "users"=>["Marlowe S. Tessmer", "Emma C. Reilly", "Laurent Brossay"], "doi"=>"https://dx.doi.org/10.1371/journal.ppat.1001254.g005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SMG_NK_cells_are_hyporesponsive_in_vivo_during_MCMV_infection_/477348", "title"=>"SMG NK cells are hyporesponsive <i>in vivo</i> during MCMV infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-13 02:02:28"}

PMC Usage Stats | Further Information

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Relative Metric

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