Hyperthermia Stimulates HIV-1 Replication
- Publication Date
- July 12, 2012
- Journal
- PLOS Pathogens
- Authors
- Ferdinand Roesch, Oussama Meziane, Anna Kula, Sébastien Nisole, et al
- Volume
- 8
- Issue
- 7
- Pages
- e1002792
- DOI
- https://dx.plos.org/10.1371/journal.ppat.1002792
- Publisher URL
- http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1002792
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22807676
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395604
- Europe PMC
- http://europepmc.org/abstract/MED/22807676
- Scopus
- 84864628996
- Mendeley
- http://www.mendeley.com/research/hyperthermia-stimulates-hiv1-replication
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Mendeley | Further Information
{"title"=>"Hyperthermia stimulates HIV-1 replication", "type"=>"journal", "authors"=>[{"first_name"=>"Ferdinand", "last_name"=>"Roesch", "scopus_author_id"=>"35485598300"}, {"first_name"=>"Oussama", "last_name"=>"Meziane", "scopus_author_id"=>"26424720300"}, {"first_name"=>"Anna", "last_name"=>"Kula", "scopus_author_id"=>"56623511900"}, {"first_name"=>"Sébastien", "last_name"=>"Nisole", "scopus_author_id"=>"55975958300"}, {"first_name"=>"Françoise", "last_name"=>"Porrot", "scopus_author_id"=>"6602764759"}, {"first_name"=>"Ian", "last_name"=>"Anderson", "scopus_author_id"=>"56457542200"}, {"first_name"=>"Fabrizio", "last_name"=>"Mammano", "scopus_author_id"=>"7006987415"}, {"first_name"=>"Ariberto", "last_name"=>"Fassati", "scopus_author_id"=>"6701807360"}, {"first_name"=>"Alessandro", "last_name"=>"Marcello", "scopus_author_id"=>"7004565839"}, {"first_name"=>"Monsef", "last_name"=>"Benkirane", "scopus_author_id"=>"7004581121"}, {"first_name"=>"Olivier", "last_name"=>"Schwartz", "scopus_author_id"=>"7006284121"}], "year"=>2012, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"22807676", "sgr"=>"84864628996", "doi"=>"10.1371/journal.ppat.1002792", "scopus"=>"2-s2.0-84864628996", "pui"=>"365384963", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "issn"=>"15537366"}, "id"=>"9d79d846-eea9-3bcb-8305-98e6a4a43dc1", "abstract"=>"HIV-infected individuals may experience fever episodes. Fever is an elevation of the body temperature accompanied by inflammation. It is usually beneficial for the host through enhancement of immunological defenses. In cultures, transient non-physiological heat shock (42-45°C) and Heat Shock Proteins (HSPs) modulate HIV-1 replication, through poorly defined mechanisms. The effect of physiological hyperthermia (38-40°C) on HIV-1 infection has not been extensively investigated. Here, we show that culturing primary CD4+ T lymphocytes and cell lines at a fever-like temperature (39.5°C) increased the efficiency of HIV-1 replication by 2 to 7 fold. Hyperthermia did not facilitate viral entry nor reverse transcription, but increased Tat transactivation of the LTR viral promoter. Hyperthermia also boosted HIV-1 reactivation in a model of latently-infected cells. By imaging HIV-1 transcription, we further show that Hsp90 co-localized with actively transcribing provirus, and this phenomenon was enhanced at 39.5°C. The Hsp90 inhibitor 17-AAG abrogated the increase of HIV-1 replication in hyperthermic cells. Altogether, our results indicate that fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity.", "link"=>"http://www.mendeley.com/research/hyperthermia-stimulates-hiv1-replication", "reader_count"=>51, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>17, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>6, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>17, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>6, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>9, "Agricultural and Biological Sciences"=>28, "Medicine and Dentistry"=>7, "Chemistry"=>2, "Social Sciences"=>1, "Immunology and Microbiology"=>2, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>28}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>1, "United Kingdom"=>1}, "group_count"=>1}CrossRef
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Scopus | Further Information
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- {"id"=>"225166996197740544", "text"=>"Premier papier publié ! C'est par ici http://t.co/E2bZ7Iiv et ça parle d'hyperthermie et de réplication du VIH !", "created_at"=>"2012-07-17T09:56:09Z", "user"=>"DonFerdie", "user_name"=>"Ferdinand Roesch", "user_profile_image"=>"http://a0.twimg.com/profile_images/1620897389/Ferdinand_ROESCHrecad_normal.jpg"}
- {"id"=>"225167493617025025", "text"=>"Youhou \\o/ @DonFerdie: Premier papier publié ! C'est par ici http://t.co/kedWbLBN et ça parle d'hyperthermie et de réplication du VIH !", "created_at"=>"2012-07-17T09:58:08Z", "user"=>"squintar", "user_name"=>"squin tar", "user_profile_image"=>"http://a0.twimg.com/profile_images/1265140901/Sophie-Scholl_normal.jpeg"}
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PMC Usage Stats | Further Information
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Relative Metric
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