Developmental Context Determines Latency of MYC-Induced Tumorigenesis
Publication Date
September 28, 2004
Journal
PLOS Biology
Authors
Shelly Beer, Anders Zetterberg, Rebecca A Ihrie, Ryan A Mc Taggart, et al
Volume
2
Issue
11
Pages
e332
DOI
https://dx.plos.org/10.1371/journal.pbio.0020332
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.0020332
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/15455033
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC519000
Europe PMC
http://europepmc.org/abstract/MED/15455033
Web of Science
000225160300011
Scopus
20044394527
Mendeley
http://www.mendeley.com/research/developmental-context-determines-latency-mycinduced-tumorigenesis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Developmental context determines latency of MYC-induced tumorigenesis", "type"=>"journal", "authors"=>[{"first_name"=>"Shelly", "last_name"=>"Beer", "scopus_author_id"=>"7102646461"}, {"first_name"=>"Anders", "last_name"=>"Zetterberg", "scopus_author_id"=>"7006809407"}, {"first_name"=>"Rebecca A.", "last_name"=>"Ihrie", "scopus_author_id"=>"8927862200"}, {"first_name"=>"Ryan A.", "last_name"=>"McTaggart", "scopus_author_id"=>"57188834094"}, {"first_name"=>"Qiwei", "last_name"=>"Yang", "scopus_author_id"=>"55769747147"}, {"first_name"=>"Nicole", "last_name"=>"Bradon", "scopus_author_id"=>"6507117327"}, {"first_name"=>"Constadina", "last_name"=>"Arvanitis", "scopus_author_id"=>"35576567400"}, {"first_name"=>"Laura D.", "last_name"=>"Attardi", "scopus_author_id"=>"6602153331"}, {"first_name"=>"Sandy", "last_name"=>"Feng", "scopus_author_id"=>"7402531182"}, {"first_name"=>"Boris", "last_name"=>"Ruebner", "scopus_author_id"=>"7005797833"}, {"first_name"=>"Robert D.", "last_name"=>"Cardiff", "scopus_author_id"=>"7007046776"}, {"first_name"=>"Dean W.", "last_name"=>"Felsher", "scopus_author_id"=>"6603781310"}], "year"=>2004, "source"=>"PLoS Biology", "identifiers"=>{"sgr"=>"20044394527", "doi"=>"10.1371/journal.pbio.0020332", "issn"=>"15449173", "pui"=>"40280478", "isbn"=>"1545-7885 (Electronic)\\r1544-9173 (Linking)", "pmid"=>"15455033", "scopus"=>"2-s2.0-20044394527"}, "id"=>"50599c4d-86e8-3347-928e-1b94aae4195c", "abstract"=>"One of the enigmas in tumor biology is that different types of cancers are prevalent in different age groups. One possible explanation is that the ability of a specific oncogene to cause tumorigenesis in a particular cell type depends on epigenetic parameters such as the developmental context. To address this hypothesis, we have used the tetracycline regulatory system to generate transgenic mice in which the expression of a c-MYC human transgene can be conditionally regulated in murine hepatocytes. MYC's ability to induce tumorigenesis was dependent upon developmental context. In embryonic and neonatal mice, MYC overexpression in the liver induced marked cell proliferation and immediate onset of neoplasia. In contrast, in adult mice MYC overexpression induced cell growth and DNA replication without mitotic cell division, and mice succumbed to neoplasia only after a prolonged latency. In adult hepatocytes, MYC activation failed to induce cell division, which was at least in part mediated through the activation of p53. Surprisingly, apoptosis is not a barrier to MYC inducing tumorigenesis. The ability of oncogenes to induce tumorigenesis may be generally restrained by developmentally specific mechanisms. Adult somatic cells have evolved mechanisms to prevent individual oncogenes from initiating cellular growth, DNA replication, and mitotic cellular division alone, thereby preventing any single genetic event from inducing tumorigenesis.", "link"=>"http://www.mendeley.com/research/developmental-context-determines-latency-mycinduced-tumorigenesis", "reader_count"=>56, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>7, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>7, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>37, "Medicine and Dentistry"=>6, "Physics and Astronomy"=>1, "Chemistry"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>37}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>3, "Japan"=>1, "Brazil"=>2, "United Kingdom"=>1}, "group_count"=>7}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/20044394527"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/20044394527?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=20044394527&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=20044394527&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/20044394527", "dc:identifier"=>"SCOPUS_ID:20044394527", "eid"=>"2-s2.0-20044394527", "dc:title"=>"Developmental context determines latency of MYC-induced tumorigenesis", "dc:creator"=>"Beer S.", "prism:publicationName"=>"PLoS Biology", "prism:issn"=>"15449173", "prism:volume"=>"2", "prism:issueIdentifier"=>"11", "prism:pageRange"=>nil, "prism:coverDate"=>"2004-11-01", "prism:coverDisplayDate"=>"November 2004", "prism:doi"=>"10.1371/journal.pbio.0020332", "citedby-count"=>"104", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Stanford University School of Medicine", "affiliation-city"=>"Stanford", "affiliation-country"=>"United States"}], "pubmed-id"=>"15455033", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "source-id"=>"12977", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosbiology%2Farticle%3Fid%3D10.1371%252Fjournal.pbio.0020332", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"9", "year"=>"2004", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"337"}
  • {"month"=>"10", "year"=>"2004", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"613"}
  • {"month"=>"11", "year"=>"2004", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"546"}
  • {"month"=>"12", "year"=>"2004", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"203"}
  • {"month"=>"1", "year"=>"2005", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"2", "year"=>"2005", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"3", "year"=>"2005", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"166"}
  • {"month"=>"4", "year"=>"2005", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"5", "year"=>"2005", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"6", "year"=>"2005", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2005", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"8", "year"=>"2005", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"9", "year"=>"2005", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"10", "year"=>"2005", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"11", "year"=>"2005", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"12", "year"=>"2005", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"1", "year"=>"2006", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"2", "year"=>"2006", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"3", "year"=>"2006", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"4", "year"=>"2006", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"5", "year"=>"2006", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2006", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2006", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2006", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"39"}
  • {"month"=>"9", "year"=>"2006", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2006", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2006", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2006", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2007", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"2", "year"=>"2007", "pdf_views"=>"8", "xml_views"=>"6", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2007", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2007", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"12", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"4", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"5", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"185"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"91"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"114"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"92"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"4", "html_views"=>"89"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"100"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"80"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"75"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"7", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"6", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"4", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"9", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"6", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"7"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/963818"], "description"=>"<div><p>(A) Histology of a normal 10-d-old neonatal liver.</p>\n <p>(B) Histology of a 10-d-old liver in which <i>MYC</i> was activated at birth.</p>\n <p>(C) Histology of a normal 18-d-old neonatal liver.</p>\n <p>(D) Histology of a MYC-induced neonatal liver tumor that developed after 18 d of MYC overexpression; <i>MYC</i> was activated at birth.</p>\n <p>(E–L) Ki67 immunofluorescence (E–H) and DAPI staining (I–L) of normal neonatal hepatocytes (E, G, I, and K), <i>MYC</i>-activated hepatocytes (F and J), and MYC-induced neonatal tumors (H and L). Upon initial <i>MYC</i> activation in neonatal mice, there was a small increase in Ki67-positive cells. MYC-induced neonatal tumors exhibited much higher levels of Ki67-positive cells.</p></div>", "links"=>[], "tags"=>["activation", "proliferation", "neonatal"], "article_id"=>633760, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g005", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_at_Birth_Induces_Proliferation_of_Neonatal_Hepatocytes_/633760", "title"=>"<i>MYC</i> Activation at Birth Induces Proliferation of Neonatal Hepatocytes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:13:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/963603"], "description"=>"<div><p>(A) A normal neonatal liver and a neonatal liver in which <i>MYC</i> was activated embryonically.</p>\n <p>(B) Histology of a normal neonatal liver in which <i>MYC</i> was not activated.</p>\n <p>(C) Histology of a neonatal liver in which <i>MYC</i> was activated embryonically.</p>\n <p>(D) DNA content of normal neonatal hepatocytes.</p>\n <p>(E) DNA content of neonatal hepatocytes in which <i>MYC</i> was activated embryonically.</p>\n <p>(F and H) Ki67 immunofluorescence and DAPI staining corresponding to a normal neonatal liver.</p>\n <p>(G and I) Ki67 immunofluorescence and DAPI staining corresponding to a neonatal liver in which <i>MYC</i> was activated embryonically.</p></div>", "links"=>[], "tags"=>["activation", "embryonic", "onset"], "article_id"=>633540, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_during_Embryonic_Development_Induces_a_Rapid_Onset_of_Neoplasia_/633540", "title"=>"<i>MYC</i> Activation during Embryonic Development Induces a Rapid Onset of Neoplasia", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:12:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/964131"], "description"=>"<p>TUNEL assay (A, C, E, G, and I) and DAPI staining (B, D, F, H, and J) of normal (A, B, E, and F) and <i>MYC</i>-activated (C, D, and G–J) hepatocytes of neonatal (A–D) and adult (E–J) mice. After 4 weeks of <i>MYC</i> activation in adult hepatocytes, there was no evidence of apoptosis either by TUNEL assay (G) or by DAPI staining of nuclei (H). <i>MYC</i> activation is associated with increased apoptosis with the neoplastic conversion of neonatal (C) and adult (I) hepatocytes. Representative data from one of three experiments are shown. Identical results were seen when <i>MYC</i> was activated for 2 or 8 weeks.</p>", "links"=>[], "tags"=>["activation", "induce", "apoptosis", "murine"], "article_id"=>634056, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g009", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_Does_Not_Induce_Apoptosis_in_Murine_Hepatocytes_/634056", "title"=>"<i>MYC</i> Activation Does Not Induce Apoptosis in Murine Hepatocytes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:16:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/963459"], "description"=>"<div><p>(A) Survival of transgenic mice demonstrates that tumorigenesis in the liver is inversely correlated with the age of the host at the time of <i>MYC</i> induction. Shown are cases where <i>MYC</i> was constitutively expressed (▪), newborn mice in which <i>MYC</i> was activated at birth (▴), young mice in which <i>MYC</i> was activated at 4 weeks of age (•), adult mice in which <i>MYC</i> was activated at 6–12 weeks of age (♦), and transgenic mice treated with doxycycline (□). Cohorts consisted of 15–30 mice. Mice were scored when moribund. <i>MYC</i> transgene expression was induced to similar levels in the differently aged cohorts of mice. Survival time is measured as the time after <i>MYC</i> induction.</p>\n <p>(B) Western blot examining total MYC protein levels (human MYC and endogenous murine c-MYC) in mice when <i>MYC</i> is induced during embryonic development, activated at birth, and activated during adulthood (after 10 weeks of age). Adult mice exhibited a progressive increase in MYC protein levels during the course of <i>MYC</i> induction, with a significant increase in MYC protein in tumors. MYC protein levels in neonatal mice in which <i>MYC</i> was activated at birth were slightly increased at 10 d of age, and significantly increased at 18 d of age when these mice developed liver tumors. Liver tumors in 2- and 6-d-old neonatal mice that overexpressed MYC during embryonic development exhibited MYC protein levels similar to those observed in neonatal and adult tumors.</p>\n <p>(C) Real-time PCR analysis showing human <i>MYC</i> RNA levels in mice after different durations of <i>MYC</i> transgene induction. Adult livers exhibited a small increase in <i>MYC</i> RNA levels upon <i>MYC</i> activation, and a much greater increase in <i>MYC</i> RNA in MYC-induced tumors (black bars). In neonatal mice in which the <i>MYC</i> transgene was induced at birth, <i>MYC</i> RNA levels rose after 10 d of <i>MYC</i> activation. When these neonatal mice developed liver tumors, they exhibited <i>MYC</i> RNA levels similar to those seen in adult tumors (gray bars). Mice in which <i>MYC</i> was overexpressed during embryonic development developed liver tumors by 2 d of age and exhibited <i>MYC</i> RNA levels similar to those observed in neonatal and adult tumors (white bars).</p></div>", "links"=>[], "tags"=>["induce", "hcc", "inversely", "correlated"], "article_id"=>633387, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_s_Ability_to_Induce_HCC_Is_Inversely_Correlated_with_the_Age_of_the_Host_at_the_Time_of_MYC_Activation_/633387", "title"=>"MYC's Ability to Induce HCC Is Inversely Correlated with the Age of the Host at the Time of <i>MYC</i> Activation", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:11:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/963939"], "description"=>"<div><p>(A) Histology of a normal liver.</p>\n <p>(B) Histology of a liver 2 months after <i>MYC</i> activation.</p>\n <p>(C) Histology of a MYC-induced liver tumor.</p>\n <p>(D and G) Ki67 immunofluorescence and DAPI staining of a normal adult liver.</p>\n <p>(E and H) Ki67 and DAPI staining of an adult liver after 8 weeks of <i>MYC</i> activation.</p>\n <p>(F and I) Ki67 and DAPI staining of a MYC-induced adult tumor.</p>\n <p>(J) DNA content measured in normal hepatocytes.</p>\n <p>(K) DNA content measured after <i>MYC</i> induction for 2 months.</p>\n <p>(L) DNA content of a representative MYC-induced liver tumor.</p></div>", "links"=>[], "tags"=>["activation", "hepatocytes", "proliferation", "neoplastic"], "article_id"=>633868, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g006", "stats"=>{"downloads"=>4, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_in_Adult_Hepatocytes_Induces_Increased_Cell_Size_and_Endoreduplication_and_Only_Results_in_Cell_Proliferation_upon_Neoplastic_Conversion_of_Hepatocytes_/633868", "title"=>"<i>MYC</i> Activation in Adult Hepatocytes Induces Increased Cell Size and Endoreduplication, and Only Results in Cell Proliferation upon Neoplastic Conversion of Hepatocytes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:14:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/964039"], "description"=>"<p>A histogram obtained by FACS forward versus light scatter analysis of adult hepatocytes from normal FVB/N livers (green), doxycycline-treated transgenic livers (red), and livers in which the <i>MYC</i> transgene was overexpressed for 3 months (blue). The <i>x</i>-axis represents cell size and the <i>y</i>-axis represents cell count. Adult mice were matched for age.</p>", "links"=>[], "tags"=>["activation", "hepatocytes"], "article_id"=>633970, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g007", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_in_Adult_Hepatocytes_Induces_Increased_Cell_Size_/633970", "title"=>"<i>MYC</i> Activation in Adult Hepatocytes Induces Increased Cell Size", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:15:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/964198"], "description"=>"<div><p>(A) Western blot analysis for p53 protein expression after <i>MYC</i> activation for 1 month, 2 months, and in MYC-induced tumors. As a positive control, we used a lymphoma cell line that overexpresses a mutant p53, kindly provided by Dr. Kevin Smith.</p>\n <p>(B) Western blot analysis for p53 protein expression in a normal neonatal liver, in a neonatal liver in which MYC was activated during embryonic development that was obtained from a 2-d-old mouse, and in MYC-induced neonatal tumors. As a positive control, we used a lymphoma cell line generated in our lab that overexpresses a mutant p53.</p>\n <p>(C) Northern blot analysis for <i>p21</i> and <i>MDM2</i> in neonatal and adult liver tumors.</p>\n <p>(D) Survival of adult mice after activation of <i>MYC</i> in the presence of the wild type or the loss of one <i>p53</i> allele.</p>\n <p>(E) Loss of heterozygosity analysis of <i>MYC/p53<sup>+/−</sup></i> tumors by PCR analysis.</p></div>", "links"=>[], "tags"=>["activation", "p53", "myc", "induce", "tumorigenesis"], "article_id"=>634133, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g010", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_Induces_p53_Function_and_Loss_of_p53_Function_Is_Necessary_for_MYC_to_Induce_Tumorigenesis_in_Adult_Hepatocytes_/634133", "title"=>"<i>MYC</i> Activation Induces p53 Function, and Loss of p53 Function Is Necessary for MYC to Induce Tumorigenesis in Adult Hepatocytes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:16:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/963687"], "description"=>"<div><p>(A) Relative volumes of neonatal hepatocytes and nuclei after <i>MYC</i> activation. Data are expressed as normalized volume plus or minus the standard error of the mean. The volume was normalized by dividing each measurement by the mean volume of normal 1-d-old neonatal mice. Three livers were measured per time point. T, tumor.</p>\n <p>(B) Neonatal liver weights of normal and <i>MY</i>C-activated livers. Three to five livers were weighed per time point. Data are expressed as the mean weight (grams) plus or minus the standard error of the mean.</p>\n <p>(C) Relative volumes of adult hepatocytes and nuclei after <i>MYC</i> activation. Volumes of cells are expressed as the mean volume divided by the mean volume of hepatocytes from normal mice plus or minus the standard error of the mean. Cells from two to three livers were measured per time point.</p>\n <p>(D) Adult liver weights after <i>MYC</i> activation. A total of nine livers were measured per time point after <i>MYC</i> activation. Data are expressed as the mean weight (grams) plus or minus the standard error of the mean.</p></div>", "links"=>[], "tags"=>["activation", "hepatocytes", "causes", "cellular"], "article_id"=>633625, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g008", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Activation_in_Adult_Hepatocytes_Causes_Cellular_Hypertrophy_/633625", "title"=>"<i>MYC</i> Activation in Adult Hepatocytes Causes Cellular Hypertrophy", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:12:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/964341"], "description"=>"<div><p>(A) Liver from an adult mouse 7 weeks after <i>MYC</i> activation exhibited no gross phenotypic changes (left), whereas the liver from an adult mouse 7 weeks after <i>MYC</i> activation that had undergone partial hepatectomy exhibited a multifocal liver tumor (right).</p>\n <p>(B) The histology of the liver from an adult mouse 7 weeks after <i>MYC</i> activation exhibited no evidence of a tumor.</p>\n <p>(C) The histology of a liver from an adult mouse after <i>MYC</i> activation that had undergone partial hepatectomy exhibited a multifocal HCC.</p>\n <p>(D) Survival after <i>MYC</i> activation in adult mice that have either not undergone surgery (▪) or undergone a partial hepatectomy (□). Results are pooled from two independent experiments with a total of ten mice per group.</p></div>", "links"=>[], "tags"=>["hepatectomy", "accelerates", "myc", "induce", "hcc"], "article_id"=>634271, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g011", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Partial_Hepatectomy_Accelerates_the_Ability_of_MYC_to_Induce_HCC_in_Adult_Mice_/634271", "title"=>"Partial Hepatectomy Accelerates the Ability of MYC to Induce HCC in Adult Mice", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:17:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/963380"], "description"=>"<div><p>(A) Adult mouse with <i>MYC</i>-induced liver tumor that has metastasized to the abdomen and the lungs.</p>\n <p>(B) Histology of an adult <i>MYC</i>-induced lung metastasis.</p>\n <p>(C) Histology of an adult <i>MYC</i>-induced liver tumor.</p>\n <p>(D) Gross pathology of a liver tumor from a neonatal host transplanted subcutaneously into a <i>scid</i> mouse.</p></div>", "links"=>[], "tags"=>["hepatic", "tumors", "invasive"], "article_id"=>633310, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Induced_Hepatic_Tumors_Are_Invasive_and_Metastatic_/633310", "title"=>"MYC-Induced Hepatic Tumors Are Invasive and Metastatic", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:10:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/963282"], "description"=>"<div><p>(A) Western blot analysis demonstrating that mice transgenic for both LAP-<i>tTA</i> and TRE-MYC conditionally express <i>MYC</i> protein in their hepatocytes in the absence (−) but not in the presence (+) of doxycycline.</p>\n <p>(B) Adult mouse with <i>MYC</i>-induced liver tumor.</p>\n <p>(C) Histology of an adult <i>MYC</i>-induced liver tumor.</p>\n <p>(D) Gross pathology of an adult liver tumor transplanted subcutaneously into a <i>scid</i> mouse.</p>\n <p>(E) Histology of an adult tumor transplanted subcutaneously into a <i>scid</i> mouse.</p></div>", "links"=>[], "tags"=>["overexpression", "hepatocytes"], "article_id"=>633215, "categories"=>["Cancer"], "users"=>["Shelly Beer", "Anders Zetterberg", "Rebecca A Ihrie", "Ryan A McTaggart", "Qiwei Yang", "Nicole Bradon", "Constadina Arvanitis", "Laura D Attardi", "Sandy Feng", "Boris Ruebner", "Robert D Cardiff", "Dean W Felsher"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.0020332.g001", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYC_Overexpression_in_Adult_Hepatocytes_Results_in_HCC_/633215", "title"=>"MYC Overexpression in Adult Hepatocytes Results in HCC", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:10:05"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"14", "pdf"=>"2", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "year"=>"2010", "pdf"=>"1", "unique-ip"=>"15", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "unique-ip"=>"19", "pdf"=>"11", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2010", "pdf"=>"9", "unique-ip"=>"10", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"7", "unique-ip"=>"13", "pdf"=>"6", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2010", "pdf"=>"8", "unique-ip"=>"9", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"10", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"2", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"14", "year"=>"2010", "pdf"=>"7", "unique-ip"=>"16", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"16", "unique-ip"=>"14", "pdf"=>"5", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"13", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"4", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"14", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "unique-ip"=>"15", "pdf"=>"10", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"12", "year"=>"2011", "pdf"=>"11", "unique-ip"=>"18", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"8", "unique-ip"=>"9", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"7", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"8", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"10", "unique-ip"=>"10", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"8", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"4", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2011", "pdf"=>"0", "unique-ip"=>"2", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"7", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "year"=>"2004", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"9", "full-text"=>"148", "unique-ip"=>"126", "pdf"=>"82", "year"=>"2004", "figure"=>"54", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"8", "full-text"=>"50", "year"=>"2004", "pdf"=>"35", "unique-ip"=>"46", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"10", "full-text"=>"48", "unique-ip"=>"33", "pdf"=>"31", "year"=>"2004", "figure"=>"41", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"44", "year"=>"2005", "pdf"=>"33", "unique-ip"=>"41", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"14", "unique-ip"=>"18", "pdf"=>"7", "year"=>"2005", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"28", "year"=>"2005", "pdf"=>"34", "unique-ip"=>"33", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"17", "unique-ip"=>"21", "pdf"=>"8", "year"=>"2005", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"36", "year"=>"2005", "pdf"=>"17", "unique-ip"=>"31", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"30", "unique-ip"=>"28", "pdf"=>"27", "year"=>"2005", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"22", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2005", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"60", "scanned-summary"=>"34", "supp-data"=>"24"}
  • {"scanned-page-browse"=>"16", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2005", "figure"=>"49", "scanned-summary"=>"33", "supp-data"=>"29"}
  • {"month"=>"9", "scanned-page-browse"=>"21", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "year"=>"2005", "pdf"=>"0", "unique-ip"=>"12", "figure"=>"76", "scanned-summary"=>"39", "supp-data"=>"36"}
  • {"scanned-page-browse"=>"17", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"0", "year"=>"2005", "figure"=>"69", "scanned-summary"=>"36", "supp-data"=>"31"}
  • {"month"=>"11", "scanned-page-browse"=>"27", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2005", "pdf"=>"0", "unique-ip"=>"12", "figure"=>"85", "scanned-summary"=>"45", "supp-data"=>"35"}
  • {"scanned-page-browse"=>"16", "month"=>"12", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"6", "pdf"=>"0", "year"=>"2005", "figure"=>"54", "scanned-summary"=>"32", "supp-data"=>"29"}
  • {"month"=>"1", "scanned-page-browse"=>"30", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"74", "scanned-summary"=>"40", "supp-data"=>"43"}
  • {"scanned-page-browse"=>"13", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"15", "pdf"=>"0", "year"=>"2006", "figure"=>"64", "scanned-summary"=>"35", "supp-data"=>"28"}
  • {"month"=>"3", "scanned-page-browse"=>"27", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"30", "figure"=>"89", "scanned-summary"=>"31", "supp-data"=>"34"}
  • {"scanned-page-browse"=>"5", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"19", "pdf"=>"0", "year"=>"2006", "figure"=>"52", "scanned-summary"=>"28", "supp-data"=>"25"}
  • {"month"=>"5", "scanned-page-browse"=>"16", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"2", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"11", "figure"=>"70", "scanned-summary"=>"41", "supp-data"=>"36"}
  • {"scanned-page-browse"=>"9", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2006", "figure"=>"32", "scanned-summary"=>"20", "supp-data"=>"20"}
  • {"month"=>"7", "scanned-page-browse"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"33", "scanned-summary"=>"19", "supp-data"=>"17"}
  • {"scanned-page-browse"=>"6", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2006", "figure"=>"31", "scanned-summary"=>"23", "supp-data"=>"21"}
  • {"month"=>"9", "scanned-page-browse"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"39", "scanned-summary"=>"25", "supp-data"=>"28"}
  • {"scanned-page-browse"=>"11", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"14", "pdf"=>"0", "year"=>"2006", "figure"=>"52", "scanned-summary"=>"26", "supp-data"=>"27"}
  • {"month"=>"11", "scanned-page-browse"=>"9", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"3", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"53", "scanned-summary"=>"41", "supp-data"=>"33"}
  • {"scanned-page-browse"=>"11", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2006", "figure"=>"36", "scanned-summary"=>"21", "supp-data"=>"19"}
  • {"month"=>"1", "scanned-page-browse"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"32", "scanned-summary"=>"20", "supp-data"=>"20"}
  • {"scanned-page-browse"=>"6", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2007", "figure"=>"86", "scanned-summary"=>"57", "supp-data"=>"14"}
  • {"month"=>"3", "scanned-page-browse"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"29", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"103", "scanned-summary"=>"67", "supp-data"=>"23"}
  • {"scanned-page-browse"=>"2", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"29", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"92", "scanned-summary"=>"61", "supp-data"=>"23"}
  • {"month"=>"5", "scanned-page-browse"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"87", "scanned-summary"=>"48", "supp-data"=>"23"}
  • {"scanned-page-browse"=>"22", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2007", "figure"=>"55", "scanned-summary"=>"23", "supp-data"=>"15"}
  • {"month"=>"7", "scanned-page-browse"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"10", "scanned-summary"=>"7", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"9", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"7", "pdf"=>"0", "year"=>"2007", "figure"=>"40", "scanned-summary"=>"22", "supp-data"=>"21"}
  • {"month"=>"9", "scanned-page-browse"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"29", "scanned-summary"=>"20", "supp-data"=>"16"}
  • {"scanned-page-browse"=>"8", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"1", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"39", "scanned-summary"=>"29", "supp-data"=>"26"}
  • {"month"=>"11", "scanned-page-browse"=>"21", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"50", "scanned-summary"=>"28", "supp-data"=>"25"}
  • {"scanned-page-browse"=>"11", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2007", "figure"=>"32", "scanned-summary"=>"19", "supp-data"=>"15"}
  • {"month"=>"1", "scanned-page-browse"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"25", "scanned-summary"=>"17", "supp-data"=>"17"}
  • {"scanned-page-browse"=>"8", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"8", "pdf"=>"0", "year"=>"2008", "figure"=>"34", "scanned-summary"=>"18", "supp-data"=>"16"}
  • {"month"=>"3", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"27", "scanned-summary"=>"18", "supp-data"=>"16"}
  • {"scanned-page-browse"=>"8", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2008", "figure"=>"23", "scanned-summary"=>"13", "supp-data"=>"15"}
  • {"month"=>"5", "scanned-page-browse"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"23", "scanned-summary"=>"18", "supp-data"=>"17"}
  • {"scanned-page-browse"=>"1", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2008", "figure"=>"9", "scanned-summary"=>"7", "supp-data"=>"7"}
  • {"month"=>"7", "scanned-page-browse"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"28", "scanned-summary"=>"15", "supp-data"=>"16"}
  • {"scanned-page-browse"=>"3", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2008", "figure"=>"12", "scanned-summary"=>"9", "supp-data"=>"8"}
  • {"month"=>"9", "scanned-page-browse"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"27", "scanned-summary"=>"16", "supp-data"=>"20"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "unique-ip"=>"12", "pdf"=>"10", "year"=>"2008", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "year"=>"2008", "pdf"=>"2", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"10", "pdf"=>"8", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "year"=>"2009", "pdf"=>"14", "unique-ip"=>"21", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"17", "unique-ip"=>"15", "pdf"=>"4", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"11", "year"=>"2009", "pdf"=>"3", "unique-ip"=>"11", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"16", "pdf"=>"6", "year"=>"2009", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "year"=>"2009", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "unique-ip"=>"14", "pdf"=>"12", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"28", "year"=>"2009", "pdf"=>"17", "unique-ip"=>"26", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "unique-ip"=>"16", "pdf"=>"10", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2009", "pdf"=>"19", "unique-ip"=>"20", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"5", "pdf"=>"2", "year"=>"2009", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "year"=>"2009", "pdf"=>"6", "unique-ip"=>"19", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "unique-ip"=>"12", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"18", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"24", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2004-01-01T00:00:00Z", "end_date"=>"2004-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[436, 971, 1103, 1228, 1340, 1454, 1535, 1617, 1684, 1774, 1867, 1909, 2058, 2114, 2171, 2228, 2277, 2336, 2404, 2476, 2592, 2654, 2715, 2763, 2794, 2833, 2871, 2913, 2946, 2976, 3005, 3036, 3047, 3084, 3123, 3166, 3177, 3195, 3217, 3230, 3252, 3282, 3301, 3323, 3344, 3366, 3380, 3401, 3432, 3479, 3514, 3545, 3582, 3617, 3652, 3692, 3706, 3731, 3759, 3787, 3843, 3880, 3922, 3958, 3989, 4057, 4104, 4168, 4212, 4262, 4317, 4360, 4400, 4432, 4470, 4524, 4554, 4600, 4644, 4700, 4733, 4762, 4797, 4845, 4877, 4914, 4950, 4989, 5035, 5090, 5128, 5179, 5236, 5293, 5331, 5385, 5420, 5451, 5493, 5524, 5551, 5604, 5631, 5669, 5771, 5814, 5848, 5881, 5919, 6027, 6073, 6113, 6162, 6229, 6297, 6351, 6415, 6523, 6602, 6688, 6748]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[559, 1152, 1396, 1517, 1645, 1806, 1909, 2042, 2146, 2274, 2416, 2567, 2665, 2717, 2788, 2891, 3050, 3194, 3260, 3343, 3441, 3633, 3728, 3806, 3884, 3974, 4022, 4097, 4137, 4208, 4257, 4288, 4326, 4360, 4409, 4473, 4533, 4597, 4653, 4699, 4740, 4800, 4848, 4895, 4933, 4977, 5065, 5133, 5186, 5228, 5265, 5325, 5496, 5658, 5801, 5871, 5955, 6043, 6100, 6151, 6190, 6241, 6284, 6321, 6365, 6413, 6459, 6501, 6548, 6611, 6676, 6732, 6807, 6861, 6918, 6973, 7050, 7137, 7200, 7252, 7296, 7367, 7478, 7512, 7556, 7599, 7627, 7666, 7710, 7758, 7803, 7846, 7883, 7922, 7984, 8026, 8056, 8089, 8121, 8154, 8189, 8256, 8340, 8394, 8509, 8543, 8568, 8614]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[549, 1057, 1391, 1558, 1679, 1769, 1882, 1950, 2067, 2149, 2241, 2316, 2378, 2529, 2594, 2671, 2698, 2757, 2817, 2865, 2916, 2977, 3041, 3115, 3157, 3208, 3239, 3268, 3316, 3358, 3438, 3504, 3561, 3591, 3629, 3661, 3689, 3722, 3767, 3823, 3857, 3888, 3917, 3947, 3988, 4030, 4090, 4135, 4156, 4183, 4208, 4255, 4323, 4350, 4399, 4448, 4483, 4507, 4530, 4578, 4613, 4634, 4659, 4682, 4714, 4744, 4772, 4802, 4820, 4867, 4925, 4979, 5035, 5048, 5076, 5140, 5205, 5243, 5280, 5312, 5334, 5380, 5415, 5443, 5467, 5542, 5613, 5648, 5685, 5727, 5778, 5819, 5874, 5976, 6021, 6075, 6095, 6127, 6152, 6178, 6232, 6266, 6307, 6511, 6596, 6650, 6681, 6735, 6831, 6894, 6936, 6958, 7088, 7162, 7220, 7311, 7362, 7441, 7530, 7575, 7608]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[618, 1223, 1427, 1588, 1699, 1816, 1955, 2040, 2121, 2257, 2343, 2465, 2588, 2687, 2772, 2872, 2938, 2997, 3100, 3180, 3259, 3324, 3380, 3439, 3544, 3601, 3640, 3724, 3865, 3931, 3981, 4027, 4073, 4118, 4176, 4248, 4282, 4321, 4375, 4407, 4460, 4497, 4532, 4567, 4627, 4677, 4723, 4772, 4831, 4889, 4935, 4986, 5041, 5116, 5201, 5240, 5285, 5349, 5426, 5468, 5526, 5579, 5630, 5664, 5707, 5762, 5816, 5849, 5889, 5928, 5977, 6038, 6080, 6124, 6156, 6189, 6230, 6259, 6291, 6331, 6354, 6387, 6429, 6480, 6535, 6588, 6627, 6675, 6716, 6746, 6765, 6797, 6824, 6870, 6931, 6953, 6981, 7058, 7105, 7145, 7189, 7230, 7281, 7362, 7477, 7516, 7558, 7639, 7695, 7756, 7807, 7860, 7916, 7974, 8032, 8090, 8189, 8249, 8307, 8368, 8423]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[390, 919, 1103, 1228, 1340, 1454, 1535, 1601, 1676, 1774, 1842, 1906, 2016, 2105, 2179, 2217, 2269, 2314, 2369, 2429, 2512, 2553, 2616, 2649, 2685, 2725, 2744, 2762, 2798, 2839, 2855, 2880, 2921, 2961, 2993, 3014, 3018, 3031, 3052, 3074, 3093, 3120, 3143, 3169, 3192, 3202, 3214, 3227, 3267, 3295, 3323, 3348, 3373, 3413, 3436, 3470, 3490, 3504, 3524, 3540, 3586, 3626, 3670, 3711, 3738, 3801, 3852, 3908, 3947, 3997, 4061, 4117, 4159, 4186, 4221, 4268, 4306, 4349, 4381, 4420, 4450, 4475, 4512, 4549, 4583, 4613, 4657, 4693, 4739, 4779, 4819, 4862, 4907, 4959, 5004, 5049, 5084, 5112, 5148, 5255, 5293, 5339, 5394, 5451, 5482, 5531, 5603, 5640, 5725, 5859, 5921, 5972, 6034, 6091, 6181, 6254, 6315, 6475, 6549, 6607, 6641]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[522, 1140, 1418, 1490, 1630, 1796, 1866, 1939, 2023, 2259, 2353, 2537, 2588, 2602, 2666, 2779, 3041, 3114, 3187, 3279, 3368, 3627, 3741, 3826, 3892, 3999, 4026, 4119, 4156, 4241, 4284, 4302, 4326, 4361, 4424, 4470, 4514, 4556, 4602, 4664, 4724, 4793, 4847, 4890, 4937, 4984, 5084, 5150, 5207, 5245, 5282, 5327, 5579, 5799, 6054, 6124, 6183, 6253, 6345, 6378, 6407, 6443, 6483, 6506, 6555, 6591, 6630, 6664, 6703, 6730, 6765, 6814, 6903, 6965, 7011, 7051, 7091, 7149, 7209, 7274, 7330, 7427, 7513, 7550, 7590, 7624, 7660, 7696, 7741, 7785, 7833, 7862, 7910, 7950, 7994, 8039, 8063, 8091, 8123, 8157, 8205, 8296, 8436, 8505, 8565, 8599, 8621, 8678]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[615, 1132, 1429, 1490, 1568, 1648, 1716, 1790, 1848, 1882, 1895, 1984, 2105, 2225, 2355, 2442, 2480, 2521, 2552, 2584, 2629, 2667, 2708, 2792, 2828, 2864, 2963, 3027, 3072, 3117, 3168, 3257, 3303, 3349, 3410, 3452, 3506, 3545, 3615, 3688, 3765, 3845, 3895, 3980, 4059, 4135, 4179, 4185, 4192, 4215, 4252, 4283, 4311, 4324, 4355, 4378, 4400, 4428, 4443, 4469, 4501, 4525, 4543, 4568, 4590, 4626, 4642, 4655, 4662, 4688, 4715, 4738, 4756, 4778, 4823, 4876, 4912, 4953, 4994, 5038, 5074, 5163, 5229, 5263, 5319, 5400, 5457, 5500, 5548, 5621, 5703, 5770, 5838, 5976, 6048, 6131, 6217, 6310, 6366, 6427, 6479, 6525, 6575, 6607, 6666, 6728, 6773, 6822, 6858, 6896, 7046, 7144, 7263, 7308, 7377, 7474, 7539, 7624, 7694, 7767, 7820, 7893]}, {"subject_area"=>"/People and places", "average_usage"=>[727, 1359, 1513, 1647, 1793, 1847, 1931, 2067, 2193, 2290, 2370, 2496, 2634, 2697, 2757, 2816, 2870, 3087, 3154, 3177, 3219, 3253, 3282, 3327, 3366, 3420, 3477, 3525, 3577, 3609, 3637, 3675, 3700, 3722, 3740, 3771, 3808, 3842, 3862, 3879, 3897, 3910, 3933, 3945, 3965, 3988, 4017, 4046, 4070, 4095, 4115, 4142, 4177, 4209, 4232, 4258, 4287, 4307, 4328, 4354, 4376, 4409, 4442, 4465, 4485, 4501, 4509, 4532, 4552, 4571, 4587, 4613, 4633, 4649, 4671, 4698, 4716, 4729, 4744, 4756, 4771, 4793, 4833, 4869, 4901, 4930, 4961, 4996, 5028, 5058, 5086, 5124, 5167, 5191, 5211, 5235, 5257, 5282, 5316, 5353, 5405, 5434, 5464, 5495, 5527, 5560, 5591, 5625, 5642, 5675, 5776, 5824, 5849, 5892, 5925, 5960, 5982, 6018, 6054, 6081, 6094]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[752, 1341, 1512, 1645, 1723, 1817, 1893, 2071, 2195, 2290, 2396, 2505, 2680, 2759, 2882, 2983, 3055, 3140, 3166, 3190, 3237, 3294, 3333, 3386, 3458, 3492, 3554, 3613, 3684, 3719, 3804, 3882, 3952, 3991, 4026, 4047, 4107, 4163, 4187, 4209, 4292, 4355, 4396, 4458, 4525, 4593, 4660, 4729, 4795, 4845, 4891, 4970, 5022, 5075, 5129, 5197, 5229, 5259, 5325, 5347, 5367, 5400, 5489, 5522, 5580, 5613, 5646, 5685, 5722, 5752, 5778, 5798, 5833, 5875, 5913, 5938, 5961, 5993, 6018, 6032, 6063, 6081, 6115, 6133, 6166, 6197, 6233, 6255, 6279, 6304, 6353, 6394, 6422, 6449, 6509, 6526, 6549, 6562, 6583, 6618, 6664, 6807, 6824, 6831, 6843, 6885, 6927, 6984, 7089, 7148, 7165, 7186, 7220, 7238, 7266, 7301, 7322, 7332, 7352, 7371, 7384]}]}
Loading … Spinner
There are currently no alerts