Force-Velocity Measurements of a Few Growing Actin Filaments
Publication Date
April 26, 2011
Journal
PLOS Biology
Authors
Coraline Brangbour, Olivia Du Roure, Emmanuèle Helfer, Damien Démoulin, et al
Volume
9
Issue
4
Pages
e1000613
DOI
https://dx.plos.org/10.1371/journal.pbio.1000613
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1000613
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21541364
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082516
Europe PMC
http://europepmc.org/abstract/MED/21541364
Web of Science
000289938900008
Scopus
79955505469
Mendeley
http://www.mendeley.com/research/forcevelocity-measurements-few-growing-actin-filaments
Events
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/780221"], "description"=>"<p>Experimental data are discrete open symbols, while the curves are the predictions from our model (red circles, <i>N</i><sub>GS</sub> = 10,000, 42 measurements; blue triangles, <i>N</i><sub>GS</sub> = 4,000, 41 measurements).</p>", "links"=>[], "tags"=>["profiles", "filament"], "article_id"=>450581, "categories"=>["Biochemistry", "Cell Biology", "Biophysics"], "users"=>["Coraline Brangbour", "Olivia du Roure", "Emmanuèle Helfer", "Damien Démoulin", "Alexis Mazurier", "Marc Fermigier", "Marie-France Carlier", "Jérôme Bibette", "Jean Baudry"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000613.g005", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Velocity_versus_force_profiles_for_different_filament_densities_/450581", "title"=>"Velocity versus force profiles for different filament densities.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:09:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/780174"], "description"=>"<p>(A) The number of active filaments is estimated from the area of the red surface and the measured filament density. (B) When the distance between black surfaces is large enough (<i>X</i>><i>L</i>), the filament explores the whole half sphere shaded on the figure because of thermal fluctuations (left). When <i>X, the accessible surface Ω decreases (right), leading to a repulsive force.</i></p>", "links"=>[], "tags"=>["entropy", "filament", "bead"], "article_id"=>450535, "categories"=>["Biochemistry", "Cell Biology", "Biophysics"], "users"=>["Coraline Brangbour", "Olivia du Roure", "Emmanuèle Helfer", "Damien Démoulin", "Alexis Mazurier", "Marc Fermigier", "Marie-France Carlier", "Jérôme Bibette", "Jean Baudry"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000613.g004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Orientational_entropy_of_the_filament_at_the_bead_surface_/450535", "title"=>"Orientational entropy of the filament at the bead surface.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:08:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/391380"], "description"=>"<div><p>The polymerization of actin in filaments generates forces that play a pivotal role in many cellular processes. We introduce a novel technique to determine the force-velocity relation when a few independent anchored filaments grow between magnetic colloidal particles. When a magnetic field is applied, the colloidal particles assemble into chains under controlled loading or spacing. As the filaments elongate, the beads separate, allowing the force-velocity curve to be precisely measured. In the widely accepted Brownian ratchet model, the transduced force is associated with the slowing down of the on-rate polymerization. Unexpectedly, in our experiments, filaments are shown to grow at the same rate as when they are free in solution. However, as they elongate, filaments are more confined in the interspace between beads. Higher repulsive forces result from this higher confinement, which is associated with a lower entropy. In this mechanism, the production of force is not controlled by the polymerization rate, but is a consequence of the restriction of filaments' orientational fluctuations at their attachment point.</p></div>", "links"=>[], "tags"=>["force-velocity", "measurements", "actin", "filaments"], "article_id"=>137289, "categories"=>["Biochemistry", "Cell Biology", "Biophysics"], "users"=>["Coraline Brangbour", "Olivia du Roure", "Emmanuèle Helfer", "Damien Démoulin", "Alexis Mazurier", "Marc Fermigier", "Marie-France Carlier", "Jérôme Bibette", "Jean Baudry"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000613", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Force_Velocity_Measurements_of_a_Few_Growing_Actin_Filaments/137289", "title"=>"Force-Velocity Measurements of a Few Growing Actin Filaments", "pos_in_sequence"=>0, "defined_type"=>2, "published_date"=>"2011-04-26 02:01:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/780101"], "description"=>"<p>Instantaneous force-distance profile for different filament initial lengths: applied force <i>f</i> as a function of the distance <i>X</i> between the surfaces of adjacent beads. Experimental data correspond to a cycle of compression and decompression (<i>N</i><sub>GS</sub> = 4,000; blue triangles, <i>L</i><sub>0</sub> = 400 nm and <i>t</i><sub>0</sub> = 1,020 s; green circles, <i>L</i><sub>0</sub> = 200 nm and <i>t</i><sub>0</sub> = 480 s). For clarity, the <i>L</i><sub>0</sub> = 400 nm data are shifted by 5 nm to the right). Solid and dash lines are predictions of our model with <i>c</i> = 0.2±0.1, with <i>L</i> = 200 nm and <i>L</i> = 400 nm, respectively.</p>", "links"=>[], "tags"=>["biochemistry/experimental biophysical methods", "biochemistry/macromolecular assemblies and machines", "biophysics/macromolecular assemblies and machines", "cell biology/cytoskeleton"], "article_id"=>450458, "categories"=>["Biochemistry", "Cell Biology", "Biophysics"], "users"=>["Coraline Brangbour", "Olivia du Roure", "Emmanuèle Helfer", "Damien Démoulin", "Alexis Mazurier", "Marc Fermigier", "Marie-France Carlier", "Jérôme Bibette", "Jean Baudry"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000613.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Elastic_response_of_filaments_/450458", "title"=>"Elastic response of filaments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/779915"], "description"=>"<p>(A) Schematics of the experiment: actin polymerization is initiated at the bead surface by gelsolin, and pushes the beads apart. (B) Bright-field images of a colloid chain, aligned under a 5-mT magnetic field, at two different times. Actin filaments are not dense enough to be seen. Scale bar, 5 µm. (C) Evolution of the center-to-center distance <i>d</i> with time for different loading forces. The distance increases linearly with time, allowing a direct measurement of the beads relative velocity. (D) Velocity versus loading force profile. Error bars indicate estimated error (standard deviation) from the slope determination in (C). For the largest forces, the error bars are smaller than the symbols. Number of filaments per particle: <i>N</i><sub>GS</sub> = 10,000.</p>", "links"=>[], "tags"=>["velocity"], "article_id"=>450283, "categories"=>["Biochemistry", "Cell Biology", "Biophysics"], "users"=>["Coraline Brangbour", "Olivia du Roure", "Emmanuèle Helfer", "Damien Démoulin", "Alexis Mazurier", "Marc Fermigier", "Marie-France Carlier", "Jérôme Bibette", "Jean Baudry"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000613.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Experimental_scheme_and_representative_velocity_versus_force_measurements_/450283", "title"=>"Experimental scheme and representative velocity versus force measurements.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:04:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/780018"], "description"=>"<p>The bottom graph shows the evolution of the center-to-center distance <i>d</i> as a function of the time <i>t</i> for an experiment where the applied force is represented in top graph as a function of <i>t</i>. Circles are experimental data. In this experiment, the chain is formed at low force (<i>f</i> = 0.8 pN). At time <i>t</i> = 650 s the force is increased to a higher value (<i>f</i> = 39 pN), and at time <i>t</i> = 855 s the force is reduced to the first value. The line is the best linear fit for the points at low forces: <i>v</i><sub>bead</sub> = 0.302±0.004 nm/s; the intercept is 1,132±3 nm, which is the beads' diameter. <i>N</i><sub>GS</sub> = 10,000.</p>", "links"=>[], "tags"=>["actin", "filaments", "applied"], "article_id"=>450380, "categories"=>["Biochemistry", "Cell Biology", "Biophysics"], "users"=>["Coraline Brangbour", "Olivia du Roure", "Emmanuèle Helfer", "Damien Démoulin", "Alexis Mazurier", "Marc Fermigier", "Marie-France Carlier", "Jérôme Bibette", "Jean Baudry"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1000613.g002", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Growth_of_actin_filaments_is_independent_of_applied_force_/450380", "title"=>"Growth of actin filaments is independent of applied force.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-26 00:06:20"}

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