Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass
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{"title"=>"Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass", "type"=>"journal", "authors"=>[{"first_name"=>"Amandine", "last_name"=>"Girousse", "scopus_author_id"=>"26633739100"}, {"first_name"=>"Geneviève", "last_name"=>"Tavernier", "scopus_author_id"=>"7004596044"}, {"first_name"=>"Carine", "last_name"=>"Valle", "scopus_author_id"=>"16679949100"}, {"first_name"=>"Cedric", "last_name"=>"Moro", "scopus_author_id"=>"7005879492"}, {"first_name"=>"Niklas", "last_name"=>"Mejhert", "scopus_author_id"=>"32167659900"}, {"first_name"=>"Anne Laure", "last_name"=>"Dinel", "scopus_author_id"=>"53871362300"}, {"first_name"=>"Marianne", "last_name"=>"Houssier", "scopus_author_id"=>"22234252200"}, {"first_name"=>"Balbine", "last_name"=>"Roussel", "scopus_author_id"=>"27067986100"}, {"first_name"=>"Aurèle", "last_name"=>"Besse-Patin", "scopus_author_id"=>"46061875300"}, {"first_name"=>"Marion", "last_name"=>"Combes", "scopus_author_id"=>"57197914959"}, {"first_name"=>"Lucile", "last_name"=>"Mir", "scopus_author_id"=>"55616692100"}, {"first_name"=>"Laurent", "last_name"=>"Monbrun", "scopus_author_id"=>"6504212017"}, {"first_name"=>"Véronic", "last_name"=>"Bézaire", "scopus_author_id"=>"6507729802"}, {"first_name"=>"Bénédicte", "last_name"=>"Prunet-Marcassus", "scopus_author_id"=>"22944989700"}, {"first_name"=>"Aurélie", "last_name"=>"Waget", "scopus_author_id"=>"25222234100"}, {"first_name"=>"Isabelle", "last_name"=>"Vila", "scopus_author_id"=>"55616465300"}, {"first_name"=>"Sylvie", "last_name"=>"Caspar-Bauguil", "scopus_author_id"=>"6603043880"}, {"first_name"=>"Katie", "last_name"=>"Louche", "scopus_author_id"=>"22953892200"}, {"first_name"=>"Marie Adeline", "last_name"=>"Marques", "scopus_author_id"=>"7201744157"}, {"first_name"=>"Aline", "last_name"=>"Mairal", "scopus_author_id"=>"6701496147"}, {"first_name"=>"Marie Laure", "last_name"=>"Renoud", "scopus_author_id"=>"36167389300"}, {"first_name"=>"Jean", "last_name"=>"Galitzky", "scopus_author_id"=>"7006153950"}, {"first_name"=>"Cecilia", "last_name"=>"Holm", "scopus_author_id"=>"7101642167"}, {"first_name"=>"Etienne", "last_name"=>"Mouisel", "scopus_author_id"=>"8577400500"}, {"first_name"=>"Claire", "last_name"=>"Thalamas", "scopus_author_id"=>"6701537689"}, {"first_name"=>"Nathalie", "last_name"=>"Viguerie", "scopus_author_id"=>"6603947200"}, {"first_name"=>"Thierry", "last_name"=>"Sulpice", "scopus_author_id"=>"23482589700"}, {"first_name"=>"Rémy", "last_name"=>"Burcelin", "scopus_author_id"=>"20435540000"}, {"first_name"=>"Peter", "last_name"=>"Arner", "scopus_author_id"=>"35418283400"}, {"first_name"=>"Dominique", "last_name"=>"Langin", "scopus_author_id"=>"7005382989"}], "year"=>2013, "source"=>"PLoS Biology", "identifiers"=>{"doi"=>"10.1371/journal.pbio.1001485", "sgr"=>"84874692963", "isbn"=>"1544-9173", "pmid"=>"23431266", "issn"=>"15449173", "arxiv"=>"NIHMS150003", "scopus"=>"2-s2.0-84874692963", "pui"=>"368467344"}, "id"=>"890700fe-5116-394c-8ae6-1709cf3091a9", "abstract"=>"When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. However, whether and how chronic inhibition of fat mobilization from WAT modulates insulin sensitivity remains elusive. Hormone-sensitive lipase (HSL) participates in the breakdown of WAT triacylglycerol into FAs. HSL haploinsufficiency and treatment with a HSL inhibitor resulted in improvement of insulin tolerance without impact on body weight, fat mass, and WAT inflammation in high-fat-diet-fed mice. In vivo palmitate turnover analysis revealed that blunted lipolytic capacity is associated with diminution in FA uptake and storage in peripheral tissues of obese HSL haploinsufficient mice. The reduction in FA turnover was accompanied by an improvement of glucose metabolism with a shift in respiratory quotient, increase of glucose uptake in WAT and skeletal muscle, and enhancement of de novo lipogenesis and insulin signalling in liver. In human adipocytes, HSL gene silencing led to improved insulin-stimulated glucose uptake, resulting in increased de novo lipogenesis and activation of cognate gene expression. In clinical studies, WAT lipolytic rate was positively and negatively correlated with indexes of insulin resistance and WAT de novo lipogenesis gene expression, respectively. In obese individuals, chronic inhibition of lipolysis resulted in induction of WAT de novo lipogenesis gene expression. Thus, reduction in WAT lipolysis reshapes FA fluxes without increase of fat mass and improves glucose metabolism through cell-autonomous induction of fat cell de novo lipogenesis, which contributes to improved insulin sensitivity.", "link"=>"http://www.mendeley.com/research/partial-inhibition-adipose-tissue-lipolysis-improves-glucose-metabolism-insulin-sensitivity-without", "reader_count"=>128, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>9, "Student > Doctoral Student"=>8, "Researcher"=>34, "Student > Ph. D. Student"=>33, "Student > Postgraduate"=>10, "Other"=>6, "Student > Master"=>16, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>9, "Student > Doctoral Student"=>8, "Researcher"=>34, "Student > Ph. D. Student"=>33, "Student > Postgraduate"=>10, "Other"=>6, "Student > Master"=>16, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>69, "Arts and Humanities"=>1, "Chemistry"=>2, "Biochemistry, Genetics and Molecular Biology"=>18, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>23, "Neuroscience"=>2, "Sports and Recreations"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>2, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>23}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>69}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>18}}, "reader_count_by_country"=>{"Austria"=>1, "United States"=>4, "Mexico"=>1, "France"=>1, "Portugal"=>3, "Germany"=>3}, "group_count"=>9}

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  • {"files"=>["https://ndownloader.figshare.com/files/690530"], "description"=>"<p>(A) Up-regulation of glucose transporter 4 and de novo lipogenesis-related pathways. Induction of gene expression (red boxes) in hMADS adipocytes with HSL gene silencing were determined by DNA microarray analysis and validated by reverse transcription-quantitative PCR (indicated by *). (B) Up-regulation of glucose transporter 4 and de novo lipogenesis-related pathway gene expression in hMADS adipocytes. mRNA levels were determined by reverse transcription-quantitative PCR (<i>n</i> = 9–12). ** <i>p</i><0.01 versus siGFP. (C) Correlations between glucose transporter 4, carbohydrate responsive element-binding protein, and fatty acid synthase mRNA levels and, lipolysis in human WAT (<i>n</i> = 45). (D) Up-regulation of glucose transporter 4 and de novo lipogenesis-related pathway gene expression in adipocytes from obese individuals treated with placebo or nicotinic acid (<i>n</i> = 12 per group). * <i>p</i><0.05, ** <i>p</i><0.01 versus before treatment. ACC, acetylCoA carboxylase; ACL, ATP citrate lyase; ACS, acetyl-CoA synthase; ChREBP, carbohydrate responsive element-binding protein; DCT, dicarboxylate transporter; FAE, fatty acid elongase; FAS, fatty acid synthase; GPDH, glycerol-3-phosphate dehydrogenase; GLUT4, glucose transporter 4; G6PDH, glucose-6-phosphate dehydrogenase; LDH, lactate dehydrogenase; MDH, malate dehydrogenase; ME, malic enzyme; PC, pyruvate carboxylase; PDH, pyruvate dehydrogenase; PK, pyruvate kinase; SCD, stearoylCoA desaturase.</p>", "links"=>[], "tags"=>["wat", "lipolysis", "de", "novo"], "article_id"=>361032, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g009", "stats"=>{"downloads"=>0, "page_views"=>88, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_WAT_lipolysis_and_de_novo_lipogenesis_/361032", "title"=>"Relationship between WAT lipolysis and de novo lipogenesis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:17:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/690015"], "description"=>"<p>(A) Plasma parameters of fatty acid fluxes. (B) Rate of radiolabelled fatty acid incorporation in the TG pool of tissues. (C) Total TG content in tissues. Values are means ± SEM. WT mice (▪) (<i>n</i> = 5) and HSL<sup>+/<b>−</b></sup> mice (□) (<i>n</i> = 6). * <i>p</i><0.05, *** <i>p</i><0.001 versus WT mice.</p>", "links"=>[], "tags"=>["vivo", "fatty", "fluxes", "hfd-fed", "wt"], "article_id"=>360522, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g005", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_vivo_fatty_acid_fluxes_in_HFD_fed_HSL_8722_and_WT_mice_/360522", "title"=>"In vivo fatty acid fluxes in HFD-fed HSL<sup>+/−</sup> and WT mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:08:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/690665", "https://ndownloader.figshare.com/files/690727", "https://ndownloader.figshare.com/files/690790", "https://ndownloader.figshare.com/files/690857", "https://ndownloader.figshare.com/files/690915"], "description"=>"<div><p>When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. However, whether and how chronic inhibition of fat mobilization from WAT modulates insulin sensitivity remains elusive. Hormone-sensitive lipase (HSL) participates in the breakdown of WAT triacylglycerol into FAs. HSL haploinsufficiency and treatment with a HSL inhibitor resulted in improvement of insulin tolerance without impact on body weight, fat mass, and WAT inflammation in high-fat-diet–fed mice. In vivo palmitate turnover analysis revealed that blunted lipolytic capacity is associated with diminution in FA uptake and storage in peripheral tissues of obese HSL haploinsufficient mice. The reduction in FA turnover was accompanied by an improvement of glucose metabolism with a shift in respiratory quotient, increase of glucose uptake in WAT and skeletal muscle, and enhancement of de novo lipogenesis and insulin signalling in liver. In human adipocytes, HSL gene silencing led to improved insulin-stimulated glucose uptake, resulting in increased de novo lipogenesis and activation of cognate gene expression. In clinical studies, WAT lipolytic rate was positively and negatively correlated with indexes of insulin resistance and WAT de novo lipogenesis gene expression, respectively. In obese individuals, chronic inhibition of lipolysis resulted in induction of WAT de novo lipogenesis gene expression. Thus, reduction in WAT lipolysis reshapes FA fluxes without increase of fat mass and improves glucose metabolism through cell-autonomous induction of fat cell de novo lipogenesis, which contributes to improved insulin sensitivity.</p> </div>", "links"=>[], "tags"=>["inhibition", "adipose", "lipolysis", "improves", "glucose", "metabolism", "insulin", "alteration", "mass"], "article_id"=>361165, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.1001485.s001", "https://dx.doi.org/10.1371/journal.pbio.1001485.s002", "https://dx.doi.org/10.1371/journal.pbio.1001485.s003", "https://dx.doi.org/10.1371/journal.pbio.1001485.s004", "https://dx.doi.org/10.1371/journal.pbio.1001485.s005"], "stats"=>{"downloads"=>14, "page_views"=>144, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Partial_Inhibition_of_Adipose_Tissue_Lipolysis_Improves_Glucose_Metabolism_and_Insulin_Sensitivity_Without_Alteration_of_Fat_Mass__/361165", "title"=>"Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-02-19 00:19:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/690053"], "description"=>"<p>(A) Insulin tolerance test performed on wild type and HSL<sup>+/−</sup> mice fed a HFD for 12 wk. (B) Glucose tolerance test performed on wild type and HSL<sup>+/−</sup> mice fed a HFD for 12 wk. (C) Insulin tolerance test performed on the same animals fed first a chow diet for 6 wk (dotted curve) and then a HFD for 6 wk (solid curve). (D) Insulin tolerance test performed on wild type and HSL<sup>+/−</sup> mice fed a diet enriched in fructose for 45 wk after weaning. (E–F) Insulin tolerance test (E) and body weight and body composition (F) in 12-wk HFD-fed B6D2 mice treated with a specific HSL inhibitor for 7 d. (G) Insulin tolerance test in 7-wk HFD-C3H/HeJ mice treated with a specific HSL inhibitor for 7 d. (H–I) Glucose tolerance test (H) and plasma insulin at 15 min (I) in LepR<sup>db</sup>/LepR<sup>db</sup> mice treated with a specific HSL inhibitor for 13 d. AUC, area-under-curve expressed as arbitrary units (a.u.). Body weights at the time of the tolerance tests are shown. Values are means ± SEM. WT mice (▪) (<i>n</i> = 6–10) and HSL<sup>+/−</sup> mice (□) (<i>n</i> = 8–10). B6D2 (▪) and HSL inhibitor-treated B6D2 (□) mice (<i>n</i> = 10). C3H/HeJ (▪) and HSL inhibitor-treated C3H/HeJ (□) mice (<i>n</i> = 8–10). Vehicle- (▪) and HSL inhibitor-treated LepR<sup>db</sup>/LepR<sup>db</sup> (□) mice (<i>n</i> = 12). * <i>p</i><0.05, ** <i>p</i><0.01 versus control mice.</p>", "links"=>[], "tags"=>["glucose", "mice", "diminished", "hsl"], "article_id"=>360558, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g006", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Insulin_and_glucose_tolerance_in_mice_with_diminished_HSL_activity_/360558", "title"=>"Insulin and glucose tolerance in mice with diminished HSL activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:09:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/689603"], "description"=>"<p>(A) Simple linear regression between lipolysis and HOMA-IR (<i>n</i> = 367). (B) Simple linear regression between lipolysis and insulin tolerance (<i>n</i> = 126). (C) BMI and HOMA-IR before and 2 y after bariatric surgery (<i>n</i> = 25). (D) Correlation between variations in lipolysis and changes in HOMA-IR following bariatric surgery (<i>n</i> = 25).</p>", "links"=>[], "tags"=>["wat", "lipolytic", "capacities", "insulin"], "article_id"=>360112, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_WAT_lipolytic_capacities_and_insulin_sensitivity_in_human_subjects_/360112", "title"=>"Relationship between WAT lipolytic capacities and insulin sensitivity in human subjects.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:01:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1004671"], "description"=>"<p>Values (<i>n</i> = 6–17) are means ± SEM. NEFA, nonesterified fatty acid; QUICKI, quantitative insulin sensitivity check index; RBP4, retinol binding protein 4.</p>", "links"=>[], "tags"=>["plasma", "12-wk", "hfd-fed", "mice", "treated", "hsl", "inhibitor"], "article_id"=>665266, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fasting_plasma_parameters_in_12_wk_wild_type_WT_and_HSL_8722_HFD_fed_mice_and_in_12_wk_wild_type_HFD_fed_mice_treated_with_vehicle_or_HSL_specific_inhibitor_HSLi_for_7_consecutive_days_/665266", "title"=>"Fasting plasma parameters in 12-wk wild type (WT) and HSL<sup>+/−</sup> HFD-fed mice and in 12-wk wild type HFD-fed mice treated with vehicle or HSL specific inhibitor (HSLi) for 7 consecutive days.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 01:27:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/690601"], "description"=>"<p>Partial inhibition of lipolysis modifies FA flux with a decrease in WAT FA uptake concurring to maintenance of fat mass and an increase in glucose uptake that favours de novo lipogenesis, which may be a key player in the restoration of insulin sensitivity. DNL, de novo lipogenesis; FA, fatty acid; NEFA, nonesterified fatty acid; TG, triacylglycerol.</p>", "links"=>[], "tags"=>["inhibition", "wat", "lipolysis", "fatty", "glucose", "metabolism", "insulin"], "article_id"=>361102, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g010", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Consequence_of_partial_inhibition_of_WAT_lipolysis_on_fatty_acid_and_glucose_metabolism_and_insulin_sensitivity_/361102", "title"=>"Consequence of partial inhibition of WAT lipolysis on fatty acid and glucose metabolism and insulin sensitivity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:18:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/689959"], "description"=>"<p>(A) Macrophage (CD45/F480/CD11b triple positive cells) number per milligram of WAT assessed by flow cytometry. (B) mRNA expression of WAT macrophage surface markers. (C) mRNA expression of WAT inflammatory markers. Values are means ± SEM. WT mice (▪) (<i>n</i> = 7) and HSL<sup>+/<b>−</b></sup> mice (□) (<i>n</i> = 8).</p>", "links"=>[], "tags"=>["inflammation", "12-wk", "hfd-fed", "wt"], "article_id"=>360470, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WAT_inflammation_in_12_wk_HFD_fed_HSL_8722_and_WT_mice_/360470", "title"=>"WAT inflammation in 12-wk HFD-fed HSL<sup>+/−</sup> and WT mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:07:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/689808"], "description"=>"<p>Mice were first provided <i>ad libitum</i> access to a standard diet for 8 wk after weaning. Then they received a HFD shown as a thick line for 12 to 16 wk. (A) Body weight curves. (B) Fat mass. (C) Fat pad weight. (D) WAT morphology. Scale bar, 100 µm. (E) Frequency of adipocyte diameter observed on histological preparation of WAT. (F) In vitro adipogenesis of progenitor cells from the subcutaneous WAT stromavascular fraction. Values show results of WAT pools from 2–3 mice. (G) WAT neutral lipids. CE, cholesterol ester; chol, free cholesterol; DG, diacylglycerol; TG, triacylglycerol. (H) Food intake. (I) Energy expenditure assessed by indirect calorimetry. Values are means ± SEM. WT mice (black bars) (<i>n</i> = 5–10), HSL<sup>+/−</sup> mice (white bars) (<i>n</i> = 5–10), and HSL<sup>−/−</sup> mice (gray bars) (<i>n</i> = 4). *** <i>p</i><0.001 versus WT mice.</p>", "links"=>[], "tags"=>["hfd-fed", "wt"], "article_id"=>360312, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g003", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Energy_balance_of_HFD_fed_HSL_8722_and_WT_mice_/360312", "title"=>"Energy balance of HFD-fed HSL<sup>+/−</sup> and WT mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:05:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/689650"], "description"=>"<p>(A) mRNA expression of HSL (lipe), ATGL (pnpla2), CGI-58 (abhd5), and plin1 in epididymal WAT. (B–C) Western blot analysis of HSL (B) and ATGL (C) protein expression. (D–E) In vitro hydrolase activities against cholesterol ester (D) and TG (E) analogs in the absence and presence of HSL specific inhibitor. (F) In vitro basal and isoproterenol-stimulated (ISO) lipolysis in isolated adipocytes. (G) In vivo lipolysis expressed as fold increase over saline. Plasma glycerol levels were measured 15 min after saline or isoproterenol injection. Values are means ± SEM. WT mice (black bars) (<i>n</i> = 6–8); HSL<sup>+/−</sup> mice (white bars) (<i>n</i> = 6–9); HSL<sup>−/−</sup> mice (gray bars) (<i>n</i> = 4). * <i>p</i><0.05, ** <i>p</i><0.01, *** <i>p</i><0.001 versus WT mice; <sup>### </sup><i>p</i><0.001 versus basal condition.</p>", "links"=>[], "tags"=>["lipases", "lipolysis", "hfd-fed"], "article_id"=>360154, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g002", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WAT_lipases_and_lipolysis_in_HFD_fed_WT_HSL_8722_and_HSL_8722_8722_mice_/360154", "title"=>"WAT lipases and lipolysis in HFD-fed WT, HSL<sup>+/−</sup>, and HSL<sup>−/−</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:02:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/690225"], "description"=>"<p>(A) In vivo 2-deoxy-D-[<sup>3</sup>H] glucose uptake under stimulation by insulin in skeletal muscle (<i>biceps femoris</i>—BF—and <i>soleus</i>) and WAT. (B) Ex vivo glucose oxidation in <i>soleus</i> muscle. (C) Respiratory quotient assessed by indirect calorimetry and expressed as percentage of cumulative relative frequencies (PCRF). EC<sub>50</sub> are represented by arrows. (D) In vivo insulin bolus. Variation in plasma glucose 15 min after injection of saline or insulin (a.u., arbitrary unit). (E) Effect of insulin bolus in vivo on hepatic insulin signalling. IRS1, insulin receptor substrate 1; Akt, protein kinase B. (F) Hepatic de novo lipogenesis. Measurement of radiolabelled glucose incorporation in lipid fraction of liver after insulin stimulation. (G) Pyruvate tolerance test. (H) Liver glycogen content assessed in mice starved for 24 h and then refed for 18 h. Values are means ± SEM. WT mice (▪ or ▴) and HSL<sup>+/−</sup> mice (□) mice (<i>n</i> = 4–10 in each group). * <i>p</i><0.05, ** <i>p</i><0.01 versus WT mice.</p>", "links"=>[], "tags"=>["metabolism", "insulin", "mice", "reduced", "hsl"], "article_id"=>360732, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g007", "stats"=>{"downloads"=>1, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glucose_metabolism_and_insulin_sensitivity_in_mice_with_reduced_HSL_activity_/360732", "title"=>"Glucose metabolism and insulin sensitivity in mice with reduced HSL activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:12:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/690353"], "description"=>"<p>(A) HSL (LIPE) expression as mRNA (upper panel) and protein (lower panel). (B) Fatty acid oxidation. (C) Basal and insulin-stimulated glucose uptake. (D) Basal and insulin-stimulated glucose oxidation. (E–F) Basal and insulin-stimulated glucose carbon incorporation into glycerol (E) or fatty acid (F) of neutral lipids. hMADS adipocytes were transfected either with a siRNA against GFP (control; siGFP) or HSL (siHSL). Data are fold induction of siGFP values (means ± SEM). siGFP adipocytes (▪) and siHSL adipocytes (□) (<i>n</i> = 5–10). * <i>p</i><0.05, ** <i>p</i><0.01 versus siGFP.</p>", "links"=>[], "tags"=>["glucose", "fatty", "hmads"], "article_id"=>360853, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry"], "users"=>["Amandine Girousse", "Geneviève Tavernier", "Carine Valle", "Cedric Moro", "Niklas Mejhert", "Anne-Laure Dinel", "Marianne Houssier", "Balbine Roussel", "Aurèle Besse-Patin", "Marion Combes", "Lucile Mir", "Laurent Monbrun", "Véronic Bezaire", "Bénédicte Prunet-Marcassus", "Aurélie Waget", "Isabelle Vila", "Sylvie Caspar-Bauguil", "Katie Louche", "Marie-Adeline Marques", "Aline Mairal", "Marie-Laure Renoud", "Jean Galitzky", "Cecilia Holm", "Etienne Mouisel", "Claire Thalamas", "Nathalie Viguerie", "Thierry Sulpice", "Rémy Burcelin", "Peter Arner", "Dominique Langin"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1001485.g008", "stats"=>{"downloads"=>2, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fate_of_glucose_and_fatty_acid_in_hMADS_adipocytes_/360853", "title"=>"Fate of glucose and fatty acid in hMADS adipocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 00:14:13"}

PMC Usage Stats | Further Information

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Relative Metric

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