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{"title"=>"Chronos: Stress Makes the Clock Tick", "type"=>"journal", "authors"=>[{"first_name"=>"Richard", "last_name"=>"Robinson", "scopus_author_id"=>"8057217000"}], "year"=>2014, "source"=>"PLoS Biology", "identifiers"=>{"scopus"=>"2-s2.0-84900459204", "pmid"=>"24736971", "sgr"=>"84900459204", "doi"=>"10.1371/journal.pbio.1001838", "isbn"=>"10.1371/journal.pbio.1001838", "issn"=>"15457885", "pui"=>"373077097"}, "id"=>"4ea0c3c8-d29d-30c2-b2b9-571f988eee90", "abstract"=>"This article discusses the role of canonical clock genes in eliciting stress responses. There is a clock inside every mammalian cell whose complexity exceeds that of any Swiss watch. Beginning in the early 1990s, the pieces of the clock have gradually become known, with most researchers believing that most of the major components have now been identified. The parts list takes another major step towards completion in this issue of PLoS Biology as two independent groups describe the discovery of an important new clock gene. The first group of researchers began their search for new clock genes by defining five features of known ones: an endogenous expression cycle with an approximately 24-hour period; loss of expression causing an effect on circadian behavioral rhythm; interaction with other known clock components; expression in most tissues; and sequence conservation between flies and vertebrates. The second group of researchers performed a genome-wide chromatin immunoprecipitation analysis for genes that were the target of BMAL1, a core clock component that binds to many clock genes, regulating their transcription and found that CHRONO CHRONO interacted with histone deacetylase, in so doing helping to regulate multiple other genes by repressing their translation and showed that organism-wide organism-wide stress responses were regulated by CHRONO, through its interaction with the glucocorticoid receptor, repressing the receptor’s function in a circadian fashion. (PsycINFO Database Record (c) 2014 APA, all rights reserved)", "link"=>"http://www.mendeley.com/research/chronos-stress-makes-clock-tick", "reader_count"=>29, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>15, "Physics and Astronomy"=>1, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "France"=>2, "Portugal"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Relative Metric

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