Why Is Aging Conserved and What Can We Do about It?
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{"title"=>"Why Is Aging Conserved and What Can We Do about It?", "type"=>"generic", "authors"=>[{"first_name"=>"Jason N.", "last_name"=>"Pitt", "scopus_author_id"=>"7103389549"}, {"first_name"=>"Matt", "last_name"=>"Kaeberlein", "scopus_author_id"=>"6602710772"}], "year"=>2015, "source"=>"PLoS Biology", "identifiers"=>{"issn"=>"15457885", "scopus"=>"2-s2.0-84929493833", "sgr"=>"84929493833", "pui"=>"604135617", "isbn"=>"1545-7885", "pmid"=>"25923592", "doi"=>"10.1371/journal.pbio.1002131"}, "id"=>"e88b4dd2-cd56-32f5-81bc-d0b70092cc17", "abstract"=>"Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic response and has been a prime therapeutic target for ischemia/reperfusion (I/R)-derived myocardial dysfunction and tissue damage. There is also increasing evidence that HIF-1 plays a central role in regulating aging, both through interactions with key longevity factors including Sirtuins and mTOR, as well as by directly promoting longevity in Caenorhabditis elegans.We investigated a novel function and the underlying mechanism of syringaresinol, a lignan compound, in modulation of HIF-1 and protection against cellular damage and death in a cardiomyocyte model of I/R injury. Syringaresinol caused destabilization of HIF-1α following H/R and then protected against hypoxia/reoxygenation (H/R)-induced cellular damage, apoptosis, and mitochondrial dysfunction in a dose-dependent manner. Knock-down of FOXO3 by specific siRNAs completely abolished the ability of syringaresinol to inhibit HIF-1 stabilization and apoptosis caused by H/R. Syringaresinol stimulated the nuclear localization and activity of FOXO3 leading to increased expression of antioxidant genes and decreased levels of reactive oxygen species (ROS) following H/R. Our results provide a new mechanistic insight into a functional role of syringaresinol against H/R-induced cardiomyocyte injury and death. The degradation of HIF-1α through activation of FOXO3 is a potential therapeutic strategy for ischemia-related diseases.", "link"=>"http://www.mendeley.com/research/aging-conserved-we-about-it", "reader_count"=>121, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>3, "Researcher"=>34, "Student > Ph. D. Student"=>35, "Student > Postgraduate"=>4, "Student > Master"=>10, "Other"=>9, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>10}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>3, "Researcher"=>34, "Student > Ph. D. Student"=>35, "Student > Postgraduate"=>4, "Student > Master"=>10, "Other"=>9, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>10}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>70, "Chemistry"=>1, "Computer Science"=>1, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>26, "Medicine and Dentistry"=>7, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Psychology"=>2, "Immunology and Microbiology"=>2, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>70}, "Computer Science"=>{"Computer Science"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>26}}, "reader_count_by_country"=>{"Sweden"=>1, "Austria"=>1, "Netherlands"=>2, "Turkey"=>1, "United States"=>5, "Japan"=>1, "Brazil"=>1, "United Kingdom"=>2, "France"=>1, "Switzerland"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2044105"], "description"=>"<p>Organisms have evolved to grow and reproduce rapidly when environmental conditions, including temperature, oxygen levels, and food availability, are within optimal ranges. When these parameters are suboptimal but not lethal, organisms tend to become stress resistant and, perhaps as a by-product, longer lived. Conserved sensory pathways mediate this relationship, although there is also evidence that signals from the germ line can affect stress resistance and longevity and vice versa.</p>", "links"=>[], "tags"=>["Genetic modulators", "intervention", "research", "briefly review", "Aging Conserved"], "article_id"=>1397805, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Jason N. Pitt", "Matt Kaeberlein"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002131.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Environmental_signals_that_modulate_growth_and_reproduction_also_modulate_aging_/1397805", "title"=>"Environmental signals that modulate growth and reproduction also modulate aging.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-29 02:59:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2044106"], "description"=>"<p>**There is indirect evidence that each of these is associated with health span or longevity in humans. For specific examples, see references [<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002131#pbio.1002131.ref008\" target=\"_blank\">8</a>–<a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002131#pbio.1002131.ref049\" target=\"_blank\">49</a>] and <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002131#pbio.1002131.s001\" target=\"_blank\">S1 Text</a>. Abbreviations: AMPK, 5ʹ adenosine monophosphate-activated protein kinase; ILS, insulin-like signaling; mTOR, mechanistic target of rapamycin; NAD, nicotinamide adenine dinucleotide; SOD, superoxide dismutase.</p><p>Some conserved pathways and interventions of aging.</p>", "links"=>[], "tags"=>["Genetic modulators", "intervention", "research", "briefly review", "Aging Conserved"], "article_id"=>1397806, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Jason N. Pitt", "Matt Kaeberlein"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002131.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Some_conserved_pathways_and_interventions_of_aging_/1397806", "title"=>"Some conserved pathways and interventions of aging.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-29 02:59:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2044104"], "description"=>"<p>Incidence of disparate pathological conditions all showing a strong correlation with advanced human age. Many of these same conditions are also seen in aged dogs.</p>", "links"=>[], "tags"=>["Genetic modulators", "intervention", "research", "briefly review", "Aging Conserved"], "article_id"=>1397804, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Jason N. Pitt", "Matt Kaeberlein"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002131.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Common_pathologies_of_aging_/1397804", "title"=>"Common pathologies of aging.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-29 02:59:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2044107"], "description"=>"<div><p>The field of aging research has progressed rapidly over the past few decades. Genetic modulators of aging rate that are conserved over a broad evolutionary distance have now been identified. Several physiological and environmental interventions have also been shown to influence the rate of aging in organisms ranging from yeast to mammals. Here we briefly review these conserved pathways and interventions and highlight some key unsolved challenges that remain. Although the molecular mechanisms by which these modifiers of aging act are only partially understood, interventions to slow aging are nearing clinical application, and it is likely that we will begin to reap the benefits of aging research prior to solving all of the mysteries that the biology of aging has to offer.</p></div>", "links"=>[], "tags"=>["Genetic modulators", "intervention", "research", "briefly review", "Aging Conserved"], "article_id"=>1397807, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Jason N. Pitt", "Matt Kaeberlein"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002131", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Why_Is_Aging_Conserved_and_What_Can_We_Do_about_It_/1397807", "title"=>"Why Is Aging Conserved and What Can We Do about It?", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-29 02:59:18"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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