Membrane Potential Dynamics of Spontaneous and Visually Evoked Gamma Activity in V1 of Awake Mice
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{"title"=>"Membrane Potential Dynamics of Spontaneous and Visually Evoked Gamma Activity in V1 of Awake Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Quentin", "last_name"=>"Perrenoud", "scopus_author_id"=>"35300239900"}, {"first_name"=>"Cyriel M.A.", "last_name"=>"Pennartz", "scopus_author_id"=>"7003645919"}, {"first_name"=>"Luc J.", "last_name"=>"Gentet", "scopus_author_id"=>"6505888501"}], "year"=>2016, "source"=>"PLoS Biology", "identifiers"=>{"doi"=>"10.1371/journal.pbio.1002383", "sgr"=>"84959476754", "pmid"=>"26890123", "issn"=>"15457885", "scopus"=>"2-s2.0-84959476754", "pui"=>"608714029"}, "id"=>"f82df965-270c-38cd-99a3-c82313c416a6", "abstract"=>"Cortical gamma activity (30-80 Hz) is believed to play important functions in neural computation and arises from the interplay of parvalbumin-expressing interneurons (PV) and pyramidal cells (PYRs). However, the subthreshold dynamics underlying its emergence in the cortex of awake animals remain unclear. Here, we characterized the intracellular dynamics of PVs and PYRs during spontaneous and visually evoked gamma activity in layers 2/3 of V1 of awake mice using targeted patch-clamp recordings and synchronous local field potentials (LFPs). Strong gamma activity patterned in short bouts (one to three cycles), occurred when PVs and PYRs were depolarizing and entrained their membrane potential dynamics regardless of the presence of visual stimulation. PV firing phase locked unconditionally to gamma activity. However, PYRs only phase locked to visually evoked gamma bouts. Taken together, our results indicate that gamma activity corresponds to short pulses of correlated background synaptic activity synchronizing the output of cortical neurons depending on external sensory drive.", "link"=>"http://www.mendeley.com/research/membrane-potential-dynamics-spontaneous-visually-evoked-gamma-activity-v1-awake-mice", "reader_count"=>58, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>17, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>5, "Student > Master"=>8, "Other"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>17, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>5, "Student > Master"=>8, "Other"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>21, "Neuroscience"=>23, "Physics and Astronomy"=>3, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>23}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}}, "reader_count_by_country"=>{"United States"=>3, "United Kingdom"=>1, "South Africa"=>1, "Israel"=>1, "France"=>1, "Switzerland"=>1, "Germany"=>1}, "group_count"=>4}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4235758"], "description"=>"<p>(<b>A</b>) Experimental design: LFP and two-photon targeted whole-cell (WC) or cell attached recordings of V1 L2/3 PVs and PYRs are performed in awake mice visually stimulated with drifting gratings. Right: micrograph taken during an example PV whole-cell recording. (<b>B</b>) Visual stimulation elicits an average increase in LFP power in the beta (12–28 Hz) and gamma (30–80 Hz) range. Left: grand mean spectro-temporal representation of LFP power around stimulation (<i>n</i> = 34; grey rectangle: visual stimulation period). Right: average power spectra during (Stim On: grey) and outside (Stim off: black) visual stimulation (shaded areas: +/- standard error of the mean (s.e.m); horizontal black line: statistical significance, False Detection Rate (FDR) corrected signed-rank test, α = 0.05). (<b>C, D</b>) Simultaneous LFP and whole-cell recordings of a PV (C) and a PYR (D) (Top: whole-cell recording; Middle: inverted LFP recording; Bottom: spectro-temporal representation of the LFP; grey rectangle: visual stimulation period). (<b>E</b>) Vm is correlated with the inverted LFP (-LFP) in PVs (<i>n</i> = 10) and PYR (<i>n</i> = 10; thin lines: individual neurons; thick line and filled circles with error bars: mean +/- s.e.m; **: <i>p</i> < 0.01, signed-rank test). (<b>F</b>) Vm is correlated with gamma power in PVs (<i>n</i> = 10) and PYRs (<i>n</i> = 10; thin lines: individual neurons; thick line and filled circles with error bars: mean +/- s.e.m; *: <i>p</i> < 0.05, signed-rank test).</p>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589040, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002383.g001", "stats"=>{"downloads"=>13, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/LFP_Gamma_power_correlates_with_the_membrane_potential_dynamics_of_PVs_and_PYRs_/2589040", "title"=>"LFP Gamma power correlates with the membrane potential dynamics of PVs and PYRs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 16:40:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/4235728", "https://ndownloader.figshare.com/files/4235731", "https://ndownloader.figshare.com/files/4235734", "https://ndownloader.figshare.com/files/4235737", "https://ndownloader.figshare.com/files/4235743", "https://ndownloader.figshare.com/files/4235746"], "description"=>"<div><p>Cortical gamma activity (30–80 Hz) is believed to play important functions in neural computation and arises from the interplay of parvalbumin-expressing interneurons (PV) and pyramidal cells (PYRs). However, the subthreshold dynamics underlying its emergence in the cortex of awake animals remain unclear. Here, we characterized the intracellular dynamics of PVs and PYRs during spontaneous and visually evoked gamma activity in layers 2/3 of V1 of awake mice using targeted patch-clamp recordings and synchronous local field potentials (LFPs). Strong gamma activity patterned in short bouts (one to three cycles), occurred when PVs and PYRs were depolarizing and entrained their membrane potential dynamics regardless of the presence of visual stimulation. PV firing phase locked unconditionally to gamma activity. However, PYRs only phase locked to visually evoked gamma bouts. Taken together, our results indicate that gamma activity corresponds to short pulses of correlated background synaptic activity synchronizing the output of cortical neurons depending on external sensory drive.</p></div>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589025, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>["https://dx.doi.org/10.1371/journal.pbio.1002383.s001", "https://dx.doi.org/10.1371/journal.pbio.1002383.s002", "https://dx.doi.org/10.1371/journal.pbio.1002383.s003", "https://dx.doi.org/10.1371/journal.pbio.1002383.s004", "https://dx.doi.org/10.1371/journal.pbio.1002383.s005", "https://dx.doi.org/10.1371/journal.pbio.1002383.s006"], "stats"=>{"downloads"=>5, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Membrane_Potential_Dynamics_of_Spontaneous_and_Visually_Evoked_Gamma_Activity_in_V1_of_Awake_Mice/2589025", "title"=>"Membrane Potential Dynamics of Spontaneous and Visually Evoked Gamma Activity in V1 of Awake Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-02-18 16:40:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/4235776"], "description"=>"<p>(<b>A, D</b>) Grand mean firing rate of PVs, outside (A, Stim Off) and during (D, Stim On) visual stimulation, as a function of gamma quintile at spike time (<i>n</i> = 23; error bars: s.e.m.; **: <i>p</i> < 0.01, ***: <i>p</i> < 0.001, signed rank test). (<b>B, E</b>) PV spikes occur preferentially before the trough of strong gamma outside (B) and during (E) visual stimulation (color-code in (E): fraction of spikes falling in one of ten bins of gamma phase as a function of gamma quintile at spike time; black and gray lines in (B) and (E): statistical difference from a uniform distribution, Rayleigh’s test, α = 10<sup>−5</sup>). (<b>C, F</b>) Strong gamma increases Spike-LFP Pairwise Phase Consistency (PPC) in the gamma range (30–80 Hz) outside (C) and during (F) visual stimulation (<i>n</i> = 23; light and dark blue traces: grand mean PPC respectively in the four weakest quintiles and in the strongest gamma quintile; shaded areas: +/- s.e.m; horizontal lines: statistical significance between the four weakest quintiles and the strongest gamma quintile (black) and between Stim Off and Stim On for the four weakest quintiles (light blue) and the strongest gamma quintile (dark blue), FDR corrected signed-rank test, α = 0.05).</p>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589058, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002383.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_firing_of_PVs_phase_locks_to_strong_gamma_oscillations_/2589058", "title"=>"The firing of PVs phase locks to strong gamma oscillations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 16:40:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/4235791"], "description"=>"<p>(<b>A, D</b>) Grand mean of trough-centered segments of the gamma-filtered LFP, outside (A) and during (D) visual stimulation, as a function of gamma quintile at trough time (<i>n</i> = 10; shaded areas: +/- s.e.m.). (<b>B, E</b>) Grand mean of simultaneously recorded PYR Vm segments (<i>n</i> = 10; shaded areas: +/- s.e.m.). (<b>C, F</b>) Strong gamma oscillations increase PYR Vm-LFP coherence in the gamma range (30–80 Hz) outside (C) and during (F) visual stimulation (<i>n</i> = 10; light and dark blue traces: grand mean coherence respectively in the four weakest quintiles and in the strongest gamma quintile; shaded areas: +/- s.e.m; black horizontal line: statistical significance between the four weakest quintiles and the strongest gamma quintile, FDR corrected signed-rank test, α = 0.05). (<b>G</b>) Grand mean DC Vm of PYRs as a function of gamma quintile outside (Stim Off, black) and during (Stim On, grey) visual stimulation (<i>n</i> = 10; error bars: s.e.m.; **: <i>p</i> < 0.01, signed-rank test). (<b>H</b>) Grand mean amplitude of gamma-centered Vm averages outside (Stim Off, black) and during (Stim On, grey) visual stimulation (<i>n</i> = 10; error bars: s.e.m.; **: <i>p</i> < 0.01, signed-rank test). (<b>I</b>) Grand mean slope of linear fits to gamma-centered Vm averages outside (Stim Off, black) and during (Stim On, grey) visual stimulation (<i>n</i> = 10; error bars: s.e.m.).</p>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589073, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002383.g006", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Strong_gamma_oscillations_entrain_Vm_in_PYRs_and_occur_when_PYRs_depolarize_/2589073", "title"=>"Strong gamma oscillations entrain Vm in PYRs and occur when PYRs depolarize.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 16:40:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/4235767"], "description"=>"<p>(<b>A</b>) Distribution of LFP gamma amplitude over time in an example PV recording. Quintiles are color-coded from light to dark blue as a function of gamma amplitude and represent amplitude ranges occurring during one-fifth of the recording time. (<b>B</b>) Visual stimulation biases LFP gamma amplitude toward the range of strong gamma quintiles (<i>n</i> = 34; red line: overall fraction of time spent in each quintile; error bars: s.e.m.; ***: <i>p</i> < 0.001, signed-rank test). (<b>C</b>) Example trace of the recording shown in (A) (top: whole-cell recording; middle: gamma-filtered LFP (light blue) and gamma amplitude envelope computed with the Hilbert transform (dark blue); bottom: gamma quintiles color coded as in (A); grey rectangle: visual stimulation period). (<b>D</b>) Enlargement of the portion enclosed in the black rectangle in (C) showing examples of spontaneous gamma bouts. (<b>E, F</b>) Distribution of the duration of gamma bouts outside (E, Stim Off) and during (F, Stim On) visual stimulation in gamma cycles (number hemicycles of the gamma filtered LFP divided by two; <i>n</i> = 34; error bars: s.e.m.; black line in (F): statistical difference between Stim Off and Stim On, FDR-corrected signed-rank test, α = 0.05).</p>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589049, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002383.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Gamma_occurs_in_short_bouts_/2589049", "title"=>"Gamma occurs in short bouts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 16:40:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/4235785"], "description"=>"<p>(<b>A, D</b>) Grand mean of trough-centered segments of the gamma-filtered LFP, outside (A) and during (D) visual stimulation, as a function of gamma quintile at trough time (<i>n</i> = 10; shaded areas: +/- s.e.m.). (<b>B, E</b>) Grand mean of simultaneously recorded PV Vm segments (<i>n</i> = 10; shaded areas: +/- s.e.m.). (<b>C, F</b>) Strong gamma oscillations increase PV Vm-LFP coherence in the gamma range (30–80 Hz) outside (C) and during (F) visual stimulation (<i>n</i> = 10; light and dark blue traces: grand mean coherence respectively in the four weakest quintiles and in the strongest gamma quintile; shaded areas: +/- s.e.m; black horizontal line: statistical significance between the four weakest quintiles and the strongest gamma quintile, FDR corrected signed-rank test, α = 0.05). (<b>G</b>) Grand mean DC Vm of PVs as a function of gamma quintile outside (Stim Off, black) and during (Stim On, grey) visual stimulation (<i>n</i> = 10; error bars: s.e.m.; *: <i>p</i> < 0.05, signed rank test). (<b>H</b>) Grand mean amplitude of gamma-centered Vm averages outside (Stim Off, black) and during (Stim On, grey) visual stimulation (<i>n</i> = 10; error bars: s.e.m.; **: <i>p</i> < 0.01, signed rank test). (<b>I</b>) Grand mean slope of linear fits to gamma-centered Vm averages outside (Stim Off, black) and during (Stim On, grey) visual stimulation (<i>n</i> = 10; error bars: s.e.m.; *: <i>p</i> < 0.05, **: <i>p</i> < 0.01, signed-rank test).</p>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589067, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002383.g004", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Strong_gamma_oscillations_entrain_Vm_in_PVs_and_occur_when_PVs_depolarize_/2589067", "title"=>"Strong gamma oscillations entrain Vm in PVs and occur when PVs depolarize.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 16:40:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/4235788"], "description"=>"<p>(<b>A, D</b>) Grand mean firing rate of PYRs, outside (A, Stim Off) and during (D, Stim On) visual stimulation, as a function of gamma quintile at spike time (<i>n</i> = 10; error bars: s.e.m.). (<b>B, E</b>) PYR spikes occur preferentially before the trough of strong gamma oscillations during (E) but not outside (B) visual stimulation (color-code in (E): fraction of spikes falling in one of ten bins of gamma phase as a function of gamma quintile at spike time; gray line in (E): statistical difference from a uniform distribution, Rayleigh’s test, α = 10<sup>−5</sup>). (<b>C, F</b>) Strong gamma increases spike-LFP PPC in the gamma range (30–80 Hz) during visual stimulation (F) but not outside (C) (<i>n</i> = 10; light and dark blue traces: pooled PPC respectively in the four weakest quintiles and in the strongest gamma quintile; shaded areas: +/- Jackknife 95% confidence interval; horizontal lines: statistical significance between the four weakest quintiles and the strongest gamma quintile [black] and between Stim Off and Stim On for the four weakest quintiles [light blue] and the strongest gamma quintile [dark blue], <a href=\"http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002383#sec010\" target=\"_blank\">Materials and Methods</a>).</p>", "links"=>[], "tags"=>["dynamic", "Evoked Gamma Activity", "PV", "LFP", "Strong gamma activity", "V 1", "gamma activity", "PYR", "background synaptic activity synchronizing"], "article_id"=>2589070, "categories"=>["Biochemistry", "Cell Biology", "Neuroscience", "Physiology", "Science Policy", "Biological Sciences not elsewhere classified", "Cancer", "Mental Health"], "users"=>["Quentin Perrenoud", "Cyriel M. A. Pennartz", "Luc J. Gentet"], "doi"=>"https://dx.doi.org/10.1371/journal.pbio.1002383.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_firing_of_PYRs_phase_locks_to_strong_gamma_oscillations_during_visual_stimulation_/2589070", "title"=>"The firing of PYRs phase locks to strong gamma oscillations during visual stimulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 16:40:13"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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