Sex Chromosome-wide Transcriptional Suppression and Compensatory Cis-Regulatory Evolution Mediate Gene Expression in the Drosophila Male Germline
Publication Date
July 12, 2016
Journal
PLOS Biology
Authors
Emily L. Landeen, Christina A. Muirhead, Lori Wright, Colin D. Meiklejohn, et al
Volume
14
Issue
7
Pages
e1002499
DOI
https://dx.plos.org/10.1371/journal.pbio.1002499
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1002499
Web of Science
000380768700001
Scopus
84980693220
Mendeley
http://www.mendeley.com/research/sex-chromosomewide-transcriptional-suppression-compensatory-cisregulatory-evolution-mediate-gene-exp
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Mendeley | Further Information

{"title"=>"Sex Chromosome-wide Transcriptional Suppression and Compensatory Cis-Regulatory Evolution Mediate Gene Expression in the Drosophila Male Germline", "type"=>"journal", "authors"=>[{"first_name"=>"Emily L.", "last_name"=>"Landeen", "scopus_author_id"=>"51161447500"}, {"first_name"=>"Christina A.", "last_name"=>"Muirhead", "scopus_author_id"=>"7005974614"}, {"first_name"=>"Lori", "last_name"=>"Wright", "scopus_author_id"=>"57196895232"}, {"first_name"=>"Colin D.", "last_name"=>"Meiklejohn", "scopus_author_id"=>"6602672818"}, {"first_name"=>"Daven C.", "last_name"=>"Presgraves", "scopus_author_id"=>"6602188861"}], "year"=>2016, "source"=>"PLoS Biology", "identifiers"=>{"sgr"=>"84982859383", "doi"=>"10.1371/journal.pbio.1002499", "pui"=>"611573159", "pmid"=>"27404402", "scopus"=>"2-s2.0-84982859383", "issn"=>"15457885"}, "id"=>"e1e7540b-5bf3-379d-86f2-d927ebe4ad04", "abstract"=>"The evolution of heteromorphic sex chromosomes has repeatedly resulted in the evolution of sex chromosome-specific forms of regulation, including sex chromosome dosage compensation in the soma and meiotic sex chromosome inactivation in the germline. In the male germline of Drosophila melanogaster, a novel but poorly understood form of sex chromosome-specific transcriptional regulation occurs that is distinct from canonical sex chromosome dosage compensation or meiotic inactivation. Previous work shows that expression of reporter genes driven by testis-specific promoters is considerably lower—approximately 3-fold or more—for transgenes inserted into X chromosome versus autosome locations. Here we characterize this transcriptional suppression of X-linked genes in the male germline and its evolutionary consequences. Using transgenes and transpositions, we show that most endogenous X-linked genes, not just testis-specific ones, are transcriptionally suppressed several-fold specifically in the Drosophila male germline. In wild-type testes, this sex chromosome-wide transcriptional suppression is generally undetectable, being effectively compensated by the gene-by-gene evolutionary recruitment of strong promoters on the X chromosome. We identify and experimentally validate a promoter element sequence motif that is enriched upstream of the transcription start sites of hundreds of testis-expressed genes; evolutionarily conserved across species; associated with strong gene expression levels in testes; and overrepresented on the X chromosome. These findings show that the expression of X-linked genes in the Drosophila testes reflects a balance between chromosome-wide epigenetic transcriptional suppression and long-term compensatory adaptation by sex-linked genes. Our results have broad implications for the evolution of gene expression in the Drosophila male germline and for genome evolution.", "link"=>"http://www.mendeley.com/research/sex-chromosomewide-transcriptional-suppression-compensatory-cisregulatory-evolution-mediate-gene-exp", "reader_count"=>69, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>29, "Other"=>3, "Student > Bachelor"=>10, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>29, "Other"=>3, "Student > Bachelor"=>10, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>38, "Agricultural and Biological Sciences"=>26}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>26}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>38}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"Netherlands"=>1}, "group_count"=>1}

Scopus | Further Information

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