Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
Publication Date
December 15, 2016
Authors
Wanil Kim, Andrew T. Ludlow, Jaewon Min, Jerome D. Robin, et al
Volume
14
Issue
12
Pages
e2000016
DOI
https://dx.plos.org/10.1371/journal.pbio.2000016
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.2000016
Web of Science
000392120100017
Scopus
85009090862
Mendeley
http://www.mendeley.com/research/regulation-human-telomerase-gene-tert-telomere-position-effectover-long-distances-tpeold-implication
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Mendeley | Further Information

{"title"=>"Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Wanil", "last_name"=>"Kim", "scopus_author_id"=>"7405813437"}, {"first_name"=>"Andrew T.", "last_name"=>"Ludlow", "scopus_author_id"=>"23980278300"}, {"first_name"=>"Jaewon", "last_name"=>"Min", "scopus_author_id"=>"57191968735"}, {"first_name"=>"Jerome D.", "last_name"=>"Robin", "scopus_author_id"=>"55314242700"}, {"first_name"=>"Guido", "last_name"=>"Stadler", "scopus_author_id"=>"23981607700"}, {"first_name"=>"Ilgen", "last_name"=>"Mender", "scopus_author_id"=>"55646001500"}, {"first_name"=>"Tsung Po", "last_name"=>"Lai", "scopus_author_id"=>"36793789800"}, {"first_name"=>"Ning", "last_name"=>"Zhang", "scopus_author_id"=>"57191613679"}, {"first_name"=>"Woodring E.", "last_name"=>"Wright", "scopus_author_id"=>"35420025000"}, {"first_name"=>"Jerry W.", "last_name"=>"Shay", "scopus_author_id"=>"7103373158"}], "year"=>2016, "source"=>"PLoS Biology", "identifiers"=>{"sgr"=>"85009090862", "doi"=>"10.1371/journal.pbio.2000016", "pui"=>"613987206", "pmid"=>"27977688", "scopus"=>"2-s2.0-85009090862", "issn"=>"15457885", "isbn"=>"1545-7885 (Electronic)\r1544-9173 (Linking)"}, "id"=>"75dc1266-4217-34d5-bcb8-65394e5b418a", "abstract"=>"Telomerase is expressed in early human development and then becomes silenced in most normal tissues. Because ~90% of primary human tumors express telomerase and generally maintain very short telomeres, telomerase is carefully regulated, particularly in large, long-lived mammals. In the current report, we provide substantial evidence for a new regulatory control mechanism of the rate limiting catalytic protein component of telomerase (hTERT) that is determined by the length of telomeres. We document that normal, young human cells with long telomeres have a repressed hTERT epigenetic status (chromatin and DNA methylation), but the epigenetic status is altered when telomeres become short. The change in epigenetic status correlates with altered expression of TERT and genes near to TERT, indicating a change in chromatin. Furthermore, we identified a chromosome 5p telomere loop to a region near TERT in human cells with long telomeres that is disengaged with increased cell divisions as telomeres progressively shorten. Finally, we provide support for a role of the TRF2 protein, and possibly TERRA, in the telomere looping maintenance mechanism through interactions with interstitial TTAGGG repeats. This provides new insights into how the changes in genome structure during replicative aging result in an increased susceptibility to age-related diseases and cancer prior to the initiation of a DNA damage signal.", "link"=>"http://www.mendeley.com/research/regulation-human-telomerase-gene-tert-telomere-position-effectover-long-distances-tpeold-implication", "reader_count"=>64, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>2, "Researcher"=>8, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>10, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>2, "Researcher"=>8, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>10, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>28, "Agricultural and Biological Sciences"=>19, "Medicine and Dentistry"=>7, "Social Sciences"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>19}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>28}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"Netherlands"=>1, "Czech Republic"=>1, "Italy"=>1}, "group_count"=>2}

Scopus | Further Information

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