Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector
Publication Date
April 12, 2017
Authors
Dawn L. Taylor Mulneix, Liron Bendor, Bodo Linz, Israel Rivera, et al
Volume
15
Issue
4
Pages
e2000420
DOI
https://dx.plos.org/10.1371/journal.pbio.2000420
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.2000420
Scopus
85019050201
Mendeley
http://www.mendeley.com/research/bordetella-bronchiseptica-exploits-complex-life-cycle-dictyostelium-discoideum-amplifying-transmissi
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Mendeley | Further Information

{"title"=>"Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector", "type"=>"journal", "authors"=>[{"first_name"=>"Dawn L.", "last_name"=>"Taylor-Mulneix", "scopus_author_id"=>"57194176657"}, {"first_name"=>"Liron", "last_name"=>"Bendor", "scopus_author_id"=>"37033395300"}, {"first_name"=>"Bodo", "last_name"=>"Linz", "scopus_author_id"=>"6603195490"}, {"first_name"=>"Israel", "last_name"=>"Rivera", "scopus_author_id"=>"56924881200"}, {"first_name"=>"Valerie E.", "last_name"=>"Ryman", "scopus_author_id"=>"55674927700"}, {"first_name"=>"Kalyan K.", "last_name"=>"Dewan", "scopus_author_id"=>"57194172131"}, {"first_name"=>"Shannon M.", "last_name"=>"Wagner", "scopus_author_id"=>"57194175891"}, {"first_name"=>"Emily F.", "last_name"=>"Wilson", "scopus_author_id"=>"57193058781"}, {"first_name"=>"Lindsay J.", "last_name"=>"Hilburger", "scopus_author_id"=>"57194175560"}, {"first_name"=>"Laura E.", "last_name"=>"Cuff", "scopus_author_id"=>"36980725200"}, {"first_name"=>"Christopher M.", "last_name"=>"West", "scopus_author_id"=>"7402187736"}, {"first_name"=>"Eric T.", "last_name"=>"Harvill", "scopus_author_id"=>"6701542885"}], "year"=>2017, "source"=>"PLoS Biology", "identifiers"=>{"pui"=>"615947488", "pmid"=>"28403138", "issn"=>"15457885", "doi"=>"10.1371/journal.pbio.2000420", "isbn"=>"2002015880", "scopus"=>"2-s2.0-85019050201", "sgr"=>"85019050201"}, "id"=>"e8e00f8f-a45a-357f-b792-a7835c074c08", "abstract"=>"Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined. The Bordetella virulence gene (BvgAS) two-component system, a paradigm for a global virulence regulon, controls the expression of many \"virulence factors\" expressed in the Bvg positive (Bvg+) phase that are necessary for successful respiratory tract infection. A similarly large set of highly conserved genes are expressed under Bvg negative (Bvg-) phase growth conditions; however, these appear to be primarily expressed outside of the host and are thus hypothesized to be important in an undefined extrahost reservoir. Here, we show that Bvg- phase genes are involved in the ability of Bordetella bronchiseptica to grow and disseminate via the complex life cycle of the amoeba Dictyostelium discoideum. Unlike bacteria that serve as an amoeba food source, B. bronchiseptica evades amoeba predation, survives within the amoeba for extended periods of time, incorporates itself into the amoeba sori, and disseminates along with the amoeba. Remarkably, B. bronchiseptica continues to be transferred with the amoeba for months, through multiple life cycles of amoebae grown on the lawns of other bacteria, thus demonstrating a stable relationship that allows B. bronchiseptica to expand and disperse geographically via the D. discoideum life cycle. Furthermore, B. bronchiseptica within the sori can efficiently infect mice, indicating that amoebae may represent an environmental vector within which pathogenic bordetellae expand and disseminate to encounter new mammalian hosts. These data identify amoebae as potential environmental reservoirs as well as amplifying and disseminating vectors for B. bronchiseptica and reveal an important role for the Bvg- phase in these interactions.", "link"=>"http://www.mendeley.com/research/bordetella-bronchiseptica-exploits-complex-life-cycle-dictyostelium-discoideum-amplifying-transmissi", "reader_count"=>27, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>8, "Agricultural and Biological Sciences"=>12, "Chemistry"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Belgium"=>1}, "group_count"=>0}

Scopus | Further Information

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