Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni", "type"=>"journal", "authors"=>[{"first_name"=>"Beile", "last_name"=>"Gao", "scopus_author_id"=>"9275727900"}, {"first_name"=>"Hanne", "last_name"=>"Vorwerk", "scopus_author_id"=>"56331990000"}, {"first_name"=>"Claudia", "last_name"=>"Huber", "scopus_author_id"=>"7203045457"}, {"first_name"=>"Maria", "last_name"=>"Lara-Tejero", "scopus_author_id"=>"6602550866"}, {"first_name"=>"Juliane", "last_name"=>"Mohr", "scopus_author_id"=>"55512288500"}, {"first_name"=>"Andrew L.", "last_name"=>"Goodman", "scopus_author_id"=>"7202697360"}, {"first_name"=>"Wolfgang", "last_name"=>"Eisenreich", "scopus_author_id"=>"7006598190"}, {"first_name"=>"Jorge E.", "last_name"=>"Galán", "scopus_author_id"=>"7102096155"}, {"first_name"=>"Dirk", "last_name"=>"Hofreuter", "scopus_author_id"=>"6603165936"}], "year"=>2017, "source"=>"PLoS Biology", "identifiers"=>{"issn"=>"15457885", "scopus"=>"2-s2.0-85020201074", "sgr"=>"85020201074", "pui"=>"616620605", "isbn"=>"1111111111", "pmid"=>"28542173", "doi"=>"10.1371/journal.pbio.2001390"}, "id"=>"6ab641ab-c47c-3869-97d1-b3e1dee89502", "abstract"=>"Campylobacter jejuni is one of the leading infectious causes of food-borne illness around the world. Its ability to persistently colonize the intestinal tract of a broad range of hosts, including food-producing animals, is central to its epidemiology since most infections are due to the consumption of contaminated food products. Using a highly saturated transposon insertion library combined with next-generation sequencing and a mouse model of infection, we have carried out a comprehensive genome-wide analysis of the fitness determinants for growth in vitro and in vivo of a highly pathogenic strain of C. jejuni. A comparison of the C. jejuni requirements to colonize the mouse intestine with those necessary to grow in different culture media in vitro, combined with isotopologue profiling and metabolic flow analysis, allowed us to identify its metabolic requirements to establish infection, including the ability to acquire certain nutrients, metabolize specific substrates, or maintain intracellular ion homeostasis. This comprehensive analysis has identified metabolic pathways that could provide the basis for the development of novel strategies to prevent C. jejuni colonization of food-producing animals or to treat human infections.", "link"=>"http://www.mendeley.com/research/metabolic-fitness-determinants-vitro-growth-intestinal-colonization-bacterial-pathogen-campylobacter", "reader_count"=>23, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>15, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}}, "reader_count_by_country"=>{"New Zealand"=>1, "Ecuador"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85020201074"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85020201074?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020201074&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85020201074&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85020201074", "dc:identifier"=>"SCOPUS_ID:85020201074", "eid"=>"2-s2.0-85020201074", "dc:title"=>"Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni", "dc:creator"=>"Gao B.", "prism:publicationName"=>"PLoS Biology", "prism:issn"=>"15449173", "prism:eIssn"=>"15457885", "prism:volume"=>"15", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-05-19", "prism:coverDisplayDate"=>"19 May 2017", "prism:doi"=>"10.1371/journal.pbio.2001390", "citedby-count"=>"12", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"South China Seas Institute of Oceanography Chinese Academy of Sciences", "affiliation-city"=>"Guangzhou", "affiliation-country"=>"China"}, {"@_fa"=>"true", "affilname"=>"Yale School of Medicine", "affiliation-city"=>"New Haven", "affiliation-country"=>"United States"}], "pubmed-id"=>"28542173", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e2001390", "source-id"=>"12977", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"233", "xml_views"=>"7", "html_views"=>"2578"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"165", "xml_views"=>"10", "html_views"=>"3201"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"35", "xml_views"=>"10", "html_views"=>"151"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"50", "xml_views"=>"2", "html_views"=>"154"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"35", "xml_views"=>"3", "html_views"=>"116"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"46", "xml_views"=>"8", "html_views"=>"125"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"173"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"7", "html_views"=>"74"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"74", "xml_views"=>"11", "html_views"=>"111"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"56", "xml_views"=>"4", "html_views"=>"56"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"68"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"6", "html_views"=>"59"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"8", "html_views"=>"54"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"4", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"5", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"40", "xml_views"=>"2", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"5", "html_views"=>"66"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"22"}

PMC Usage Stats

  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"61", "full-text"=>"64", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"38", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"41", "full-text"=>"36", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"56", "full-text"=>"38", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"23", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"34", "full-text"=>"37", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"28", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
Loading … Spinner
There are currently no alerts