Identifying genetic variants that affect viability in large cohorts
Publication Date
September 05, 2017
Authors
Hakhamanesh Mostafavi, Tomaz Berisa, Felix R. Day, John R. B. Perry, et al
Volume
15
Issue
9
Pages
e2002458
DOI
https://dx.plos.org/10.1371/journal.pbio.2002458
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.2002458
Scopus
85030673849
Mendeley
http://www.mendeley.com/research/identifying-genetic-variants-affect-viability-large-cohorts
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Identifying genetic variants that affect viability in large cohorts", "type"=>"journal", "authors"=>[{"first_name"=>"Hakhamanesh", "last_name"=>"Mostafavi", "scopus_author_id"=>"56734285600"}, {"first_name"=>"Tomaz", "last_name"=>"Berisa", "scopus_author_id"=>"57194750575"}, {"first_name"=>"Felix R.", "last_name"=>"Day", "scopus_author_id"=>"57188649095"}, {"first_name"=>"John R.B.", "last_name"=>"Perry", "scopus_author_id"=>"57195195144"}, {"first_name"=>"Molly", "last_name"=>"Przeworski", "scopus_author_id"=>"6603966439"}, {"first_name"=>"Joseph K.", "last_name"=>"Pickrell", "scopus_author_id"=>"26634283400"}], "year"=>2017, "source"=>"PLoS Biology", "identifiers"=>{"isbn"=>"1111111111", "sgr"=>"85030673849", "scopus"=>"2-s2.0-85030673849", "issn"=>"15457885", "pui"=>"618542607", "doi"=>"10.1371/journal.pbio.2002458", "arxiv"=>"085969", "pmid"=>"28873088"}, "id"=>"3b94daed-2374-38fb-bb1b-298c6d32baa1", "abstract"=>"A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness. As a step towards this goal, we developed a method to examine whether individual genetic variants, or sets of genetic variants, currently influence viability. The approach consists in testing whether the frequency of an allele varies across ages, accounting for variation in ancestry. We applied it to the Genetic Epidemiology Research on Aging (GERA) cohort and to the parents of participants in the UK Biobank . Across the genome , we find only a few common variants with large effects on age - ­‐specific mortality : tagging the APOE ε4 allele and near CHRNA3 . These results suggest that when large , even late onset effects are kept at low frequency by purifying selection . Testing viability effects of sets of genetic variants that jointly influence one of 42 traits , we detect a number of strong signals . In participants of the UK Biobank study of British ancestry , we find that variants that delay puberty timing are enriched in longer - ­‐lived parents (í µí±\u0083~6×10 '(", "link"=>"http://www.mendeley.com/research/identifying-genetic-variants-affect-viability-large-cohorts", "reader_count"=>164, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>8, "Researcher"=>40, "Student > Ph. D. Student"=>44, "Student > Postgraduate"=>3, "Other"=>10, "Student > Master"=>15, "Student > Bachelor"=>23, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>9}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>8, "Researcher"=>40, "Student > Ph. D. Student"=>44, "Student > Postgraduate"=>3, "Other"=>10, "Student > Master"=>15, "Student > Bachelor"=>23, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>9}, "reader_count_by_subject_area"=>{"Unspecified"=>18, "Agricultural and Biological Sciences"=>58, "Computer Science"=>6, "Economics, Econometrics and Finance"=>3, "Engineering"=>2, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>43, "Nursing and Health Professions"=>2, "Mathematics"=>2, "Medicine and Dentistry"=>7, "Neuroscience"=>2, "Physics and Astronomy"=>2, "Psychology"=>4, "Social Sciences"=>10, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>10}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>4}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>18}, "Environmental Science"=>{"Environmental Science"=>3}, "Engineering"=>{"Engineering"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>58}, "Computer Science"=>{"Computer Science"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>43}}, "reader_count_by_country"=>{"Finland"=>1, "Brazil"=>1}, "group_count"=>5}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85030673849"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85030673849?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85030673849&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85030673849&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85030673849", "dc:identifier"=>"SCOPUS_ID:85030673849", "eid"=>"2-s2.0-85030673849", "dc:title"=>"Identifying genetic variants that affect viability in large cohorts", "dc:creator"=>"Mostafavi H.", "prism:publicationName"=>"PLoS Biology", "prism:issn"=>"15449173", "prism:eIssn"=>"15457885", "prism:volume"=>"15", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-09-05", "prism:coverDisplayDate"=>"5 September 2017", "prism:doi"=>"10.1371/journal.pbio.2002458", "citedby-count"=>"14", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Columbia University in the City of New York", "affiliation-city"=>"New York", "affiliation-country"=>"United States"}], "pubmed-id"=>"28873088", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e2002458", "source-id"=>"12977", "openaccess"=>"1", "openaccessFlag"=>true}

Article Coverage Curated

Twitter

Counter

  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3207", "xml_views"=>"55", "html_views"=>"20523"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"490", "xml_views"=>"20", "html_views"=>"5643"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"184", "xml_views"=>"2", "html_views"=>"2162"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"134", "xml_views"=>"3", "html_views"=>"1260"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"176", "xml_views"=>"0", "html_views"=>"837"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"131", "xml_views"=>"5", "html_views"=>"420"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"132", "xml_views"=>"4", "html_views"=>"415"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"142", "xml_views"=>"4", "html_views"=>"446"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"79", "xml_views"=>"9", "html_views"=>"315"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"65", "xml_views"=>"13", "html_views"=>"188"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"47", "xml_views"=>"9", "html_views"=>"187"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"85", "xml_views"=>"10", "html_views"=>"186"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"90", "xml_views"=>"7", "html_views"=>"220"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"59", "xml_views"=>"8", "html_views"=>"245"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"64", "xml_views"=>"3", "html_views"=>"209"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"53", "xml_views"=>"6", "html_views"=>"199"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"51", "xml_views"=>"2", "html_views"=>"213"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"154"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"85", "xml_views"=>"7", "html_views"=>"178"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"72", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"67", "xml_views"=>"0", "html_views"=>"207"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"141"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"64"}

PMC Usage Stats

  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"64", "full-text"=>"57", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"39", "full-text"=>"35", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"22", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"96", "full-text"=>"29", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"81", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"36", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"9", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"24", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
Loading … Spinner
There are currently no alerts