Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
Publication Date
December 18, 2017
Authors
Andrew E. Shaw, Joseph Hughes, Quan Gu, Abdelkader Behdenna, et al
Volume
15
Issue
12
Pages
e2004086
DOI
https://dx.plos.org/10.1371/journal.pbio.2004086
Publisher URL
http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.2004086
Scopus
85040002649
Mendeley
http://www.mendeley.com/research/fundamental-properties-mammalian-innate-immune-system-revealed-multispecies-comparison-type-i-interf
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Mendeley | Further Information

{"title"=>"Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses", "type"=>"journal", "authors"=>[{"first_name"=>"Andrew E.", "last_name"=>"Shaw", "scopus_author_id"=>"8863043500"}, {"first_name"=>"Joseph", "last_name"=>"Hughes", "scopus_author_id"=>"55738339200"}, {"first_name"=>"Quan", "last_name"=>"Gu", "scopus_author_id"=>"56599737600"}, {"first_name"=>"Abdelkader", "last_name"=>"Behdenna", "scopus_author_id"=>"36631513100"}, {"first_name"=>"Joshua B.", "last_name"=>"Singer", "scopus_author_id"=>"57195981306"}, {"first_name"=>"Tristan", "last_name"=>"Dennis", "scopus_author_id"=>"57200167433"}, {"first_name"=>"Richard J.", "last_name"=>"Orton", "scopus_author_id"=>"10046378000"}, {"first_name"=>"Mariana", "last_name"=>"Varela", "scopus_author_id"=>"23096027200"}, {"first_name"=>"Robert J.", "last_name"=>"Gifford", "scopus_author_id"=>"15520423400"}, {"first_name"=>"Sam J.", "last_name"=>"Wilson", "scopus_author_id"=>"8725657900"}, {"first_name"=>"Massimo", "last_name"=>"Palmarini", "scopus_author_id"=>"6603800293"}], "year"=>2017, "source"=>"PLoS Biology", "identifiers"=>{"doi"=>"10.1371/journal.pbio.2004086", "issn"=>"15457885", "pmid"=>"29253856", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85040002649", "pui"=>"620025262", "sgr"=>"85040002649"}, "id"=>"89758110-d5f7-3742-a94e-e586ed7343fa", "abstract"=>"The host innate immune response mediated by type I interferon (IFN) and the resulting up- regulation of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to virus infection. Studies of the type I ‘interferome’ have mainly been carried out at a single species level, often lacking the power necessary to understand key evolutionary features of this pathway. Here, using a single experimental platform, we determined the properties of the interferomes of multiple vertebrate species and developed a webserver to mine the data- set. This approach revealed a conserved ‘core’ of 62 ISGs, including genes not previously associated with IFN, underscoring the ancestral functions associated with this antiviral host response. Weshow that gene expansion contributes to the evolution of the IFN system and that interferomes are shaped by lineage-specific pressures. Consequently, each mammal possesses a unique repertoire of ISGs, including genes common to all mammals and others unique to their specific species or phylogenetic lineages. An analysis of genes commonly down-regulated by IFN suggests that epigenetic regulation of transcription is a fundamental aspect of the IFN response. Our study provides a resource for the scientific community highlighting key paradigms of the type I IFN response", "link"=>"http://www.mendeley.com/research/fundamental-properties-mammalian-innate-immune-system-revealed-multispecies-comparison-type-i-interf", "reader_count"=>30, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>4, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>4, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>7, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>9, "Immunology and Microbiology"=>7}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>5}}, "group_count"=>1}

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Scopus | Further Information

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