A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes
Publication Date
November 11, 2005
Journal
PLOS Computational Biology
Authors
Daniel H Haft, Jeremy Selengut, Emmanuel F Mongodin & Karen E Nelson
Volume
1
Issue
6
Pages
e60
DOI
https://dx.plos.org/10.1371/journal.pcbi.0010060
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.0010060
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/16292354
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282333
Europe PMC
http://europepmc.org/abstract/MED/16292354
Web of Science
000234713300005
Events
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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/960792"], "description"=>"<div><p>A representative selection of Cas1 protein sequences were aligned using ClustalW, and columns with greater than 20% gaps were removed. A neighbor-joining tree was calculated in Belvu using the Storm and Sonnhammer distance correction. Trees calculated using more computationally intensive methods showed insignificant differences.</p><p><sup>a</sup>From the preliminary annotation of the <i>Haloferax volcanii</i> genome, currently sequenced at The Institute for Genomic Research (<a href=\"http://www.tigr.org/tdb/mdb/mdbinprogress.html\" target=\"_blank\">http://www.tigr.org/tdb/mdb/mdbinprogress.html</a>).</p></div>", "links"=>[], "tags"=>["phylogeny", "cas1", "54", "prokaryotic"], "article_id"=>630793, "categories"=>["Biological Sciences", "Microbiology", "Evolutionary Biology"], "users"=>["Daniel H Haft", "Jeremy Selengut", "Emmanuel F Mongodin", "Karen E Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0010060.g002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Molecular_Phylogeny_of_the_Cas1_Protein_across_54_Prokaryotic_Genomes_/630793", "title"=>"Molecular Phylogeny of the Cas1 Protein across 54 Prokaryotic Genomes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:52:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/960659"], "description"=>"<div><p>The taxonomy of each species/strain is indicated on the left side of the figure. The CRISPR/<i>cas</i> loci of a number of illustrative examples for the different CRISPR subtypes are displayed on the right side of the figure.</p><p><sup>a</sup><i>E. coli</i> K12-MG1655, O157:H7 EDL933, and O157:H7 VT2-Sakai.</p><p><sup>b</sup><i>Salmonella enterica</i> Paratyphi ATCC9150, serovar Typhi CT18, and Ty2; <i>Salmonella typhimurium</i> LT2 SGSC1412.</p><p><sup>c</sup><i>Y. pestis</i> CO92, KIM, and biovar Mediaevalis 91001; <i>Yersinia pseudotuberculosis</i> IP32593.</p><p><sup>d</sup>“<i>p</i>” indicates a partial cluster lacking some of the genes usually associated with this subtype, the repeats, or both. Such clusters may represent autonomous functional units, degradation from the common subtype, or cases in which the missing components are supplied by distantly located CRISPR clusters within the same genome.</p></div>", "links"=>[], "tags"=>["subtypes", "prokaryotic", "whole-genome"], "article_id"=>630662, "categories"=>["Biological Sciences", "Microbiology", "Evolutionary Biology"], "users"=>["Daniel H Haft", "Jeremy Selengut", "Emmanuel F Mongodin", "Karen E Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0010060.g001", "stats"=>{"downloads"=>5, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_the_Different_CRISPR_Cas_Subtypes_across_Some_of_the_Prokaryotic_Species_for_Which_a_Whole_Genome_Sequence_Is_Available_/630662", "title"=>"Distribution of the Different CRISPR/Cas Subtypes across Some of the Prokaryotic Species for Which a Whole-Genome Sequence Is Available", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:51:44"}

PMC Usage Stats | Further Information

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Relative Metric

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