Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches", "type"=>"journal", "authors"=>[{"first_name"=>"Feilim", "last_name"=>"Mac Gabhann", "scopus_author_id"=>"9845563500"}, {"first_name"=>"Aleksander S.", "last_name"=>"Popel", "scopus_author_id"=>"7007057177"}], "year"=>2006, "source"=>"PLoS Computational Biology", "identifiers"=>{"issn"=>"1553734X", "scopus"=>"2-s2.0-33846025118", "sgr"=>"33846025118", "pui"=>"46045177", "isbn"=>"1553-7358 (Electronic)\\r1553-734X (Linking)", "pmid"=>"17196035", "doi"=>"10.1371/journal.pcbi.0020180"}, "id"=>"e1c5bea2-0c95-3e1c-9a1f-120911246ee7", "abstract"=>"Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and pathological conditions including cancer, cardiovascular disease, and wound healing. Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis. Multiple VEGF receptors are expressed on endothelial cells, including signaling receptor tyrosine kinases (VEGFR1 and VEGFR2) and the nonsignaling co-receptor Neuropilin-1. Neuropilin-1 binds only the isoform of VEGF responsible for pathological angiogenesis (VEGF165), and is thus a potential target for inhibiting VEGF signaling. Using the first molecularly detailed computational model of VEGF and its receptors, we have shown previously that the VEGFR-Neuropilin interactions explain the observed differential effects of VEGF isoforms on VEGF signaling in vitro, and demonstrated potent VEGF inhibition by an antibody to Neuropilin-1 that does not block ligand binding but blocks subsequent receptor coupling. In the present study, we extend that computational model to simulation of in vivo VEGF transport and binding, and predict the in vivo efficacy of several Neuropilin-targeted therapies in inhibiting VEGF signaling: (a) blocking Neuropilin-1 expression; (b) blocking VEGF binding to Neuropilin-1; (c) blocking Neuropilin-VEGFR coupling. The model predicts that blockade of Neuropilin-VEGFR coupling is significantly more effective than other approaches in decreasing VEGF-VEGFR2 signaling. In addition, tumor types with different receptor expression levels respond differently to each of these treatments. In designing human therapeutics, the mechanism of attacking the target plays a significant role in the outcome: of the strategies tested here, drugs with similar properties to the Neuropilin-1 antibody are predicted to be most effective. The tumor type and the microenvironment of the target tissue are also significant in determining therapeutic efficacy of each of the treatments studied.", "link"=>"http://www.mendeley.com/research/targeting-neuropilin1-inhibit-vegf-signaling-cancer-comparison-therapeutic-approaches-10", "reader_count"=>52, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Engineering"=>8, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Mathematics"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>27, "Chemistry"=>3, "Computer Science"=>1, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>8}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>27}, "Computer Science"=>{"Computer Science"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Japan"=>1, "Slovenia"=>1, "France"=>1, "Switzerland"=>1, "Germany"=>2}, "group_count"=>7}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/33846025118"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/33846025118?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33846025118&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33846025118&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/33846025118", "dc:identifier"=>"SCOPUS_ID:33846025118", "eid"=>"2-s2.0-33846025118", "dc:title"=>"Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches", "dc:creator"=>"Mac Gabhann F.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"2", "prism:issueIdentifier"=>"12", "prism:pageRange"=>"1649-1662", "prism:coverDate"=>"2006-12-01", "prism:coverDisplayDate"=>"December 2006", "prism:doi"=>"10.1371/journal.pcbi.0020180", "citedby-count"=>"56", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Johns Hopkins University", "affiliation-city"=>"Baltimore", "affiliation-country"=>"United States"}], "pubmed-id"=>"17196035", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%252Fjournal.pcbi.0020180", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"11", "year"=>"2006", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2006", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"1", "year"=>"2007", "pdf_views"=>"106", "xml_views"=>"1", "html_views"=>"248"}
  • {"month"=>"2", "year"=>"2007", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"3", "year"=>"2007", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"4", "year"=>"2007", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"5", "year"=>"2007", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"6", "xml_views"=>"5", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"80"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"5", "html_views"=>"67"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"368"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"4", "html_views"=>"68"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"75"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"91"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"84"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"56"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"31"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"74"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"4", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"8"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/954149"], "description"=>"<p>Tissues that express low levels of Neuropilin-1 are insensitive to all Neuropilin-targeting treatments. The inhibition of VEGF–VEGFR2 signaling is directly proportional to Neuropilin-1 density (A–C), except at very high Neuropilin levels, which can overcome the inhibition. Tissues that express intermediate and high levels of Neuropilin-1 are further distinguished by the level of expression of VEGFR1. Blocking VEGFR–Neuropilin coupling is the most effective treatment to reduce VEGF–VEGFR2 signaling for tissues with any VEGFR1 expression level. However, in high VEGFR1 tissues, the other treatments are also quite effective. All three treatments significantly induce VEGF–VEGFR1 complex formation (D–F). The circles in each figure denote the conditions for <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g003\" target=\"_blank\">Figures 3</a> and <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g004\" target=\"_blank\">4</a> (left, VEGFR1 actually zero in simulations) and <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g005\" target=\"_blank\">Figures 5</a> and <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g006\" target=\"_blank\">6</a> (right) to compare the efficacy of the treatments for different tumors. The results shown are for a Neuropilin-1 expression knockdown to 1%, for 1 μM PlGF<sub>2Δ</sub>, and 1 μM Ab<sub>NRP</sub>.</p>", "links"=>[], "tags"=>["specificity", "neuropilin-targeted", "inhibition", "vegf"], "article_id"=>624448, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g007", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_Specificity_of_Neuropilin_Targeted_Inhibition_of_VEGF_Signaling_/624448", "title"=>"Tissue Specificity of Neuropilin-Targeted Inhibition of VEGF Signaling", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:56:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/953826"], "description"=>"<div><p>(A–C) The time course of VEGF–VEGFR2 complex formation on the endothelial cells following each of the three treatments. For blocking VEGF–Neuropilin-1 binding (B) and VEGFR–Neuropilin-1 coupling (C), this figure represents bolus intratissue protein delivery at time 0. For Neuropilin-1 expression blockade, insertion of Neuropilin-1 into the membrane decreases to the indicated level at time 0. The VEGF<sub>121</sub>–VEGFR2 binding curve is indistinguishable from the no-treatment line in each case. The tumor modeled here expresses 10,000 VEGFR2 and 100,000 Neuropilin per endothelial cell.</p><p>(D–F) Free (unbound) VEGF concentration in the interstitial space. *VEGF<sub>121</sub> secreted at the same rate as VEGF<sub>165</sub>.</p><p>(G–I) The concentration of VEGF inhibitor in the interstitial space, or density of Neuropilin, on the blood vessel endothelial cell surface.</p></div>", "links"=>[], "tags"=>["binding", "vegfr2", "vivo", "inhibited", "targeting"], "article_id"=>624129, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g003", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_VEGF_Binding_to_VEGFR2_In_Vivo_Is_Inhibited_by_Targeting_Neuropilin_1_/624129", "title"=>"VEGF Binding to VEGFR2 In Vivo Is Inhibited by Targeting Neuropilin-1", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:54:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/954345"], "description"=>"<p>The gray lines represent the case of 2% vascular volume (as depicted in <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g004\" target=\"_blank\">Figure 4</a>); the colored lines represent a 4.2% vascular volume. The peak inhibition due to the blockade of VEGFR–Neuropilin coupling is the same for both vascular densities; however, the peak for the other two treatments is lower. Endothelial cells expressing 10,000 VEGFR2 and 100,000 Neuropilin-1.</p>", "links"=>[], "tags"=>["vegf", "48", "inhibition", "higher", "microvascular"], "article_id"=>624641, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g009", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_VEGF_Signaling_for_the_48_Hours_Following_Treatment_Inhibition_Is_Decreased_at_Higher_Microvascular_Density_/624641", "title"=>"Average VEGF Signaling for the 48 Hours Following Treatment Inhibition Is Decreased at Higher Microvascular Density", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:58:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/953901"], "description"=>"<p>The average inhibition of VEGF–VEGFR2 complex formation over the 48 hours following blockade of Neuropilin-1 expression (A), or bolus intratissue protein delivery (B) of competitive binding inhibitor or VEGFR–Neuropilin-1 coupling blocker. Endothelial cells expressing 10,000 VEGFR2 and 100,000 Neuropilin-1.</p>", "links"=>[], "tags"=>["cell biology", "Computational biology", "molecular biology", "oncology"], "article_id"=>624202, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g004", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_VEGF_8211_VEGFR2_Signaling_Inhibition_/624202", "title"=>"Average VEGF–VEGFR2 Signaling Inhibition", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:55:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/954069"], "description"=>"<p>Endothelial cells expressing 10,000 VEGFR1, 10,000 VEGFR2, and 100,000 Neuropilin-1.</p>", "links"=>[], "tags"=>["inhibition", "48"], "article_id"=>624371, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_VEGF_8211_VEGFR2_Signaling_Inhibition_over_the_48_Hours_Following_Treatment_/624371", "title"=>"Average VEGF–VEGFR2 Signaling Inhibition over the 48 Hours Following Treatment", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:56:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/954261"], "description"=>"<div><p>(A–C) VEGF–VEGFR2 complex formation on the endothelial cells following each of the three treatments. The tumor modeled here expresses 10,000 VEGFR2 and 100,000 Neuropilin per endothelial cell. Gray lines represent the case of 2% vascular volume, as depicted in <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g003\" target=\"_blank\">Figure 3</a>; the black lines represent 4.2% vascular volume. Note that while the 10<sup>3</sup>/cell, pM, and nM scales apply to both the gray and black lines, the pmol/L tissue scales apply only to the black lines; the normalization is different for the gray lines (see <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g003\" target=\"_blank\">Figure 3</a> for the correct scales).</p><p>(D–F) Free (unbound) VEGF concentration in the interstitial space. *VEGF<sub>121</sub> secreted at the same rate as VEGF<sub>165</sub>.</p><p>(G–I) The concentration of VEGF inhibitor in the interstitial space, or density of Neuropilin on the blood vessel endothelial cell surface.</p></div>", "links"=>[], "tags"=>["inhibition", "shorter", "higher", "microvascular"], "article_id"=>624565, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g008", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_VEGF_Signaling_Inhibition_Is_Effective_for_a_Shorter_Period_of_Time_for_a_Tissue_with_a_Higher_Microvascular_Density_/624565", "title"=>"VEGF Signaling Inhibition Is Effective for a Shorter Period of Time for a Tissue with a Higher Microvascular Density", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:57:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/953748"], "description"=>"<div><p>(A) VEGF<sub>121</sub> binds to VEGFR2 but not Neuropilin-1. VEGF<sub>165</sub> binds both receptors as well as GAG chains in the interstitial space. VEGF<sub>165</sub> bound to Neuropilin-1 can diffuse laterally on the cell membrane and bind VEGFR2 (and vice versa), coupling these receptors together, even though the receptors themselves do not interact.</p><p>(B) VEGF<sub>121</sub> and VEGF<sub>165</sub> both bind VEGFR1. Neuropilin-1 and VEGFR1 interact directly, forming a complex that is permissive for VEGF<sub>121</sub> binding but not VEGF<sub>165</sub>.</p><p>(C) Inhibition of Neuropilin-1 expression results in a decrease in the insertion rate of Neuropilin receptors into the cell membrane (s<sub>N</sub>).</p><p>(D) PlGF<sub>2Δ</sub>, a fragment of placental growth factor, competes with VEGF<sub>165</sub> for the binding site on Neuropilin-1.</p><p>(E) An antibody to Neuropilin-1 that does not interfere with VEGF<sub>165</sub> binding can block the coupling of VEGF<sub>165</sub>–Neuropilin to VEGFR2, resulting in sequestration of VEGF on nonsignaling Neuropilin.</p></div>", "links"=>[], "tags"=>["receptors", "interstitial", "gag", "binding"], "article_id"=>624054, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g002", "stats"=>{"downloads"=>4, "page_views"=>174, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interactions_between_VEGF_121_VEGF_165_and_Their_Cell_Surface_Receptors_VEGFR1_VEGFR2_and_Neuropilin_1_and_Interstitial_GAG_Binding_Sites_/624054", "title"=>"Interactions between VEGF<sub>121</sub>, VEGF<sub>165</sub>, and Their Cell Surface Receptors VEGFR1, VEGFR2, and Neuropilin-1, and Interstitial GAG Binding Sites", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:54:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/953985"], "description"=>"<div><p>(A–C) Formation of VEGF–VEGFR2 complexes over time following anti-Neuropilin treatment, for a tumor expressing 10,000 VEGFR1 per endothelial cell in addition to the VEGFR2 and Neuropilin-1 expression of <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g003\" target=\"_blank\">Figures 3</a> and <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020180#pcbi-0020180-g004\" target=\"_blank\">4</a>.</p><p>(D–F) VEGF–VEGFR1 complex formation.</p><p>(G–I) Free (unbound) interstitial VEGF concentration. *VEGF<sub>121</sub> secreted at the same rate as VEGF<sub>165</sub>.</p></div>", "links"=>[], "tags"=>["expressing", "vegfr1", "responds"], "article_id"=>624284, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_Expressing_High_VEGFR1_Levels_Responds_Differently_to_Treatment_/624284", "title"=>"Tissue Expressing High VEGFR1 Levels Responds Differently to Treatment", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:55:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/953656"], "description"=>"<div><p>(A) Schematic of the in vivo model. Parenchymal cells secrete VEGF; VEGF<sub>121</sub> is freely diffusible, but VEGF<sub>165</sub> can be sequestered by proteoglycans in the ECM (light gray) and the basement membranes (dark gray). The isoforms bind to VEGF receptors on the endothelial cells.</p><p>(B) VEGF isoforms bind to VEGFR2 that transduces the angiogenic signal intracellularly. VEGF<sub>121</sub> does not bind Neuropilin-1; VEGF<sub>165</sub> may bind both VEGFR2 and Neuropilin-1 simultaneously. Thus there are two pathways for the binding of VEGF<sub>165</sub> to the signaling VEGFR2 receptor: first by binding directly, and second by binding Neuropilin-1 and then diffusing laterally on the cell surface to couple to VEGFR2. VEGFR1, which modulates the signaling of VEGFR2, binds both isoforms of VEGF. VEGFR1 also binds directly to Neuropilin-1. This complex is permissive for VEGF<sub>121</sub>–VEGFR1 binding but not VEGF<sub>165</sub>–VEGFR1; thus, high levels of Neuropilin-1 displace VEGF<sub>165</sub> from VEGFR1, making it available for VEGFR2 binding. Only VEGF<sub>165</sub> binds directly to the ECM binding site (represented by GAG chains).</p><p>(C) By targeting Neuropilin-1, we can target specifically VEGF<sub>165</sub>-induced signaling. Three methods for targeting Neuropilin-1 are analyzed here: blockade of Neuropilin-1 expression (e.g., using siRNA); blockade of VEGF–Neuropilin binding (e.g., using a fragment of placental growth factor to occupy the binding site); and blockade of VEGFR–Neuropilin coupling (e.g., using an antibody for Neuropilin-1 that does not interfere with VEGF–Neuropilin binding).</p></div>", "links"=>[], "tags"=>["vegf", "receptor", "therapeutic"], "article_id"=>623965, "categories"=>["Molecular Biology", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Feilim Mac Gabhann", "Aleksander S Popel"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.0020180.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematics_of_VEGF_Transport_in_Tumors_VEGF_Receptor_Binding_and_Therapeutic_Strategies_/623965", "title"=>"Schematics of VEGF Transport in Tumors, VEGF Receptor Binding, and Therapeutic Strategies", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:53:35"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"7", "unique-ip"=>"12", "pdf"=>"6", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2010", "pdf"=>"6", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"9", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "year"=>"2010", "pdf"=>"1", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"10", "pdf"=>"4", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2010", "pdf"=>"6", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"2", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"9", "year"=>"2010", "pdf"=>"13", "unique-ip"=>"15", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"12", "unique-ip"=>"13", "pdf"=>"6", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2010", "pdf"=>"12", "unique-ip"=>"12", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"6", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"3", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"2", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "unique-ip"=>"6", "pdf"=>"6", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"8", "year"=>"2011", "pdf"=>"0", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"5", "unique-ip"=>"6", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"7", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "unique-ip"=>"9", "pdf"=>"1", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"2", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"5", "pdf"=>"5", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"8", "pdf"=>"6", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"11", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"8", "pdf"=>"4", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"9", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"95", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"34", "figure"=>"276", "scanned-summary"=>"144", "supp-data"=>"114"}
  • {"scanned-page-browse"=>"61", "month"=>"2", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"12", "pdf"=>"0", "year"=>"2007", "figure"=>"171", "scanned-summary"=>"96", "supp-data"=>"86"}
  • {"month"=>"3", "scanned-page-browse"=>"50", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"6", "figure"=>"134", "scanned-summary"=>"76", "supp-data"=>"73"}
  • {"scanned-page-browse"=>"30", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"6", "pdf"=>"0", "year"=>"2007", "figure"=>"80", "scanned-summary"=>"44", "supp-data"=>"58"}
  • {"month"=>"5", "scanned-page-browse"=>"27", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"12", "figure"=>"94", "scanned-summary"=>"55", "supp-data"=>"43"}
  • {"scanned-page-browse"=>"22", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"7", "pdf"=>"0", "year"=>"2007", "figure"=>"70", "scanned-summary"=>"40", "supp-data"=>"32"}
  • {"month"=>"7", "scanned-page-browse"=>"18", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"51", "scanned-summary"=>"28", "supp-data"=>"24"}
  • {"scanned-page-browse"=>"27", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"3", "pdf"=>"0", "year"=>"2007", "figure"=>"64", "scanned-summary"=>"31", "supp-data"=>"32"}
  • {"month"=>"9", "scanned-page-browse"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"2", "figure"=>"33", "scanned-summary"=>"19", "supp-data"=>"20"}
  • {"scanned-page-browse"=>"12", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"6", "pdf"=>"0", "year"=>"2007", "figure"=>"41", "scanned-summary"=>"23", "supp-data"=>"22"}
  • {"month"=>"11", "scanned-page-browse"=>"16", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"5", "figure"=>"46", "scanned-summary"=>"23", "supp-data"=>"27"}
  • {"scanned-page-browse"=>"28", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2007", "figure"=>"68", "scanned-summary"=>"34", "supp-data"=>"33"}
  • {"month"=>"1", "scanned-page-browse"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"50", "scanned-summary"=>"31", "supp-data"=>"31"}
  • {"scanned-page-browse"=>"23", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2008", "figure"=>"51", "scanned-summary"=>"22", "supp-data"=>"20"}
  • {"month"=>"3", "scanned-page-browse"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"34", "scanned-summary"=>"21", "supp-data"=>"19"}
  • {"scanned-page-browse"=>"21", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"16", "pdf"=>"0", "year"=>"2008", "figure"=>"65", "scanned-summary"=>"28", "supp-data"=>"22"}
  • {"month"=>"5", "scanned-page-browse"=>"13", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"5", "figure"=>"35", "scanned-summary"=>"16", "supp-data"=>"15"}
  • {"scanned-page-browse"=>"1", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2008", "figure"=>"10", "scanned-summary"=>"6", "supp-data"=>"7"}
  • {"month"=>"7", "scanned-page-browse"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"10", "figure"=>"38", "scanned-summary"=>"17", "supp-data"=>"13"}
  • {"scanned-page-browse"=>"6", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2008", "figure"=>"24", "scanned-summary"=>"14", "supp-data"=>"17"}
  • {"month"=>"9", "scanned-page-browse"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"22", "scanned-summary"=>"10", "supp-data"=>"17"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "unique-ip"=>"17", "pdf"=>"19", "year"=>"2008", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "year"=>"2008", "pdf"=>"16", "unique-ip"=>"17", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "unique-ip"=>"21", "pdf"=>"13", "year"=>"2008", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "year"=>"2009", "pdf"=>"7", "unique-ip"=>"14", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"9", "unique-ip"=>"13", "pdf"=>"7", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"29", "year"=>"2009", "pdf"=>"18", "unique-ip"=>"22", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"14", "pdf"=>"9", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "year"=>"2009", "pdf"=>"6", "unique-ip"=>"17", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"6", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"2", "full-text"=>"7", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"9", "pdf"=>"2", "year"=>"2009", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2009", "pdf"=>"8", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "unique-ip"=>"3", "pdf"=>"1", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "year"=>"2009", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"8", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"35", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"0", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2006-01-01T00:00:00Z", "end_date"=>"2006-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[273, 883, 1129, 1240, 1339, 1450, 1551, 1621, 1699, 1757, 1826, 1915, 1973, 2047, 2120, 2194, 2238, 2293, 2378, 2440, 2473, 2512, 2625, 2691, 2766, 2809, 2895, 2958, 3014, 3100, 3175, 3220, 3283, 3332, 3387, 3416, 3466, 3515, 3594, 3648, 3696, 3753, 3804, 3867, 3927, 3980, 4023, 4098, 4152, 4207, 4257, 4320, 4361, 4426, 4477, 4516, 4575, 4600, 4649, 4698, 4760, 4827, 4869, 4929, 5005, 5052, 5127, 5170, 5226, 5295, 5371, 5440, 5474, 5501, 5595, 5748, 5826, 5893, 5948, 5998, 6140, 6219, 6285, 6351, 6452, 6513, 6562, 6618, 6690, 6760, 6820, 6862, 6890, 6915, 6953, 7060, 7084]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[254, 1007, 1335, 1458, 1619, 1705, 1802, 1885, 1991, 2101, 2155, 2217, 2297, 2340, 2406, 2474, 2552, 2618, 2662, 2719, 2780, 2832, 2902, 2962, 3046, 3113, 3197, 3287, 3400, 3471, 3550, 3628, 3723, 3809, 3884, 3938, 3982, 4017, 4055, 4092, 4148, 4179, 4226, 4279, 4368, 4448, 4515, 4563, 4616, 4689, 4741, 4786, 4827, 4853, 4883, 4940, 4988, 5053, 5107, 5162, 5227, 5276, 5332, 5392, 5480, 5541, 5599, 5659, 5729, 5807, 5866, 5922, 5995, 6061, 6115, 6164, 6249, 6360, 6435, 6496, 6548, 6607, 6729, 6797, 6913, 6985, 7091, 7197, 7312, 7397, 7461, 7538, 7611, 7696, 7822, 7908, 7944]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[273, 880, 1132, 1273, 1358, 1457, 1551, 1621, 1699, 1757, 1826, 1907, 1961, 2035, 2111, 2191, 2238, 2290, 2363, 2410, 2449, 2508, 2625, 2691, 2785, 2845, 2899, 2966, 3016, 3106, 3204, 3278, 3347, 3372, 3393, 3448, 3497, 3558, 3600, 3649, 3710, 3781, 3841, 3892, 4003, 4065, 4104, 4142, 4186, 4216, 4257, 4320, 4361, 4426, 4477, 4516, 4575, 4644, 4700, 4779, 4842, 4900, 4932, 4965, 5014, 5179, 5212, 5287, 5348, 5380, 5422, 5459, 5508, 5578, 5651, 5748, 5847, 5917, 5971, 6009, 6068, 6204, 6242, 6327, 6414, 6475, 6555, 6605, 6642, 6691, 6794, 6858, 6890, 6915, 6953, 7060, 7084]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[272, 843, 1058, 1195, 1304, 1387, 1511, 1569, 1643, 1741, 1791, 1847, 1897, 1935, 1990, 2044, 2092, 2155, 2186, 2256, 2276, 2307, 2370, 2453, 2527, 2618, 2679, 2736, 2784, 2853, 2888, 2918, 2985, 3029, 3123, 3182, 3248, 3305, 3369, 3427, 3474, 3536, 3602, 3654, 3722, 3764, 3809, 3856, 3899, 3961, 4022, 4059, 4108, 4139, 4176, 4221, 4273, 4329, 4388, 4417, 4467, 4506, 4552, 4589, 4629, 4696, 4762, 4845, 4917, 4965, 5029, 5079, 5139, 5181, 5211, 5256, 5371, 5438, 5480, 5543, 5685, 5727, 5775, 5826]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[231, 843, 1040, 1180, 1269, 1355, 1437, 1538, 1590, 1629, 1684, 1780, 1810, 1851, 1893, 1933, 1987, 2039, 2097, 2144, 2182, 2215, 2330, 2385, 2434, 2471, 2507, 2546, 2586, 2625, 2667, 2700, 2733, 2854, 2960, 3004, 3045, 3089, 3149, 3196, 3234, 3292, 3328, 3366, 3425, 3471, 3517, 3564, 3602, 3664, 3724, 3776, 3801, 3838, 3923, 3989, 4022, 4053, 4078, 4118, 4152, 4182, 4213, 4225, 4258, 4281, 4304, 4331, 4356, 4396, 4435, 4469, 4501, 4540, 4592, 4647, 4716, 4883, 4932, 4971, 5045, 5147, 5260, 5300, 5374, 5492, 5613, 5745, 5943, 6024, 6101, 6226, 6296, 6374, 6443, 6503, 6559]}]}
Loading … Spinner
There are currently no alerts